{"id":"https://openalex.org/W2105041796","doi":"https://doi.org/10.1073/pnas.1213471110","title":"Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics","display_name":"Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics","publication_year":2013,"publication_date":"2013-02-19","ids":{"openalex":"https://openalex.org/W2105041796","doi":"https://doi.org/10.1073/pnas.1213471110","mag":"2105041796","pmid":"https://pubmed.ncbi.nlm.nih.gov/23431149","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3593844"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1213471110","doi":"https://doi.org/10.1073/pnas.1213471110","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1213471110","pdf_url":"https://www.pnas.org/content/pnas/110/10/E958.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/content/pnas/110/10/E958.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087840465","display_name":"Marie Schroeder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marie A. Schroeder","raw_affiliation_strings":["Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084350290","display_name":"Mohammad A. Ali","orcid":"https://orcid.org/0000-0003-1311-4616","observed_orcids":["https://orcid.org/0000-0003-1311-4616"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mohammad A. Ali","raw_affiliation_strings":["Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","aBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"aBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074911713","display_name":"Al\u017ebeta Hul\u0131\u0301kov\u00e1","orcid":"https://orcid.org/0000-0001-8305-2890","observed_orcids":["https://orcid.org/0000-0001-8305-2890"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alzbeta Hulikova","raw_affiliation_strings":["Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","aBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"aBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035013697","display_name":"Claudiu Trandafir Supuran","orcid":"https://orcid.org/0000-0003-4262-0323","observed_orcids":["https://orcid.org/0000-0003-4262-0323"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudiu T. Supuran","raw_affiliation_strings":["Dipartimento di Scienze farmaceutiche, Universit\u00e0 degli Studi di Firenze, 50019 Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze farmaceutiche, Universit\u00e0 degli Studi di Firenze, 50019 Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032891489","display_name":"Kieran Clarke","orcid":"https://orcid.org/0000-0002-3237-7553","observed_orcids":["https://orcid.org/0000-0002-3237-7553"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kieran Clarke","raw_affiliation_strings":["Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","aBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"aBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109833833","display_name":"Richard D. Vaughan\u2010Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard D. Vaughan-Jones","raw_affiliation_strings":["Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","aBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"aBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022593647","display_name":"Damian J. Tyler","orcid":"https://orcid.org/0000-0002-0780-8905","observed_orcids":["https://orcid.org/0000-0002-0780-8905"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Damian J. Tyler","raw_affiliation_strings":["Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","aBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"aBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026204246","display_name":"Pawel Swietach","orcid":"https://orcid.org/0000-0002-9945-9473","observed_orcids":["https://orcid.org/0000-0002-9945-9473"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pawel Swietach","raw_affiliation_strings":["Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","aBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"aBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; and","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8802,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.9464101,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"110","issue":"10","first_page":"E958","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbonic-anhydrase","display_name":"carbonic anhydrase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/myocardial-energetics","display_name":"myocardial energetics","score":0.8059999942779541},{"id":"https://openalex.org/keywords/carbonic-anhydrase-ii","display_name":"carbonic anhydrase II","score":0.5849999785423279},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum","display_name":"sarcoplasmic reticulum","score":0.9039999842643738},{"id":"https://openalex.org/keywords/cardiac-mitochondria","display_name":"heart mitochondria","score":0.5730000138282776},{"id":"https://openalex.org/keywords/phosphocreatine-atp-ratio","display_name":"phosphocreatine to ATP ratio","score":0.890999972820282},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.902999997138977},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase","display_name":"pyruvate dehydrogenase","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hyperpolarized-1-13c-pyruvate","display_name":"hyperpolarized [1-13C]pyruvate","score":0.8429999947547913},{"id":"https://openalex.org/keywords/13c-nmr-spectroscopy","display_name":"13C NMR","score":0.7549999952316284},{"id":"https://openalex.org/keywords/31p-nmr-spectroscopy","display_name":"31P NMR","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6687610745429993},{"id":"https://openalex.org/C2778626300","wikidata":"https://www.wikidata.org/wiki/Q1984607","display_name":"Phosphocreatine","level":3,"score":0.6499829292297363},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.6242091655731201},{"id":"https://openalex.org/C2775914622","wikidata":"https://www.wikidata.org/wiki/Q284089","display_name":"Carbonic anhydrase","level":3,"score":0.6126023530960083},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5286351442337036},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5269559025764465},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4836050570011139},{"id":"https://openalex.org/C134897140","wikidata":"https://www.wikidata.org/wiki/Q6058355","display_name":"Intracellular pH","level":3,"score":0.479868084192276},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47698789834976196},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.476754754781723},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.4594823122024536},{"id":"https://openalex.org/C11701378","wikidata":"https://www.wikidata.org/wiki/Q3493378","display_name":"Mitochondrial matrix","level":4,"score":0.4582999348640442},{"id":"https://openalex.org/C88099638","wikidata":"https://www.wikidata.org/wiki/Q412856","display_name":"Pyruvate dehydrogenase complex","level":3,"score":0.45208775997161865},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4088512659072876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38632068037986755},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.31900495290756226},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2557714879512787},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19375699758529663},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.17466694116592407},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.1399480700492859}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002256","descriptor_name":"Carbonic Anhydrases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024402","descriptor_name":"Carbonic Anhydrase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030741","descriptor_name":"Carbonic Anhydrase IV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.1213471110","doi":"https://doi.org/10.1073/pnas.1213471110","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1213471110","pdf_url":"https://www.pnas.org/content/pnas/110/10/E958.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2600373","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3593844","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3593844","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3593844","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:23431149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23431149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:flore.unifi.it:2158/1010228","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2158/1010228","pdf_url":"http://www.pnas.org/content/110/10/E958.full.pdf+html","source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1073/pnas.1213471110","doi":"https://doi.org/10.1073/pnas.1213471110","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1213471110","pdf_url":"https://www.pnas.org/content/pnas/110/10/E958.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1168607608","display_name":"Development of cardiac hyperpolarised magnetic resonance imaging","funder_award_id":"FS/10/002/28078","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G1294022029","display_name":null,"funder_award_id":"PS/02/002/14893","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G4390301394","display_name":"RENEWAL: Regulation of intracellular pH in ventricular myocardium","funder_award_id":"RG/08/016/26423","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G4402121095","display_name":"Effects of nitric oxide signalling on proton dynamics in the healthy and diseased heart","funder_award_id":"PG/12/2/29324","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G487764931","display_name":"Establishing human cardiac hyperpolarised magnetic resonance: initial development and application","funder_award_id":"RG/11/9/28921","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G7526470689","display_name":"RENEWAL: Substrates, transcription and control of cardiac energy metabolism and function","funder_award_id":"RG/07/004/22659","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G8962529655","display_name":null,"funder_award_id":"RG/08/016","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2105041796.pdf"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W98248430","https://openalex.org/W140776867","https://openalex.org/W153631639","https://openalex.org/W607920654","https://openalex.org/W1512080163","https://openalex.org/W1565417780","https://openalex.org/W1587846921","https://openalex.org/W1759750343","https://openalex.org/W1970716297","https://openalex.org/W1970794990","https://openalex.org/W1972718661","https://openalex.org/W1981502020","https://openalex.org/W1982796477","https://openalex.org/W1990179610","https://openalex.org/W1990331048","https://openalex.org/W1997997206","https://openalex.org/W2002980097","https://openalex.org/W2004311009","https://openalex.org/W2015118732","https://openalex.org/W2015221597","https://openalex.org/W2018892630","https://openalex.org/W2019480743","https://openalex.org/W2021879007","https://openalex.org/W2032589955","https://openalex.org/W2038923997","https://openalex.org/W2046004905","https://openalex.org/W2046257292","https://openalex.org/W2049338248","https://openalex.org/W2052491625","https://openalex.org/W2053056001","https://openalex.org/W2054236849","https://openalex.org/W2055484304","https://openalex.org/W2059900570","https://openalex.org/W2060189417","https://openalex.org/W2060302805","https://openalex.org/W2064991426","https://openalex.org/W2071667444","https://openalex.org/W2072080136","https://openalex.org/W2076100006","https://openalex.org/W2080918594","https://openalex.org/W2082014302","https://openalex.org/W2086619682","https://openalex.org/W2092340487","https://openalex.org/W2095464946","https://openalex.org/W2096251685","https://openalex.org/W2101300328","https://openalex.org/W2104818591","https://openalex.org/W2107567775","https://openalex.org/W2117419630","https://openalex.org/W2117833766","https://openalex.org/W2120349119","https://openalex.org/W2129458751","https://openalex.org/W2131695984","https://openalex.org/W2135871241","https://openalex.org/W2137844183","https://openalex.org/W2141323297","https://openalex.org/W2141599743","https://openalex.org/W2143753516","https://openalex.org/W2148708585","https://openalex.org/W2150994243","https://openalex.org/W2153819921","https://openalex.org/W2155962841","https://openalex.org/W2158797526","https://openalex.org/W2162163939","https://openalex.org/W2164820318","https://openalex.org/W2173622786","https://openalex.org/W2258953297","https://openalex.org/W2471827245","https://openalex.org/W2779095753","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2261444039","https://openalex.org/W2606670691","https://openalex.org/W1544666832","https://openalex.org/W1552838137","https://openalex.org/W2064991426","https://openalex.org/W2006071625","https://openalex.org/W1970794990","https://openalex.org/W4379375756","https://openalex.org/W2471827245","https://openalex.org/W2800201312"],"abstract_inverted_index":{"CO2":[0,33,37,48,237],"is":[1,14],"produced":[2],"abundantly":[3],"by":[4,35,103,120,183,196,201],"cardiac":[5,193],"mitochondria.":[6],"Thus":[7],"an":[8],"efficient":[9],"means":[10],"for":[11,47,225],"its":[12],"venting":[13],"required":[15],"to":[16,53,79,235],"support":[17,236],"metabolism.":[18],"Carbonic":[19],"anhydrase":[20],"(CA)":[21],"enzymes,":[22],"expressed":[23],"at":[24],"various":[25],"sites":[26],"in":[27,56,70,100,186,218],"ventricular":[28,75,88],"myocytes,":[29],"may":[30,252],"affect":[31],"mitochondrial":[32,147],"clearance":[34],"catalyzing":[36],"hydration":[38,62],"(to":[39],"H(+)":[40],"and":[41,169,189,209,242],"HCO3(-)),":[42],"thereby":[43],"changing":[44],"the":[45,60,71,109,137,163,179,197,215,254],"gradient":[46],"venting.":[49],"Using":[50],"fluorescent":[51,141],"dyes":[52],"measure":[54],"changes":[55],"pH":[57],"arising":[58],"from":[59,108,114,118,214],"intracellular":[61],"of":[63,73,111,124,174,206,229,248],"extracellularly":[64],"supplied":[65],"CO2,":[66],"overall":[67],"CA":[68,93,95,127,142,166,176,231,249],"activity":[69,96,128,177,232,250],"cytoplasm":[72],"isolated":[74,190],"myocytes":[76,188],"was":[77,97,133],"found":[78],"be":[80],"modest":[81],"(2.7-fold":[82],"above":[83],"spontaneous":[84],"kinetics).":[85],"Experiments":[86],"on":[87,158],"mitochondria":[89,119,151,234],"demonstrated":[90],"negligible":[91],"intramitochondrial":[92],"activity.":[94,245],"also":[98],"investigated":[99],"intact":[101],"hearts":[102],"(13)C":[104],"magnetic":[105,203],"resonance":[106,204],"spectroscopy":[107,205],"rate":[110],"H(13)CO3(-)":[112],"production":[113],"(13)CO2":[115],"released":[116],"specifically":[117],"pyruvate":[121],"dehydrogenase-mediated":[122],"metabolism":[123],"hyperpolarized":[125],"[1-(13)C]pyruvate.":[126],"measured":[129,200,213],"upon":[130],"[1-(13)C]pyruvate":[131],"infusion":[132],"fourfold":[134],"higher":[135],"than":[136],"cytoplasm-averaged":[138],"value.":[139],"A":[140],"ligand":[143],"colocalized":[144],"with":[145],"a":[146,154,226],"marker,":[148],"indicating":[149],"that":[150],"are":[152],"near":[153],"CA-rich":[155],"domain.":[156],"Based":[157],"immunoreactivity,":[159],"this":[160],"domain":[161,228],"comprises":[162],"nominally":[164],"cytoplasmic":[165],"isoform":[167],"CAII":[168],"sarcoplasmic":[170],"reticulum-associated":[171],"CAXIV.":[172],"Inhibition":[173],"extramitochondrial":[175],"acidified":[178],"matrix":[180],"(as":[181,212],"determined":[182],"fluorescence":[184],"measurements":[185],"permeabilized":[187],"mitochondria),":[191],"impaired":[192],"energetics":[194],"(indexed":[195],"phosphocreatine-to-ATP":[198],"ratio":[199],"(31)P":[202],"perfused":[207,219],"hearts),":[208],"reduced":[210],"contractility":[211],"pressure":[216],"developed":[217],"hearts).":[220],"These":[221],"data":[222],"provide":[223],"evidence":[224],"functional":[227],"high":[230],"around":[233],"venting,":[238],"particularly":[239],"during":[240],"elevated":[241],"fluctuating":[243],"respiratory":[244],"Aberrant":[246],"distribution":[247],"therefore":[251],"reduce":[253],"heart's":[255],"energetic":[256],"efficiency.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
