{"id":"https://openalex.org/W2105128805","doi":"https://doi.org/10.1093/carcin/11.11.1903","title":"Serological characterization of polycyclic aromatic hydrocarbon diolepoxide -DNA adducts using monoclonal antibodies","display_name":"Serological characterization of polycyclic aromatic hydrocarbon diolepoxide -DNA adducts using monoclonal antibodies","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W2105128805","doi":"https://doi.org/10.1093/carcin/11.11.1903","mag":"2105128805","pmid":"https://pubmed.ncbi.nlm.nih.gov/2225321"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/11.11.1903","doi":"https://doi.org/10.1093/carcin/11.11.1903","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/11.11.1903","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088019995","display_name":"Mark J. Newman","orcid":"https://orcid.org/0000-0002-0433-6690","observed_orcids":["https://orcid.org/0000-0002-0433-6690"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.J. Newman","raw_affiliation_strings":["School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109808364","display_name":"Ainsley Weston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Weston","raw_affiliation_strings":["Laboratory of Human Carcinogenesis, NCI, NIH Bethesda, MA 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Carcinogenesis, NCI, NIH Bethesda, MA 20892","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050358824","display_name":"D.C. Carver","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D.C. Carver","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105358727","display_name":"Dean L. Mann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.L. Mann","raw_affiliation_strings":["Laboratory of Viral Carcinogenesis, NCI-Frederick Cancer Research Facility Frederick, MD 21701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Viral Carcinogenesis, NCI-Frederick Cancer Research Facility Frederick, MD 21701, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050126669","display_name":"Curtis C. Harris","orcid":"https://orcid.org/0000-0001-5268-0181","observed_orcids":["https://orcid.org/0000-0001-5268-0181"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.C. Harris","raw_affiliation_strings":["Laboratory of Human Carcinogenesis, NCI, NIH Bethesda, MA 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Carcinogenesis, NCI, NIH Bethesda, MA 20892","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":0.2143,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.51732807,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"11","first_page":"1903","last_page":"1907"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.03750000149011612,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pah-dna-adducts","display_name":"PAH-DNA adducts","score":0.9120000004768372},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.968999981880188},{"id":"https://openalex.org/keywords/serological-cross-reactivity","display_name":"serological cross-reactivity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/epitopes","display_name":"antigenic determinants","score":0.8349999785423279},{"id":"https://openalex.org/keywords/biodosimetry","display_name":"biological dosimetry","score":0.8169999718666077},{"id":"https://openalex.org/keywords/pah-exposure","display_name":"PAH exposure","score":0.7089999914169312},{"id":"https://openalex.org/keywords/pah-metabolites","display_name":"PAH metabolites","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cancer-risk-assessment","display_name":"cancer risk assessment","score":0.6079999804496765},{"id":"https://openalex.org/keywords/pah-toxicity","display_name":"PAH toxicity","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6008691787719727},{"id":"https://openalex.org/C2779033964","wikidata":"https://www.wikidata.org/wiki/Q407212","display_name":"Polycyclic aromatic hydrocarbon","level":2,"score":0.5333951115608215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5107431411743164},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.49047037959098816},{"id":"https://openalex.org/C2777207669","wikidata":"https://www.wikidata.org/wiki/Q43648","display_name":"Hydrocarbon","level":2,"score":0.4682729244232178},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.4193260669708252},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.35988423228263855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2912270724773407},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2183399200439453},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18950071930885315},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10234478116035461}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001551","descriptor_name":"Benz(a)Anthracenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001564","descriptor_name":"Benzo(a)pyrene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016056","descriptor_name":"Immunodominant Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/carcin/11.11.1903","doi":"https://doi.org/10.1093/carcin/11.11.1903","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/11.11.1903","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:2225321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2225321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2086162242","https://openalex.org/W2084674696","https://openalex.org/W144006618","https://openalex.org/W2110478875","https://openalex.org/W972061510","https://openalex.org/W2088221629","https://openalex.org/W1972485805","https://openalex.org/W2420466628","https://openalex.org/W2058997287","https://openalex.org/W2330498167"],"abstract_inverted_index":{"Polycyclic":[0],"aromatic":[1],"hydrocarbons":[2],"(PAHs)":[3],"are":[4,12],"a":[5,75,175,240,336],"group":[6],"of":[7,30,88,132,216,243,250,339,356],"structurally":[8],"related":[9],"compounds":[10,24],"that":[11,41,49,81,105,135,157,166,232,260,312,325,353],"present":[13],"in":[14,17,67,363,370],"the":[15,128,139,187,247,286,354],"environment":[16],"complex":[18],"mixtures":[19],"as":[20,74],"common":[21,108],"pollutants.":[22],"These":[23,154,309],"have":[25,82,180],"been":[26,83],"studied":[27],"extensively":[28],"because":[29,142],"their":[31,279],"carcinogenic":[32],"and":[33,61,210,224,268,284,321],"toxic":[34],"properties":[35],"to":[36,44,51,59,64,85,114,116,126,149,185,189,219,225,237,263,296,301,304,328,333,345,366],"humans.":[37],"We":[38,179,230],"reported":[39],"previously":[40],"humans":[42,167],"exposed":[43,84,113],"certain":[45],"PAHs":[46,227,267,287],"produce":[47,117,169,346],"antibodies":[48,63,118,141,199,218,235,257,290,327,348],"bind":[50,332],"different":[52,158,191,204,251,318],"PAH":[53,115,269],"diolepoxide-DNA":[54,208,212,298],"(PAH-DNA)":[55],"adducts.":[56,121,253,308],"The":[57,214],"ability":[58,344],"detect":[60],"measure":[62,367],"PAH-DNA":[65,120,133,159,177,192,205,221,244,252,282,307,319,329,340,368],"adducts":[66,134,160,193,283,320,369],"human":[68,326],"blood":[69],"samples":[70,145,372],"could":[71],"prove":[72],"useful":[73],"biological":[76,371],"dosimeter":[77],"for":[78,109,281,361],"identifying":[79],"persons":[80,91,110],"high":[86,96],"levels":[87],"PAHs,":[89],"i.e.":[90],"who":[92,111],"may":[93,161],"be":[94,162],"at":[95],"cancer":[97],"risk.":[98],"In":[99],"our":[100,323,343],"initial":[101],"studies":[102],"we":[103,123],"found":[104,231],"it":[106],"was":[107,228],"were":[112,124,136,200,258,271],"against":[119,172,202,292],"However,":[122,254,342],"unable":[125],"identify":[127],"actual":[129],"chemical":[130],"types":[131],"recognized":[137,196,273],"by":[138,274],"serum":[140,144],"many":[143],"contained":[146],"antibody":[147,183,359],"activity":[148],"more":[150,173,238,334],"than":[151,174,239,335],"one":[152],"adduct.":[153,178,341],"data":[155,310],"indicate":[156],"serologically":[163,195],"similar":[164],"or":[165,303],"actually":[168],"immune":[170],"responses":[171],"single":[176,241,337],"used":[181],"monoclonal":[182,234,256,347,358],"technology":[184],"determine":[186],"extent":[188],"which":[190],"share":[194],"epitopes.":[197],"Monoclonal":[198,289],"produced":[201,259,291],"two":[203,255,305],"adducts,":[206],"benzo[a]pyrene":[207],"(BPDE-DNA)":[209],"benz[a]anthracene":[211],"(BADE-DNA).":[213],"binding":[215],"these":[217,275],"five":[220],"adduct":[222],"preparations":[223],"soluble":[226],"assessed.":[229],"most":[233],"bound":[236,261,295],"type":[242,338],"adduct,":[245],"documenting":[246],"serological":[248,314],"relatedness":[249],"only":[262],"BPDE-DNA.":[264],"Soluble":[265],"non-metabolized":[266],"tetraols":[270],"not":[272,285,300],"antibodies,":[276],"thus":[277],"demonstrating":[278],"specificity":[280,351],"alone.":[288],"BADE-DNA":[293],"also":[294],"chrysene":[297],"but":[299],"BPDE-DNA":[302],"other":[306],"demonstrate":[311],"significant":[313],"cross-reactivity":[315],"exists":[316],"between":[317],"support":[322],"contention":[324],"can":[330],"often":[331],"with":[349],"restricted":[350],"suggest":[352],"production":[355],"highly":[357],"reagents":[360],"use":[362],"assays":[364],"designed":[365],"is":[373],"feasible.":[374]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}