{"id":"https://openalex.org/W2104859384","doi":"https://doi.org/10.1152/ajplung.00268.2004","title":"Integrated control of lung fluid balance","display_name":"Integrated control of lung fluid balance","publication_year":2004,"publication_date":"2004-11-06","ids":{"openalex":"https://openalex.org/W2104859384","doi":"https://doi.org/10.1152/ajplung.00268.2004","mag":"2104859384","pmid":"https://pubmed.ncbi.nlm.nih.gov/15531757"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.00268.2004","doi":"https://doi.org/10.1152/ajplung.00268.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00268.2004","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087479152","display_name":"Dolly Mehta","orcid":"https://orcid.org/0000-0003-0945-9304","observed_orcids":["https://orcid.org/0000-0003-0945-9304"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dolly Mehta","raw_affiliation_strings":["Department of Pharmacology, University of Illinois-Chicago Medical Center, Chicago, IL 60612, USA. dmehta@uic.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Illinois-Chicago Medical Center, Chicago, IL 60612, USA. dmehta@uic.edu","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076054649","display_name":"Jahar Bhattacharya","orcid":"https://orcid.org/0000-0002-5588-6211","observed_orcids":["https://orcid.org/0000-0002-5588-6211"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jahar Bhattacharya","raw_affiliation_strings":["","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052576862","display_name":"Michael A. Matthay","orcid":"https://orcid.org/0000-0003-3039-8155","observed_orcids":["https://orcid.org/0000-0003-3039-8155"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Matthay","raw_affiliation_strings":["","University of California at San Francisco,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"University of California at San Francisco,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011756238","display_name":"Asrar B. Malik","orcid":"https://orcid.org/0000-0002-8205-7128","observed_orcids":["https://orcid.org/0000-0002-8205-7128"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Asrar B. Malik","raw_affiliation_strings":["","Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6431,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.54159292,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"287","issue":"6","first_page":"L1081","last_page":"L1090"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.8740000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.8740000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.04520000144839287,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-fluid-balance","display_name":"lung fluid balance","score":0.9919999837875366},{"id":"https://openalex.org/keywords/alveolar-fluid-clearance","display_name":"alveolar fluid clearance","score":0.6809999942779541},{"id":"https://openalex.org/keywords/endothelial-permeability","display_name":"endothelial permeability","score":0.8149999976158142},{"id":"https://openalex.org/keywords/caveolae","display_name":"caveolae","score":0.8109999895095825},{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/endothelial-barrier","display_name":"endothelial barrier","score":0.5899999737739563},{"id":"https://openalex.org/keywords/alveolar-epithelial-barrier","display_name":"alveolar epithelial barrier","score":0.9679999947547913},{"id":"https://openalex.org/keywords/store-operated-calcium-entry","display_name":"store-operated calcium entry","score":0.7250000238418579},{"id":"https://openalex.org/keywords/trpc4","display_name":"TRPC4","score":0.8259999752044678},{"id":"https://openalex.org/keywords/myosin-light-chain-kinase","display_name":"myosin light chain kinase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cytosolic-calcium-signaling","display_name":"cytosolic calcium signaling","score":0.7710000276565552},{"id":"https://openalex.org/keywords/mitochondrial-calcium-signaling","display_name":"mitochondrial calcium signaling","score":0.6779999732971191},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.9150000214576721},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.6019999980926514},{"id":"https://openalex.org/keywords/alveolar-edema","display_name":"alveolar edema","score":0.7770000100135803},{"id":"https://openalex.org/keywords/beta-adrenergic-agonists","display_name":"beta-adrenergic agonists","score":0.9710000157356262},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.6470000147819519},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C49866891","wikidata":"https://www.wikidata.org/wiki/Q1051872","display_name":"Caveolae","level":3,"score":0.8150910139083862},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7422812581062317},{"id":"https://openalex.org/C185350488","wikidata":"https://www.wikidata.org/wiki/Q615386","display_name":"Transcytosis","level":4,"score":0.6819539070129395},{"id":"https://openalex.org/C2776436680","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microvessel","level":3,"score":0.5061983466148376},{"id":"https://openalex.org/C2779403975","wikidata":"https://www.wikidata.org/wiki/Q24724230","display_name":"Caveolin","level":4,"score":0.5059677958488464},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4787023365497589},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.4696356952190399},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45380523800849915},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.419938325881958},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.4156741499900818},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3353261947631836},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3242425322532654},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2916867136955261},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.16195568442344666},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.14831513166427612},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12322232127189636},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011652","descriptor_name":"Pulmonary Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajplung.00268.2004","doi":"https://doi.org/10.1152/ajplung.00268.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00268.2004","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"pmid:15531757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15531757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Lung cellular and molecular physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.828.2630","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.828.2630","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajplung.physiology.org/content/ajplung/287/6/L1081.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8775383557","display_name":"Rho Regulation of Pulmonary Vascular Permeability","funder_award_id":"R01HL071794","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W1233997596","https://openalex.org/W1536686003","https://openalex.org/W1566111314","https://openalex.org/W1573413261","https://openalex.org/W1643087207","https://openalex.org/W1669180776","https://openalex.org/W1705619492","https://openalex.org/W1767546005","https://openalex.org/W1811402656","https://openalex.org/W1900319011","https://openalex.org/W1951612395","https://openalex.org/W1957246104","https://openalex.org/W1958244357","https://openalex.org/W1966629642","https://openalex.org/W1981647923","https://openalex.org/W1991940875","https://openalex.org/W1993326230","https://openalex.org/W1993803695","https://openalex.org/W1993952427","https://openalex.org/W1995515664","https://openalex.org/W2003971843","https://openalex.org/W2004554331","https://openalex.org/W2007513694","https://openalex.org/W2007610433","https://openalex.org/W2008850478","https://openalex.org/W2009328749","https://openalex.org/W2010776189","https://openalex.org/W2012690424","https://openalex.org/W2013725292","https://openalex.org/W2018207852","https://openalex.org/W2018404032","https://openalex.org/W2019862207","https://openalex.org/W2022723700","https://openalex.org/W2029255946","https://openalex.org/W2033997987","https://openalex.org/W2036127937","https://openalex.org/W2040945595","https://openalex.org/W2044053783","https://openalex.org/W2045621468","https://openalex.org/W2046774437","https://openalex.org/W2047878721","https://openalex.org/W2048592427","https://openalex.org/W2049967046","https://openalex.org/W2056688534","https://openalex.org/W2059159382","https://openalex.org/W2060593058","https://openalex.org/W2063829324","https://openalex.org/W2064327485","https://openalex.org/W2064804782","https://openalex.org/W2066765839","https://openalex.org/W2068800887","https://openalex.org/W2069017442","https://openalex.org/W2069444054","https://openalex.org/W2070223063","https://openalex.org/W2074782193","https://openalex.org/W2077206645","https://openalex.org/W2079941180","https://openalex.org/W2081394769","https://openalex.org/W2081513562","https://openalex.org/W2082649287","https://openalex.org/W2084725453","https://openalex.org/W2087957246","https://openalex.org/W2091629951","https://openalex.org/W2091638984","https://openalex.org/W2101496432","https://openalex.org/W2107132365","https://openalex.org/W2107567984","https://openalex.org/W2108810940","https://openalex.org/W2110569992","https://openalex.org/W2110707896","https://openalex.org/W2111833940","https://openalex.org/W2119483908","https://openalex.org/W2128963767","https://openalex.org/W2129179416","https://openalex.org/W2139345025","https://openalex.org/W2142742500","https://openalex.org/W2144304154","https://openalex.org/W2144819568","https://openalex.org/W2145247599","https://openalex.org/W2151959697","https://openalex.org/W2153331362","https://openalex.org/W2154394909","https://openalex.org/W2154529942","https://openalex.org/W2155313983","https://openalex.org/W2157873754","https://openalex.org/W2163133008","https://openalex.org/W2172210768","https://openalex.org/W2195283270","https://openalex.org/W2253765481","https://openalex.org/W2261467449","https://openalex.org/W2270110742","https://openalex.org/W2399895627","https://openalex.org/W2402864238","https://openalex.org/W2407400602","https://openalex.org/W2409838205","https://openalex.org/W2415089416","https://openalex.org/W4211094368"],"related_works":["https://openalex.org/W2935951014","https://openalex.org/W2257981597","https://openalex.org/W4280583988","https://openalex.org/W2890304419","https://openalex.org/W194657879","https://openalex.org/W3043327438","https://openalex.org/W4286669614","https://openalex.org/W2090744060","https://openalex.org/W2907390141","https://openalex.org/W2065433187"],"abstract_inverted_index":{"This":[0],"review":[1],"summarizes":[2],"the":[3,6,12,16,30,43,51,73,102,114,125,132,151,178,216],"highlights":[4],"of":[5,15,25,33,50,75,104,116,170,175,184,211,218,238],"EB2004":[7],"symposium":[8],"that":[9,23],"dealt":[10],"with":[11,54],"integrated":[13,236],"aspects":[14],"lung":[17,26,84,165,239],"fluid":[18,27,176,196,240],"balance.":[19,241],"It":[20],"is":[21,181],"apparent":[22],"maintenance":[24],"balance":[28],"requires":[29],"proper":[31],"functioning":[32],"vascular":[34],"endothelial":[35,81,117,159],"and":[36,64,113,234],"alveolar":[37,171,195],"epithelial":[38],"barriers.":[39],"Under":[40],"physiological":[41],"conditions,":[42],"transcytotic":[44],"pathway":[45],"requiring":[46,173],"repeated":[47],"fission-fusion":[48],"events":[49,202],"caveolar":[52],"membrane":[53],"other":[55],"caveolae":[56],"solely":[57],"transports":[58],"albumin.":[59,76],"Caveolin-1,":[60],"which":[61,215],"forms":[62],"caveolae,":[63],"albumin-binding":[65],"proteins":[66,220],"play":[67],"a":[68,232],"central":[69],"role":[70],"in":[71,83,86,96,123,127,131,135,137,164,187,203,214,222],"signaling":[72,106,198],"transcytosis":[74],"Signals":[77],"responsible":[78],"for":[79],"increasing":[80],"permeability":[82],"microvessels":[85],"response":[87],"to":[88,207],"inflammatory":[89],"mediators":[90],"were":[91],"also":[92],"described.":[93],"These":[94],"studies":[95],"gene":[97],"knockout":[98],"mouse":[99,212],"models":[100,213],"revealed":[101],"importance":[103],"Ca(2+)":[105,134],"via":[107],"store-operated":[108],"transient":[109],"receptor":[110],"channel":[111],"4":[112],"activation":[115],"myosin":[118],"light":[119],"chain":[120],"kinase":[121],"isoform":[122],"mediating":[124],"increase":[126],"microvessel":[128,138],"permeability.":[129],"Increases":[130],"cytosolic":[133],"situ":[136],"endothelia":[139],"can":[140,193,226],"occur":[141],"by":[142,157],"mitochondria-dependent":[143],"as":[144,146,150],"well":[145],"mitochondria-independent":[147],"pathways":[148,199],"(such":[149],"endoplasmic":[152],"reticulum).":[153],"Both":[154],"these":[155,201],"pathways,":[156],"triggering":[158],"cell":[160,223],"activation,":[161],"may":[162],"result":[163],"microvascular":[166],"injury.":[167],"The":[168],"resolution":[169],"edema,":[172],"clearance":[174],"from":[177],"air":[179],"space,":[180],"another":[182],"area":[183],"intense":[185],"investigation":[186],"animal":[188],"models.":[189],"Although":[190],"beta-adrenergic":[191],"agonists":[192],"activate":[194],"clearance,":[197],"regulating":[200],"intact":[204],"alveoli":[205],"remain":[206],"be":[208,227],"established.":[209],"Development":[210],"function":[217],"regulatory":[219],"(identified":[221],"culture":[224],"studies)":[225],"systematically":[228],"analyzed":[229],"will":[230],"provide":[231],"better":[233],"more":[235],"picture":[237],"In":[242],"vivo":[243],"veritas!":[244]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
