{"id":"https://openalex.org/W2104901487","doi":null,"title":"p53 controls global nucleotide excision repair of low levels of structurally diverse benzo(g)chrysene-DNA adducts in human fibroblasts.","display_name":"p53 controls global nucleotide excision repair of low levels of structurally diverse benzo(g)chrysene-DNA adducts in human fibroblasts.","publication_year":2002,"publication_date":"2002-09-15","ids":{"openalex":"https://openalex.org/W2104901487","mag":"2104901487","pmid":"https://pubmed.ncbi.nlm.nih.gov/12234998"},"language":"en","primary_location":{"id":"pmid:12234998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12234998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101484831","display_name":"D R Lloyd","orcid":"https://orcid.org/0000-0002-4888-6790","observed_orcids":["https://orcid.org/0000-0002-4888-6790"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel R Lloyd","raw_affiliation_strings":["Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305-5020, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305-5020, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003203263","display_name":"Philip C. Hanawalt","orcid":"https://orcid.org/0000-0003-2331-0768","observed_orcids":["https://orcid.org/0000-0003-2331-0768"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip C Hanawalt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0526,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.7175634,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"62","issue":"18","first_page":"5288","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7109000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7109000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.23729999363422394,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.890999972820282},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.9950000047683716},{"id":"https://openalex.org/keywords/p53-deficient-cells","display_name":"p53-deficient cells","score":0.8259999752044678},{"id":"https://openalex.org/keywords/human-fibroblasts","display_name":"human fibroblasts","score":0.7379999756813049},{"id":"https://openalex.org/keywords/carcinogen-metabolism","display_name":"carcinogen metabolism","score":0.43299999833106995},{"id":"https://openalex.org/keywords/adduct-persistence","display_name":"adduct persistence","score":0.39399999380111694},{"id":"https://openalex.org/keywords/32p-postlabeling","display_name":"32P-postlabeling","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C2775959351","wikidata":"https://www.wikidata.org/wiki/Q415465","display_name":"Chrysene","level":3,"score":0.861289381980896},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.7729535102844238},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.7549827098846436},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.6710444092750549},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.627375066280365},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6006802320480347},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5902974605560303},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.5810756087303162},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.49471423029899597},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4732005298137665},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.46776267886161804},{"id":"https://openalex.org/C2781247443","wikidata":"https://www.wikidata.org/wiki/Q4153410","display_name":"DNA adduct","level":3,"score":0.4675762951374054},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4672626852989197},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4299180507659912},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3393585681915283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3024456202983856},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18235385417938232},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.10196414589881897},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002274","descriptor_name":"Carcinogens, Environmental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002274","descriptor_name":"Carcinogens, Environmental","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002911","descriptor_name":"Chrysenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002911","descriptor_name":"Chrysenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010761","descriptor_name":"Phosphorus Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:12234998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12234998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:kar.kent.ac.uk:10135","doi":null,"is_oa":false,"landing_page_url":"https://kar.kent.ac.uk/10135/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196264","display_name":"Kent Academic Repository (University of Kent)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20581793","host_organization_name":"University of Kent","host_organization_lineage":["https://openalex.org/I20581793"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"mag:2104901487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12234998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6689000129699707}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2497836427","display_name":"Role of transcription in genomic stability","funder_award_id":"R01CA077712","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G459596815","display_name":"CELLULAR PROCESSING OF DAMAGED DNA--ROLE IN ONCOGENESIS","funder_award_id":"R35CA044349","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W146130513","https://openalex.org/W574632868","https://openalex.org/W588815137","https://openalex.org/W1491876634","https://openalex.org/W1521044274","https://openalex.org/W1945199494","https://openalex.org/W1964825907","https://openalex.org/W1965552819","https://openalex.org/W1974648730","https://openalex.org/W1982403101","https://openalex.org/W1984201646","https://openalex.org/W1985651419","https://openalex.org/W2005762860","https://openalex.org/W2008800164","https://openalex.org/W2012053348","https://openalex.org/W2014644281","https://openalex.org/W2015853472","https://openalex.org/W2016492849","https://openalex.org/W2017498643","https://openalex.org/W2030581552","https://openalex.org/W2033602942","https://openalex.org/W2036103078","https://openalex.org/W2038144895","https://openalex.org/W2054115112","https://openalex.org/W2059901912","https://openalex.org/W2062093570","https://openalex.org/W2065091408","https://openalex.org/W2069252425","https://openalex.org/W2069681995","https://openalex.org/W2075968056","https://openalex.org/W2079016866","https://openalex.org/W2079257797","https://openalex.org/W2081111771","https://openalex.org/W2090566390","https://openalex.org/W2092416035","https://openalex.org/W2097520737","https://openalex.org/W2101704373","https://openalex.org/W2109654261","https://openalex.org/W2113724086","https://openalex.org/W2121081337","https://openalex.org/W2122613732","https://openalex.org/W2126784037","https://openalex.org/W2128442121","https://openalex.org/W2130441748","https://openalex.org/W2136979107","https://openalex.org/W2138489088","https://openalex.org/W2140118545","https://openalex.org/W2142000541","https://openalex.org/W2144232168","https://openalex.org/W2153089799","https://openalex.org/W2165704764","https://openalex.org/W2168131938","https://openalex.org/W2171585151","https://openalex.org/W2188321461","https://openalex.org/W2411544633"],"related_works":["https://openalex.org/W2144232168","https://openalex.org/W1521044274","https://openalex.org/W2782519880","https://openalex.org/W7099759213","https://openalex.org/W1980312841","https://openalex.org/W2056303147","https://openalex.org/W1992836428","https://openalex.org/W2053140908","https://openalex.org/W2139939236","https://openalex.org/W1974392697"],"abstract_inverted_index":{"Benzo(g)chrysene":[0],"is":[1,222,301,326],"a":[2,46,107,164],"widespread":[3],"environmental":[4,321,336],"contaminant":[5],"and":[6,14,63,117,150,233,236,288],"potent":[7],"carcinogen.":[8],"We":[9],"have":[10],"measured":[11],"the":[12,24,37,87,91,135,193,226,229,244,255,262,274,290],"formation":[13,237],"nucleotide":[15,285],"excision":[16,286],"repair":[17,287],"of":[18,27,36,89,109,121,138,159,166,196,225,228,238,254,264,276,305,320],"covalent":[19],"DNA":[20,64,75,81,306],"adducts":[21,65,82,122,140,239,256,278,307],"formed":[22],"by":[23,45,72,282],"DNA-reactive":[25],"metabolite":[26],"this":[28,298],"compound":[29],"in":[30,33,106,126,147,154,163,170,181,192,199,231,279,312],"human":[31,280,313,332],"fibroblasts,":[32],"which":[34],"expression":[35,266],"p53":[38,265,270],"tumor":[39],"suppressor":[40],"gene":[41],"could":[42],"be":[43],"controlled":[44],"tetracycline-inducible":[47],"promoter.":[48],"Cells":[49],"were":[50,66,83,189],"exposed":[51],"for":[52,114,240],"1":[53],"h":[54,143],"to":[55,76,86,261,272,331,335],"0.01,":[56],"0.1,":[57],"or":[58,93,99,209],"1.2":[59,103],"microM":[60,104,161,208],"(+/-)-anti-benzo(g)chrysene":[61],"diol-epoxide,":[62],"assessed":[67],"at":[68,141,173,184,303],"various":[69],"post-treatment":[70],"times":[71],"subjecting":[73],"isolated":[74],"(32)P-postlabeling":[77],"analysis.":[78],"Four":[79],"major":[80],"detected,":[84],"corresponding":[85],"reaction":[88],"either":[90,127],"(+)-":[92],"(-)-anti-benzo(g)chrysene":[94],"diol-epoxide":[95,230],"stereoisomer":[96],"with":[97,102,132,202,206,259,329],"adenine":[98],"guanine.":[100],"Treatment":[101],"resulted":[105,162],"level":[108,137],"1100":[110],"total":[111,139],"adducts/10(8)":[112,152,168,178,317],"nucleotides":[113,146,153,169,179],"both":[115],"p53-proficient":[116,148,171,200],"-deficient":[118],"cells;":[119],"removal":[120],"was":[123,144],"not":[124,215],"observed":[125],"case.":[128],"In":[129],"cells":[130,149,172,183,204,281],"treated":[131,205],"0.1":[133,207],"microM,":[134,211],"maximum":[136,165,291],"24":[142,185],"150/10(8)":[145],"210":[151],"p53-deficient":[155,182,203],"cells.":[156],"A":[157],"concentration":[158],"0.01":[160,210],"20":[167],"4":[174,253],"h,":[175],"but":[176],"40":[177],"persisted":[180],"h.":[186],"Whereas":[187],"there":[188],"clear":[190],"differences":[191],"time":[194],"course":[195],"adduct":[197,292],"levels":[198,213,293,304],"compared":[201],"these":[212],"did":[214],"decrease":[216],"extensively":[217],"over":[218],"3":[219],"days.":[220],"This":[221],"likely":[223],"because":[224,319],"stabilization":[227],"cells,":[232],"consequent":[234],"exposure":[235],"many":[241],"hours":[242],"after":[243],"initial":[245],"treatment.":[246],"Furthermore,":[247],"despite":[248],"minor":[249],"quantitative":[250],"differences,":[251],"all":[252],"behaved":[257],"similarly":[258],"respect":[260,330],"effect":[263,300],"on":[267],"their":[268],"removal.":[269],"appears":[271],"minimize":[273],"appearance":[275],"benzo(g)chrysene":[277],"up-regulating":[283],"global":[284],"reducing":[289],"achieved.":[294],"The":[295],"fact":[296],"that":[297,308],"p53-dependent":[299],"noted":[302],"are":[309],"commonly":[310],"found":[311],"tissues":[314],"(i.e.,":[315],"<100":[316],"nucleotides)":[318],"factors":[322],"such":[323],"as":[324],"smoking":[325],"particularly":[327],"significant":[328],"carcinogenesis":[333],"related":[334],"exposure.":[337]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
