{"id":"https://openalex.org/W2104953243","doi":"https://doi.org/10.1093/cvr/cvs168","title":"Mechanical regulation of cellular phenotype: implications for vascular tissue regeneration","display_name":"Mechanical regulation of cellular phenotype: implications for vascular tissue regeneration","publication_year":2012,"publication_date":"2012-05-23","ids":{"openalex":"https://openalex.org/W2104953243","doi":"https://doi.org/10.1093/cvr/cvs168","mag":"2104953243","pmid":"https://pubmed.ncbi.nlm.nih.gov/22628449"},"language":"en","primary_location":{"id":"doi:10.1093/cvr/cvs168","doi":"https://doi.org/10.1093/cvr/cvs168","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cvr/cvs168","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013515186","display_name":"Wendy F. Liu","orcid":"https://orcid.org/0000-0002-8904-7643","observed_orcids":["https://orcid.org/0000-0002-8904-7643"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. F. Liu","raw_affiliation_strings":["Department of Biomedical Engineering and the Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, 2412 Engineering Hall, Irvine, CA 92697-2730, USA. wendy.liu@uci.edu","Department of Biomedical Engineering and the Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, 2412 Engineering Hall, Irvine, #N#CA 92697-2730, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and the Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, 2412 Engineering Hall, Irvine, CA 92697-2730, USA. wendy.liu@uci.edu","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Biomedical Engineering and the Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, 2412 Engineering Hall, Irvine, #N#CA 92697-2730, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013515186"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":4715,"currency":"EUR","value_usd":5329},"apc_paid":null,"fwci":0.3544,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.31059683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"95","issue":"2","first_page":"215","last_page":"222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.8889999985694885},{"id":"https://openalex.org/keywords/mechanical-cues","display_name":"mechanical cues","score":0.6819999814033508},{"id":"https://openalex.org/keywords/extracellular-matrix-stiffness","display_name":"extracellular matrix stiffness","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cell-shape","display_name":"cell shape","score":0.6420000195503235},{"id":"https://openalex.org/keywords/stem-cells","display_name":"stem cells","score":0.7630000114440918},{"id":"https://openalex.org/keywords/stemness","display_name":"stemness","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7710000276565552},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cell-differentiation","display_name":"vascular smooth muscle cell differentiation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cardiovascular-tissue-engineering","display_name":"cardiovascular tissue engineering","score":0.8970000147819519},{"id":"https://openalex.org/keywords/vascular-tissue-regeneration","display_name":"vascular tissue regeneration","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.8068745136260986},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7370356321334839},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5844244956970215},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5101914405822754},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5024611949920654},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.49160274863243103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48987099528312683},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4786442518234253},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44189196825027466},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.41819655895233154},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.41134777665138245},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34973594546318054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24666041135787964},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1171640157699585},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/cvr/cvs168","doi":"https://doi.org/10.1093/cvr/cvs168","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cvr/cvs168","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},{"id":"pmid:22628449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22628449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W1576773659","https://openalex.org/W1936770188","https://openalex.org/W1964281587","https://openalex.org/W1969929083","https://openalex.org/W1970199527","https://openalex.org/W1973089587","https://openalex.org/W1973615948","https://openalex.org/W1975209939","https://openalex.org/W1975854407","https://openalex.org/W1982406314","https://openalex.org/W1991237283","https://openalex.org/W1993006648","https://openalex.org/W1994076220","https://openalex.org/W1994339637","https://openalex.org/W1995029094","https://openalex.org/W1995065021","https://openalex.org/W1998643734","https://openalex.org/W1998901389","https://openalex.org/W1999382014","https://openalex.org/W2000465700","https://openalex.org/W2004181539","https://openalex.org/W2004754771","https://openalex.org/W2007097623","https://openalex.org/W2019456180","https://openalex.org/W2019731805","https://openalex.org/W2021488944","https://openalex.org/W2026632078","https://openalex.org/W2028183845","https://openalex.org/W2040003917","https://openalex.org/W2051430013","https://openalex.org/W2054635074","https://openalex.org/W2063736240","https://openalex.org/W2063753069","https://openalex.org/W2068092779","https://openalex.org/W2069370313","https://openalex.org/W2071145526","https://openalex.org/W2075775205","https://openalex.org/W2076922024","https://openalex.org/W2079595896","https://openalex.org/W2090063730","https://openalex.org/W2094111146","https://openalex.org/W2095301611","https://openalex.org/W2095601153","https://openalex.org/W2098947128","https://openalex.org/W2099293007","https://openalex.org/W2100454719","https://openalex.org/W2101818773","https://openalex.org/W2102661335","https://openalex.org/W2111412288","https://openalex.org/W2111811045","https://openalex.org/W2112418598","https://openalex.org/W2113547540","https://openalex.org/W2125332169","https://openalex.org/W2125987139","https://openalex.org/W2126326508","https://openalex.org/W2126432370","https://openalex.org/W2126466803","https://openalex.org/W2127394968","https://openalex.org/W2132089035","https://openalex.org/W2134208433","https://openalex.org/W2135073071","https://openalex.org/W2141075109","https://openalex.org/W2144023435","https://openalex.org/W2146337514","https://openalex.org/W2147604745","https://openalex.org/W2156413973","https://openalex.org/W2159999899","https://openalex.org/W2160912589","https://openalex.org/W2161368770","https://openalex.org/W2163504716","https://openalex.org/W2167159325","https://openalex.org/W2167243609","https://openalex.org/W2171179595"],"related_works":["https://openalex.org/W1993139974","https://openalex.org/W2602176380","https://openalex.org/W2135073071","https://openalex.org/W2278485442","https://openalex.org/W7098855130","https://openalex.org/W2040788343","https://openalex.org/W7099692635","https://openalex.org/W1988858456","https://openalex.org/W7061932287","https://openalex.org/W2793632119"],"abstract_inverted_index":{"Cells":[0],"sense":[1],"a":[2,62],"myriad":[3],"of":[4,38,44,87,98,104,123],"cues":[5,25],"from":[6],"their":[7,12,58,116],"surrounding":[8],"microenvironment":[9,59],"to":[10,74,82,114],"regulate":[11],"function.":[13,35],"In":[14,90],"recent":[15],"years,":[16],"it":[17],"has":[18],"become":[19],"clear":[20],"that":[21],"physical":[22,53],"and":[23,47,57,60,69,107,119,132],"mechanical":[24,100],"are":[26],"as":[27,29],"critical":[28],"biochemical":[30],"factors":[31],"in":[32,65],"regulating":[33,66],"cellular":[34,88],"The":[36,121],"geometry":[37],"the":[39,52,84],"extracellular":[40],"matrix":[41,108],"(ECM),":[42],"degree":[43],"cell":[45,77,105,130],"spreading,":[46],"ECM":[48],"rigidity":[49],"all":[50],"influence":[51],"connection":[54],"between":[55],"cells":[56,113],"play":[61],"major":[63],"role":[64],"proliferation,":[67,118],"differentiation,":[68],"migration.":[70],"Leveraging":[71],"these":[72,124],"findings":[73,125],"promote":[75],"specific":[76],"behaviours":[78],"will":[79,136],"be":[80,137],"paramount":[81],"realize":[83],"full":[85],"potential":[86],"therapies.":[89],"this":[91],"review,":[92],"I":[93],"examine":[94],"our":[95],"current":[96],"understanding":[97],"how":[99],"cues-specifically,":[101],"geometric":[102],"control":[103,115],"shape":[106],"rigidity-are":[109],"transduced":[110],"by":[111],"stem":[112],"stemness,":[117],"differentiation.":[120],"implications":[122],"for":[126],"vascular":[127],"smooth":[128],"muscle":[129],"differentiation":[131],"cardiovascular":[133],"tissue":[134],"engineering":[135],"highlighted.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
