{"id":"https://openalex.org/W2104959246","doi":null,"title":"Synthesis and Structure-activity Relationships of Flavonoids Derived from Scutellaria baicalensis Georgi as Potent Anti-flu Agents against Tamiflu- resistant H1N1 Virus and H3N2 Virus","display_name":"Synthesis and Structure-activity Relationships of Flavonoids Derived from Scutellaria baicalensis Georgi as Potent Anti-flu Agents against Tamiflu- resistant H1N1 Virus and H3N2 Virus","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2104959246","mag":"2104959246"},"language":"en","primary_location":{"id":"mag:2104959246","doi":null,"is_oa":false,"landing_page_url":"http://www.academicpub.org/DownLoadPaper.aspx?PaperID=1142","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079875144","display_name":"An\u2010Rong Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"An\u2010Rong Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047301778","display_name":"Chia-Wei Liao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chia-Wei Liao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109961660","display_name":"Wen-Liang Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-Liang Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076943129","display_name":"Chen\u2010Wen Yao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen\u2010Wen Yao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110182299","display_name":"Wen\u2010Hsin Huang","orcid":"https://orcid.org/0009-0005-1297-1204","observed_orcids":["https://orcid.org/0009-0005-1297-1204"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen\u2010Hsin Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.5903000235557556,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.5903000235557556,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13023","display_name":"Synthesis of Organic Compounds","score":0.384799987077713,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scutellaria-baicalensis","display_name":"Scutellaria baicalensis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9480000138282776},{"id":"https://openalex.org/keywords/anti-influenza-activity","display_name":"anti-influenza activity","score":0.7960000038146973},{"id":"https://openalex.org/keywords/h1n1-influenza-virus","display_name":"H1N1 influenza virus","score":0.8569999933242798},{"id":"https://openalex.org/keywords/h3n2-influenza-virus","display_name":"H3N2 influenza virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.781000018119812},{"id":"https://openalex.org/keywords/baicalein","display_name":"baicalein","score":0.703000009059906},{"id":"https://openalex.org/keywords/cinnamoyl-chloride","display_name":"cinnamoyl chloride","score":0.8560000061988831},{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":0.7400000095367432},{"id":"https://openalex.org/keywords/selectivity-index","display_name":"selectivity index","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2780374985","wikidata":"https://www.wikidata.org/wiki/Q211509","display_name":"Oseltamivir","level":5,"score":0.8074604868888855},{"id":"https://openalex.org/C2780391423","wikidata":"https://www.wikidata.org/wiki/Q42171","display_name":"Rimantadine","level":4,"score":0.7695862650871277},{"id":"https://openalex.org/C2781442963","wikidata":"https://www.wikidata.org/wiki/Q146075","display_name":"Zanamivir","level":5,"score":0.7625054121017456},{"id":"https://openalex.org/C2777374534","wikidata":"https://www.wikidata.org/wiki/Q409761","display_name":"Amantadine","level":2,"score":0.6802725791931152},{"id":"https://openalex.org/C2778153525","wikidata":"https://www.wikidata.org/wiki/Q803769","display_name":"Scutellaria baicalensis","level":4,"score":0.6593576073646545},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6443933844566345},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.5564068555831909},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4858519732952118},{"id":"https://openalex.org/C2777538117","wikidata":"https://www.wikidata.org/wiki/Q425196","display_name":"Neuraminidase inhibitor","level":5,"score":0.4173429012298584},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3989640772342682},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.300126850605011},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.10867971181869507},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2104959246","doi":null,"is_oa":false,"landing_page_url":"http://www.academicpub.org/DownLoadPaper.aspx?PaperID=1142","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1964798833","https://openalex.org/W1968215787","https://openalex.org/W1985709964","https://openalex.org/W2006577301","https://openalex.org/W2007661701","https://openalex.org/W2019494984","https://openalex.org/W2039103923","https://openalex.org/W2044372728","https://openalex.org/W2046745698","https://openalex.org/W2050205112","https://openalex.org/W2061782770","https://openalex.org/W2068310957","https://openalex.org/W2074943221","https://openalex.org/W2078368610","https://openalex.org/W2088195624","https://openalex.org/W2089791999","https://openalex.org/W2090126922","https://openalex.org/W2103561226","https://openalex.org/W2114918609","https://openalex.org/W2118888626","https://openalex.org/W2128924487","https://openalex.org/W2132591613","https://openalex.org/W2144868623","https://openalex.org/W2314639456"],"related_works":["https://openalex.org/W2048841611","https://openalex.org/W2022109802","https://openalex.org/W2116367919","https://openalex.org/W2073038629","https://openalex.org/W2377185243","https://openalex.org/W2082398230","https://openalex.org/W3009190417","https://openalex.org/W2003495727","https://openalex.org/W2615118263","https://openalex.org/W2314639456"],"abstract_inverted_index":{"Annual":[0],"global":[1],"pandemic":[2],"and/or":[3,118],"epidemic":[4],"influenza":[5,32,134,137,320,348],"threats":[6],"continually":[7],"threaten":[8],"human":[9],"beings.":[10],"Despite":[11],"annual":[12],"vaccination":[13],"and":[14,25,40,95,141,196,204,214,222,229,263,275,281,292,322,330,338],"the":[15,50,59,83,105,116,125,153,223,234,282,317,328],"use":[16],"of":[17,31,42,52,61,86,107,152,169,307,319,332],"four":[18],"approved":[19],"antiviral":[20],"agents":[21,63],"(amantadine,":[22],"rimantadine,":[23],"zanamivir,":[24],"oseltamivir)":[26],"to":[27,64,67,111,315,326,341],"control":[28,316],"viral":[29,191],"infectivity":[30],"viruses,":[33],"there":[34],"is":[35],"still":[36],"a":[37,98,197,208,266],"limited":[38],"effectiveness":[39],"suffering":[41],"severe":[43],"drug":[44],"side":[45],"effects":[46],"as":[47,49,101,343],"well":[48],"emergence":[51],"drug-resistant":[53],"variants":[54],"after":[55,312],"treatments":[56],"that":[57,150,168,184],"prompt":[58],"needs":[60],"new":[62],"be":[65],"developed":[66],"treat":[68],"flu.":[69],"Some":[70],"Chinese":[71],"medicines":[72],"have":[73],"been":[74],"shown":[75],"potential":[76,344],"treatment":[77],"for":[78,104,347],"influenza.":[79],"In":[80],"this":[81,128,244,299],"study,":[82],"direct":[84],"acylation":[85],"dimethoxyphenol":[87],"with":[88,120,132,335],"substituted":[89],"cinnamoyl":[90],"chlorides":[91],"by":[92],"fries":[93],"reaction":[94],"cyclization":[96],"affords":[97],"practical":[99],"route":[100],"standard":[102],"manipulations":[103],"synthesis":[106],"novel":[108],"flavonoids":[109,126,308],"related":[110],"baicalein/oroxyllin-A,":[112],"which":[113],"functionalized":[114],"on":[115],"A-":[117],"B-ring":[119],"good":[121,209,267],"overall":[122],"yields.":[123],"All":[124],"in":[127,143,212,233,243,270,298],"study":[129,245,300],"were":[130,164],"screened":[131],"anti-":[133],"activity":[135,192,211,250],"against":[136,174,218,237,252,278],"virus":[138,221,321],"(H1N1-Tamiflu":[139],"resistant":[140,176,190,220,254],"H3N2)-infected":[142],"MDCK":[144],"cell":[145],"line.":[146],"Our":[147],"results":[148],"showed":[149],"most":[151,179],"synthetic":[154,241],"products":[155],"possessed":[156],"significant":[157],"activity.":[158],"Among":[159,256],"them,":[160,257],"4a,":[161],"4c,":[162],"5c":[163,205],"more":[165,247],"potent":[166,180,248],"than":[167,251],"ribavirin":[170],"(a":[171],"positive":[172],"control)":[173],"H1N1-Tamiflu":[175,219,253],"virus.":[177,255],"The":[178],"compound":[181],"was":[182],"4a":[183],"displayed":[185,246],"an":[186],"effectively":[187],"anti-H1N1-":[188],"Tamiflu":[189],"at":[193],"2.9":[194],"\u03bcM":[195,277],"selectivity":[198,225,284],"index":[199,226,285],">":[200,227,286,288,293],"103.4.":[201],"Compound":[202],"4c":[203],"also":[206],"exhibited":[207,265],"inhibitory":[210,249,268],"5.2":[213],"5.4":[215],"\u03bcM,":[216],"respectively,":[217],"corresponding":[224,283],"57.7":[228],"8.0,":[230],"respectively.":[231,295],"Moreover,":[232],"screening":[235],"test":[236],"H3N2":[238,279],"virus,":[239,280],"some":[240],"compounds":[242,258,334],"3a,":[259],"5a,":[260],"7c,":[261],"10":[262],"11":[264],"action":[269],"5.5,":[271],"6.2,":[272],"4.5":[273],"4.0":[274],"6.1":[276],"54.4,":[287],"48.3,":[289],"4.0,":[290],"32.4":[291],"49.2,":[294],"Those":[296],"findings":[297],"provide":[301,324],"somewhat":[302],"important":[303],"chemical":[304,333],"structural":[305],"features":[306],"relating":[309],"their":[310],"ability":[311],"SAR":[313],"analysis":[314],"replication":[318],"would":[323],"basis":[325],"expedite":[327],"design":[329],"development":[331],"higher":[336],"potency":[337],"lower":[339],"toxicity":[340],"serve":[342],"NA":[345],"inhibitors":[346],"treatment.":[349]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}