{"id":"https://openalex.org/W2104909686","doi":"https://doi.org/10.1051/vetres:2007064","title":"Progress and limits of PrP gene selection policy","display_name":"Progress and limits of PrP gene selection policy","publication_year":2008,"publication_date":"2008-02-07","ids":{"openalex":"https://openalex.org/W2104909686","doi":"https://doi.org/10.1051/vetres:2007064","mag":"2104909686","pmid":"https://pubmed.ncbi.nlm.nih.gov/18258168"},"language":"en","primary_location":{"id":"doi:10.1051/vetres:2007064","doi":"https://doi.org/10.1051/vetres:2007064","is_oa":true,"landing_page_url":"https://doi.org/10.1051/vetres:2007064","pdf_url":"http://www.vetres.org/articles/vetres/pdf/2008/04/v08061.pdf","source":{"id":"https://openalex.org/S134003780","display_name":"Veterinary Research","issn_l":"0928-4249","issn":["0928-4249","1297-9716"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.vetres.org/articles/vetres/pdf/2008/04/v08061.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109932863","display_name":"Michael Dawson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Dawson","raw_affiliation_strings":["National Scrapie Plan Administration Centre, Animal Health, Worcester, WR5 2SU, UK. michael.dawson@ah.gsi.gov.uk","National Scrapie Plan Administration Centre, Animal Health, Worcester, WR5 2SU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Scrapie Plan Administration Centre, Animal Health, Worcester, WR5 2SU, UK. michael.dawson@ah.gsi.gov.uk","institution_ids":[]},{"raw_affiliation_string":"National Scrapie Plan Administration Centre, Animal Health, Worcester, WR5 2SU, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard C. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard C. Moore","raw_affiliation_strings":["Roslin Institute, Roslin, Midlothian, EH25 9PS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roslin Institute, Roslin, Midlothian, EH25 9PS, UK","institution_ids":["https://openalex.org/I133960621"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110497211","display_name":"Stephen Christopher Bishop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen C. Bishop","raw_affiliation_strings":["Roslin Institute and Royal (Dick) School of Veterinary Studies, Roslin Biocentre, Midlothian, EH25 9PS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roslin Institute and Royal (Dick) School of Veterinary Studies, Roslin Biocentre, Midlothian, EH25 9PS, UK","institution_ids":["https://openalex.org/I133960621"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":null,"fwci":0.6205,"has_fulltext":true,"cited_by_count":84,"citation_normalized_percentile":{"value":0.49943934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"39","issue":"4","first_page":"25","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14499","display_name":"Livestock Farming and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/classical-scrapie","display_name":"classical scrapie","score":0.9729999899864197},{"id":"https://openalex.org/keywords/prp-genotype","display_name":"PrP genotype","score":0.7850000262260437},{"id":"https://openalex.org/keywords/selective-breeding","display_name":"selective breeding","score":0.8289999961853027},{"id":"https://openalex.org/keywords/sheep","display_name":"sheep","score":0.39100000262260437},{"id":"https://openalex.org/keywords/bovine-spongiform-encephalopathy","display_name":"bovine spongiform encephalopathy","score":0.843999981880188},{"id":"https://openalex.org/keywords/genetic-diversity","display_name":"genetic diversity","score":0.527999997138977},{"id":"https://openalex.org/keywords/inbreeding","display_name":"inbreeding","score":0.9769999980926514},{"id":"https://openalex.org/keywords/performance-traits","display_name":"performance traits","score":0.8740000128746033},{"id":"https://openalex.org/keywords/semen-banks","display_name":"semen banks","score":0.9710000157356262},{"id":"https://openalex.org/keywords/feed-contamination","display_name":"feed contamination","score":0.3240000009536743},{"id":"https://openalex.org/keywords/disease-risk","display_name":"disease risk","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7681251764297485},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.6579954624176025},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45787638425827026},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4158872961997986},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41396433115005493},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.33376336097717285},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09830975532531738},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.06476089358329773}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001947","descriptor_name":"Breeding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1051/vetres:2007064","doi":"https://doi.org/10.1051/vetres:2007064","is_oa":true,"landing_page_url":"https://doi.org/10.1051/vetres:2007064","pdf_url":"http://www.vetres.org/articles/vetres/pdf/2008/04/v08061.pdf","source":{"id":"https://openalex.org/S134003780","display_name":"Veterinary Research","issn_l":"0928-4249","issn":["0928-4249","1297-9716"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Research","raw_type":"journal-article"},{"id":"pmid:18258168","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18258168","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary research","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00902922v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-00902922v1/file/hal-00902922.pdf","pdf_url":"https://hal.science/hal-00902922v1/file/hal-00902922.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Veterinary Research, 2008, 39 (4), pp.1-12. ⟨10.1051/vetres:2007064⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:edpsciences.org:dkey/10.1051/vetres:2007064","doi":null,"is_oa":true,"landing_page_url":"https://www.vetres.org/10.1051/vetres:2007064/pdf","pdf_url":"https://www.vetres.org/10.1051/vetres:2007064/pdf","source":{"id":"https://openalex.org/S4306400744","display_name":"Springer Link (Chiba Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8488066","host_organization_name":"Chiba Institute of Technology","host_organization_lineage":["https://openalex.org/I8488066"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1051/vetres:2007064","raw_type":"Text"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/264f40c9-fe16-491b-9826-10a7a6aa5f26","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/264f40c9-fe16-491b-9826-10a7a6aa5f26","pdf_url":"https://www.research.ed.ac.uk/files/13552963/Progress_and_limits_of_PrP_gene_selection_policy.pdf","source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dawson, M, Moore, R C & Bishop, S C 2008, 'Progress and limits of PrP gene selection policy', Veterinary Research, vol. 39, no. 4, 25, pp. -. https://doi.org/10.1051/vetres:2007064","raw_type":"info:eu-repo/semantics/review"}],"best_oa_location":{"id":"doi:10.1051/vetres:2007064","doi":"https://doi.org/10.1051/vetres:2007064","is_oa":true,"landing_page_url":"https://doi.org/10.1051/vetres:2007064","pdf_url":"http://www.vetres.org/articles/vetres/pdf/2008/04/v08061.pdf","source":{"id":"https://openalex.org/S134003780","display_name":"Veterinary Research","issn_l":"0928-4249","issn":["0928-4249","1297-9716"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3121798489","display_name":"Epidemiology and Population Biology","funder_award_id":"BBS/E/D/05191133","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320319995","display_name":"Department for Environment, Food and Rural Affairs, UK Government","ror":"https://ror.org/00tnppw48"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104909686.pdf","grobid_xml":"https://content.openalex.org/works/W2104909686.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W50682593","https://openalex.org/W988977234","https://openalex.org/W1488907068","https://openalex.org/W1519879529","https://openalex.org/W1624018543","https://openalex.org/W1841689210","https://openalex.org/W1883683135","https://openalex.org/W1964701956","https://openalex.org/W1965132458","https://openalex.org/W1985150889","https://openalex.org/W1994111832","https://openalex.org/W2012456627","https://openalex.org/W2021326765","https://openalex.org/W2026539771","https://openalex.org/W2037016416","https://openalex.org/W2047626450","https://openalex.org/W2048278838","https://openalex.org/W2050025870","https://openalex.org/W2052317760","https://openalex.org/W2057060905","https://openalex.org/W2057353524","https://openalex.org/W2069110552","https://openalex.org/W2075789718","https://openalex.org/W2082573664","https://openalex.org/W2088012365","https://openalex.org/W2091165070","https://openalex.org/W2103657847","https://openalex.org/W2105545870","https://openalex.org/W2106295755","https://openalex.org/W2108078938","https://openalex.org/W2121611717","https://openalex.org/W2129150732","https://openalex.org/W2133409665","https://openalex.org/W2137295513","https://openalex.org/W2138988119","https://openalex.org/W2146246590","https://openalex.org/W2150307432","https://openalex.org/W2151788345","https://openalex.org/W2155913624","https://openalex.org/W2156060029","https://openalex.org/W2469032563"],"related_works":["https://openalex.org/W2123194134","https://openalex.org/W2037016416","https://openalex.org/W2036061379","https://openalex.org/W4300716827","https://openalex.org/W2048278838","https://openalex.org/W2070175624","https://openalex.org/W2138988119","https://openalex.org/W4293231249","https://openalex.org/W2159466232","https://openalex.org/W2026171504"],"abstract_inverted_index":{"Classical":[0],"scrapie":[1,74],"has":[2,30,109],"proved":[3],"to":[4,10,13,27,45,71,82,164,207,224,243,263],"be":[5,165,208,225,256],"a":[6,14,35,67,168],"notoriously":[7],"difficult":[8],"disease":[9,24,36,171,266],"control":[11,37,72],"due":[12],"poor":[15],"understanding":[16],"of":[17,23,34,63,116,132,144,182,248],"its":[18],"natural":[19],"history.":[20],"The":[21,54,96],"recognition":[22],"risk":[25],"linkage":[26],"PrP":[28,158,186,251],"genotype":[29,159],"offered":[31],"the":[32,52,61,77,87,113,117,259,271],"prospect":[33],"strategy,":[38],"viz.":[39],"genotyping":[40],"and":[41,75,107,194,199],"selective":[42],"breeding,":[43],"novel":[44],"veterinary":[46],"medicine":[47],"when":[48],"first":[49],"considered":[50],"in":[51,66,105,128,148,152,157,170,231,240,258,270],"1990s.":[53],"UK":[55],"Spongiform":[56],"Encephalopathy":[57],"Advisory":[58],"Committee":[59],"recommended":[60],"exploitation":[62],"this":[64],"approach":[65],"voluntary,":[68],"national":[69,88],"programme":[70],"classical":[73],"protect":[76],"public":[78],"against":[79],"food-borne":[80],"exposure":[81],"bovine":[83],"spongiform":[84],"encephalopathy,":[85],"should":[86,253],"flock":[89],"have":[90,139,175,214,237],"been":[91,110,140,176,215,238],"exposed":[92],"via":[93],"contaminated":[94],"feed.":[95],"National":[97],"Scrapie":[98],"Plan":[99],"for":[100],"Great":[101,241],"Britain":[102,242],"was":[103],"launched":[104],"2001":[106],"uptake":[108],"widespread":[111,183],"throughout":[112],"purebreeding":[114],"sector":[115],"sheep":[118],"industry,":[119],"with":[120,150,167,217],"membership":[121],"peaking":[122],"at":[123],"over":[124],"12":[125],"000":[126,134],"flocks":[127],"2006.":[129],"A":[130,142],"total":[131],"700":[133],"rams":[135],"from":[136,246],"90":[137],"breeds":[138],"genotyped.":[141],"comparison":[143],"ram":[145],"lambs":[146],"born":[147],"2002":[149],"those":[151],"2006":[153],"shows":[154],"evident":[155],"changes":[156],"frequencies":[160],"which":[161],"are":[162,221,268],"predicted":[163],"associated":[166],"reduction":[169],"risk.":[172],"Various":[173,261],"concerns":[174,205],"raised":[177],"regarding":[178],"possible":[179,195],"unintended":[180],"consequences":[181],"selection":[184],"on":[185,190,197,229],"genotype,":[187],"including":[188],"impacts":[189,228],"other":[191],"performance":[192,218],"traits":[193],"effects":[196],"inbreeding":[198,230],"genetic":[200],"diversity.":[201],"To":[202],"date,":[203],"these":[204,254],"appear":[206],"unfounded,":[209],"as":[210],"no":[211],"consistent":[212],"associations":[213],"found":[216],"traits,":[219],"nor":[220],"there":[222],"likely":[223],"any":[226],"detectable":[227],"mainstream":[232],"breeds.":[233],"Currently,":[234],"semen":[235],"banks":[236],"implemented":[239],"store":[244],"samples":[245],"animals":[247],"all":[249],"common":[250],"genotypes,":[252],"genotypes":[255],"required":[257],"future.":[260],"strategies":[262],"minimise":[264],"future":[265],"risks":[267],"discussed":[269],"paper.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}