{"id":"https://openalex.org/W2104951611","doi":"https://doi.org/10.1007/s00192-014-2608-2","title":"First evidence of neosaxitoxin as a long-acting pain blocker in bladder pain syndrome","display_name":"First evidence of neosaxitoxin as a long-acting pain blocker in bladder pain syndrome","publication_year":2015,"publication_date":"2015-01-08","ids":{"openalex":"https://openalex.org/W2104951611","doi":"https://doi.org/10.1007/s00192-014-2608-2","mag":"2104951611","pmid":"https://pubmed.ncbi.nlm.nih.gov/25571865"},"language":"en","primary_location":{"id":"doi:10.1007/s00192-014-2608-2","doi":"https://doi.org/10.1007/s00192-014-2608-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00192-014-2608-2","pdf_url":null,"source":{"id":"https://openalex.org/S90591482","display_name":"International Urogynecology Journal","issn_l":"0937-3462","issn":["0937-3462","1433-3023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Urogynecology Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://repositorio.uchile.cl/handle/2250/132921","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102942272","display_name":"Valent\u00edn Manr\u00edquez G","orcid":"https://orcid.org/0000-0002-8858-5757","observed_orcids":["https://orcid.org/0000-0002-8858-5757"]},"institutions":[{"id":"https://openalex.org/I4210131012","display_name":"Hospital Cl\u00ednico de la Universidad de Chile","ror":"https://ror.org/02xtpdq88","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210131012"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Valentin Manr\u00edquez","raw_affiliation_strings":["Female Pelvic Floor Unit, Gynecologic and Obstetric Department, Hospital Cl\u00ednico de la Universidad de Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Female Pelvic Floor Unit, Gynecologic and Obstetric Department, Hospital Cl\u00ednico de la Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I4210131012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037997546","display_name":"Daniela Castro Caperan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131012","display_name":"Hospital Cl\u00ednico de la Universidad de Chile","ror":"https://ror.org/02xtpdq88","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210131012"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Daniela Castro Caperan","raw_affiliation_strings":["Female Pelvic Floor Unit, Gynecologic and Obstetric Department, Hospital Cl\u00ednico de la Universidad de Chile, Santiago, Chile","Hospital Cl\u00ednico Universidad de Chile de Santiago, Santos Dumont 999, Independencia, Santiago, Chile, 8380456","Membrane Laboratory, Physiology and Biophysics Department, Faculty of Medicine, Universidad de Chile, Santiago, Chile","Hospital Cl\u00ednico Universidad de Chile de Santiago, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Female Pelvic Floor Unit, Gynecologic and Obstetric Department, Hospital Cl\u00ednico de la Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I4210131012"]},{"raw_affiliation_string":"Hospital Cl\u00ednico Universidad de Chile de Santiago, Santos Dumont 999, Independencia, Santiago, Chile, 8380456","institution_ids":["https://openalex.org/I4210131012","https://openalex.org/I69737025"]},{"raw_affiliation_string":"Membrane Laboratory, Physiology and Biophysics Department, Faculty of Medicine, Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Hospital Cl\u00ednico Universidad de Chile de Santiago, Santiago, Chile","institution_ids":["https://openalex.org/I4210131012","https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110216525","display_name":"Rodrigo Guzm\u00e1n","orcid":"https://orcid.org/0000-0003-0647-1797","observed_orcids":["https://orcid.org/0000-0003-0647-1797"]},"institutions":[{"id":"https://openalex.org/I4210131012","display_name":"Hospital Cl\u00ednico de la Universidad de Chile","ror":"https://ror.org/02xtpdq88","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210131012"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Rodrigo Guzm\u00e1n","raw_affiliation_strings":["Female Pelvic Floor Unit, Gynecologic and Obstetric Department, Hospital Cl\u00ednico de la Universidad de Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Female Pelvic Floor Unit, Gynecologic and Obstetric Department, Hospital Cl\u00ednico de la Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I4210131012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055181643","display_name":"Michel Naser N.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131012","display_name":"Hospital Cl\u00ednico de la Universidad de Chile","ror":"https://ror.org/02xtpdq88","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210131012"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Michel Naser","raw_affiliation_strings":["Female Pelvic Floor Unit, Gynecologic and Obstetric Department, Hospital Cl\u00ednico de la Universidad de Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Female Pelvic Floor Unit, Gynecologic and Obstetric Department, Hospital Cl\u00ednico de la Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I4210131012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080898120","display_name":"Veronica Iglesia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Veronica Iglesia","raw_affiliation_strings":["Public Health School, Faculty of Medicine, Universidad de Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health School, Faculty of Medicine, Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110156102","display_name":"N\u00e9stor Lagos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Nestor Lagos","raw_affiliation_strings":["Membrane Laboratory, Physiology and Biophysics Department, Faculty of Medicine, Universidad de Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Membrane Laboratory, Physiology and Biophysics Department, Faculty of Medicine, Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037997546"],"corresponding_institution_ids":["https://openalex.org/I4210131012","https://openalex.org/I69737025"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":2.9834,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.90907521,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"26","issue":"6","first_page":"853","last_page":"858"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neosaxitoxin","display_name":"neosaxitoxin","score":1.0},{"id":"https://openalex.org/keywords/interstitial-cystitis","display_name":"interstitial cystitis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/voltage-gated-sodium-channel-blockade","display_name":"voltage-gated sodium channel blockade","score":0.765999972820282},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.5649999976158142},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9528322219848633},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6062314510345459},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.5281881093978882},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.5122448801994324},{"id":"https://openalex.org/C2909931192","wikidata":"https://www.wikidata.org/wiki/Q1671412","display_name":"Bladder Pain Syndrome","level":4,"score":0.5041600465774536},{"id":"https://openalex.org/C2778769751","wikidata":"https://www.wikidata.org/wiki/Q246090","display_name":"Cystoscopy","level":3,"score":0.49706366658210754},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.48293086886405945},{"id":"https://openalex.org/C2779052585","wikidata":"https://www.wikidata.org/wiki/Q1760245","display_name":"Submucosa","level":2,"score":0.42740023136138916},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2818511128425598},{"id":"https://openalex.org/C2778508898","wikidata":"https://www.wikidata.org/wiki/Q1671412","display_name":"Interstitial cystitis","level":3,"score":0.23618388175964355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21637806296348572},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.15384316444396973},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D003558","descriptor_name":"Cystoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009466","descriptor_name":"Neuromuscular Blocking Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009466","descriptor_name":"Neuromuscular Blocking Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010148","descriptor_name":"Intractable Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012530","descriptor_name":"Saxitoxin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012530","descriptor_name":"Saxitoxin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D012530","descriptor_name":"Saxitoxin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00192-014-2608-2","doi":"https://doi.org/10.1007/s00192-014-2608-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00192-014-2608-2","pdf_url":null,"source":{"id":"https://openalex.org/S90591482","display_name":"International Urogynecology Journal","issn_l":"0937-3462","issn":["0937-3462","1433-3023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Urogynecology Journal","raw_type":"journal-article"},{"id":"pmid:25571865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25571865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International urogynecology journal","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.uchile.cl:2250/132921","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.uchile.cl/handle/2250/132921","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Art\u00edculo de revista"}],"best_oa_location":{"id":"pmh:oai:repositorio.uchile.cl:2250/132921","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.uchile.cl/handle/2250/132921","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Art\u00edculo de revista"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W121901842","https://openalex.org/W1538104538","https://openalex.org/W1977618273","https://openalex.org/W1990024764","https://openalex.org/W1991589291","https://openalex.org/W2002556755","https://openalex.org/W2004035920","https://openalex.org/W2004932558","https://openalex.org/W2007252060","https://openalex.org/W2013942626","https://openalex.org/W2021954956","https://openalex.org/W2030236866","https://openalex.org/W2034277696","https://openalex.org/W2048449730","https://openalex.org/W2053743803","https://openalex.org/W2075137723","https://openalex.org/W2080445164","https://openalex.org/W2095401957","https://openalex.org/W2095570215","https://openalex.org/W2115064235","https://openalex.org/W2115946392","https://openalex.org/W2132085141","https://openalex.org/W2164676774","https://openalex.org/W2168556036","https://openalex.org/W2170208729","https://openalex.org/W4247531755","https://openalex.org/W4249666043"],"related_works":["https://openalex.org/W2770645973","https://openalex.org/W2004035920","https://openalex.org/W3004998190","https://openalex.org/W2461083406","https://openalex.org/W2038274447","https://openalex.org/W2153671469","https://openalex.org/W1535931985","https://openalex.org/W4408473870","https://openalex.org/W2019838484","https://openalex.org/W7120310074"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}