{"id":"https://openalex.org/W2105189307","doi":"https://doi.org/10.1093/annonc/mdi188","title":"A monoclonal antibody against HER-2 (trastuzumab) for metastatic breast cancer: a model-based cost-effectiveness analysis","display_name":"A monoclonal antibody against HER-2 (trastuzumab) for metastatic breast cancer: a model-based cost-effectiveness analysis","publication_year":2005,"publication_date":"2005-04-23","ids":{"openalex":"https://openalex.org/W2105189307","doi":"https://doi.org/10.1093/annonc/mdi188","mag":"2105189307","pmid":"https://pubmed.ncbi.nlm.nih.gov/15849222"},"language":"en","primary_location":{"id":"doi:10.1093/annonc/mdi188","doi":"https://doi.org/10.1093/annonc/mdi188","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdi188","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1093/annonc/mdi188","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025585146","display_name":"Jan Norum","orcid":"https://orcid.org/0000-0001-9341-3506","observed_orcids":["https://orcid.org/0000-0001-9341-3506"]},"institutions":[{"id":"https://openalex.org/I1298853749","display_name":"University Hospital of North Norway","ror":"https://ror.org/030v5kp38","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1298853749","https://openalex.org/I63903255"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"J. Norum","raw_affiliation_strings":["Department of Oncology, University Hospital of North Norway, Troms\u00f8, Norway. jan.norum@unn.no","Department of Oncology, University Hospital of North Norway","Institute of Clinical Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University Hospital of North Norway, Troms\u00f8, Norway. jan.norum@unn.no","institution_ids":["https://openalex.org/I1298853749"]},{"raw_affiliation_string":"Department of Oncology, University Hospital of North Norway","institution_ids":["https://openalex.org/I1298853749"]},{"raw_affiliation_string":"Institute of Clinical Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003481595","display_name":"Terje Risberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298853749","display_name":"University Hospital of North Norway","ror":"https://ror.org/030v5kp38","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1298853749","https://openalex.org/I63903255"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"T. Risberg","raw_affiliation_strings":["Department of Oncology, University Hospital of North Norway","Institute of Clinical Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University Hospital of North Norway","institution_ids":["https://openalex.org/I1298853749"]},{"raw_affiliation_string":"Institute of Clinical Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052181611","display_name":"Jan Abel Olsen","orcid":"https://orcid.org/0000-0001-9472-2669","observed_orcids":["https://orcid.org/0000-0001-9472-2669"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"J.A. Olsen","raw_affiliation_strings":["Health Economics Research Programme, University of Oslo, Oslo, Norway","Institute of Community Medicine, University of Troms\u00f8, Troms\u00f8"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Economics Research Programme, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Institute of Community Medicine, University of Troms\u00f8, Troms\u00f8","institution_ids":["https://openalex.org/I78037679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025585146"],"corresponding_institution_ids":["https://openalex.org/I1298853749"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":15.9747,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.98731391,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"6","first_page":"909","last_page":"914"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12708","display_name":"Economic and Financial Impacts of Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":1.0},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.7919999957084656},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.9039999842643738},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8370000123977661},{"id":"https://openalex.org/keywords/her2-overexpression","display_name":"HER2 overexpression","score":0.8379999995231628},{"id":"https://openalex.org/keywords/life-years-gained","display_name":"life-years gained","score":0.828000009059906},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9179999828338623},{"id":"https://openalex.org/keywords/survival-benefit","display_name":"survival benefit","score":0.7139999866485596},{"id":"https://openalex.org/keywords/drug-costs","display_name":"drug costs","score":0.6499999761581421},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.9395525455474854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9287903904914856},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.8486999273300171},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6632083654403687},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6311858892440796},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5426263809204102},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.4439551830291748},{"id":"https://openalex.org/C515549039","wikidata":"https://www.wikidata.org/wiki/Q1754768","display_name":"Cost-effectiveness analysis","level":3,"score":0.4437706172466278},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41210055351257324},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28939053416252136},{"id":"https://openalex.org/C3019080777","wikidata":"https://www.wikidata.org/wiki/Q1754768","display_name":"Cost effectiveness","level":2,"score":0.2777571678161621},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2577860653400421},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1520197093486786},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016527","descriptor_name":"Drug Costs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/annonc/mdi188","doi":"https://doi.org/10.1093/annonc/mdi188","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdi188","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},{"id":"pmid:15849222","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15849222","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of oncology : official journal of the European Society for Medical Oncology","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.483.7879","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.483.7879","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://annonc.oxfordjournals.org/content/16/6/909.full.pdf","raw_type":"text"},{"id":"pmh:oai:open-archive.highwire.org:annonc:mdi188v1","doi":null,"is_oa":false,"landing_page_url":"http://annonc.oxfordjournals.org/cgi/content/short/mdi188v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/annonc/mdi188","doi":"https://doi.org/10.1093/annonc/mdi188","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdi188","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W168811426","https://openalex.org/W1491647197","https://openalex.org/W1531300355","https://openalex.org/W1974226434","https://openalex.org/W1976682363","https://openalex.org/W1977758857","https://openalex.org/W1984274637","https://openalex.org/W1987140112","https://openalex.org/W1997692902","https://openalex.org/W2007256480","https://openalex.org/W2019895529","https://openalex.org/W2043711125","https://openalex.org/W2048686497","https://openalex.org/W2048708488","https://openalex.org/W2078876278","https://openalex.org/W2094627540","https://openalex.org/W2095156669","https://openalex.org/W2095950656","https://openalex.org/W2108410343","https://openalex.org/W2122884257","https://openalex.org/W2130708807","https://openalex.org/W2141393790","https://openalex.org/W2146114745","https://openalex.org/W2159363679","https://openalex.org/W2159459001","https://openalex.org/W2226378560","https://openalex.org/W2245229130","https://openalex.org/W2318605753","https://openalex.org/W2395794062","https://openalex.org/W2597619238","https://openalex.org/W6629533272","https://openalex.org/W6670297701","https://openalex.org/W6676090270"],"related_works":["https://openalex.org/W2272557138","https://openalex.org/W7098679313","https://openalex.org/W2019707316","https://openalex.org/W2734040110","https://openalex.org/W2130308762","https://openalex.org/W2070674958","https://openalex.org/W2101341097","https://openalex.org/W2090416595","https://openalex.org/W2059170159","https://openalex.org/W4398764825"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
