{"id":"https://openalex.org/W2104863953","doi":"https://doi.org/10.2174/1568026054679290","title":"Donors of HNO","display_name":"Donors of HNO","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W2104863953","doi":"https://doi.org/10.2174/1568026054679290","mag":"2104863953","pmid":"https://pubmed.ncbi.nlm.nih.gov/16101426"},"language":"en","primary_location":{"id":"doi:10.2174/1568026054679290","doi":"https://doi.org/10.2174/1568026054679290","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1568026054679290","pdf_url":null,"source":{"id":"https://openalex.org/S107732428","display_name":"Current Topics in Medicinal Chemistry","issn_l":"1568-0266","issn":["1568-0266","1873-4294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Topics in Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028796924","display_name":"Katrina M. Miranda","orcid":"https://orcid.org/0000-0002-9175-5091","observed_orcids":["https://orcid.org/0000-0002-9175-5091"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katrina Miranda","raw_affiliation_strings":["Department of Chemistry, University of Arizona, Tucson, 85721, USA. kmiranda@email.arizona.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Arizona, Tucson, 85721, USA. kmiranda@email.arizona.edu","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045095689","display_name":"Herbert T. Nagasawa","orcid":"https://orcid.org/0000-0002-9106-1823","observed_orcids":["https://orcid.org/0000-0002-9106-1823"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert Nagasawa","raw_affiliation_strings":["University of\u00a0Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of\u00a0Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047937683","display_name":"John P. Toscano","orcid":"https://orcid.org/0000-0002-4277-3533","observed_orcids":["https://orcid.org/0000-0002-4277-3533"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Toscano","raw_affiliation_strings":["Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8904,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.84456573,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"7","first_page":"649","last_page":"664"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitroxyl","display_name":"nitroxyl","score":0.8970000147819519},{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.8629999756813049},{"id":"https://openalex.org/keywords/redox-signaling","display_name":"redox signaling","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.5929999947547913},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9750000238418579},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9860000014305115},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.996999979019165},{"id":"https://openalex.org/keywords/cyanamide","display_name":"cyanamide","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hydroxylamine","display_name":"hydroxylamine","score":0.9860000014305115},{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C2776142628","wikidata":"https://www.wikidata.org/wiki/Q2919470","display_name":"Nitroxyl","level":2,"score":0.936600923538208},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.8124262094497681},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6565378308296204},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.4809671938419342},{"id":"https://openalex.org/C2779606280","wikidata":"https://www.wikidata.org/wiki/Q414555","display_name":"Cyanamide","level":2,"score":0.4609556496143341},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4360898435115814},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3836286962032318},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26556044816970825},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2260424792766571},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2164914608001709}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009589","descriptor_name":"Nitrogen Oxides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009589","descriptor_name":"Nitrogen Oxides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020030","descriptor_name":"Nitric Oxide Donors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020030","descriptor_name":"Nitric Oxide Donors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1568026054679290","doi":"https://doi.org/10.2174/1568026054679290","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1568026054679290","pdf_url":null,"source":{"id":"https://openalex.org/S107732428","display_name":"Current Topics in Medicinal Chemistry","issn_l":"1568-0266","issn":["1568-0266","1873-4294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Topics in Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:16101426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16101426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current topics in medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2043286086","https://openalex.org/W2526500371","https://openalex.org/W2887953628","https://openalex.org/W3187947295","https://openalex.org/W2805293177","https://openalex.org/W7101111430","https://openalex.org/W2765555750","https://openalex.org/W2531488604","https://openalex.org/W2070784055","https://openalex.org/W2015791471"],"abstract_inverted_index":{"Recent":[0],"comparisons":[1],"of":[2,6,34,42,46,53,59,74,91,97,107],"the":[3,17,32,57,64,92,105],"pharmacological":[4,65],"effects":[5],"nitric":[7,112],"oxide":[8],"(NO)":[9],"and":[10,48,83],"nitroxyl":[11],"(HNO)":[12],"donors":[13,96],"have":[14,30],"demonstrated":[15],"that":[16],"responses":[18,66],"to":[19,67],"these":[20],"redox-related":[21],"nitrogen":[22],"oxides":[23],"are":[24,61,69],"nearly":[25],"universally":[26],"dissimilar.":[27],"These":[28],"analyses":[29],"suggested":[31],"existence":[33],"mutually":[35],"exclusive":[36],"signaling":[37],"pathways":[38],"as":[39,78,99,101],"a":[40,51,88,102],"result":[41],"discrete":[43],"chemical":[44],"interactions":[45],"HNO":[47,68,98],"NO":[49],"with":[50],"variety":[52],"critical":[54],"biomolecules.":[55],"Although":[56],"mechanisms":[58],"action":[60],"currently":[62],"unresolved,":[63],"promising":[70],"for":[71,104],"clinical":[72],"treatment":[73],"cardiovascular":[75],"diseases":[76],"such":[77],"heart":[79],"failure,":[80],"myocardial":[81],"infarction":[82],"stroke.":[84],"This":[85],"review":[86],"provides":[87],"detailed":[89],"discussion":[90],"most":[93],"commonly":[94],"utilized":[95],"well":[100],"guideline":[103],"characterization":[106],"novel":[108],"donors.":[109],"Keywords:":[110],"nitroxyl,":[111],"oxide,":[113],"angelis":[114],"salt,":[115],"pilotys":[116],"acid,":[117],"cyanamide,":[118],"hydroxylamines,":[119],"sulfohydroxamic":[120],"acids,":[121],"acylnitroso":[122],"compounds,":[123],"prodrugs,":[124],"detection":[125]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}