{"id":"https://openalex.org/W2104836622","doi":"https://doi.org/10.1128/mcb.19.2.1569","title":"The MKK7 Gene Encodes a Group of c-Jun NH 2 -Terminal Kinase Kinases","display_name":"The MKK7 Gene Encodes a Group of c-Jun NH 2 -Terminal Kinase Kinases","publication_year":1999,"publication_date":"1999-02-01","ids":{"openalex":"https://openalex.org/W2104836622","doi":"https://doi.org/10.1128/mcb.19.2.1569","mag":"2104836622","pmid":"https://pubmed.ncbi.nlm.nih.gov/9891090","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/116085"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.19.2.1569","doi":"https://doi.org/10.1128/mcb.19.2.1569","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.19.2.1569","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2104836622"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC116085/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088464340","display_name":"Cathy Tournier","orcid":"https://orcid.org/0000-0002-4618-2570","observed_orcids":["https://orcid.org/0000-0002-4618-2570"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cathy Tournier","raw_affiliation_strings":["Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School","Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078982842","display_name":"Alan J. Whitmarsh","orcid":"https://orcid.org/0000-0003-1184-6610","observed_orcids":["https://orcid.org/0000-0003-1184-6610"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan J. Whitmarsh","raw_affiliation_strings":["Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School","Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111457464","display_name":"Julie Cavanagh","orcid":"https://orcid.org/0000-0001-7003-516X","observed_orcids":["https://orcid.org/0000-0001-7003-516X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Cavanagh","raw_affiliation_strings":["Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School","Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081735713","display_name":"Tamera Barrett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamera Barrett","raw_affiliation_strings":["Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School","Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028742170","display_name":"Roger J. Davis","orcid":"https://orcid.org/0000-0002-0130-1652","observed_orcids":["https://orcid.org/0000-0002-0130-1652"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger J. Davis","raw_affiliation_strings":["Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School","Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.2672,"has_fulltext":false,"cited_by_count":175,"citation_normalized_percentile":{"value":0.96919295,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"19","issue":"2","first_page":"1569","last_page":"1581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.801800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.801800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.09889999777078629,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.05939999967813492,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mkk7","display_name":"MKK7","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mkk4","display_name":"MKK4","score":0.9390000104904175},{"id":"https://openalex.org/keywords/c-jun-n-terminal-kinase","display_name":"c-Jun N-terminal kinase","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mapk-kinase","display_name":"MAPK kinase","score":0.800000011920929},{"id":"https://openalex.org/keywords/jnk-activation","display_name":"JNK activation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9100000262260437},{"id":"https://openalex.org/keywords/protein-isoforms","display_name":"protein isoforms","score":0.7289999723434448},{"id":"https://openalex.org/keywords/protein-kinases","display_name":"protein kinases","score":0.4180000126361847},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.6650000214576721},{"id":"https://openalex.org/keywords/stress-signaling","display_name":"stress signaling","score":0.5979999899864197},{"id":"https://openalex.org/keywords/nuclear-localization","display_name":"nuclear localization","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7375243902206421},{"id":"https://openalex.org/C137361374","wikidata":"https://www.wikidata.org/wiki/Q6714442","display_name":"MAP kinase kinase kinase","level":4,"score":0.5965362191200256},{"id":"https://openalex.org/C159479382","wikidata":"https://www.wikidata.org/wiki/Q18030801","display_name":"MAP2K7","level":5,"score":0.5816391706466675},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.5514447093009949},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5390182733535767},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4849527180194855},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.43614262342453003},{"id":"https://openalex.org/C2779087070","wikidata":"https://www.wikidata.org/wiki/Q5005943","display_name":"c-jun","level":4,"score":0.42974555492401123},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4292006194591522},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.319616436958313},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.29538434743881226},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.26288655400276184},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25108492374420166},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.057238250970840454}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020930","descriptor_name":"MAP Kinase Kinase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048670","descriptor_name":"MAP Kinase Kinase 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048688","descriptor_name":"MAP Kinase Kinase 7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1128/mcb.19.2.1569","doi":"https://doi.org/10.1128/mcb.19.2.1569","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.19.2.1569","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmid:9891090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9891090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:116085","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC116085/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.589.9074","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.589.9074","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mcb.asm.org/content/19/2/1569.full.pdf","raw_type":"text"},{"id":"pmh:oai:escholarship.umassmed.edu:oapubs-2444","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/oapubs/1445","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications by UMass Chan Authors","raw_type":"text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/a0d21ef6-370c-4199-8799-62a677c3eddf","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/a0d21ef6-370c-4199-8799-62a677c3eddf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tournier, C, Whitmarsh, A J, Cavanagh, J, Barrett, T & Davis, R J 1999, 'The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases', Mol Cell Biol, vol. 19, no. 2, pp. 1569-81.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:116085","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC116085/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7429336277","display_name":"CARBORANYL NUCLEOTIDES--POTENTIAL DNA PROBES FOR BNCT","funder_award_id":"R01CA053896","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W29946730","https://openalex.org/W122546422","https://openalex.org/W161910285","https://openalex.org/W1531194664","https://openalex.org/W1539871462","https://openalex.org/W1553651506","https://openalex.org/W1555692789","https://openalex.org/W1821277660","https://openalex.org/W1888645976","https://openalex.org/W1964100540","https://openalex.org/W1967218150","https://openalex.org/W1968590447","https://openalex.org/W1969393277","https://openalex.org/W1970328728","https://openalex.org/W1977052613","https://openalex.org/W1980090694","https://openalex.org/W1980303501","https://openalex.org/W1981705099","https://openalex.org/W1982390204","https://openalex.org/W1983917564","https://openalex.org/W1984903682","https://openalex.org/W1985462906","https://openalex.org/W1986559713","https://openalex.org/W1987931310","https://openalex.org/W1989526588","https://openalex.org/W1991170866","https://openalex.org/W1992207607","https://openalex.org/W1992555403","https://openalex.org/W1993657069","https://openalex.org/W1994881800","https://openalex.org/W1995035611","https://openalex.org/W1995771448","https://openalex.org/W1997966434","https://openalex.org/W1998487776","https://openalex.org/W2001521752","https://openalex.org/W2005900169","https://openalex.org/W2009667315","https://openalex.org/W2013044374","https://openalex.org/W2013208185","https://openalex.org/W2014473902","https://openalex.org/W2020466484","https://openalex.org/W2020549199","https://openalex.org/W2021021216","https://openalex.org/W2023189063","https://openalex.org/W2027880172","https://openalex.org/W2029055264","https://openalex.org/W2029242493","https://openalex.org/W2030102504","https://openalex.org/W2030271387","https://openalex.org/W2030900078","https://openalex.org/W2031272027","https://openalex.org/W2034586348","https://openalex.org/W2036123452","https://openalex.org/W2036985660","https://openalex.org/W2039674021","https://openalex.org/W2040357332","https://openalex.org/W2042216100","https://openalex.org/W2042584344","https://openalex.org/W2043363663","https://openalex.org/W2045395146","https://openalex.org/W2047330178","https://openalex.org/W2051538397","https://openalex.org/W2054363543","https://openalex.org/W2055181868","https://openalex.org/W2060913542","https://openalex.org/W2061013276","https://openalex.org/W2063501226","https://openalex.org/W2072061824","https://openalex.org/W2074267409","https://openalex.org/W2074725588","https://openalex.org/W2075104267","https://openalex.org/W2078065785","https://openalex.org/W2079712059","https://openalex.org/W2084952038","https://openalex.org/W2087172814","https://openalex.org/W2087701697","https://openalex.org/W2091364041","https://openalex.org/W2108173771","https://openalex.org/W2118188078","https://openalex.org/W2118457425","https://openalex.org/W2120957537","https://openalex.org/W2127195256","https://openalex.org/W2132188426","https://openalex.org/W2147678437","https://openalex.org/W2148481391","https://openalex.org/W2152589434","https://openalex.org/W2155868854","https://openalex.org/W2158584175","https://openalex.org/W2159947323","https://openalex.org/W2162128189","https://openalex.org/W2165039877","https://openalex.org/W4230068240"],"related_works":["https://openalex.org/W2054363543","https://openalex.org/W2104896634","https://openalex.org/W1992207607","https://openalex.org/W2127195256","https://openalex.org/W2041231132","https://openalex.org/W2170989878","https://openalex.org/W1994101634","https://openalex.org/W1997110892","https://openalex.org/W1981713972","https://openalex.org/W2020549199"],"abstract_inverted_index":{"The":[0,128,202],"c-Jun":[1],"NH2-terminal":[2,133,144],"protein":[3,12,107,231],"kinase":[4,13,51],"(JNK)":[5],"is":[6,17,26,37,136],"a":[7,22,48,104,170,228],"member":[8],"of":[9,21,30,76,86,106,154,157,173,199,204,230,240],"the":[10,83,87,139,149,155,158,163,178,207,222],"mitogen-activated":[11],"(MAPK)":[14],"group":[15,105,229],"and":[16,44,56,69,92,116,119,125,181,196,224],"an":[18,132],"essential":[19],"component":[20],"signaling":[23],"cascade":[24],"that":[25,67,89,94,135,162,187,221,237],"activated":[27],"by":[28,39,47,99],"exposure":[29],"cells":[31],"to":[32,102,148,244],"environmental":[33],"stress.":[34],"JNK":[35,62,77,214,241],"activation":[36,215,239],"regulated":[38],"phosphorylation":[40],"on":[41],"both":[42,194],"Thr":[43],"Tyr":[45],"residues":[46],"dual-specificity":[49],"MAPK":[50],"(MAPKK).":[52],"Two":[53],"MAPKKs,":[54],"MKK4":[55,68,223],"MKK7,":[57],"have":[58],"been":[59],"identified":[60],"as":[61,74],"activators.":[63],"Genetic":[64],"studies":[65],"demonstrate":[66,93],"MKK7":[70,91,141,150,159,189,205,225],"serve":[71],"nonredundant":[72],"functions":[73],"activators":[75],"in":[78,138,193,206,216,242],"vivo.":[79,217],"We":[80],"report":[81],"here":[82],"molecular":[84],"cloning":[85],"gene":[88],"encodes":[90],"six":[95],"isoforms":[96,130,160,165,190],"are":[97,191],"created":[98],"alternative":[100],"splicing":[101],"generate":[103],"kinases":[108,232],"with":[109,233],"three":[110],"different":[111,121,234],"NH2":[112],"termini":[113,123],"(alpha,":[114],"beta,":[115],"gamma":[117],"isoforms)":[118],"two":[120],"COOH":[122],"(1":[124],"2":[126],"isoforms).":[127],"MKK7alpha":[129,164],"lack":[131],"extension":[134,145],"present":[137],"other":[140],"isoforms.":[142,183],"This":[143],"binds":[146],"directly":[147],"substrate":[151],"JNK.":[152],"Comparison":[153],"activities":[156],"demonstrates":[161,186],"exhibit":[166],"lower":[167],"activity,":[168],"but":[169],"higher":[171],"level":[172],"inducible":[174],"fold":[175],"activation,":[176],"than":[177],"corresponding":[179],"MKK7beta":[180],"MKK7gamma":[182],"Immunofluorescence":[184],"analysis":[185],"these":[188],"detected":[192],"cytoplasmic":[195],"nuclear":[197],"compartments":[198],"cultured":[200],"cells.":[201],"presence":[203],"nucleus":[208],"was":[209],"not,":[210],"however,":[211],"required":[212],"for":[213],"These":[218],"data":[219],"establish":[220],"genes":[226],"encode":[227],"biochemical":[235],"properties":[236],"mediate":[238],"response":[243],"extracellular":[245],"stimuli.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}