{"id":"https://openalex.org/W2104833716","doi":"https://doi.org/10.3399/bjgp12x654605","title":"Accuracy of symptoms, signs, and C-reactive protein for early chronic obstructive pulmonary disease","display_name":"Accuracy of symptoms, signs, and C-reactive protein for early chronic obstructive pulmonary disease","publication_year":2012,"publication_date":"2012-08-27","ids":{"openalex":"https://openalex.org/W2104833716","doi":"https://doi.org/10.3399/bjgp12x654605","mag":"2104833716","pmid":"https://pubmed.ncbi.nlm.nih.gov/22947584","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3426602"},"language":"en","primary_location":{"id":"doi:10.3399/bjgp12x654605","doi":"https://doi.org/10.3399/bjgp12x654605","is_oa":true,"landing_page_url":"https://doi.org/10.3399/bjgp12x654605","pdf_url":"https://bjgp.org/content/bjgp/62/602/e632.full.pdf","source":{"id":"https://openalex.org/S92370695","display_name":"British Journal of General Practice","issn_l":"0960-1643","issn":["0960-1643","1478-5242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311776","host_organization_name":"Royal College of General Practitioners","host_organization_lineage":["https://openalex.org/P4310311776"],"host_organization_lineage_names":["Royal College of General Practitioners"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of General Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://bjgp.org/content/bjgp/62/602/e632.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109040331","display_name":"Berna DL Broekhuizen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Berna DL Broekhuizen","raw_affiliation_strings":["University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands. b.d.l.broekhuizen@umcutrecht.nl","University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The\u00a0Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands. b.d.l.broekhuizen@umcutrecht.nl","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The\u00a0Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113657800","display_name":"Alfred P. E. Sachs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800996342","display_name":"Gelre Hospitals","ror":"https://ror.org/05275vm15","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800996342"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Alfred PE Sachs","raw_affiliation_strings":["Research","Boeijen Care Provider, Assen, the Netherlands","Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","Mapi Consultancy, Houten, the Netherlands","University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research","institution_ids":[]},{"raw_affiliation_string":"Boeijen Care Provider, Assen, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]},{"raw_affiliation_string":"Mapi Consultancy, Houten, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041746833","display_name":"Theo JM Verheij","orcid":"https://orcid.org/0000-0002-0166-1498","observed_orcids":["https://orcid.org/0000-0002-0166-1498"]},"institutions":[{"id":"https://openalex.org/I2800996342","display_name":"Gelre Hospitals","ror":"https://ror.org/05275vm15","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800996342"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Theo J Verheij","raw_affiliation_strings":["professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","Boeijen Care Provider, Assen, the Netherlands","Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","Mapi Consultancy, Houten, the Netherlands","Research","University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Boeijen Care Provider, Assen, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]},{"raw_affiliation_string":"Mapi Consultancy, Houten, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"Research","institution_ids":[]},{"raw_affiliation_string":"University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111824945","display_name":"Kristel J.M. Janssen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800996342","display_name":"Gelre Hospitals","ror":"https://ror.org/05275vm15","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800996342"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Kristel JM Janssen","raw_affiliation_strings":["Mapi Consultancy, Houten, the Netherlands","University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","Boeijen Care Provider, Assen, the Netherlands","Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","Research","professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mapi Consultancy, Houten, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Boeijen Care Provider, Assen, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]},{"raw_affiliation_string":"Research","institution_ids":[]},{"raw_affiliation_string":"professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009571830","display_name":"Gerard Asma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800996342","display_name":"Gelre Hospitals","ror":"https://ror.org/05275vm15","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800996342"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gerard Asma","raw_affiliation_strings":["Boeijen Care Provider, Assen, the Netherlands","Research","Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","Mapi Consultancy, Houten, the Netherlands","University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boeijen Care Provider, Assen, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"Research","institution_ids":[]},{"raw_affiliation_string":"Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]},{"raw_affiliation_string":"Mapi Consultancy, Houten, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087881363","display_name":"Jan\u2010Willem J. Lammers","orcid":"https://orcid.org/0000-0002-6684-9889","observed_orcids":["https://orcid.org/0000-0002-6684-9889"]},"institutions":[{"id":"https://openalex.org/I2800996342","display_name":"Gelre Hospitals","ror":"https://ror.org/05275vm15","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800996342"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan-Willem J Lammers","raw_affiliation_strings":["professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","Boeijen Care Provider, Assen, the Netherlands","Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","Mapi Consultancy, Houten, the Netherlands","Research","University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Boeijen Care Provider, Assen, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]},{"raw_affiliation_string":"Mapi Consultancy, Houten, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"Research","institution_ids":[]},{"raw_affiliation_string":"University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048043800","display_name":"Ren\u00e9 Hage","orcid":"https://orcid.org/0000-0002-1994-7443","observed_orcids":["https://orcid.org/0000-0002-1994-7443"]},"institutions":[{"id":"https://openalex.org/I2800996342","display_name":"Gelre Hospitals","ror":"https://ror.org/05275vm15","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800996342"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ren\u00e9 Hage","raw_affiliation_strings":["Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","Research","Boeijen Care Provider, Assen, the Netherlands","Mapi Consultancy, Houten, the Netherlands","University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]},{"raw_affiliation_string":"Research","institution_ids":[]},{"raw_affiliation_string":"Boeijen Care Provider, Assen, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"Mapi Consultancy, Houten, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082447781","display_name":"Ernst Lammers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800996342","display_name":"Gelre Hospitals","ror":"https://ror.org/05275vm15","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800996342"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ernst Lammers","raw_affiliation_strings":["Research","pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands","Boeijen Care Provider, Assen, the Netherlands","Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","Mapi Consultancy, Houten, the Netherlands","University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research","institution_ids":[]},{"raw_affiliation_string":"pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]},{"raw_affiliation_string":"Boeijen Care Provider, Assen, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]},{"raw_affiliation_string":"Mapi Consultancy, Houten, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032508279","display_name":"Arno Wilhelmus Hoes","orcid":"https://orcid.org/0000-0002-8747-6479","observed_orcids":["https://orcid.org/0000-0002-8747-6479"]},"institutions":[{"id":"https://openalex.org/I2800996342","display_name":"Gelre Hospitals","ror":"https://ror.org/05275vm15","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800996342"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Arno W Hoes","raw_affiliation_strings":["Research","Boeijen Care Provider, Assen, the Netherlands","Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","Mapi Consultancy, Houten, the Netherlands","University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research","institution_ids":[]},{"raw_affiliation_string":"Boeijen Care Provider, Assen, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]},{"raw_affiliation_string":"Mapi Consultancy, Houten, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083104697","display_name":"Karel G.M. Moons","orcid":"https://orcid.org/0000-0003-2118-004X","observed_orcids":["https://orcid.org/0000-0003-2118-004X","https://orcid.org/0009-0004-7797-1056","https://orcid.org/0000-0003-2112-0047"]},"institutions":[{"id":"https://openalex.org/I2800996342","display_name":"Gelre Hospitals","ror":"https://ror.org/05275vm15","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800996342"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Karel G Moons","raw_affiliation_strings":["University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","Boeijen Care Provider, Assen, the Netherlands","Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","Mapi Consultancy, Houten, the Netherlands","Research","professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, 3508 GA Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"professor in clinical epidemiology, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Boeijen Care Provider, Assen, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"Gelre Hospital, Department of Pulmonology, Apeldoorn, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]},{"raw_affiliation_string":"Mapi Consultancy, Houten, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"Research","institution_ids":[]},{"raw_affiliation_string":"professor in pulmonary medicine, University Medical Center Utrecht, Department of Pulmonology, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"pulmonologist, Gelre Hospital, Department of Pulmonology, Zutphen, the Netherlands","institution_ids":["https://openalex.org/I2800996342"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.47,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.84179295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"62","issue":"602","first_page":"e632","last_page":"e638"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11590","display_name":"Primary Care and Health Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9070000052452087},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9539999961853027},{"id":"https://openalex.org/keywords/symptoms-and-signs","display_name":"symptoms and signs","score":0.7110000252723694},{"id":"https://openalex.org/keywords/chronic-cough","display_name":"chronic cough","score":0.9129999876022339},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.7080000042915344},{"id":"https://openalex.org/keywords/primary-care","display_name":"primary care","score":0.6850000023841858},{"id":"https://openalex.org/keywords/body-plethysmography","display_name":"body plethysmography","score":0.8370000123977661},{"id":"https://openalex.org/keywords/pulmonary-function-tests","display_name":"pulmonary function tests","score":0.5989999771118164},{"id":"https://openalex.org/keywords/wheezing","display_name":"wheezing","score":0.8629999756813049},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.35100001096725464},{"id":"https://openalex.org/keywords/cardiovascular-comorbidity","display_name":"cardiovascular comorbidity","score":0.9070000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9341061115264893},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.8694475889205933},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6719655990600586},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5644052028656006},{"id":"https://openalex.org/C2777324038","wikidata":"https://www.wikidata.org/wiki/Q779054","display_name":"Auscultation","level":2,"score":0.5632564425468445},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5296471118927002},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.5097255110740662},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.42855238914489746},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4073582589626312}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003371","descriptor_name":"Cough","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003371","descriptor_name":"Cough","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009426","descriptor_name":"Netherlands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012015","descriptor_name":"Reference Standards","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012135","descriptor_name":"Respiratory Sounds","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012135","descriptor_name":"Respiratory Sounds","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014797","descriptor_name":"Vital Capacity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058006","descriptor_name":"General Practice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3399/bjgp12x654605","doi":"https://doi.org/10.3399/bjgp12x654605","is_oa":true,"landing_page_url":"https://doi.org/10.3399/bjgp12x654605","pdf_url":"https://bjgp.org/content/bjgp/62/602/e632.full.pdf","source":{"id":"https://openalex.org/S92370695","display_name":"British Journal of General Practice","issn_l":"0960-1643","issn":["0960-1643","1478-5242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311776","host_organization_name":"Royal College of General Practitioners","host_organization_lineage":["https://openalex.org/P4310311776"],"host_organization_lineage_names":["Royal College of General Practitioners"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of General Practice","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2750595","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3426602","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3426602","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3426602","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Gen Pract","raw_type":"Text"},{"id":"pmid:22947584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22947584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of general practice : the journal of the Royal College of General Practitioners","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3399/bjgp12x654605","doi":"https://doi.org/10.3399/bjgp12x654605","is_oa":true,"landing_page_url":"https://doi.org/10.3399/bjgp12x654605","pdf_url":"https://bjgp.org/content/bjgp/62/602/e632.full.pdf","source":{"id":"https://openalex.org/S92370695","display_name":"British Journal of General Practice","issn_l":"0960-1643","issn":["0960-1643","1478-5242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311776","host_organization_name":"Royal College of General Practitioners","host_organization_lineage":["https://openalex.org/P4310311776"],"host_organization_lineage_names":["Royal College of General Practitioners"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of General Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104833716.pdf","grobid_xml":"https://content.openalex.org/works/W2104833716.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W59366018","https://openalex.org/W1967089637","https://openalex.org/W1968735064","https://openalex.org/W1985096201","https://openalex.org/W1988467379","https://openalex.org/W1989380810","https://openalex.org/W1989870129","https://openalex.org/W1989981365","https://openalex.org/W2002915397","https://openalex.org/W2033323458","https://openalex.org/W2042618243","https://openalex.org/W2051295907","https://openalex.org/W2053154970","https://openalex.org/W2068499457","https://openalex.org/W2073662824","https://openalex.org/W2075896585","https://openalex.org/W2104168490","https://openalex.org/W2115709314","https://openalex.org/W2117573110","https://openalex.org/W2119068637","https://openalex.org/W2125078269","https://openalex.org/W2127500894","https://openalex.org/W2127951128","https://openalex.org/W2129303461","https://openalex.org/W2129777536","https://openalex.org/W2129946128","https://openalex.org/W2140259385","https://openalex.org/W2150613910","https://openalex.org/W2166561686","https://openalex.org/W2168988090","https://openalex.org/W2191391362","https://openalex.org/W2197553214","https://openalex.org/W2994597783","https://openalex.org/W3175417087","https://openalex.org/W4211263216"],"related_works":["https://openalex.org/W1601188286","https://openalex.org/W1589695795","https://openalex.org/W2081752470","https://openalex.org/W2372720852","https://openalex.org/W2159073486","https://openalex.org/W2350198776","https://openalex.org/W2364883935","https://openalex.org/W2759144744","https://openalex.org/W2374128924","https://openalex.org/W2378855624"],"abstract_inverted_index":{"BACKGROUND:":[0],"Guidelines":[1],"recommend":[2],"detection":[3,249],"of":[4,30,41,58,92,104,133,197,211,250],"early":[5,35,221,251],"chronic":[6],"obstructive":[7],"pulmonary":[8],"disease":[9],"(COPD),":[10],"but":[11,223],"evidence":[12],"on":[13,180],"the":[14,28,38,64,96,146,190,241],"diagnostic":[15,56,102,159,228],"work-up":[16,103],"for":[17,34,248],"COPD":[18,90,125,152],"only":[19],"concerns":[20],"advanced":[21],"and":[22,32,37,111,119,155,178,232],"established":[23,89],"COPD.":[24,252],"AIM:":[25],"To":[26],"quantify":[27],"accuracy":[29],"symptoms":[31,231],"signs":[33,156],"COPD,":[36,222],"added":[39,225,246],"value":[40,132,160,247],"C-reactive":[42],"protein":[43],"(CRP),":[44],"in":[45,63,186,218],"primary":[46,60,69],"care":[47,61,70],"patients":[48,71,150],"presenting":[49,82,237],"with":[50,83,157,213,220,238],"cough.":[51],"DESIGN":[52],"AND":[53],"SETTING:":[54],"Cross-sectional":[55],"study":[57],"73":[59],"practices":[62],"Netherlands.":[65],"METHOD:":[66],"Four":[67],"hundred":[68],"(182":[72],"males,":[73],"mean":[74],"age":[75],"63":[76],"years)":[77],"older":[78],"than":[79,168],"50":[80],"years,":[81],"persistent":[84,239],"cough":[85],"(>14":[86],"days)":[87],"without":[88],"participated,":[91],"whom":[93],"382":[94],"completed":[95],"study.":[97],"They":[98],"underwent":[99],"a":[100],"systematic":[101],"symptoms,":[105],"signs,":[106],"conventional":[107],"laboratory":[108],"CRP":[109,215,224,242],"level,":[110],"hospital":[112],"lung":[113],"functions":[114],"tests,":[115],"including":[116],"body":[117],"plethysmography,":[118],"an":[120,187],"expert":[121,147],"panel":[122],"decided":[123],"whether":[124],"was":[126,136,216],"present":[127],"(reference":[128],"test).":[129],"The":[130,209],"independent":[131,158],"all":[134],"items":[135,184],"estimated":[137],"by":[138],"multivariable":[139],"logistic":[140],"regression":[141],"analysis.":[142],"RESULTS:":[143],"According":[144],"to":[145,204],"panel,":[148],"118":[149],"had":[151],"(30%).":[153],"Symptoms":[154],"were":[161],"age,":[162],"sex,":[163],"current":[164],"smoking,":[165],"smoking":[166],"more":[167],"20":[169],"pack-years,":[170],"cardiovascular":[171],"comorbidity,":[172],"wheezing":[173,179],"complaints,":[174],"diminished":[175],"breath":[176],"sounds,":[177],"auscultation.":[181],"Combining":[182],"these":[183],"resulted":[185],"area":[188],"under":[189],"receiver":[191],"operating":[192],"characteristic":[193],"curve":[194],"(ROC":[195],"area)":[196],"0.79":[198],"(95%":[199],"confidence":[200],"interval":[201],"=":[202],"0.74":[203],"0.83)":[205],"after":[206],"internal":[207],"validation.":[208],"proportion":[210],"subjects":[212,236],"elevated":[214],"higher":[217],"those":[219],"no":[226,245],"relevant":[227],"information":[229],"above":[230],"signs.":[233],"CONCLUSION:":[234],"In":[235],"cough,":[240],"level":[243],"has":[244]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}