{"id":"https://openalex.org/W2104863299","doi":"https://doi.org/10.1016/j.tim.2008.09.007","title":"Drug:H+ antiporters in chemical stress response in yeast","display_name":"Drug:H+ antiporters in chemical stress response in yeast","publication_year":2008,"publication_date":"2008-12-05","ids":{"openalex":"https://openalex.org/W2104863299","doi":"https://doi.org/10.1016/j.tim.2008.09.007","mag":"2104863299","pmid":"https://pubmed.ncbi.nlm.nih.gov/19062291"},"language":"en","primary_location":{"id":"doi:10.1016/j.tim.2008.09.007","doi":"https://doi.org/10.1016/j.tim.2008.09.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tim.2008.09.007","pdf_url":null,"source":{"id":"https://openalex.org/S587692","display_name":"Trends in Microbiology","issn_l":"0966-842X","issn":["0966-842X","1878-4380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011114213","display_name":"Isabel S\u00e1\u2010Correia","orcid":"https://orcid.org/0000-0003-2208-5183","observed_orcids":["https://orcid.org/0000-0003-2208-5183"]},"institutions":[{"id":"https://openalex.org/I4210167387","display_name":"Institute for Biotechnology and Bioengineering","ror":"https://ror.org/05ws8g470","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210167387"]},{"id":"https://openalex.org/I4387152517","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/03db2by73","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4387152517"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Isabel S\u00e1-Correia","raw_affiliation_strings":["Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal. isacorreia@ist.utl.pt","Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal. isacorreia@ist.utl.pt","institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"]},{"raw_affiliation_string":"Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal","institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060792625","display_name":"Sandra Costa dos Santos","orcid":"https://orcid.org/0000-0002-2906-1021","observed_orcids":["https://orcid.org/0000-0002-2906-1021"]},"institutions":[{"id":"https://openalex.org/I4210167387","display_name":"Institute for Biotechnology and Bioengineering","ror":"https://ror.org/05ws8g470","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210167387"]},{"id":"https://openalex.org/I4387152517","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/03db2by73","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4387152517"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sandra C. dos Santos","raw_affiliation_strings":["Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal","institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046370719","display_name":"Miguel Cacho Teixeira","orcid":"https://orcid.org/0000-0002-5676-6174","observed_orcids":["https://orcid.org/0000-0002-5676-6174"]},"institutions":[{"id":"https://openalex.org/I4210167387","display_name":"Institute for Biotechnology and Bioengineering","ror":"https://ror.org/05ws8g470","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210167387"]},{"id":"https://openalex.org/I4387152517","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/03db2by73","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4387152517"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Miguel C. Teixeira","raw_affiliation_strings":["Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal","institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029661436","display_name":"T\u00e2nia R. Cabrito","orcid":"https://orcid.org/0009-0006-4114-0052","observed_orcids":["https://orcid.org/0009-0006-4114-0052"]},"institutions":[{"id":"https://openalex.org/I4210167387","display_name":"Institute for Biotechnology and Bioengineering","ror":"https://ror.org/05ws8g470","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210167387"]},{"id":"https://openalex.org/I4387152517","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/03db2by73","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4387152517"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"T\u00e2nia R. Cabrito","raw_affiliation_strings":["Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal","institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083137468","display_name":"Nuno Pereira Mira","orcid":"https://orcid.org/0000-0001-7556-0385","observed_orcids":["https://orcid.org/0000-0001-7556-0385"]},"institutions":[{"id":"https://openalex.org/I4210167387","display_name":"Institute for Biotechnology and Bioengineering","ror":"https://ror.org/05ws8g470","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210167387"]},{"id":"https://openalex.org/I4387152517","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/03db2by73","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4387152517"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Nuno P. Mira","raw_affiliation_strings":["Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal","institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011114213"],"corresponding_institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":1.1625,"has_fulltext":false,"cited_by_count":166,"citation_normalized_percentile":{"value":0.76009281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"22","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-facilitator-superfamily","display_name":"major facilitator superfamily","score":0.9150000214576721},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9860000014305115},{"id":"https://openalex.org/keywords/drug-efflux-pumps","display_name":"drug efflux pumps","score":0.8669999837875366},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9559999704360962},{"id":"https://openalex.org/keywords/chemical-stress-response","display_name":"chemical stress response","score":0.9539999961853027},{"id":"https://openalex.org/keywords/transporter-expression-regulation","display_name":"transporter expression regulation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/fungal-pathogens","display_name":"fungal pathogens","score":0.6629999876022339},{"id":"https://openalex.org/keywords/higher-eukaryotes","display_name":"higher eukaryotes","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C62465871","wikidata":"https://www.wikidata.org/wiki/Q1886097","display_name":"Major facilitator superfamily","level":4,"score":0.8993583917617798},{"id":"https://openalex.org/C2910532024","wikidata":"https://www.wikidata.org/wiki/Q2853339","display_name":"Antiporters","level":4,"score":0.8219683170318604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7908761501312256},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.6168885231018066},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.5344001650810242},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.5177521109580994},{"id":"https://openalex.org/C86380466","wikidata":"https://www.wikidata.org/wiki/Q5308872","display_name":"Drug action","level":3,"score":0.48919084668159485},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.45310255885124207},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.43335655331611633},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.43302100896835327},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4169501066207886},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.40022820234298706},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39454764127731323},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34291571378707886},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26842182874679565},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23801618814468384},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19892579317092896}],"mesh":[{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017920","descriptor_name":"Antiporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018869","descriptor_name":"Heat-Shock Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018892","descriptor_name":"Proton-Motive Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026141","descriptor_name":"Drug Resistance, Multiple, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027361","descriptor_name":"Organic Anion Transporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tim.2008.09.007","doi":"https://doi.org/10.1016/j.tim.2008.09.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tim.2008.09.007","pdf_url":null,"source":{"id":"https://openalex.org/S587692","display_name":"Trends in Microbiology","issn_l":"0966-842X","issn":["0966-842X","1878-4380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Microbiology","raw_type":"journal-article"},{"id":"pmid:19062291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19062291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6021000146865845,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W184607604","https://openalex.org/W1483463110","https://openalex.org/W1954232128","https://openalex.org/W1963490149","https://openalex.org/W1968443428","https://openalex.org/W1970250905","https://openalex.org/W1972750701","https://openalex.org/W1976277865","https://openalex.org/W1976459325","https://openalex.org/W1978152532","https://openalex.org/W1983963722","https://openalex.org/W1984325151","https://openalex.org/W1987272829","https://openalex.org/W1987433777","https://openalex.org/W1990987722","https://openalex.org/W1991069455","https://openalex.org/W1991206583","https://openalex.org/W1992927522","https://openalex.org/W1993099483","https://openalex.org/W1993236717","https://openalex.org/W1997241897","https://openalex.org/W1999788391","https://openalex.org/W2002933410","https://openalex.org/W2004961601","https://openalex.org/W2006472880","https://openalex.org/W2008088115","https://openalex.org/W2011183807","https://openalex.org/W2032392662","https://openalex.org/W2032758517","https://openalex.org/W2034787982","https://openalex.org/W2034979953","https://openalex.org/W2037240543","https://openalex.org/W2038683205","https://openalex.org/W2042111866","https://openalex.org/W2047065718","https://openalex.org/W2060078356","https://openalex.org/W2062311025","https://openalex.org/W2063036465","https://openalex.org/W2073707814","https://openalex.org/W2075152935","https://openalex.org/W2082440113","https://openalex.org/W2083167998","https://openalex.org/W2083405680","https://openalex.org/W2085577984","https://openalex.org/W2088551831","https://openalex.org/W2093358776","https://openalex.org/W2101447091","https://openalex.org/W2101814517","https://openalex.org/W2103580208","https://openalex.org/W2105957574","https://openalex.org/W2106252547","https://openalex.org/W2106693806","https://openalex.org/W2106745617","https://openalex.org/W2111491246","https://openalex.org/W2111862518","https://openalex.org/W2113543622","https://openalex.org/W2115130703","https://openalex.org/W2115525909","https://openalex.org/W2119468629","https://openalex.org/W2119791629","https://openalex.org/W2121539149","https://openalex.org/W2130131612","https://openalex.org/W2131393988","https://openalex.org/W2134224359","https://openalex.org/W2136254499","https://openalex.org/W2137683543","https://openalex.org/W2138910991","https://openalex.org/W2153763693","https://openalex.org/W2163797429","https://openalex.org/W2166447056","https://openalex.org/W2166952132","https://openalex.org/W2172104036","https://openalex.org/W4404106488","https://openalex.org/W6873721179"],"related_works":["https://openalex.org/W2008088115","https://openalex.org/W2051114736","https://openalex.org/W6982339797","https://openalex.org/W1552357701","https://openalex.org/W7159849403","https://openalex.org/W2344925260","https://openalex.org/W3116541166","https://openalex.org/W2329301477","https://openalex.org/W3211765020","https://openalex.org/W2072963835"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
