{"id":"https://openalex.org/W2104836037","doi":"https://doi.org/10.1021/jm00021a010","title":"N-Aryl-N'-Benzylpiperazines as Potential Antipsychotic Agents","display_name":"N-Aryl-N'-Benzylpiperazines as Potential Antipsychotic Agents","publication_year":1995,"publication_date":"1995-10-01","ids":{"openalex":"https://openalex.org/W2104836037","doi":"https://doi.org/10.1021/jm00021a010","mag":"2104836037","pmid":"https://pubmed.ncbi.nlm.nih.gov/7473548"},"language":"en","primary_location":{"id":"doi:10.1021/jm00021a010","doi":"https://doi.org/10.1021/jm00021a010","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm00021a010","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077715628","display_name":"Allen B. Reitz","orcid":"https://orcid.org/0000-0003-2780-4044","observed_orcids":["https://orcid.org/0000-0003-2780-4044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allen B. Reitz","raw_affiliation_strings":["R.W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R.W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114896595","display_name":"Ellen W. Baxer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ellen W. Baxer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023476078","display_name":"Debra J. Bennett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debra J. Bennett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111902792","display_name":"Ellen E. Codd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ellen E. Codd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012890531","display_name":"Alfonzo D. Jordan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alfonzo D. Jordan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001940670","display_name":"Elizabeth A. Malloy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth A. Malloy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070787633","display_name":"Bruce E. Maryanoff","orcid":"https://orcid.org/0000-0003-3590-2357","observed_orcids":["https://orcid.org/0000-0003-3590-2357"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce E. Maryanoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031754297","display_name":"Mark E. McDonnell","orcid":"https://orcid.org/0000-0002-9972-5217","observed_orcids":["https://orcid.org/0000-0002-9972-5217"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark E. McDonnell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065769178","display_name":"Marta E. Orteg\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta E. Ortegon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.4216,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.81023062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"38","issue":"21","first_page":"4211","last_page":"4222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.43140000104904175,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.43140000104904175,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.25440001487731934,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13454","display_name":"Phenothiazines and Benzothiazines Synthesis and Activities","score":0.08250000327825546,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hydantoin-derivatives","display_name":"hydantoin derivatives","score":0.753000020980835},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.6140000224113464},{"id":"https://openalex.org/keywords/5-ht1a-receptor","display_name":"5-HT1A receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/alpha1-adrenergic-receptors","display_name":"alpha1-adrenoceptors","score":0.9150000214576721},{"id":"https://openalex.org/keywords/conditioned-avoidance-response","display_name":"conditioned avoidance response","score":0.9409999847412109},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7139999866485596},{"id":"https://openalex.org/keywords/uracil-derivatives","display_name":"uracil derivatives","score":0.6380000114440918},{"id":"https://openalex.org/keywords/benzyl-alcohol-derivatives","display_name":"benzyl alcohol derivatives","score":0.7089999914169312},{"id":"https://openalex.org/keywords/acetylated-derivatives","display_name":"acetyl derivatives","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8826010227203369},{"id":"https://openalex.org/C2777346176","wikidata":"https://www.wikidata.org/wiki/Q418082","display_name":"Hydantoin","level":2,"score":0.8635808229446411},{"id":"https://openalex.org/C2777604212","wikidata":"https://www.wikidata.org/wiki/Q407944","display_name":"Imide","level":2,"score":0.6744193434715271},{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.6437873840332031},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5990593433380127},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5850858688354492},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.5303856730461121},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.499176025390625},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4598013758659363},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.417524516582489},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.41407421231269836},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3324875831604004},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1311018168926239},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12758666276931763},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001362","descriptor_name":"Avoidance Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003213","descriptor_name":"Conditioning, Psychological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010881","descriptor_name":"Piperidones","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010881","descriptor_name":"Piperidones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010881","descriptor_name":"Piperidones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011942","descriptor_name":"Receptors, Adrenergic, alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm00021a010","doi":"https://doi.org/10.1021/jm00021a010","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm00021a010","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:7473548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7473548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W14947124","https://openalex.org/W941598985","https://openalex.org/W996135575","https://openalex.org/W1565565175","https://openalex.org/W1833805811","https://openalex.org/W1954888178","https://openalex.org/W1996735957","https://openalex.org/W2006097049","https://openalex.org/W2007682162","https://openalex.org/W2015965164","https://openalex.org/W2022875984","https://openalex.org/W2039169654","https://openalex.org/W2039594742","https://openalex.org/W2040236695","https://openalex.org/W2066773748","https://openalex.org/W2074631079","https://openalex.org/W2087688448","https://openalex.org/W2092489933","https://openalex.org/W2122767035","https://openalex.org/W2254342710","https://openalex.org/W2258060570","https://openalex.org/W2261854704","https://openalex.org/W2759884874","https://openalex.org/W2953285221"],"related_works":["https://openalex.org/W2040140559","https://openalex.org/W2149989196","https://openalex.org/W2953164386","https://openalex.org/W1982354254","https://openalex.org/W7097936634","https://openalex.org/W2399643633","https://openalex.org/W2039169654","https://openalex.org/W2952727595","https://openalex.org/W1993273313","https://openalex.org/W2950890025"],"abstract_inverted_index":{"N1-(2-Alkoxyphenyl)piperazines":[0],"additionally":[1],"containing":[2],"an":[3],"N4-benzyl":[4],"group":[5],"bearing":[6,51,192],"alcohol,":[7],"amide,":[8,53],"imide,":[9],"or":[10,117],"hydantoin":[11,85,97],"functionalities":[12,57],"were":[13,123],"prepared":[14],"and":[15,29,46,55,74,79,94,121,132,175,199,211,213,227],"evaluated":[16],"in":[17,30,31,136,142,167,217,220],"the":[18,37,43,66,72,127,143,146,158,221],"conditioned":[19],"avoidance":[20],"response":[21],"(CAR)":[22],"test":[23,223],"predictive":[24],"of":[25,36,84,126,145,189],"clinical":[26],"antipsychotic":[27],"activity":[28,179,219],"vitro":[32],"receptor-binding":[33],"assays.":[34],"Certain":[35],"compounds":[38,171,202],"display":[39,58,172],"high":[40],"affinity":[41,156],"for":[42,65,157],"D2,":[44],"5-HT1A,":[45],"alpha":[47],"1-adrenergic":[48],"receptors.":[49],"Structures":[50],"acyclic":[52],"lactam,":[54],"imide":[56],"good":[59,107],"biological":[60,108],"activity,":[61,109,138],"with":[62,113,224],"a":[63,193],"preference":[64],"1,3-disubstituted":[67],"phenyl":[68],"ring":[69],"relative":[70],"to":[71,100,105,115],"1,4-":[73],"1,2-congeners":[75],"(7":[76],"vs":[77,196],"10":[78],"12).":[80],"Every":[81],"possible":[82],"position":[83],"attachment":[86,99,114],"was":[87,103,140],"investigated":[88],"(e.g.,":[89],"substitution":[90],"at":[91],"N1,":[92],"N3,":[93],"C5).":[95],"The":[96],"involving":[98],"N1":[101],"(24)":[102],"found":[104],"have":[106,134,181],"whereas":[110],"those":[111,188],"hydantoins":[112],"N3":[116],"C5":[118],"(22,":[119],"23,":[120],"25)":[122],"inactive.":[124],"Several":[125],"smaller":[128],"acetylated":[129],"derivatives":[130],"(30":[131],"33)":[133],"fair":[135],"vivo":[137,168,218],"which":[139],"lost":[141],"case":[144],"larger":[147],"benzoyl":[148],"analog":[149],"31.":[150],"Uracil":[151],"congener":[152],"34":[153],"had":[154],"modest":[155,225],"D2":[159,226],"receptor":[160,183,229],"(65":[161],"nM)":[162],"as":[163,165],"well":[164],"excellent":[166,216],"activity.":[169],"Benzylamino":[170],"(viz.":[173],"27":[174,210],"35-38)":[176],"moderate":[177],"CAR":[178,222],"but":[180],"surprising":[182],"affinity,":[184],"often":[185],"greater":[186],"than":[187,207],"comparable":[190],"structures":[191,209],"carbonyl":[194],"(36":[195],"7).":[197],"Benzyl":[198],"benzhydryl":[200],"alcohol":[201],"40-48":[203],"are":[204],"more":[205],"active":[206],"amino":[208],"35-38":[212],"also":[214],"exhibit":[215],"5-HT1A":[228],"binding.":[230]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
