{"id":"https://openalex.org/W2104829340","doi":"https://doi.org/10.1097/wnr.0000000000000055","title":"Inhibition of amyloid-\u03b2 production by anti-amyloid precursor protein antibodies in primary mouse cortical neurones","display_name":"Inhibition of amyloid-\u03b2 production by anti-amyloid precursor protein antibodies in primary mouse cortical neurones","publication_year":2013,"publication_date":"2013-10-21","ids":{"openalex":"https://openalex.org/W2104829340","doi":"https://doi.org/10.1097/wnr.0000000000000055","mag":"2104829340","pmid":"https://pubmed.ncbi.nlm.nih.gov/24145776","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4493351"},"language":"en","primary_location":{"id":"doi:10.1097/wnr.0000000000000055","doi":"https://doi.org/10.1097/wnr.0000000000000055","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wnr.0000000000000055","pdf_url":null,"source":{"id":"https://openalex.org/S121278948","display_name":"Neuroreport","issn_l":"0959-4965","issn":["0959-4965","1473-558X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroReport","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4493351","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073194262","display_name":"Rhian S. Thomas","orcid":"https://orcid.org/0000-0002-7286-2764","observed_orcids":["https://orcid.org/0000-0002-7286-2764"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rhian S. Thomas","raw_affiliation_strings":["aSchool of Pharmacy and Pharmaceutical Sciences bSchool of Psychology, Cardiff University, Cardiff, UK","School of Pharmacy and Pharmaceutical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aSchool of Pharmacy and Pharmaceutical Sciences bSchool of Psychology, Cardiff University, Cardiff, UK","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074685885","display_name":"Martha Hvoslef\u2010Eide","orcid":"https://orcid.org/0000-0002-5922-5824","observed_orcids":["https://orcid.org/0000-0002-5922-5824"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martha Hvoslef-Eide","raw_affiliation_strings":["Present address: Martha Hvoslef-Eide, Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK","School of Pharmacy and Pharmaceutical Sciences","School of Psychology, Cardiff University, Cardiff, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Present address: Martha Hvoslef-Eide, Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences","institution_ids":[]},{"raw_affiliation_string":"School of Psychology, Cardiff University, Cardiff, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017556521","display_name":"Mark A. Good","orcid":"https://orcid.org/0000-0002-1824-1203","observed_orcids":["https://orcid.org/0000-0002-1824-1203"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark A. Good","raw_affiliation_strings":["School of Psychology, Cardiff University, Cardiff, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Psychology, Cardiff University, Cardiff, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045809090","display_name":"Emma J. Kidd","orcid":"https://orcid.org/0000-0001-5507-1170","observed_orcids":["https://orcid.org/0000-0001-5507-1170"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Emma J. Kidd","raw_affiliation_strings":["School of Pharmacy and Pharmaceutical Sciences","to Emma J. Kidd, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, UK Tel: +44 29 20875803; fax: +44 29 20874149; e-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences","institution_ids":[]},{"raw_affiliation_string":"to Emma J. Kidd, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, UK Tel: +44 29 20875803; fax: +44 29 20874149; e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I79510175"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045809090"],"corresponding_institution_ids":["https://openalex.org/I79510175"],"apc_list":null,"apc_paid":null,"fwci":0.2471,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.49477466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"24","issue":"18","first_page":"1058","last_page":"1061"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7570000290870667},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9819999933242798},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.5630000233650208},{"id":"https://openalex.org/keywords/app-transgenic-mice","display_name":"APP transgenic mice","score":0.718999981880188},{"id":"https://openalex.org/keywords/steric-hindrance","display_name":"steric hindrance","score":0.875},{"id":"https://openalex.org/keywords/antibody-therapy","display_name":"antibody therapy","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.6228944659233093},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6063987612724304},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5762746334075928},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5598766803741455},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.5413020253181458},{"id":"https://openalex.org/C151484617","wikidata":"https://www.wikidata.org/wiki/Q4834493","display_name":"BACE1-AS","level":5,"score":0.4793687164783478},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4764837920665741},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46141016483306885},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.44445574283599854},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43864381313323975},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38977402448654175},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3590910732746124},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.35857415199279785},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.32305487990379333},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3156239092350006},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3121557831764221},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3042845129966736},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2407582402229309},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21295246481895447},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12102434039115906},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10187327861785889},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1097/wnr.0000000000000055","doi":"https://doi.org/10.1097/wnr.0000000000000055","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wnr.0000000000000055","pdf_url":null,"source":{"id":"https://openalex.org/S121278948","display_name":"Neuroreport","issn_l":"0959-4965","issn":["0959-4965","1473-558X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroReport","raw_type":"journal-article"},{"id":"pmid:24145776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24145776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroreport","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4493351","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4493351","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuroreport","raw_type":"Text"},{"id":"pmh:oai:cronfa.swan.ac.uk:cronfa62827","doi":null,"is_oa":false,"landing_page_url":"https://cronfa.swan.ac.uk/Record/cronfa62827","pdf_url":null,"source":{"id":"https://openalex.org/S4306401612","display_name":"Cronfa (Swansea University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39586589","host_organization_name":"Swansea University","host_organization_lineage":["https://openalex.org/I39586589"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:54071","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/54071/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4493351","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4493351","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuroreport","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317015","display_name":"Alzheimer's Society","ror":"https://ror.org/0472gwq90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1483703465","https://openalex.org/W1547758273","https://openalex.org/W1586576025","https://openalex.org/W1644122431","https://openalex.org/W1825753969","https://openalex.org/W1984996311","https://openalex.org/W2001704669","https://openalex.org/W2016698723","https://openalex.org/W2075829521","https://openalex.org/W2082429191","https://openalex.org/W2084972185","https://openalex.org/W2096410114","https://openalex.org/W2124097986","https://openalex.org/W2133019124","https://openalex.org/W2162815565","https://openalex.org/W2169152986","https://openalex.org/W2169308121"],"related_works":["https://openalex.org/W1825753969","https://openalex.org/W1586576025","https://openalex.org/W2104229988","https://openalex.org/W1999940407","https://openalex.org/W1982628718","https://openalex.org/W2000231434","https://openalex.org/W2538877427","https://openalex.org/W2549192672","https://openalex.org/W2896900184","https://openalex.org/W2026422955"],"abstract_inverted_index":{"Current":[0],"therapies":[1],"for":[2,112,246],"Alzheimer's":[3,247],"disease":[4],"only":[5,168],"treat":[6],"the":[7,10,24,35,47,94,154,161,176,193],"symptoms":[8],"of":[9,37,57,93,123,156,160,175,224],"disease.":[11,248],"We":[12],"have":[13],"previously":[14],"developed":[15],"a":[16],"novel":[17],"monoclonal":[18],"antibody,":[19],"2B3,":[20],"which":[21],"binds":[22,200],"to":[23,51,69,127,136,201,211],"\u03b2-secretase":[25,225],"cleavage":[26],"site":[27],"in":[28,40,54,60,71,141,181,203,235,237],"amyloid":[29,58],"precursor":[30],"protein":[31],"(APP)":[32],"and":[33,85,115,132,147,206,226,239],"reduces":[34],"production":[36,155],"amyloid-\u03b2":[38],"(A\u03b2)":[39],"human":[41],"cell":[42],"lines.":[43],"To":[44],"determine":[45],"whether":[46,64],"antibody":[48,216],"was":[49,97,125,186],"likely":[50],"be":[52,233,241],"effective":[53,234],"mouse":[55,72,204],"models":[56],"pathology":[59],"vivo,":[61],"we":[62],"investigated":[63],"2B3":[65,107,133,151,185,199],"could":[66,240],"also":[67],"bind":[68],"APP":[70,202],"primary":[73],"cortical":[74,77],"neurones.":[75],"Primary":[76],"neurones":[78,131,205],"were":[79,102,143],"produced":[80,183],"from":[81],"E15.5-17.5":[82],"C57Bl/6":[83],"wild-type":[84,146],"transgenic":[86,148],"APP/V717I":[87],"(London":[88],"mutation)":[89],"embryos.":[90],"The":[91,121,179,215],"percentage":[92],"neuronal":[95],"population":[96,122],"determined":[98,118],"by":[99,119,158,173,184,192,221],"immunocytochemistry.":[100],"Cells":[101],"treated":[103],"with":[104],"10":[105],"\u03bcg/ml":[106],"or":[108],"an":[109,165,242],"irrelevant":[110,166],"IgG":[111,167],"48":[113],"h":[114],"A\u03b240":[116,142,157,171,182],"levels":[117,172],"ELISA.":[120],"cells":[124],"found":[126],"contain":[128],"over":[129],"75%":[130],"bound":[134],"effectively":[135],"these":[137,227],"cells.":[138,149],"No":[139],"differences":[140],"detected":[144],"between":[145],"Importantly,":[150],"significantly":[152,169,187],"inhibited":[153],"75.15\u00b11.37%":[159],"media":[162,177],"control,":[163],"whereas":[164],"reduced":[170],"23.35\u00b15.55%":[174],"control.":[178],"reduction":[180],"greater":[188],"than":[189],"that":[190,198,230],"caused":[191],"IgG.":[194],"These":[195],"data":[196,228],"indicate":[197],"can":[207],"inhibit":[208],"A\u03b240,":[209],"similar":[210],"our":[212],"previous":[213],"findings.":[214],"is":[217],"probably":[218],"therefore":[219],"acting":[220],"steric":[222],"hindrance":[223],"suggest":[229],"it":[231],"will":[232],"mice":[236],"vivo":[238],"alternative":[243],"potential":[244],"therapy":[245]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}