{"id":"https://openalex.org/W2104954848","doi":"https://doi.org/10.1182/blood-2013-04-497644","title":"Potent inhibition of DOT1L as treatment of MLL-fusion leukemia","display_name":"Potent inhibition of DOT1L as treatment of MLL-fusion leukemia","publication_year":2013,"publication_date":"2013-06-25","ids":{"openalex":"https://openalex.org/W2104954848","doi":"https://doi.org/10.1182/blood-2013-04-497644","mag":"2104954848","pmid":"https://pubmed.ncbi.nlm.nih.gov/23801631","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3739029"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2013-04-497644","doi":"https://doi.org/10.1182/blood-2013-04-497644","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2013-04-497644","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3739029","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108833682","display_name":"Scott R. Daigle","orcid":"https://orcid.org/0009-0009-5711-7641","observed_orcids":["https://orcid.org/0009-0009-5711-7641"]},"institutions":[{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott R. Daigle","raw_affiliation_strings":["Epizyme, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epizyme, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210109703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049740405","display_name":"Edward J. Olhava","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward J. Olhava","raw_affiliation_strings":["Epizyme, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epizyme, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210109703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059868438","display_name":"Carly A. Therkelsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carly A. Therkelsen","raw_affiliation_strings":["Epizyme, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epizyme, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210109703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006265865","display_name":"Aravind Basavapathruni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aravind Basavapathruni","raw_affiliation_strings":["Epizyme, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epizyme, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210109703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100740373","display_name":"Lei Jin","orcid":"https://orcid.org/0000-0002-5602-1818","observed_orcids":["https://orcid.org/0000-0002-5602-1818"]},"institutions":[{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Jin","raw_affiliation_strings":["Epizyme, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epizyme, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210109703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052339827","display_name":"P. Ann Boriack\u2010Sjodin","orcid":"https://orcid.org/0000-0003-0179-5936","observed_orcids":["https://orcid.org/0000-0003-0179-5936"]},"institutions":[{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Ann Boriack-Sjodin","raw_affiliation_strings":["Epizyme, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epizyme, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210109703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041663671","display_name":"Christina J. Allain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina J. Allain","raw_affiliation_strings":["Epizyme, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epizyme, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210109703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081590980","display_name":"Christine R. Klaus","orcid":"https://orcid.org/0000-0002-5880-6870","observed_orcids":["https://orcid.org/0000-0002-5880-6870"]},"institutions":[{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine R. Klaus","raw_affiliation_strings":["Epizyme, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epizyme, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210109703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079181273","display_name":"Alejandra Raimondi","orcid":"https://orcid.org/0009-0009-2497-8402","observed_orcids":["https://orcid.org/0009-0009-2497-8402"]},"institutions":[{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandra Raimondi","raw_affiliation_strings":["Epizyme, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epizyme, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210109703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022609500","display_name":"Margaret Porter Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Porter Scott","raw_affiliation_strings":["Epizyme, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epizyme, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210109703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002606637","display_name":"Nigel J. Waters","orcid":"https://orcid.org/0000-0002-5063-295X","observed_orcids":["https://orcid.org/0000-0002-5063-295X"]},"institutions":[{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nigel J. Waters","raw_affiliation_strings":["Epizyme, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epizyme, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210109703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015187022","display_name":"Richard Chesworth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Chesworth","raw_affiliation_strings":["Epizyme, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epizyme, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210109703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111682318","display_name":"Mikel P. Moyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikel P. Moyer","raw_affiliation_strings":["Epizyme, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epizyme, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210109703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103131022","display_name":"Robert A. Copeland","orcid":"https://orcid.org/0000-0003-2606-2288","observed_orcids":["https://orcid.org/0000-0003-2606-2288"]},"institutions":[{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Copeland","raw_affiliation_strings":["Epizyme, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epizyme, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210109703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027363771","display_name":"Victoria M. Richon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria M. Richon","raw_affiliation_strings":["Epizyme, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epizyme, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210109703"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004903148","display_name":"Roy M. Pollock","orcid":"https://orcid.org/0000-0002-6182-6725","observed_orcids":["https://orcid.org/0000-0002-6182-6725"]},"institutions":[{"id":"https://openalex.org/I4210109703","display_name":"Epizyme (United States)","ror":"https://ror.org/01mmhvx47","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy M. Pollock","raw_affiliation_strings":["Epizyme, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epizyme, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4210109703"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210109703"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":47.0628,"has_fulltext":false,"cited_by_count":737,"citation_normalized_percentile":{"value":0.9991503,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"122","issue":"6","first_page":"1017","last_page":"1025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.06520000100135803,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dot1l","display_name":"DOT1L","score":0.8349999785423279},{"id":"https://openalex.org/keywords/histone-methyltransferase-inhibition","display_name":"histone methyltransferase inhibition","score":0.9419999718666077},{"id":"https://openalex.org/keywords/h3k79-methylation","display_name":"H3K79 methylation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acute-leukemia","display_name":"acute leukemia","score":0.6970000267028809},{"id":"https://openalex.org/keywords/mll-translocation","display_name":"MLL translocation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.5450000166893005},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.6864718794822693},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6212061643600464},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.5788020491600037},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5602737665176392},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.5162248611450195},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.4961634576320648},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4519774615764618},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.36806759238243103},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2775607705116272},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19319435954093933},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18452760577201843}],"mesh":[{"descriptor_ui":"D000076983","descriptor_name":"Histone Methyltransferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011923","descriptor_name":"Rats, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051788","descriptor_name":"Myeloid-Lymphoid Leukemia Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1182/blood-2013-04-497644","doi":"https://doi.org/10.1182/blood-2013-04-497644","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2013-04-497644","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2733411","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3739029","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3739029","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3739029","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},{"id":"pmid:23801631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23801631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2733411","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3739029","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1501954618","https://openalex.org/W1563650227","https://openalex.org/W1948730391","https://openalex.org/W1968048144","https://openalex.org/W1968677867","https://openalex.org/W1977729188","https://openalex.org/W1979157667","https://openalex.org/W1979316039","https://openalex.org/W1982315838","https://openalex.org/W1984178346","https://openalex.org/W1988547264","https://openalex.org/W1993790725","https://openalex.org/W2005829971","https://openalex.org/W2016408686","https://openalex.org/W2021486899","https://openalex.org/W2028500280","https://openalex.org/W2042871287","https://openalex.org/W2047611070","https://openalex.org/W2048613921","https://openalex.org/W2059171174","https://openalex.org/W2059382988","https://openalex.org/W2061271252","https://openalex.org/W2063529845","https://openalex.org/W2069918359","https://openalex.org/W2073652391","https://openalex.org/W2082592723","https://openalex.org/W2087188627","https://openalex.org/W2091208410","https://openalex.org/W2097370203","https://openalex.org/W2103233056","https://openalex.org/W2104460981","https://openalex.org/W2105740818","https://openalex.org/W2112075818","https://openalex.org/W2128307445","https://openalex.org/W2130020386","https://openalex.org/W2136658972","https://openalex.org/W2138807501","https://openalex.org/W2143922252","https://openalex.org/W2147138024","https://openalex.org/W2147713614","https://openalex.org/W2152258603","https://openalex.org/W2160363772","https://openalex.org/W2163668223","https://openalex.org/W2917868259","https://openalex.org/W4299422128"],"related_works":["https://openalex.org/W2297827825","https://openalex.org/W2560387731","https://openalex.org/W4220792557","https://openalex.org/W2553999007","https://openalex.org/W2596991948","https://openalex.org/W2979621184","https://openalex.org/W2099980194","https://openalex.org/W2998517224","https://openalex.org/W2318997583","https://openalex.org/W2060768557"],"abstract_inverted_index":{"Rearrangements":[0],"of":[1,10,20,55,66,74,86,129,136,159,167],"the":[2,44,51,64,148],"MLL":[3,124],"gene":[4,109],"define":[5],"a":[6,26,68,132,164],"genetically":[7],"distinct":[8],"subset":[9],"acute":[11,120],"leukemias":[12],"with":[13,152],"poor":[14],"prognosis.":[15],"Current":[16],"treatment":[17,166],"options":[18],"are":[19],"limited":[21],"effectiveness;":[22],"thus,":[23],"there":[24],"is":[25,48,162,171],"pressing":[27],"need":[28],"for":[29,32,50,119],"new":[30],"therapies":[31],"this":[33],"disease.":[34],"Genetic":[35],"and":[36,53,70,89,106,111,170],"small":[37],"molecule":[38],"inhibitor":[39,73],"studies":[40],"have":[41],"demonstrated":[42,112],"that":[43,116,143],"histone":[45,76],"methyltransferase":[46,77],"DOT1L":[47,75],"required":[49],"development":[52],"maintenance":[54],"MLL-rearranged":[56,137,168],"leukemia":[57,121,138,169],"in":[58,131],"model":[59,135],"systems.":[60],"Here":[61],"we":[62],"describe":[63],"characterization":[65],"EPZ-5676,":[67],"potent":[69,113],"selective":[71,118],"aminonucleoside":[72],"activity.":[78],"The":[79],"compound":[80,149],"has":[81],"an":[82],"inhibition":[83],"constant":[84],"value":[85],"80":[87],"pM,":[88],"demonstrates":[90],"37":[91],"000-fold":[92],"selectivity":[93],"over":[94],"all":[95],"other":[96],"methyltransferases":[97],"tested.":[98],"In":[99],"cellular":[100],"studies,":[101],"EPZ-5676":[102,130,161],"inhibited":[103],"H3K79":[104],"methylation":[105],"MLL-fusion":[107],"target":[108],"expression":[110],"cell":[114],"killing":[115],"was":[117],"lines":[122],"bearing":[123],"translocations.":[125],"Continuous":[126],"IV":[127],"infusion":[128,150],"rat":[133],"xenograft":[134],"caused":[139],"complete":[140],"tumor":[141],"regressions":[142],"were":[144],"sustained":[145],"well":[146],"beyond":[147],"period":[151],"no":[153],"significant":[154],"weight":[155],"loss":[156],"or":[157],"signs":[158],"toxicity.":[160],"therefore":[163],"potential":[165],"under":[172],"clinical":[173],"investigation.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":39},{"year":2024,"cited_by_count":38},{"year":2023,"cited_by_count":48},{"year":2022,"cited_by_count":54},{"year":2021,"cited_by_count":53},{"year":2020,"cited_by_count":57},{"year":2019,"cited_by_count":73},{"year":2018,"cited_by_count":54},{"year":2017,"cited_by_count":81},{"year":2016,"cited_by_count":65},{"year":2015,"cited_by_count":78},{"year":2014,"cited_by_count":65},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
