{"id":"https://openalex.org/W2105045003","doi":"https://doi.org/10.1111/ajt.13007","title":"Optimization of Intrabone Delivery of Hematopoietic Progenitor Cells in a Swine Model Using Cell Radiolabeling with [89]zirconium","display_name":"Optimization of Intrabone Delivery of Hematopoietic Progenitor Cells in a Swine Model Using Cell Radiolabeling with [89]zirconium","publication_year":2015,"publication_date":"2015-02-05","ids":{"openalex":"https://openalex.org/W2105045003","doi":"https://doi.org/10.1111/ajt.13007","mag":"2105045003","pmid":"https://pubmed.ncbi.nlm.nih.gov/25656824","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8391069"},"language":"en","primary_location":{"id":"doi:10.1111/ajt.13007","doi":"https://doi.org/10.1111/ajt.13007","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ajt.13007","pdf_url":"http://www.amjtransplant.org/article/S1600613522001228/pdf","source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.amjtransplant.org/article/S1600613522001228/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072164039","display_name":"Jeremy Mark Pantin","orcid":"https://orcid.org/0000-0001-7536-0623","observed_orcids":["https://orcid.org/0000-0001-7536-0623"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.M. Pantin","raw_affiliation_strings":["Division of Hematology and Medical Oncology, Georgia Regents University, Augusta, GA; Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD","Division of Hematology and Medical Oncology, Georgia Regents University, Augusta, GA","Hematology Branch; National Heart; Lung and Blood Institute; National Institutes of Health; Bethesda MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Medical Oncology, Georgia Regents University, Augusta, GA; Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I25041050","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"Division of Hematology and Medical Oncology, Georgia Regents University, Augusta, GA","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"Hematology Branch; National Heart; Lung and Blood Institute; National Institutes of Health; Bethesda MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109400250","display_name":"Robert F. Hoyt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4396570585","display_name":"Leidos Biomedical Research Inc. (United States)","ror":"https://ror.org/00bardy64","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689","https://openalex.org/I4396570585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.F. Hoyt","raw_affiliation_strings":["Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick","Laboratory of Animal Medicine and Surgery, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick","institution_ids":["https://openalex.org/I4396570585"]},{"raw_affiliation_string":"Laboratory of Animal Medicine and Surgery, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011834144","display_name":"\u00d6mer Aras","orcid":"https://orcid.org/0000-0003-1758-0542","observed_orcids":["https://orcid.org/0000-0003-1758-0542"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O. Aras","raw_affiliation_strings":["Imaging Sciences Training Program, Diagnostic Radiology Department, Warren Magnuson Clinical Center, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Sciences Training Program, Diagnostic Radiology Department, Warren Magnuson Clinical Center, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015519992","display_name":"Noriko Sato","orcid":"https://orcid.org/0000-0002-9372-1725","observed_orcids":["https://orcid.org/0000-0002-9372-1725"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Sato","raw_affiliation_strings":["Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032087476","display_name":"M. Y. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.Y. Chen","raw_affiliation_strings":["Advanced Cardiovascular Imaging Laboratory, Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Cardiovascular Imaging Laboratory, Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110182863","display_name":"T J Hunt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Hunt","raw_affiliation_strings":["Laboratory of Animal Medicine and Surgery, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Medicine and Surgery, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011755781","display_name":"Randy Clevenger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Clevenger","raw_affiliation_strings":["Laboratory of Animal Medicine and Surgery, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Medicine and Surgery, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020187186","display_name":"Philip C. Eclarinal","orcid":"https://orcid.org/0000-0002-3115-7495","observed_orcids":["https://orcid.org/0000-0002-3115-7495"]},"institutions":[{"id":"https://openalex.org/I4396570585","display_name":"Leidos Biomedical Research Inc. (United States)","ror":"https://ror.org/00bardy64","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689","https://openalex.org/I4396570585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Eclarinal","raw_affiliation_strings":["Leidos Biomedical Research, Inc., Reston, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leidos Biomedical Research, Inc., Reston, VA","institution_ids":["https://openalex.org/I4396570585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075590318","display_name":"Stephen Adler","orcid":"https://orcid.org/0000-0002-4399-6923","observed_orcids":["https://orcid.org/0000-0002-4399-6923"]},"institutions":[{"id":"https://openalex.org/I4396570585","display_name":"Leidos Biomedical Research Inc. (United States)","ror":"https://ror.org/00bardy64","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689","https://openalex.org/I4396570585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Adler","raw_affiliation_strings":["Leidos Biomedical Research, Inc., Reston, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leidos Biomedical Research, Inc., Reston, VA","institution_ids":["https://openalex.org/I4396570585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082080836","display_name":"Peter L. Choyke","orcid":"https://orcid.org/0000-0003-1086-8826","observed_orcids":["https://orcid.org/0000-0003-1086-8826"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Choyke","raw_affiliation_strings":["Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112507028","display_name":"Richard W. Childs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R.W. Childs","raw_affiliation_strings":["Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5112507028"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":{"value":4300,"currency":"USD","value_usd":4300},"fwci":2.6179,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.89973922,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":"3","first_page":"606","last_page":"617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/protamine-sulfate","display_name":"protamine sulfate","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cell-tracking","display_name":"cell tracking","score":0.656000018119812},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.9509999752044678},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.6779999732971191},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"positron emission tomography","score":0.8500000238418579},{"id":"https://openalex.org/keywords/needle-design","display_name":"needle design","score":0.5},{"id":"https://openalex.org/keywords/extravasation","display_name":"extravasation","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6606841683387756},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5826056003570557},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5441100001335144},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5009751319885254},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.48536527156829834},{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.4734988808631897},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4512821137905121},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.44656920433044434},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.42611566185951233},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.33983170986175537},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33558112382888794},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3107403516769409},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22657886147499084},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2154591977596283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11018583178520203},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08753010630607605},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011868","descriptor_name":"Radioisotopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015040","descriptor_name":"Zirconium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064847","descriptor_name":"Multimodal Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/ajt.13007","doi":"https://doi.org/10.1111/ajt.13007","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ajt.13007","pdf_url":"http://www.amjtransplant.org/article/S1600613522001228/pdf","source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},{"id":"pmid:25656824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25656824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8391069","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8391069","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Transplant","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/ajt.13007","doi":"https://doi.org/10.1111/ajt.13007","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ajt.13007","pdf_url":"http://www.amjtransplant.org/article/S1600613522001228/pdf","source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.4300000071525574,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3115470308","display_name":"Lymphatic Imaging","funder_award_id":"Z01BC010654","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4705346009","display_name":null,"funder_award_id":"Z99 HL999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000911217","display_name":"Allogeneic and Autologous Immunotherapy for cancer and nonmalignant hematological disorders","funder_award_id":"ZIAHL002345","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000918486","display_name":"Cardiovascular CT Clinical Research","funder_award_id":"ZIAHL006220","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338421","display_name":"NHLBI Division of Intramural Research","ror":"https://ror.org/023ny1p48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2105045003.pdf","grobid_xml":"https://content.openalex.org/works/W2105045003.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W94635446","https://openalex.org/W116758555","https://openalex.org/W1483295852","https://openalex.org/W1485136427","https://openalex.org/W1674932451","https://openalex.org/W1971218073","https://openalex.org/W1977380831","https://openalex.org/W1977749615","https://openalex.org/W1977866489","https://openalex.org/W1978558705","https://openalex.org/W1979202247","https://openalex.org/W1980882711","https://openalex.org/W1985568051","https://openalex.org/W1993207354","https://openalex.org/W1993388378","https://openalex.org/W1999711808","https://openalex.org/W2006351191","https://openalex.org/W2012841194","https://openalex.org/W2025013227","https://openalex.org/W2027376412","https://openalex.org/W2028860972","https://openalex.org/W2029884998","https://openalex.org/W2034158586","https://openalex.org/W2035480085","https://openalex.org/W2037749367","https://openalex.org/W2039181426","https://openalex.org/W2058732742","https://openalex.org/W2064558105","https://openalex.org/W2065226637","https://openalex.org/W2073546086","https://openalex.org/W2076834840","https://openalex.org/W2080826463","https://openalex.org/W2080878594","https://openalex.org/W2093057317","https://openalex.org/W2105961186","https://openalex.org/W2118573723","https://openalex.org/W2135027871","https://openalex.org/W2136590050","https://openalex.org/W2140845311","https://openalex.org/W2152191265","https://openalex.org/W2170250222","https://openalex.org/W2327684016","https://openalex.org/W2638561866","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2979827770","https://openalex.org/W3110991553","https://openalex.org/W2135027871","https://openalex.org/W1965266215","https://openalex.org/W7097792158","https://openalex.org/W2981024667","https://openalex.org/W2028532811","https://openalex.org/W2567713695","https://openalex.org/W2106635778","https://openalex.org/W2168941519"],"abstract_inverted_index":{"Intrabone":[0],"(IB)":[1],"hematopoietic":[2,25],"cell":[3],"transplantation":[4],"(HCT)":[5],"of":[6,88,173,180,204],"umbilical":[7],"cord":[8],"blood":[9],"in":[10,34,86,120,175,187,194],"humans":[11],"remains":[12],"experimental":[13],"and":[14,81,107,138,144,158,163,169,190],"the":[15,35,41,47,134,149,161,176,188],"technique":[16,53],"has":[17],"not":[18],"been":[19],"optimized.":[20],"It":[21],"is":[22,184],"unknown":[23],"whether":[24],"progenitor":[26],"cells":[27],"(HPCs)":[28],"injected":[29],"IB":[30,181],"are":[31],"initially":[32],"retained":[33],"marrow":[36,202],"or":[37],"rapidly":[38],"enter":[39],"into":[40,65,133,141],"venous":[42,136],"circulation":[43,137],"before":[44],"homing":[45],"to":[46,71,129],"marrow.":[48,177],"To":[49],"develop":[50],"an":[51],"IB-injection":[52,64],"that":[54,84,117],"maximizes":[55],"HPC":[56],"marrow-retention,":[57],"we":[58,165],"tracked":[59],"radiolabeled":[60],"human":[61],"HPCs":[62,73,174],"following":[63],"swine.":[66],"We":[67,115],"developed":[68],"a":[69,75],"method":[70,179],"radionuclide-label":[72],"using":[74,152],"long-lived":[76],"positron":[77,100],"emitter":[78],"(89)":[79],"Zr":[80],"protamine":[82],"sulfate":[83],"resulted":[85],"cellular-retention":[87],"low-dose":[89],"radioactivity.":[90],"This":[91,178],"approach":[92],"achieved":[93,170],"radioactivity":[94],"levels":[95],"sufficient":[96],"for":[97],"detection":[98],"by":[99,126,159],"emission":[101],"tomography":[102],"with":[103,112],"both":[104,130],"high":[105,171],"sensitivity":[106],"spatial":[108],"resolution":[109],"when":[110],"fused":[111],"computed":[113],"tomography.":[114],"found":[116],"conditions":[118],"utilized":[119,193],"pilot":[121],"IB-HCT":[122,197],"clinical":[123],"trials":[124,198],"conducted":[125],"others":[127],"led":[128],"rapid":[131],"drainage":[132],"central":[135],"cellular":[139,182],"extravasation":[140],"surrounding":[142],"muscle":[143],"soft":[145],"tissues.":[146],"By":[147],"optimizing":[148],"needle":[150],"design,":[151],"continuous":[153],"real-time":[154],"intra-marrow":[155],"pressure":[156],"monitoring,":[157],"reducing":[160],"infusion-volume":[162],"infusion-rate,":[164],"overcame":[166],"this":[167],"limitation":[168],"retention":[172,203],"delivery":[183],"readily":[185],"applicable":[186],"clinic":[189],"could":[191],"be":[192],"future":[195],"investigational":[196],"aimed":[199],"at":[200],"maximizing":[201],"HPCs.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}