{"id":"https://openalex.org/W2104846922","doi":"https://doi.org/10.1126/scisignal.aab0715","title":"DNA methylation regulates neuronal glutamatergic synaptic scaling","display_name":"DNA methylation regulates neuronal glutamatergic synaptic scaling","publication_year":2015,"publication_date":"2015-06-23","ids":{"openalex":"https://openalex.org/W2104846922","doi":"https://doi.org/10.1126/scisignal.aab0715","mag":"2104846922","pmid":"https://pubmed.ncbi.nlm.nih.gov/26106219","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4764068"},"language":"en","primary_location":{"id":"doi:10.1126/scisignal.aab0715","doi":"https://doi.org/10.1126/scisignal.aab0715","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.aab0715","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4764068","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103442076","display_name":"Jarrod P. Meadows","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jarrod P. Meadows","raw_affiliation_strings":["Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060368461","display_name":"Mikael Guzman Karlsson","orcid":"https://orcid.org/0000-0002-0183-2277","observed_orcids":["https://orcid.org/0000-0002-0183-2277"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikael C. Guzman-Karlsson","raw_affiliation_strings":["Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041900573","display_name":"Scott E. Phillips","orcid":"https://orcid.org/0000-0002-5451-0984","observed_orcids":["https://orcid.org/0000-0002-5451-0984"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Phillips","raw_affiliation_strings":["Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110460670","display_name":"Cassie Lynn Holleman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cassie Holleman","raw_affiliation_strings":["Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090998478","display_name":"Jessica L. Posey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica L. Posey","raw_affiliation_strings":["Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090805805","display_name":"Jeremy J. Day","orcid":"https://orcid.org/0000-0002-7361-3399","observed_orcids":["https://orcid.org/0000-0002-7361-3399"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy J. Day","raw_affiliation_strings":["Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071337074","display_name":"John J. Hablitz","orcid":"https://orcid.org/0000-0003-3847-8547","observed_orcids":["https://orcid.org/0000-0003-3847-8547"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John J. Hablitz","raw_affiliation_strings":["Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053267978","display_name":"J. David Sweatt","orcid":"https://orcid.org/0000-0003-3567-485X","observed_orcids":["https://orcid.org/0000-0003-3567-485X"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. David Sweatt","raw_affiliation_strings":["Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053267978","https://openalex.org/A5071337074"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":null,"apc_paid":null,"fwci":7.7396,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.98550266,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"8","issue":"382","first_page":"ra61","last_page":"ra61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glutamatergic-synapses","display_name":"glutamatergic synapses","score":0.9549999833106995},{"id":"https://openalex.org/keywords/synaptic-homeostasis","display_name":"synaptic homeostasis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/long-term-memory","display_name":"long-term memory","score":0.6869999766349792},{"id":"https://openalex.org/keywords/dna-methyltransferase-inhibition","display_name":"DNA methyltransferase inhibition","score":0.7730000019073486},{"id":"https://openalex.org/keywords/rg108","display_name":"RG108","score":0.8240000009536743},{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.8629999756813049},{"id":"https://openalex.org/keywords/dnmt3a","display_name":"DNMT3A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tet1","display_name":"TET1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/glutamate-receptors","display_name":"glutamate receptors","score":0.8769999742507935},{"id":"https://openalex.org/keywords/miniature-excitatory-postsynaptic-currents","display_name":"miniature excitatory postsynaptic currents","score":0.8740000128746033},{"id":"https://openalex.org/keywords/transcription","display_name":"transcription","score":0.515999972820282},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.8309999704360962},{"id":"https://openalex.org/keywords/tetrodotoxin","display_name":"tetrodotoxin","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.810468316078186},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6948134899139404},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5237112641334534},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4617578685283661},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.45574238896369934},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4289674758911133},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.42818158864974976},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2807563543319702},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24502399563789368},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.22077149152755737},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2110668122768402},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11324012279510498}],"mesh":[{"descriptor_ui":"D000076123","descriptor_name":"DNA (Cytosine-5-)-Methyltransferase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090205","descriptor_name":"DNA Methyltransferase 3A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004248","descriptor_name":"DNA (Cytosine-5-)-Methyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D004248","descriptor_name":"DNA (Cytosine-5-)-Methyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004248","descriptor_name":"DNA (Cytosine-5-)-Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010797","descriptor_name":"Phthalimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055366","descriptor_name":"Synaptic Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055366","descriptor_name":"Synaptic Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/scisignal.aab0715","doi":"https://doi.org/10.1126/scisignal.aab0715","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.aab0715","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},{"id":"pmid:26106219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26106219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science signaling","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4764068","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4764068","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sci Signal","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4764068","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4764068","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sci Signal","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1985838504","display_name":null,"funder_award_id":"MH091122","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2227916781","display_name":"Epigenetic Regulation of Cocaine-Induced Neuroadaptations","funder_award_id":"K99DA034681","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2415555256","display_name":null,"funder_award_id":"MH 57014","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2453193127","display_name":"UAB Neuroscience Core Center","funder_award_id":"P30NS047466","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2845221667","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM008361","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3038653181","display_name":"DNA Methylation in Memory Formation","funder_award_id":"R01MH091122","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3247297565","display_name":"Epigenetic Control of Brain Reward Systems","funder_award_id":"DP1DA039650","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G4958906454","display_name":null,"funder_award_id":"HR0011-12-1-0015","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"},{"id":"https://openalex.org/G6990972161","display_name":"Epigenetic Regulation of Cocaine-Induced Neuroadaptations","funder_award_id":"R00DA034681","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7825548580","display_name":"Biochemical Mechanisms of Neural Plasticity","funder_award_id":"R01MH057014","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7890484405","display_name":null,"funder_award_id":"DA034681","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G9000124665","display_name":null,"funder_award_id":"DA034681","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000921137","display_name":"UAB Research Training Program in Neurobiology of Cognition and Cognitive Disorders","funder_award_id":"T32NS061788","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320309465","display_name":"Evelyn F. McKnight Brain Research Foundation","ror":"https://ror.org/00vsf1v04"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1027568982","https://openalex.org/W1489333352","https://openalex.org/W1514853588","https://openalex.org/W1528346173","https://openalex.org/W1964184380","https://openalex.org/W1964914480","https://openalex.org/W1970986383","https://openalex.org/W1971156703","https://openalex.org/W1971159711","https://openalex.org/W1973759523","https://openalex.org/W1979518536","https://openalex.org/W1979526394","https://openalex.org/W1980962232","https://openalex.org/W1981463058","https://openalex.org/W1983158636","https://openalex.org/W1985534367","https://openalex.org/W1987055742","https://openalex.org/W1989803029","https://openalex.org/W1991979408","https://openalex.org/W1992024544","https://openalex.org/W1995502179","https://openalex.org/W2001036497","https://openalex.org/W2001651016","https://openalex.org/W2002788005","https://openalex.org/W2008060564","https://openalex.org/W2013154874","https://openalex.org/W2014921813","https://openalex.org/W2015337533","https://openalex.org/W2018338317","https://openalex.org/W2018419725","https://openalex.org/W2020449445","https://openalex.org/W2024088186","https://openalex.org/W2024322138","https://openalex.org/W2028704685","https://openalex.org/W2029050314","https://openalex.org/W2029291587","https://openalex.org/W2031379951","https://openalex.org/W2031898618","https://openalex.org/W2032882684","https://openalex.org/W2038990611","https://openalex.org/W2047535883","https://openalex.org/W2050066016","https://openalex.org/W2051483319","https://openalex.org/W2062872787","https://openalex.org/W2063449449","https://openalex.org/W2063915751","https://openalex.org/W2064268598","https://openalex.org/W2064756496","https://openalex.org/W2064808830","https://openalex.org/W2073902410","https://openalex.org/W2074749057","https://openalex.org/W2075969168","https://openalex.org/W2076312647","https://openalex.org/W2077237334","https://openalex.org/W2078166071","https://openalex.org/W2078908871","https://openalex.org/W2083149544","https://openalex.org/W2083535257","https://openalex.org/W2090760765","https://openalex.org/W2092597282","https://openalex.org/W2092765329","https://openalex.org/W2094813482","https://openalex.org/W2096473662","https://openalex.org/W2107277218","https://openalex.org/W2108244474","https://openalex.org/W2114559471","https://openalex.org/W2114599216","https://openalex.org/W2115818350","https://openalex.org/W2117272508","https://openalex.org/W2121423419","https://openalex.org/W2148033621","https://openalex.org/W2153122353","https://openalex.org/W2156940776","https://openalex.org/W2162596587","https://openalex.org/W2168976498","https://openalex.org/W2169980562"],"related_works":["https://openalex.org/W2290753553","https://openalex.org/W2000286376","https://openalex.org/W2008060564","https://openalex.org/W2062872787","https://openalex.org/W3046006086","https://openalex.org/W3011275958","https://openalex.org/W2115818350","https://openalex.org/W2031379951","https://openalex.org/W3130271997","https://openalex.org/W6958774749"],"abstract_inverted_index":{"Enhanced":[0],"receptiveness":[1],"at":[2],"all":[3],"synapses":[4],"on":[5,41],"a":[6,35,137,180,196,200],"neuron":[7,201],"that":[8,19,37,53,187,213,234],"receive":[9],"glutamatergic":[10,62,221],"input":[11],"is":[12],"called":[13],"cell-wide":[14],"synaptic":[15,23,59,63,107,134,222,231],"upscaling.":[16],"We":[17,51],"hypothesize":[18],"this":[20],"type":[21],"of":[22,49,61,79,84,100,175,220,240],"plasticity":[24,232],"may":[25,38,228],"be":[26],"critical":[27],"for":[28],"long-term":[29],"memory":[30],"storage":[31],"within":[32],"cortical":[33,67],"circuits,":[34],"process":[36],"also":[39,170],"depend":[40],"epigenetic":[42],"mechanisms,":[43],"such":[44],"as":[45,140],"covalent":[46,225],"chemical":[47],"modification":[48],"DNA.":[50],"found":[52],"DNA":[54,115,214,226],"cytosine":[55,77,167],"demethylation":[56],"mediates":[57],"multiplicative":[58,181],"upscaling":[60,108,135,145,159,173],"strength":[64],"in":[65,92,183,190,195],"cultured":[66],"neurons.":[68],"Inhibiting":[69,114],"neuronal":[70],"activity":[71],"with":[72],"tetrodotoxin":[73],"(TTX)":[74],"decreased":[75],"the":[76,82,95,122,152,166,172,188,236],"methylation":[78,215],"and":[80,89,131,202,238],"increased":[81,111],"expression":[83],"genes":[85],"encoding":[86],"glutamate":[87,191],"receptors":[88],"trafficking":[90],"proteins,":[91],"turn":[93],"increasing":[94],"amplitude":[96],"but":[97],"not":[98,204],"frequency":[99],"miniature":[101],"excitatory":[102],"postsynaptic":[103],"currents":[104],"(mEPSCs),":[105],"indicating":[106,186],"rather":[109],"than":[110],"spontaneous":[112],"activity.":[113],"methyltransferase":[116],"(DNMT)":[117],"activity,":[118],"either":[119],"by":[120,127,147,161],"using":[121],"small-molecule":[123],"inhibitor":[124,155],"RG108":[125],"or":[126],"knocking":[128],"down":[129,165],"Dnmt1":[130],"Dnmt3a,":[132],"induced":[133,146,160,179],"to":[136,142,206,230],"similar":[138],"magnitude":[139],"exposure":[141],"TTX.":[143],"Moreover,":[144],"DNMT":[148,162,177],"inhibition":[149,178],"required":[150],"transcription;":[151],"RNA":[153],"polymerase":[154],"actinomycin":[156],"D":[157],"blocked":[158,171],"inhibition.":[163],"Knocking":[164],"demethylase":[168],"TET1":[169],"effects":[174],"RG108.":[176],"increase":[182],"mEPSC":[184],"amplitude,":[185],"alterations":[189],"receptor":[192],"abundance":[193],"occurred":[194],"coordinated":[197],"manner":[198],"throughout":[199],"were":[203],"limited":[205],"individual":[207],"active":[208],"synapses.":[209],"Our":[210],"data":[211],"suggest":[212],"status":[216],"controls":[217],"transcription-dependent":[218],"regulation":[219],"homeostasis.":[223],"Furthermore,":[224],"modifications":[227],"contribute":[229],"events":[233],"underlie":[235],"formation":[237],"stabilization":[239],"memories.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}