{"id":"https://openalex.org/W2104810237","doi":"https://doi.org/10.4049/jimmunol.176.3.1490","title":"IL-21 Down-Regulates NKG2D/DAP10 Expression on Human NK and CD8+ T Cells","display_name":"IL-21 Down-Regulates NKG2D/DAP10 Expression on Human NK and CD8+ T Cells","publication_year":2006,"publication_date":"2006-02-01","ids":{"openalex":"https://openalex.org/W2104810237","doi":"https://doi.org/10.4049/jimmunol.176.3.1490","mag":"2104810237","pmid":"https://pubmed.ncbi.nlm.nih.gov/16424177"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.176.3.1490","doi":"https://doi.org/10.4049/jimmunol.176.3.1490","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.176.3.1490","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/176/3/1490/1217323/1490.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/176/3/1490/1217323/1490.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Steven J Burgess","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven J Burgess","raw_affiliation_strings":["Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, MD 20852","Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, MD 20852","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076958813","display_name":"Alina I. Marusina","orcid":"https://orcid.org/0000-0002-2352-315X","observed_orcids":["https://orcid.org/0000-0002-2352-315X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alina I Marusina","raw_affiliation_strings":["Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079772641","display_name":"Ishani Pathmanathan","orcid":"https://orcid.org/0000-0001-8815-2129","observed_orcids":["https://orcid.org/0000-0001-8815-2129"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ishani Pathmanathan","raw_affiliation_strings":["Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061418519","display_name":"Francisco Borrego","orcid":"https://orcid.org/0000-0002-3105-981X","observed_orcids":["https://orcid.org/0000-0002-3105-981X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francisco Borrego","raw_affiliation_strings":["Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105466343","display_name":"John E. Coligan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E Coligan","raw_affiliation_strings":["Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":4.6675,"has_fulltext":true,"cited_by_count":127,"citation_normalized_percentile":{"value":0.95664821,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"176","issue":"3","first_page":"1490","last_page":"1497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-21","display_name":"IL-21","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nkg2d","display_name":"NKG2D","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dap10","display_name":"DAP10","score":0.9980000257492065},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.7850000262260437},{"id":"https://openalex.org/keywords/receptor-downregulation","display_name":"receptor down-regulation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/nk-cell-activation","display_name":"NK cell activation","score":0.5649999976158142},{"id":"https://openalex.org/keywords/nkp30","display_name":"NKp30","score":0.8040000200271606},{"id":"https://openalex.org/keywords/2b4","display_name":"2B4","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cd28","display_name":"CD28","score":0.9470000267028809},{"id":"https://openalex.org/keywords/costimulatory-receptors","display_name":"costimulatory receptors","score":0.8579999804496765},{"id":"https://openalex.org/keywords/degranulation","display_name":"degranulation","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C2778867473","wikidata":"https://www.wikidata.org/wiki/Q17544382","display_name":"NKG2D","level":4,"score":0.8565807342529297},{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.6383525729179382},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.6255015134811401},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.6146883368492126},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.5756068825721741},{"id":"https://openalex.org/C28651165","wikidata":"https://www.wikidata.org/wiki/Q4259786","display_name":"Lymphokine-activated killer cell","level":5,"score":0.5412750244140625},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5089461803436279},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4868170917034149},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.47899529337882996},{"id":"https://openalex.org/C120642132","wikidata":"https://www.wikidata.org/wiki/Q14907110","display_name":"ZAP70","level":5,"score":0.4776407778263092},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4642767310142517},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.46229976415634155},{"id":"https://openalex.org/C182676581","wikidata":"https://www.wikidata.org/wiki/Q4201948","display_name":"CD49b","level":5,"score":0.44504380226135254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43673771619796753},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4347150921821594},{"id":"https://openalex.org/C98119934","wikidata":"https://www.wikidata.org/wiki/Q14907167","display_name":"Interleukin 15","level":4,"score":0.4345957934856415},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4128408133983612},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3463730812072754},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2914796769618988},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.22166776657104492},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1821545958518982},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0888662040233612},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07109522819519043}],"mesh":[{"descriptor_ui":"D000071176","descriptor_name":"Signaling Lymphocytic Activation Molecule Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098546","descriptor_name":"Interleukin-21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018123","descriptor_name":"Receptors, Interleukin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018123","descriptor_name":"Receptors, Interleukin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050791","descriptor_name":"STAT Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053655","descriptor_name":"Receptors, Interleukin-21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053738","descriptor_name":"Interleukin-21 Receptor alpha Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055607","descriptor_name":"Receptors, Natural Killer Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055628","descriptor_name":"Natural Cytotoxicity Triggering Receptor 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055655","descriptor_name":"NK Cell Lectin-Like Receptor Subfamily K","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.176.3.1490","doi":"https://doi.org/10.4049/jimmunol.176.3.1490","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.176.3.1490","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/176/3/1490/1217323/1490.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:16424177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16424177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.176.3.1490","doi":"https://doi.org/10.4049/jimmunol.176.3.1490","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.176.3.1490","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/176/3/1490/1217323/1490.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104810237.pdf","grobid_xml":"https://content.openalex.org/works/W2104810237.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1495069682","https://openalex.org/W1540188867","https://openalex.org/W1571796034","https://openalex.org/W1939229836","https://openalex.org/W1941517951","https://openalex.org/W1958728059","https://openalex.org/W1967684158","https://openalex.org/W1993786192","https://openalex.org/W1994748539","https://openalex.org/W1999191024","https://openalex.org/W2006192376","https://openalex.org/W2010749951","https://openalex.org/W2014349052","https://openalex.org/W2015054607","https://openalex.org/W2023370541","https://openalex.org/W2023858678","https://openalex.org/W2025267152","https://openalex.org/W2026000112","https://openalex.org/W2026697995","https://openalex.org/W2032125984","https://openalex.org/W2043791847","https://openalex.org/W2048969453","https://openalex.org/W2049996097","https://openalex.org/W2054243477","https://openalex.org/W2060387930","https://openalex.org/W2064920472","https://openalex.org/W2074572906","https://openalex.org/W2079683856","https://openalex.org/W2084292672","https://openalex.org/W2087171945","https://openalex.org/W2091128689","https://openalex.org/W2093757915","https://openalex.org/W2096223977","https://openalex.org/W2098930452","https://openalex.org/W2109877208","https://openalex.org/W2128695086","https://openalex.org/W2131053525","https://openalex.org/W2131814542","https://openalex.org/W2133588094","https://openalex.org/W2134824958","https://openalex.org/W2139127018","https://openalex.org/W2141312960","https://openalex.org/W2143645620","https://openalex.org/W2154740756","https://openalex.org/W2160108273","https://openalex.org/W2163828646","https://openalex.org/W2170069789"],"related_works":["https://openalex.org/W1992347525","https://openalex.org/W2069945021","https://openalex.org/W7096667082","https://openalex.org/W2163992046","https://openalex.org/W1958728059","https://openalex.org/W2112966339","https://openalex.org/W1971422697","https://openalex.org/W2269273952","https://openalex.org/W1991271747","https://openalex.org/W425905331"],"abstract_inverted_index":{"IL-21":[0,23,61,92,147,179,209],"is":[1,39,210],"a":[2,128,159,169],"recently":[3],"described":[4],"cytokine,":[5],"produced":[6],"by":[7,42,103,168,220],"activated":[8],"Th":[9],"cells,":[10],"that":[11,38,50,79,208],"shares":[12],"significant":[13,68],"homology":[14],"with":[15,33,60,64,78,83,112,116,127,142,146,149,152],"members":[16,43],"of":[17,21,44,52,70,75,89,131,134,186,225],"the":[18,29,34,45,71,184,187,197,222],"IL-2":[19,46,65,84,117,143],"family":[20],"cytokines.":[22],"mediates":[24],"its":[25],"biological":[26],"effects":[27],"via":[28],"IL-21R":[30],"in":[31,62,67,80,122,139,144,162],"conjunction":[32],"common":[35],"receptor":[36,199],"gamma-chain":[37],"also":[40],"shared":[41],"family.":[47],"We":[48],"report":[49],"culture":[51,93],"human":[53,123],"primary":[54],"NK":[55,98,113,124,188,214],"and":[56,108,192,215],"CD8+":[57,202,216],"T":[58,203,217],"cells":[59,81,114,125,140,150],"combination":[63,145],"results":[66],"reduction":[69,130,161],"cell":[72,99,218],"surface":[73],"expression":[74,88,185,223],"NKG2D,":[76],"compared":[77,111,148],"treated":[82,115,141],"alone.":[85,118],"The":[86],"reduced":[87],"NKG2D":[90,120,177],"after":[91],"had":[94],"functional":[95],"consequences":[96],"for":[97],"function,":[100],"as":[101,166,194,196],"assessed":[102,167],"NKG2D-mediated":[104],"redirected":[105],"lysis":[106],"assays":[107],"degranulation":[109],"assays,":[110],"IL-21-mediated":[119],"down-regulation":[121],"correlated":[126],"marked":[129],"DNAX-activating":[132],"protein":[133],"10":[135],"kDa":[136],"(DAP10)":[137],"transcription":[138],"stimulated":[151],"only":[153],"IL-2.":[154],"This":[155],"was":[156,180],"attributed":[157],"to":[158,176,182,212],"dramatic":[160],"DAP10":[163,170],"promoter":[164],"activity,":[165],"luciferase":[171],"reporter":[172],"construct.":[173],"In":[174],"contrast":[175],"expression,":[178],"able":[181,211],"induce":[183],"activation":[189],"receptors":[190],"NKp30":[191],"2B4":[193],"well":[195],"costimulatory":[198],"CD28":[200],"on":[201],"cells.":[204],"These":[205],"data":[206],"indicate":[207],"channel":[213],"function":[219],"altering":[221],"pattern":[224],"activation/costimulatory":[226],"receptors.":[227]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
