{"id":"https://openalex.org/W2104872953","doi":"https://doi.org/10.15252/msb.20145606","title":"Differential genetic interactions of yeast stress response MAPK pathways","display_name":"Differential genetic interactions of yeast stress response MAPK pathways","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W2104872953","doi":"https://doi.org/10.15252/msb.20145606","mag":"2104872953","pmid":"https://pubmed.ncbi.nlm.nih.gov/25888283","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4422557"},"language":"en","primary_location":{"id":"doi:10.15252/msb.20145606","doi":"https://doi.org/10.15252/msb.20145606","is_oa":true,"landing_page_url":"https://doi.org/10.15252/msb.20145606","pdf_url":"https://link.springer.com/content/pdf/10.15252/msb.20145606.pdf","source":{"id":"https://openalex.org/S200893805","display_name":"Molecular Systems Biology","issn_l":"1744-4292","issn":["1744-4292"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Systems Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.15252/msb.20145606.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054123884","display_name":"Humberto Mart\u0131\u0301n","orcid":"https://orcid.org/0000-0002-6736-3602","observed_orcids":["https://orcid.org/0000-0002-6736-3602"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Humberto Martin","raw_affiliation_strings":["Departamento de Microbiolog\u00eda II, Facultad de Farmacia, Universidad Complutense de Madrid and Instituto Ram\u00f3n y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Microbiolog\u00eda II, Facultad de Farmacia, Universidad Complutense de Madrid and Instituto Ram\u00f3n y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain","institution_ids":["https://openalex.org/I121748325","https://openalex.org/I4210127475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066993838","display_name":"Michael Shales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Shales","raw_affiliation_strings":["Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039726479","display_name":"Pablo Fern\u00e1ndez-Pi\u00f1ar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pablo Fernandez\u2010Pi\u00f1ar","raw_affiliation_strings":["Departamento de Microbiolog\u00eda II, Facultad de Farmacia, Universidad Complutense de Madrid and Instituto Ram\u00f3n y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Microbiolog\u00eda II, Facultad de Farmacia, Universidad Complutense de Madrid and Instituto Ram\u00f3n y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain","institution_ids":["https://openalex.org/I121748325","https://openalex.org/I4210127475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039356787","display_name":"Ping Wei","orcid":"https://orcid.org/0000-0002-1275-7145","observed_orcids":["https://orcid.org/0000-0002-1275-7145"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Wei","raw_affiliation_strings":["Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210160507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073054776","display_name":"Mar\u0131\u0301a Molina","orcid":"https://orcid.org/0000-0003-0074-3309","observed_orcids":["https://orcid.org/0000-0003-0074-3309"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Molina","raw_affiliation_strings":["Departamento de Microbiolog\u00eda II, Facultad de Farmacia, Universidad Complutense de Madrid and Instituto Ram\u00f3n y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Microbiolog\u00eda II, Facultad de Farmacia, Universidad Complutense de Madrid and Instituto Ram\u00f3n y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain","institution_ids":["https://openalex.org/I121748325","https://openalex.org/I4210127475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008781299","display_name":"Dorothea Fiedler","orcid":"https://orcid.org/0000-0002-0798-946X","observed_orcids":["https://orcid.org/0000-0002-0798-946X","https://orcid.org/0000-0003-2990-4612"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorothea Fiedler","raw_affiliation_strings":["Department of Chemistry, Princeton University, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079376363","display_name":"Kevan M. Shokat","orcid":"https://orcid.org/0000-0001-8590-7741","observed_orcids":["https://orcid.org/0000-0001-8590-7741"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevan M Shokat","raw_affiliation_strings":["Chemistry and Chemical Biology Graduate Program, University of California, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Chemical Biology Graduate Program, University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050058340","display_name":"Pedro Beltr\u00e3o","orcid":"https://orcid.org/0000-0002-2724-7703","observed_orcids":["https://orcid.org/0000-0002-2724-7703"]},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I60858718","display_name":"University of Aveiro","ror":"https://ror.org/00nt41z93","country_code":"PT","type":"education","lineage":["https://openalex.org/I60858718"]}],"countries":["GB","PT"],"is_corresponding":true,"raw_author_name":"Pedro Beltrao","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK iBiMED and Department of Health Sciences, University of Aveiro, Aveiro, Portugal pbeltrao@ebi.ac.uk nevan.krogan@ucsf.edu","European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK","iBiMED and Department of Health Sciences, University of Aveiro, Aveiro, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK iBiMED and Department of Health Sciences, University of Aveiro, Aveiro, Portugal pbeltrao@ebi.ac.uk nevan.krogan@ucsf.edu","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I60858718"]},{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK","institution_ids":["https://openalex.org/I1303153112"]},{"raw_affiliation_string":"iBiMED and Department of Health Sciences, University of Aveiro, Aveiro, Portugal","institution_ids":["https://openalex.org/I60858718"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006257775","display_name":"Wendell A. Lim","orcid":"https://orcid.org/0000-0003-4052-8056","observed_orcids":["https://orcid.org/0000-0003-4052-8056"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendell Lim","raw_affiliation_strings":["Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA USA Howard Hughes Medical Institute, University of California, San Francisco, CA, USA Center for Systems and Synthetic Biology, University of California, San Francisco, CA, USA","Center for Systems and Synthetic Biology University of California San Francisco CA USA","Department of Cellular and Molecular Pharmacology University of California San Francisco CA USA","Howard Hughes Medical Institute University of California San Francisco CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA USA Howard Hughes Medical Institute, University of California, San Francisco, CA, USA Center for Systems and Synthetic Biology, University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191"]},{"raw_affiliation_string":"Center for Systems and Synthetic Biology University of California San Francisco CA USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Cellular and Molecular Pharmacology University of California San Francisco CA USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Howard Hughes Medical Institute University of California San Francisco CA USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026080576","display_name":"Nevan J. Krogan","orcid":"https://orcid.org/0000-0003-4902-337X","observed_orcids":["https://orcid.org/0000-0003-4902-337X"]},"institutions":[{"id":"https://openalex.org/I103922791","display_name":"QB3","ror":"https://ror.org/04n1n3n22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I185103710","https://openalex.org/I95457486"]},{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nevan J Krogan","raw_affiliation_strings":["Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA USA Center for Systems and Synthetic Biology, University of California, San Francisco, CA, USA California Institute for Quantitative Biosciences, QB3, San Francisco, CA, USA J. David Gladstone Institutes, San Francisco, CA, USA pbeltrao@ebi.ac.uk nevan.krogan@ucsf.edu","California Institute for Quantitative Biosciences, QB3 San Francisco CA USA","Center for Systems and Synthetic Biology University of California San Francisco CA USA","Department of Cellular and Molecular Pharmacology University of California San Francisco CA USA","J. David Gladstone Institutes San Francisco CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA USA Center for Systems and Synthetic Biology, University of California, San Francisco, CA, USA California Institute for Quantitative Biosciences, QB3, San Francisco, CA, USA J. David Gladstone Institutes, San Francisco, CA, USA pbeltrao@ebi.ac.uk nevan.krogan@ucsf.edu","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I1321430492","https://openalex.org/I180670191"]},{"raw_affiliation_string":"California Institute for Quantitative Biosciences, QB3 San Francisco CA USA","institution_ids":["https://openalex.org/I103922791"]},{"raw_affiliation_string":"Center for Systems and Synthetic Biology University of California San Francisco CA USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Cellular and Molecular Pharmacology University of California San Francisco CA USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"J. David Gladstone Institutes San Francisco CA USA","institution_ids":["https://openalex.org/I1321430492"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5026080576","https://openalex.org/A5050058340"],"corresponding_institution_ids":["https://openalex.org/I103922791","https://openalex.org/I1303153112","https://openalex.org/I1321430492","https://openalex.org/I180670191","https://openalex.org/I60858718"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":{"value":7990,"currency":"USD","value_usd":7990},"fwci":2.1036,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.87701968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"4","first_page":"800","last_page":"800"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7929999828338623},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.8109999895095825},{"id":"https://openalex.org/keywords/osmotic-stress","display_name":"osmotic stress","score":0.9760000109672546},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/cell-wall-integrity-pathway","display_name":"cell wall integrity pathway","score":0.8529999852180481},{"id":"https://openalex.org/keywords/membrane-trafficking","display_name":"membrane trafficking","score":0.9470000267028809},{"id":"https://openalex.org/keywords/double-mutant","display_name":"double mutants","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.85905921459198},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5927025079727173},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5542826652526855},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.5294522643089294},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.5208407044410706},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.465853750705719},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44046998023986816},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4276672601699829},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.30949878692626953}],"mesh":[{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009997","descriptor_name":"Osmotic Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.15252/msb.20145606","doi":"https://doi.org/10.15252/msb.20145606","is_oa":true,"landing_page_url":"https://doi.org/10.15252/msb.20145606","pdf_url":"https://link.springer.com/content/pdf/10.15252/msb.20145606.pdf","source":{"id":"https://openalex.org/S200893805","display_name":"Molecular Systems Biology","issn_l":"1744-4292","issn":["1744-4292"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Systems Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4422557","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4422557","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Syst Biol","raw_type":"Text"},{"id":"pmid:25888283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25888283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular systems biology","raw_type":"Journal Article"},{"id":"pmh:oai:www.ucm.es:33654","doi":null,"is_oa":false,"landing_page_url":"http://eprints.ucm.es/33654/1/Martin%20Mol%20Sys%20Biol%202015.pdf","pdf_url":"http://eprints.ucm.es/33654/1/Martin%20Mol%20Sys%20Biol%202015.pdf","source":{"id":"https://openalex.org/S4306400298","display_name":"Library Open Repository (Universidad Complutense Madrid)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121748325","host_organization_name":"Universidad Complutense de Madrid","host_organization_lineage":["https://openalex.org/I121748325"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.809.8740","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.809.8740","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/78/61/msb0011-0800.PMC4422557.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.864.5167","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.864.5167","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://msb.embopress.org/content/msb/11/4/800.full.pdf","raw_type":"text"},{"id":"pmh:oai:digital.csic.es:10261/199294","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/199294","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:dnet:ricscm______::e73c30fd7c8b60272f4ad3de5044daca","doi":null,"is_oa":true,"landing_page_url":"https://repositoriosaludmadrid.es/handle/20.500.12530/22154","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:377f4684244e4ad194f4cd67d054bb98","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/377f4684244e4ad194f4cd67d054bb98","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Systems Biology, Vol 11, Iss 4, Pp 1-13 (2015)","raw_type":"article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/531916","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/531916","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Systems Biology, 11 (4)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.3929/ethz-b-000531916","doi":"https://doi.org/10.3929/ethz-b-000531916","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000531916","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.15252/msb.20145606","doi":"https://doi.org/10.15252/msb.20145606","is_oa":true,"landing_page_url":"https://doi.org/10.15252/msb.20145606","pdf_url":"https://link.springer.com/content/pdf/10.15252/msb.20145606.pdf","source":{"id":"https://openalex.org/S200893805","display_name":"Molecular Systems Biology","issn_l":"1744-4292","issn":["1744-4292"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1847720962","display_name":"Genetic Analysis of the Nucleosome and RNA Polymerase II: A Systems Approach","funder_award_id":"R01GM084448","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1868574430","display_name":null,"funder_award_id":"GM098101","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2528919290","display_name":null,"funder_award_id":"GM084448","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G37385316","display_name":null,"funder_award_id":"BIO2010-22369-C02-01","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G4926085073","display_name":"Comparative Analysis of Genetic Interaction Networks","funder_award_id":"R01GM084279","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5207984517","display_name":"Protein Recognition in Signal Transduction","funder_award_id":"R01GM055040","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5951746209","display_name":null,"funder_award_id":"GM084279","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8780018913","display_name":"Physical and Genetic Interaction Landscape of the Tyrosine Kinome","funder_award_id":"R01GM107671","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000898549","display_name":"UCSF-Bay Area Center for AIDS Research","funder_award_id":"P30AI027763","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G989968798","display_name":"Integrating computation and genetics to quantify specificity in protein networks","funder_award_id":"R01GM098101","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104872953.pdf","grobid_xml":"https://content.openalex.org/works/W2104872953.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W147290053","https://openalex.org/W1566478858","https://openalex.org/W1608335442","https://openalex.org/W1891964745","https://openalex.org/W1914046389","https://openalex.org/W1970140396","https://openalex.org/W1970250905","https://openalex.org/W1970691568","https://openalex.org/W1973487736","https://openalex.org/W1976544696","https://openalex.org/W1988263223","https://openalex.org/W1988752967","https://openalex.org/W1997859335","https://openalex.org/W1998809668","https://openalex.org/W1999594885","https://openalex.org/W2006567083","https://openalex.org/W2007097150","https://openalex.org/W2008794157","https://openalex.org/W2013520054","https://openalex.org/W2018680251","https://openalex.org/W2018896819","https://openalex.org/W2023788610","https://openalex.org/W2027145418","https://openalex.org/W2032760765","https://openalex.org/W2033318704","https://openalex.org/W2038245409","https://openalex.org/W2040838736","https://openalex.org/W2042688172","https://openalex.org/W2048233403","https://openalex.org/W2048683930","https://openalex.org/W2048983596","https://openalex.org/W2050936151","https://openalex.org/W2051338141","https://openalex.org/W2052815101","https://openalex.org/W2054885243","https://openalex.org/W2055184716","https://openalex.org/W2062185406","https://openalex.org/W2063013559","https://openalex.org/W2063661977","https://openalex.org/W2067330392","https://openalex.org/W2069200751","https://openalex.org/W2071920845","https://openalex.org/W2074743540","https://openalex.org/W2081954164","https://openalex.org/W2084459589","https://openalex.org/W2084934035","https://openalex.org/W2085060592","https://openalex.org/W2086202782","https://openalex.org/W2089245424","https://openalex.org/W2090951989","https://openalex.org/W2098066769","https://openalex.org/W2102247469","https://openalex.org/W2103491947","https://openalex.org/W2121910267","https://openalex.org/W2124721555","https://openalex.org/W2126696192","https://openalex.org/W2127073167","https://openalex.org/W2127710730","https://openalex.org/W2130139983","https://openalex.org/W2130907642","https://openalex.org/W2131610391","https://openalex.org/W2132757418","https://openalex.org/W2133102806","https://openalex.org/W2137683543","https://openalex.org/W2147566730","https://openalex.org/W2150749732","https://openalex.org/W2152600551","https://openalex.org/W2153134824","https://openalex.org/W2160042242","https://openalex.org/W2162928287","https://openalex.org/W2164002408","https://openalex.org/W2165116461","https://openalex.org/W2170780149"],"related_works":["https://openalex.org/W7099073349","https://openalex.org/W2765896410","https://openalex.org/W2107022906","https://openalex.org/W7099185323","https://openalex.org/W2102247469","https://openalex.org/W2519198477","https://openalex.org/W7095412543","https://openalex.org/W2024026979","https://openalex.org/W3026097834","https://openalex.org/W2028772908"],"abstract_inverted_index":{"Genetic":[0],"interaction":[1,55],"screens":[2],"have":[3,26,50,117],"been":[4,27],"applied":[5],"with":[6,158,167],"great":[7],"success":[8],"in":[9,57,67,84,137,161,170],"several":[10],"organisms":[11],"to":[12,40,183],"study":[13],"gene":[14,171],"function":[15],"and":[16,78,133],"the":[17,21,68,85,124,128,139,145,185,189,194],"genetic":[18,54,107,149,177],"architecture":[19],"of":[20,70,87,97,105,188,193],"cell.":[22,195],"However,":[23],"most":[24],"studies":[25],"performed":[28,51],"under":[29,42],"optimal":[30],"growth":[31],"conditions":[32],"even":[33],"though":[34],"many":[35],"functional":[36,113,186],"interactions":[37,108,150,178],"are":[38,179],"known":[39,111],"occur":[41],"specific":[43],"cellular":[44],"conditions.":[45],"In":[46],"this":[47],"study,":[48],"we":[49,116],"a":[52,88,180],"large-scale":[53],"analysis":[56],"Saccharomyces":[58],"cerevisiae":[59],"involving":[60,123],"approximately":[61],"49":[62],"\u00d7":[63],"1,200":[64],"double":[65],"mutants":[66],"presence":[69],"five":[71],"different":[72,190],"stress":[73,147],"conditions,":[74],"including":[75],"osmotic,":[76],"oxidative":[77],"cell":[79,140],"wall-altering":[80],"stresses.":[81],"This":[82,173],"resulted":[83],"generation":[86],"differential":[89,148],"E-MAP":[90],"(or":[91],"dE-MAP)":[92],"comprising":[93],"over":[94],"250,000":[95],"measurements":[96],"conditional":[98,106,159,168,176],"interactions.":[99],"We":[100],"found":[101],"an":[102],"extensive":[103],"number":[104],"that":[109,175],"recapitulate":[110],"stress-specific":[112],"associations.":[114],"Furthermore,":[115],"also":[118],"uncovered":[119],"previously":[120],"unrecognized":[121],"roles":[122],"phosphatase":[125],"regulator":[126],"Bud14,":[127],"histone":[129],"methylation":[130],"complex":[131],"COMPASS":[132],"membrane":[134],"trafficking":[135],"complexes":[136],"modulating":[138],"wall":[141],"integrity":[142],"pathway.":[143],"Finally,":[144],"osmotic":[146],"showed":[151],"enrichment":[152],"for":[153,156,165],"genes":[154,166],"coding":[155],"proteins":[157],"changes":[160,169],"phosphorylation":[162],"but":[163],"not":[164],"expression.":[172],"suggests":[174],"powerful":[181],"tool":[182],"dissect":[184],"importance":[187],"response":[191],"mechanisms":[192]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
