{"id":"https://openalex.org/W2105043890","doi":"https://doi.org/10.1093/hmg/ddp326","title":"Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases","display_name":"Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases","publication_year":2009,"publication_date":"2009-10-06","ids":{"openalex":"https://openalex.org/W2105043890","doi":"https://doi.org/10.1093/hmg/ddp326","mag":"2105043890","pmid":"https://pubmed.ncbi.nlm.nih.gov/19808793","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2758711"},"language":"en","primary_location":{"id":"doi:10.1093/hmg/ddp326","doi":"https://doi.org/10.1093/hmg/ddp326","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddp326","pdf_url":"https://academic.oup.com/hmg/article-pdf/18/R2/R169/1652163/ddp326.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/hmg/article-pdf/18/R2/R169/1652163/ddp326.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"H. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Chen","raw_affiliation_strings":["Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA","institution_ids":["https://openalex.org/I122411786","https://openalex.org/I1344073410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052542033","display_name":"David C. Chan","orcid":"https://orcid.org/0000-0002-0191-2154","observed_orcids":["https://orcid.org/0000-0002-0191-2154","https://orcid.org/0009-0000-2268-1271"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D. C. Chan","raw_affiliation_strings":["Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA","institution_ids":["https://openalex.org/I122411786","https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052542033"],"corresponding_institution_ids":["https://openalex.org/I122411786","https://openalex.org/I1344073410"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":6.3629,"has_fulltext":true,"cited_by_count":1506,"citation_normalized_percentile":{"value":0.98800738,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"18","issue":"R2","first_page":"R169","last_page":"R176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-fusion","display_name":"mitochondrial fusion","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mitochondrial-fission","display_name":"mitochondrial fission","score":1.0},{"id":"https://openalex.org/keywords/mitochondrial-transport","display_name":"mitochondrial transport","score":0.9570000171661377},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9769999980926514},{"id":"https://openalex.org/keywords/autosomal-dominant-optic-atrophy","display_name":"autosomal dominant optic atrophy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/axonal-mitochondria","display_name":"axonal mitochondria","score":0.7160000205039978},{"id":"https://openalex.org/keywords/neuronal-energy-metabolism","display_name":"neuronal energy metabolism","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.9500781297683716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7756848335266113},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7735596895217896},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.736684262752533},{"id":"https://openalex.org/C17619807","wikidata":"https://www.wikidata.org/wiki/Q6881852","display_name":"Mitochondrial fission","level":3,"score":0.7347917556762695},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5923985838890076},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.528526782989502},{"id":"https://openalex.org/C2777092462","wikidata":"https://www.wikidata.org/wiki/Q15334407","display_name":"MFN2","level":5,"score":0.4810669422149658},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.4229896366596222},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38684195280075073},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.3640395998954773},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.24517306685447693},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21836841106414795},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.18041864037513733},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12460482120513916},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07365220785140991},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.05818381905555725},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/hmg/ddp326","doi":"https://doi.org/10.1093/hmg/ddp326","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddp326","pdf_url":"https://academic.oup.com/hmg/article-pdf/18/R2/R169/1652163/ddp326.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},{"id":"pmid:19808793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19808793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human molecular genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2758711","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2758711/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Mol Genet","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1021.3018","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1021.3018","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC2758711%26blobtype%3Dpdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1029.5752","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1029.5752","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://hmg.oxfordjournals.org/content/18/R2/R169.full.pdf","raw_type":"text"},{"id":"pmh:oai:authors.library.caltech.edu:16830","doi":null,"is_oa":true,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:20091130-112530331","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/hmg/ddp326","doi":"https://doi.org/10.1093/hmg/ddp326","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddp326","pdf_url":"https://academic.oup.com/hmg/article-pdf/18/R2/R169/1652163/ddp326.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2469986259","display_name":"Analysis of mitochondrial fusion and fission in mammals","funder_award_id":"R01GM062967","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4539397838","display_name":"Structural and mechanistic studies of mitochondrial fission","funder_award_id":"R01GM083121","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2105043890.pdf","grobid_xml":"https://content.openalex.org/works/W2105043890.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W1500301258","https://openalex.org/W1967445833","https://openalex.org/W1970248089","https://openalex.org/W1970302092","https://openalex.org/W1974750801","https://openalex.org/W1976645698","https://openalex.org/W1978268445","https://openalex.org/W1983879895","https://openalex.org/W1985119207","https://openalex.org/W1987732936","https://openalex.org/W1987951773","https://openalex.org/W1989167108","https://openalex.org/W1990287702","https://openalex.org/W1993398538","https://openalex.org/W1994060945","https://openalex.org/W1996764498","https://openalex.org/W1998792500","https://openalex.org/W2003959349","https://openalex.org/W2005764967","https://openalex.org/W2015133213","https://openalex.org/W2016888445","https://openalex.org/W2017028262","https://openalex.org/W2018019380","https://openalex.org/W2020851684","https://openalex.org/W2021419707","https://openalex.org/W2022134817","https://openalex.org/W2022997027","https://openalex.org/W2024595059","https://openalex.org/W2045085957","https://openalex.org/W2050849483","https://openalex.org/W2051125954","https://openalex.org/W2055124287","https://openalex.org/W2055572268","https://openalex.org/W2058645571","https://openalex.org/W2058653820","https://openalex.org/W2059009119","https://openalex.org/W2065060908","https://openalex.org/W2065144533","https://openalex.org/W2066575706","https://openalex.org/W2072247192","https://openalex.org/W2072329091","https://openalex.org/W2073095545","https://openalex.org/W2081253095","https://openalex.org/W2085035881","https://openalex.org/W2091331379","https://openalex.org/W2091489629","https://openalex.org/W2094113524","https://openalex.org/W2094162211","https://openalex.org/W2095652212","https://openalex.org/W2098181117","https://openalex.org/W2098548022","https://openalex.org/W2104954806","https://openalex.org/W2105601225","https://openalex.org/W2107413005","https://openalex.org/W2107846158","https://openalex.org/W2109942343","https://openalex.org/W2116023338","https://openalex.org/W2120143950","https://openalex.org/W2120695551","https://openalex.org/W2124140045","https://openalex.org/W2124955411","https://openalex.org/W2127271204","https://openalex.org/W2130758099","https://openalex.org/W2131007152","https://openalex.org/W2137651420","https://openalex.org/W2139636031","https://openalex.org/W2140647923","https://openalex.org/W2143161560","https://openalex.org/W2150852495","https://openalex.org/W2152817972","https://openalex.org/W2154887758","https://openalex.org/W2155015733","https://openalex.org/W2157299674","https://openalex.org/W2158218054","https://openalex.org/W2161437961","https://openalex.org/W2162633290","https://openalex.org/W2163757074","https://openalex.org/W2164886443","https://openalex.org/W2166037982","https://openalex.org/W2166432730","https://openalex.org/W2172133399","https://openalex.org/W4297810568"],"related_works":["https://openalex.org/W7098895155","https://openalex.org/W2063239975","https://openalex.org/W2604387140","https://openalex.org/W2106877881","https://openalex.org/W1970565325","https://openalex.org/W2018659142","https://openalex.org/W2899568703","https://openalex.org/W2900229694","https://openalex.org/W2899793819","https://openalex.org/W3153897276"],"abstract_inverted_index":{"Neurons":[0],"are":[1,21,48,58,89,123,149],"metabolically":[2],"active":[3],"cells":[4,20],"with":[5,151],"high":[6],"energy":[7],"demands":[8],"at":[9],"locations":[10],"distant":[11],"from":[12,169],"the":[13,30,52,77,97,105,128,195,220],"cell":[14],"body.":[15],"As":[16],"a":[17,39,82,108,115,157,170],"result,":[18],"these":[19,146,215],"particularly":[22,50],"dependent":[23],"on":[24,51,137],"mitochondrial":[25,35,109,132,138,174,188,198,210,224],"function,":[26],"as":[27,96],"reflected":[28],"by":[29,61],"observation":[31],"that":[32,46],"diseases":[33,217],"of":[34,55,69,81,84,102,107,117,131,173,187,197],"dysfunction":[36],"often":[37],"have":[38,44],"neurodegenerative":[40,152,179,216],"component.":[41],"Recent":[42],"discoveries":[43],"highlighted":[45],"neurons":[47],"reliant":[49],"dynamic":[53,59],"properties":[54],"mitochondria.":[56,85],"Mitochondria":[57],"organelles":[60],"several":[62,177,192],"criteria.":[63],"They":[64],"engage":[65],"in":[66,119,145,191,214],"repeated":[67],"cycles":[68],"fusion":[70,199],"and":[71,79,99,142,160,183,218,228],"fission,":[72,140,226],"which":[73,120],"serve":[74],"to":[75,92],"intermix":[76],"lipids":[78],"contents":[80],"population":[83,110],"In":[86],"addition,":[87],"mitochondria":[88,122],"actively":[90],"recruited":[91],"subcellular":[93],"sites,":[94],"such":[95],"axonal":[98],"dendritic":[100],"processes":[101],"neurons.":[103],"Finally,":[104],"quality":[106],"is":[111,212],"maintained":[112],"through":[113],"mitophagy,":[114],"form":[116],"autophagy":[118],"defective":[121],"selectively":[124],"degraded.":[125],"We":[126,207],"review":[127,208],"general":[129],"features":[130,148],"dynamics,":[133],"incorporating":[134],"recent":[135],"findings":[136],"fusion,":[139,225],"transport":[141,227],"mitophagy.":[143,229],"Defects":[144],"key":[147],"associated":[150],"disease.":[153],"Charcot-Marie-Tooth":[154],"type":[155],"2A,":[156],"peripheral":[158],"neuropathy,":[159,167],"dominant":[161],"optic":[162,166],"atrophy,":[163],"an":[164],"inherited":[165],"result":[168],"primary":[171],"deficiency":[172],"fusion.":[175],"Moreover,":[176],"major":[178],"diseases--including":[180],"Parkinson's,":[181],"Alzheimer's":[182],"Huntington's":[184],"disease--involve":[185],"disruption":[186],"dynamics.":[189],"Remarkably,":[190],"disease":[193,205],"models,":[194],"manipulation":[196],"or":[200],"fission":[201],"can":[202],"partially":[203],"rescue":[204],"phenotypes.":[206],"how":[209],"dynamics":[211],"altered":[213],"discuss":[219],"reciprocal":[221],"interactions":[222],"between":[223]},"counts_by_year":[{"year":2026,"cited_by_count":57},{"year":2025,"cited_by_count":75},{"year":2024,"cited_by_count":68},{"year":2023,"cited_by_count":82},{"year":2022,"cited_by_count":79},{"year":2021,"cited_by_count":92},{"year":2020,"cited_by_count":102},{"year":2019,"cited_by_count":103},{"year":2018,"cited_by_count":98},{"year":2017,"cited_by_count":105},{"year":2016,"cited_by_count":105},{"year":2015,"cited_by_count":103},{"year":2014,"cited_by_count":84},{"year":2013,"cited_by_count":99},{"year":2012,"cited_by_count":107}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}