{"id":"https://openalex.org/W2105230499","doi":"https://doi.org/10.1085/jgp.107.5.611","title":"Fast inactivation causes rectification of the IKr channel.","display_name":"Fast inactivation causes rectification of the IKr channel.","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W2105230499","doi":"https://doi.org/10.1085/jgp.107.5.611","mag":"2105230499","pmid":"https://pubmed.ncbi.nlm.nih.gov/8740374","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2217012"},"language":"en","primary_location":{"id":"doi:10.1085/jgp.107.5.611","doi":"https://doi.org/10.1085/jgp.107.5.611","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.107.5.611","pdf_url":"https://rupress.org/jgp/article-pdf/107/5/611/1186460/611.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jgp/article-pdf/107/5/611/1186460/611.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026336264","display_name":"Peter Spector","orcid":"https://orcid.org/0000-0003-4502-6100","observed_orcids":["https://orcid.org/0000-0003-4502-6100"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P S Spector","raw_affiliation_strings":["Cardiology Division, University of Utah, Salt Lake City 84112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, University of Utah, Salt Lake City 84112, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107600575","display_name":"Mark E. Curran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M E Curran","raw_affiliation_strings":["Cardiology Division, University of Utah, Salt Lake City 84112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, University of Utah, Salt Lake City 84112, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110410386","display_name":"Anruo Zou","orcid":"https://orcid.org/0009-0008-1663-1962","observed_orcids":["https://orcid.org/0009-0008-1663-1962"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Zou","raw_affiliation_strings":["Cardiology Division, University of Utah, Salt Lake City 84112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, University of Utah, Salt Lake City 84112, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103550127","display_name":"Mark T. Keating","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M T Keating","raw_affiliation_strings":["Cardiology Division, University of Utah, Salt Lake City 84112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, University of Utah, Salt Lake City 84112, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026074309","display_name":"Michael C. Sanguinetti","orcid":"https://orcid.org/0000-0001-8974-0969","observed_orcids":["https://orcid.org/0000-0001-8974-0969"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M C Sanguinetti","raw_affiliation_strings":["Cardiology Division, University of Utah, Salt Lake City 84112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, University of Utah, Salt Lake City 84112, USA","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":null,"apc_paid":null,"fwci":8.6788,"has_fulltext":true,"cited_by_count":397,"citation_normalized_percentile":{"value":0.98534665,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"107","issue":"5","first_page":"611","last_page":"619"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herg-channel","display_name":"hERG","score":0.8360000252723694},{"id":"https://openalex.org/keywords/fast-inactivation","display_name":"fast inactivation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/channel-rectification","display_name":"channel rectification","score":0.7149999737739563},{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.7279999852180481},{"id":"https://openalex.org/keywords/recovery-from-inactivation","display_name":"recovery from inactivation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/voltage-dependent-activation","display_name":"voltage dependence of activation","score":0.6740000247955322},{"id":"https://openalex.org/keywords/cardiac-potassium-currents","display_name":"cardiac potassium currents","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C2779362680","wikidata":"https://www.wikidata.org/wiki/Q905000","display_name":"hERG","level":3,"score":0.9220004081726074},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7302695512771606},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.7183489799499512},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.6603214740753174},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.631220281124115},{"id":"https://openalex.org/C79743260","wikidata":"https://www.wikidata.org/wiki/Q2882301","display_name":"Cardiac action potential","level":4,"score":0.5214866399765015},{"id":"https://openalex.org/C100837961","wikidata":"https://www.wikidata.org/wiki/Q10290897","display_name":"Voltage clamp","level":3,"score":0.5207017064094543},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.5020871162414551},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.48589104413986206},{"id":"https://openalex.org/C74884574","wikidata":"https://www.wikidata.org/wiki/Q171407","display_name":"Divalent","level":2,"score":0.4604971408843994},{"id":"https://openalex.org/C47423411","wikidata":"https://www.wikidata.org/wiki/Q7920311","display_name":"Ventricular action potential","level":4,"score":0.43721282482147217},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.4274812340736389},{"id":"https://openalex.org/C108305142","wikidata":"https://www.wikidata.org/wiki/Q3062286","display_name":"Heterologous expression","level":4,"score":0.42687681317329407},{"id":"https://openalex.org/C131453863","wikidata":"https://www.wikidata.org/wiki/Q1641079","display_name":"Hyperpolarization (physics)","level":3,"score":0.4211837649345398},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.3779975473880768},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.2819918692111969},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.259238064289093},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.24303492903709412},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12477931380271912},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.10501837730407715},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.06739792227745056},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1085/jgp.107.5.611","doi":"https://doi.org/10.1085/jgp.107.5.611","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.107.5.611","pdf_url":"https://rupress.org/jgp/article-pdf/107/5/611/1186460/611.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1372815","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2217012","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2217012","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2217012","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gen Physiol","raw_type":"Text"},{"id":"pmid:8740374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8740374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.283.4395","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.283.4395","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f2/13/J_Gen_Physiol_1996_May_1_107(5)_611-619.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1085/jgp.107.5.611","doi":"https://doi.org/10.1085/jgp.107.5.611","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.107.5.611","pdf_url":"https://rupress.org/jgp/article-pdf/107/5/611/1186460/611.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8619708344","display_name":"SCOR IN SUDDEN CARDIAC DEATH","funder_award_id":"P50HL052338","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2105230499.pdf","grobid_xml":"https://content.openalex.org/works/W2105230499.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1966667742","https://openalex.org/W1968098810","https://openalex.org/W1975869151","https://openalex.org/W1997883766","https://openalex.org/W2015841601","https://openalex.org/W2021438486","https://openalex.org/W2026846610","https://openalex.org/W2028274352","https://openalex.org/W2030002696","https://openalex.org/W2032539806","https://openalex.org/W2039984019","https://openalex.org/W2044813037","https://openalex.org/W2051884238","https://openalex.org/W2074705578","https://openalex.org/W2075834102","https://openalex.org/W2076932158","https://openalex.org/W2087281439","https://openalex.org/W2101319853","https://openalex.org/W2116121809","https://openalex.org/W2151503017","https://openalex.org/W2346804189"],"related_works":["https://openalex.org/W2183380071","https://openalex.org/W1968371524","https://openalex.org/W1987987627","https://openalex.org/W2029476720","https://openalex.org/W2080355249","https://openalex.org/W2101929104","https://openalex.org/W2053351731","https://openalex.org/W2036860058","https://openalex.org/W2050908780","https://openalex.org/W1973237368"],"abstract_inverted_index":{"The":[0,31,76,93,111,181],"mechanism":[1,182],"of":[2,4,50,66,86,99,108,114,146,150,156,169,171,183,191,217,232],"rectification":[3,185,222],"HERG,":[5],"the":[6,47,97,147,153,167,172,220,227],"human":[7],"cardiac":[8],"delayed":[9],"rectifier":[10],"K+":[11],"channel,":[12],"was":[13,42,60,82,175],"studied":[14],"after":[15,84],"heterologous":[16],"expression":[17],"in":[18],"Xenopus":[19],"oocytes.":[20],"Currents":[21],"were":[22,104],"measured":[23],"using":[24],"two-microelectrode":[25],"and":[26,100,158,219],"macropatch":[27,52],"voltage":[28,154],"clamp":[29],"techniques.":[30],"fully":[32],"activated":[33],"current-voltage":[34],"(I-V)":[35],"relationship":[36,79],"for":[37,80,96,226],"HERG":[38,81,151,184,218],"inwardly":[39],"rectified.":[40],"Rectification":[41],"not":[43,61],"altered":[44],"by":[45,63,69,89,160],"exposing":[46],"cytoplasmic":[48],"side":[49],"a":[51,54,90,105,195],"to":[53,123,139,162,210],"divalent-free":[55],"solution,":[56],"indicating":[57],"this":[58],"property":[59],"caused":[62],"voltage-dependent":[64],"block":[65],"outward":[67,204],"current":[68,205],"Mg2+":[70],"or":[71],"other":[72],"soluble":[73],"cytosolic":[74],"molecules.":[75],"instantaneous":[77],"I-V":[78],"linear":[83],"removal":[85],"fast":[87,188],"inactivation":[88,103,115,131,159,216],"brief":[91],"hyperpolarization.":[92],"time":[94,112],"constants":[95,113],"onset":[98],"recovery":[101,129],"from":[102,117,130,133],"bell-shaped":[106],"function":[107],"membrane":[109,213],"potential.":[110],"varied":[116,132],"1.8":[118],"ms":[119,125,135,141],"at":[120,126,136,142,194],"+50":[121],"mV":[122,138],"16":[124],"-20":[127],"mV;":[128],"4.7":[134],"-120":[137],"15":[140],"-50":[143],"mV.":[144,164],"Truncation":[145],"NH2-terminal":[148],"region":[149],"shifted":[152],"dependence":[155],"activation":[157],"+20":[161],"+30":[163],"In":[165],"addition,":[166],"rate":[168,198],"deactivation":[170],"truncated":[173],"channel":[174],"much":[176,196],"faster":[177,197],"than":[178,199],"wild-type":[179],"HERG.":[180],"is":[186,206],"voltage-gated":[187],"inactivation.":[189],"Inactivation":[190],"channels":[192],"proceeds":[193],"activation,":[200],"such":[201],"that":[202],"no":[203],"observed":[207],"upon":[208],"depolarization":[209],"very":[211],"high":[212],"potentials.":[214,235],"Fast":[215],"resulting":[221],"are":[223],"partly":[224],"responsible":[225],"prolonged":[228],"plateau":[229],"phase":[230],"typical":[231],"ventricular":[233],"action":[234]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}