{"id":"https://openalex.org/W2104845499","doi":null,"title":"Characterisation and expression of copper homeostasis genes in sea bream (Sparus aurata)","display_name":"Characterisation and expression of copper homeostasis genes in sea bream (Sparus aurata)","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2104845499","mag":"2104845499"},"language":"en","primary_location":{"id":"pmh:oai:dspace.stir.ac.uk:1893/1113","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1893/1113","pdf_url":"http://dspace.stir.ac.uk/bitstream/1893/1113/4/PhD%20Thesis-Matteo%20Minghetti.pdf","source":{"id":"https://openalex.org/S4306400268","display_name":"Stirling Online Research Repository (University of Stirling)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12093191","host_organization_name":"University of Stirling","host_organization_lineage":["https://openalex.org/I12093191"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dspace.stir.ac.uk/bitstream/1893/1113/4/PhD%20Thesis-Matteo%20Minghetti.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032074638","display_name":"Matteo Minghetti","orcid":"https://orcid.org/0000-0003-3960-3805","observed_orcids":["https://orcid.org/0000-0003-3960-3805"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Matteo Minghetti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3960-3805","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5032074638"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10450","display_name":"Aquaculture Nutrition and Growth","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copper-homeostasis","display_name":"copper homeostasis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gilthead-seabream","display_name":"Sparus aurata","score":0.9390000104904175},{"id":"https://openalex.org/keywords/sea-bream","display_name":"sea bream","score":0.9300000071525574},{"id":"https://openalex.org/keywords/ctr1","display_name":"CTR1","score":0.75},{"id":"https://openalex.org/keywords/atox1","display_name":"Atox1","score":0.9010000228881836},{"id":"https://openalex.org/keywords/atp7a","display_name":"ATP7A","score":0.9570000171661377},{"id":"https://openalex.org/keywords/atp7b","display_name":"ATP7B","score":0.9869999885559082},{"id":"https://openalex.org/keywords/metallothionein","display_name":"metallothionein","score":0.9750000238418579},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7480000257492065},{"id":"https://openalex.org/keywords/dietary-copper","display_name":"dietary copper","score":0.5849999785423279},{"id":"https://openalex.org/keywords/copper-toxicity","display_name":"copper toxicity","score":0.48100000619888306},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.5339999794960022},{"id":"https://openalex.org/keywords/cadmium","display_name":"cadmium","score":0.7400000095367432},{"id":"https://openalex.org/keywords/metal-induced-oxidative-stress","display_name":"metal-induced oxidative stress","score":0.35199999809265137},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.45399999618530273},{"id":"https://openalex.org/keywords/metallothionein-induction","display_name":"metallothionein induction","score":0.5210000276565552},{"id":"https://openalex.org/keywords/metallothionein-promoter","display_name":"metallothionein promoter","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5537958741188049},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5438166260719299},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.519561767578125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5127421617507935},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.47786015272140503},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4171295762062073},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.3895415663719177},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2680601477622986},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20843341946601868},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17704284191131592},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.06707316637039185},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dspace.stir.ac.uk:1893/1113","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1893/1113","pdf_url":"http://dspace.stir.ac.uk/bitstream/1893/1113/4/PhD%20Thesis-Matteo%20Minghetti.pdf","source":{"id":"https://openalex.org/S4306400268","display_name":"Stirling Online Research Repository (University of Stirling)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12093191","host_organization_name":"University of Stirling","host_organization_lineage":["https://openalex.org/I12093191"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},{"id":"pmh:hdl:10068/967029","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/967029","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:2104845499","doi":null,"is_oa":false,"landing_page_url":"https://dspace.stir.ac.uk/bitstream/1893/1113/4/PhD%20Thesis-Matteo%20Minghetti.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.stir.ac.uk:1893/1113","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1893/1113","pdf_url":"http://dspace.stir.ac.uk/bitstream/1893/1113/4/PhD%20Thesis-Matteo%20Minghetti.pdf","source":{"id":"https://openalex.org/S4306400268","display_name":"Stirling Online Research Repository (University of Stirling)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12093191","host_organization_name":"University of Stirling","host_organization_lineage":["https://openalex.org/I12093191"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104845499.pdf","grobid_xml":"https://content.openalex.org/works/W2104845499.grobid-xml"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W132936908","https://openalex.org/W184311987","https://openalex.org/W192250034","https://openalex.org/W1489286950","https://openalex.org/W1496283406","https://openalex.org/W1502029262","https://openalex.org/W1547975753","https://openalex.org/W1555535242","https://openalex.org/W1555682241","https://openalex.org/W1573826674","https://openalex.org/W1759181620","https://openalex.org/W1820891978","https://openalex.org/W1869259273","https://openalex.org/W1926541489","https://openalex.org/W1952131548","https://openalex.org/W1969891257","https://openalex.org/W1971326367","https://openalex.org/W1972624845","https://openalex.org/W1973996613","https://openalex.org/W1977158268","https://openalex.org/W1985329347","https://openalex.org/W1986642316","https://openalex.org/W1991173530","https://openalex.org/W1993512136","https://openalex.org/W1996103014","https://openalex.org/W2006138834","https://openalex.org/W2010776189","https://openalex.org/W2011778503","https://openalex.org/W2013948741","https://openalex.org/W2016620251","https://openalex.org/W2017996363","https://openalex.org/W2019903373","https://openalex.org/W2022682828","https://openalex.org/W2023618834","https://openalex.org/W2024365580","https://openalex.org/W2026258231","https://openalex.org/W2026444546","https://openalex.org/W2026820283","https://openalex.org/W2029738881","https://openalex.org/W2033463352","https://openalex.org/W2036729969","https://openalex.org/W2038142268","https://openalex.org/W2038890616","https://openalex.org/W2040695835","https://openalex.org/W2040713211","https://openalex.org/W2040964500","https://openalex.org/W2042921396","https://openalex.org/W2043104518","https://openalex.org/W2043179564","https://openalex.org/W2044230889","https://openalex.org/W2044407123","https://openalex.org/W2055432880","https://openalex.org/W2057671039","https://openalex.org/W2058861773","https://openalex.org/W2059557323","https://openalex.org/W2061040884","https://openalex.org/W2063157862","https://openalex.org/W2064702079","https://openalex.org/W2066006292","https://openalex.org/W2070404426","https://openalex.org/W2072304649","https://openalex.org/W2075129692","https://openalex.org/W2077127842","https://openalex.org/W2077794506","https://openalex.org/W2080593419","https://openalex.org/W2080854280","https://openalex.org/W2089363773","https://openalex.org/W2090732807","https://openalex.org/W2105193668","https://openalex.org/W2109928864","https://openalex.org/W2112733461","https://openalex.org/W2113131102","https://openalex.org/W2115891976","https://openalex.org/W2116153275","https://openalex.org/W2118310701","https://openalex.org/W2130781987","https://openalex.org/W2131773446","https://openalex.org/W2132544275","https://openalex.org/W2134169695","https://openalex.org/W2135930735","https://openalex.org/W2137330738","https://openalex.org/W2140292630","https://openalex.org/W2140561339","https://openalex.org/W2141928103","https://openalex.org/W2149895469","https://openalex.org/W2152105575","https://openalex.org/W2159294156","https://openalex.org/W2165071443","https://openalex.org/W2410333136","https://openalex.org/W2580247614","https://openalex.org/W3025185345"],"related_works":["https://openalex.org/W7066171937","https://openalex.org/W1998640457","https://openalex.org/W2059557323","https://openalex.org/W2024567695","https://openalex.org/W7098325878","https://openalex.org/W1990616578","https://openalex.org/W1978529600","https://openalex.org/W7135651931","https://openalex.org/W2045419419","https://openalex.org/W4393230019"],"abstract_inverted_index":{"The":[0,63,93,552,575,713,766],"redox":[1],"properties":[2],"of":[3,25,28,65,75,95,123,147,184,212,215,228,236,248,260,291,308,327,334,355,362,378,400,404,420,425,519,556,573,625,645,697,705,717,728,828,831,834,871],"Copper":[4],"(Cu)":[5],"make":[6],"it":[7,174,241,618,807],"both":[8,205,460,557,604],"an":[9,222],"ideal":[10],"cofactor":[11],"for":[12,83,254,281,823],"many":[13],"enzymes,":[14],"and,":[15],"in":[16,71,98,106,114,171,178,231,329,366,416,433,443,452,454,459,501,507,524,534,554,560,578,612,632,660,680,685,714,790,838,848,889],"its":[17],"free":[18],"form,":[19],"a":[20,391,397,517,567,592,661,692,723,880],"highly":[21],"toxic":[22,313],"molecule":[23],"capable":[24],"stimulating":[26],"production":[27],"reactive":[29],"oxygen":[30],"species":[31],"or":[32,239,317,337,412,542,751,814],"binding":[33],"to":[34,45,80,110,136,144,153,204,209,224,244,285,315,324,350,375,395,407,448,538,570,586,628,658,694,708,720,726,731,861,864],"protein":[35,266,270,273,781],"thiol":[36],"groups.":[37],"Therefore,":[38,198],"living":[39],"organisms":[40],"have":[41,201],"evolved":[42],"homeostatic":[43,311],"systems":[44,55,67,202],"\u201chandle\u201d":[46],"Cu":[47,97,229,328,345,363,379,408,414,431,441,450,476,497,530,539,598,608,610,626,638,655,700,706,721,733,736,746,778,798,843,872,887],"avoiding":[48],"dangerous":[49],"and":[50,60,90,117,127,163,173,207,275,289,296,312,341,344,385,423,435,445,456,462,481,484,488,495,509,526,606,614,650,738,758,783,801,816,826],"wasteful":[51],"aspecific":[52],"interactions.":[53],"These":[54],"comprise":[56],"uptake,":[57,283],"carrier,":[58],"storage":[59],"excretion":[61,627],"proteins.":[62,251],"importance":[64],"Cu-homeostatic":[66],"was":[68,393],"initially":[69],"discovered":[70],"humans":[72],"where":[73],"alterations":[74],"Cu-excretory":[76],"proteins":[77],"were":[78,294,322,347,373,743,760,779],"shown":[79],"be":[81,111,132,691,821,851,862],"responsible":[82,280],"two":[84],"lethal":[85],"genetic":[86],"disorders;":[87],"the":[88,99,161,166,226,246,282,286,305,309,330,353,359,401,601,643,646,670,678,702,771,812,832,854,874],"Wilson":[89,272],"Menkes":[91,269],"diseases.":[92],"levels":[94,301,326,346,377,466,611,742,840],"bioavailable":[96],"aquatic":[100],"environment":[101],"is":[102,169,242,619,630,656,808],"important":[103,170],"because":[104],"concentrations":[105,130],"oceanic":[107],"waters":[108],"tend":[109],"minute,":[112],"whilst":[113,437,469],"some":[115],"fresh":[116],"coastal":[118],"waters,":[119],"particularly":[120],"around":[121],"areas":[122],"mineral":[124],"extraction,":[125],"viniculture":[126],"farming":[128],"operations,":[129],"can":[131,188],"excessive.":[133],"In":[134,221,389,473],"contrast":[135],"terrestrial":[137],"vertebrates,":[138],"fish":[139,172,187,199,729,791],"are":[140,150,279,583,868],"not":[141,748],"only":[142,636],"exposed":[143,152,323,374,730],"dietary":[145,185,318,413,429,449,494,563,605],"sources":[146],"copper":[148,156,261,681,792],"but":[149,532,588,747],"also":[151],"dissolved":[154],"ionic":[155],"that":[157,181,621,654,667,770,789,817,842,867],"may":[158,565,590,820,850,885],"enter":[159],"via":[160,540,811],"skin":[162],"gills.":[164],"Indeed,":[165],"latter":[167],"route":[168,624,833],"has":[175,544,793],"been":[176],"demonstrated":[177],"physiological":[179],"studies":[180],"under":[182,234],"conditions":[183,235],"deficiency,":[186,237],"satisfy":[189],"their":[190,297],"own":[191],"body":[192,213],"requirements":[193],"by":[194,745,749,762,777],"uptake":[195,572,825],"from":[196,600,640,664,668],"water.":[197],"must":[200],"relating":[203],"gill":[206,444,510,527,641,665,688,813],"gut":[208,815],"enable":[210,695],"maintenance":[211],"homeostasis":[214,230,364,844],"this":[216],"essential,":[217],"yet":[218],"toxic,":[219],"metal.":[220],"attempt":[223],"understand":[225],"mechanisms":[227],"fish,":[232,367,849],"whether":[233,806],"adequacy":[238],"excess,":[240],"essential":[243],"consider":[245],"expression":[247,300,418,523,555,644,684],"known":[249],"Cu-homeostasis":[250,421,550],"Thus,":[252,536],"cDNAs":[253],"sea":[255,320,633],"bream":[256,321],"(Sparus":[257],"aurata)":[258],"homologues":[259],"transporter":[262,799],"1":[263,267],"(Ctr1),":[264],"antioxidant":[265],"(Atox1),":[268],"(ATP7A),":[271],"(ATP7B),":[274],"metallothionein":[276],"(MT),":[277],"which":[278,884],"delivery":[284,707],"secretory":[287],"pathway":[288,704],"scavenging":[290],"intracellular":[292],"Cu,":[293,319,829],"cloned":[295],"mRNA":[298,343,458,471,500,505,741,839],"tissue":[299,342,797],"measured.":[302,348],"To":[303],"investigate":[304],"molecular":[306],"basis":[307],"different":[310,356,662],"responses":[314],"waterborne":[316,439,475,496,512,529,581,607,732],"sub-toxic":[325,376],"diet":[331,543],"(130":[332],"mg/Kg":[333],"dry":[335],"diet)":[336],"water":[338,541],"(0.3":[339],"mg/L)":[340],"Moreover,":[349,836],"discriminate":[351],"between":[352],"effect":[354],"metals":[357,764],"on":[358,549,796,805],"transcriptional":[360,402,855,882],"regulation":[361],"genes":[365,422,559,800,866],"Sparus":[368],"aurata":[369],"fibroblast":[370],"(SAF1)":[371],"cells":[372,406,719],"(25":[380,409],"\u03bcM),":[381],"Zn":[382,750],"(100":[383],"\u03bcM)":[384],"Cd":[386,752],"(10":[387],"\u03bcM).":[388,410],"addition,":[390],"microarray":[392,875],"used":[394],"gain":[396],"broader":[398],"overview":[399],"response":[403,725],"SAF1":[405,718],"Waterborne":[411],"resulted":[415,451],"distinct":[417,794],"profiles":[419],"markers":[424,648],"oxidative":[426,520,802],"stress.":[427,784],"After":[428],"exposure,":[430,531],"increased":[432,442,478,485,498,506,522,609,615,642],"intestine":[434,561,579,686],"liver,":[436,709],"after":[438,511,528,562,580,687],"exposure":[440,477,537,564,582,689,716],"liver.":[446,502],"Exposure":[447],"decreases":[453],"Ctr1":[455,465,480,487],"ATP7A":[457,470,482,491,740],"liver":[461,508,525,613,659,727],"intestine.":[463,535],"Renal":[464],"remained":[467],"unchanged,":[468],"decreased.":[472],"contrast,":[474],"intestinal":[479,703,818],"mRNA,":[483],"renal":[486,490],"decreased":[489,533],"mRNA.":[492],"Both":[493],"ATP7B":[499,617],"Metallothionein":[503],"(MT)":[504],"Cu.":[513,574],"Glutathione":[514],"reductase":[515],"(GR),":[516],"marker":[518],"stress,":[521],"different,":[545],"often":[546],"opposite":[547,576],"effects":[548,577,795],"genes.":[551],"decrease":[553],"Cu-transport":[558],"indicate":[566,841],"defensive":[568],"mechanism":[569,594,693],"limit":[571],"more":[584,858],"difficult":[585],"explain,":[587],"again":[589],"reflect":[591],"defence":[593],"against":[595],"excess":[596,698],"bloodborne":[597,699],"coming":[599],"gill.":[602],"Since":[603],"hepatic":[616,637],"likely":[620],"well-characterised":[622],"mammalian":[623],"bile":[629],"active":[631],"bream.":[634],"However,":[635],"derived":[639,672],"stress":[647,803],"MT":[649,757],"GR.":[651],"This":[652],"suggests":[653],"delivered":[657],"form":[663],"as":[666],"intestine,":[669],"intestinally":[671],"pool":[673],"being":[674],"less":[675],"toxic.":[676],"Thus":[677],"increase":[679],"transport":[682],"gene":[683],"might":[690],"incorporation":[696],"into":[701],"thus":[710],"minimizing":[711],"toxicity.":[712],"vitro":[715],"showed":[722],"similar":[724,735],"indicating":[734],"availability":[737],"complexation.":[739],"induced":[744,761],"suggesting":[753],"Cu-specific":[754],"regulation.":[755],"Conversely,":[756],"GR":[759],"all":[763],"tested.":[765],"transcriptomic":[767],"analysis":[768],"highlighted":[769],"biological":[772],"processes":[773],"most":[774],"significantly":[775],"affected":[776],"secretion,":[780],"trafficking":[782],"Overall,":[785],"these":[786],"results":[787,876],"show":[788,879],"depending":[804],"taken":[809],"up":[810],"absorption":[819],"required":[822],"normal":[824],"metabolism":[827],"regardless":[830],"uptake.":[835],"changes":[837],"genes,":[845],"at":[846,853],"least":[847],"regulated":[852],"level.":[856],"Although":[857],"work":[859],"needs":[860],"done":[863],"identify":[865],"robust":[869],"predictors":[870],"toxicity,":[873],"presented":[877],"here":[878],"clear":[881],"fingerprint":[883],"characterize":[886],"toxicity":[888],"fish.":[890]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}