{"id":"https://openalex.org/W2104797751","doi":"https://doi.org/10.1111/j.1600-0404.2007.00810.x","title":"First-line therapy for theophylline-associated seizures","display_name":"First-line therapy for theophylline-associated seizures","publication_year":2007,"publication_date":"2007-03-07","ids":{"openalex":"https://openalex.org/W2104797751","doi":"https://doi.org/10.1111/j.1600-0404.2007.00810.x","mag":"2104797751","pmid":"https://pubmed.ncbi.nlm.nih.gov/17362277"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0404.2007.00810.x","doi":"https://doi.org/10.1111/j.1600-0404.2007.00810.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0404.2007.00810.x","pdf_url":null,"source":{"id":"https://openalex.org/S66034498","display_name":"Acta Neurologica Scandinavica","issn_l":"0001-6314","issn":["0001-6314","1600-0404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neurologica Scandinavica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043200329","display_name":"Hideto Yoshikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088469","display_name":"Miyagi Children's Hospital","ror":"https://ror.org/007e71662","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088469"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"H. Yoshikawa","raw_affiliation_strings":["Department of Neurology, Miyagi Children's Hospital, Sendai, Miyagi, Japan. hideto@miyagi-children.or.jp","Department of Neurology, Miyagi Children's Hospital, Sendai, Miyagi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Miyagi Children's Hospital, Sendai, Miyagi, Japan. hideto@miyagi-children.or.jp","institution_ids":["https://openalex.org/I4210088469"]},{"raw_affiliation_string":"Department of Neurology, Miyagi Children's Hospital, Sendai, Miyagi, Japan","institution_ids":["https://openalex.org/I4210088469"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043200329"],"corresponding_institution_ids":["https://openalex.org/I4210088469"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":null,"fwci":1.7632,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.83211109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"115","issue":"s186","first_page":"57","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11921","display_name":"Electroconvulsive Therapy Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/status-epilepticus","display_name":"status epilepticus","score":0.8539999723434448},{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":0.7879999876022339},{"id":"https://openalex.org/keywords/barbiturates","display_name":"barbiturates","score":0.8579999804496765},{"id":"https://openalex.org/keywords/benzodiazepine-antagonism","display_name":"benzodiazepine antagonism","score":0.9390000104904175},{"id":"https://openalex.org/keywords/endotracheal-intubation","display_name":"endotracheal intubation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/serum-theophylline-levels","display_name":"serum theophylline concentration","score":0.8220000267028809},{"id":"https://openalex.org/keywords/generalized-tonic-clonic-seizures","display_name":"generalized tonic-clonic seizures","score":0.800000011920929},{"id":"https://openalex.org/keywords/pediatric-seizures","display_name":"pediatric seizures","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.9175422191619873},{"id":"https://openalex.org/C2778095195","wikidata":"https://www.wikidata.org/wiki/Q407308","display_name":"Theophylline","level":2,"score":0.8227963447570801},{"id":"https://openalex.org/C2777341932","wikidata":"https://www.wikidata.org/wiki/Q980709","display_name":"Status epilepticus","level":3,"score":0.8049279451370239},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7500812411308289},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7342631816864014},{"id":"https://openalex.org/C2991710064","wikidata":"https://www.wikidata.org/wiki/Q750195","display_name":"Endotracheal intubation","level":3,"score":0.6725090146064758},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.4655156135559082},{"id":"https://openalex.org/C2778716859","wikidata":"https://www.wikidata.org/wiki/Q939018","display_name":"Intubation","level":2,"score":0.4105963408946991},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.34999603033065796},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1486353874206543},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08582502603530884},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011753","descriptor_name":"Pyrones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1600-0404.2007.00810.x","doi":"https://doi.org/10.1111/j.1600-0404.2007.00810.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0404.2007.00810.x","pdf_url":null,"source":{"id":"https://openalex.org/S66034498","display_name":"Acta Neurologica Scandinavica","issn_l":"0001-6314","issn":["0001-6314","1600-0404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neurologica Scandinavica","raw_type":"journal-article"},{"id":"pmid:17362277","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17362277","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta neurologica Scandinavica","raw_type":"Journal Article"},{"id":"pmid:17784538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17784538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta neurologica Scandinavica. Supplementum","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1626450184","https://openalex.org/W1998654370","https://openalex.org/W2012582648","https://openalex.org/W2012640576","https://openalex.org/W2020231955","https://openalex.org/W2034117335","https://openalex.org/W2084773951","https://openalex.org/W2086181774","https://openalex.org/W2090867991","https://openalex.org/W2094365107","https://openalex.org/W2111981566","https://openalex.org/W2330786805","https://openalex.org/W2413122921"],"related_works":["https://openalex.org/W2436359194","https://openalex.org/W2041980444","https://openalex.org/W2330786805","https://openalex.org/W2103846388","https://openalex.org/W1975210079","https://openalex.org/W2042587883","https://openalex.org/W1718164771","https://openalex.org/W4205245644","https://openalex.org/W2012791992","https://openalex.org/W1999865811"],"abstract_inverted_index":{"Theophylline-associated":[0],"seizures":[1],"(TAS)":[2],"are":[3,189],"considered":[4],"a":[5,28,30,72],"neurologic":[6],"emergency,":[7],"as":[8,22,187],"they":[9],"can":[10],"sometimes":[11],"be":[12,126],"intractable":[13],"and":[14,77,106,131,154,180],"difficult":[15],"to":[16,125,174,209,215],"stop":[17],"with":[18,63,90,144],"standard":[19],"treatments":[20],"such":[21,186],"intravenous":[23,132],"administration":[24,133],"of":[25,32,61,66,83,104,117,122,134,152,178,200],"diazepam.":[26],"As":[27],"consequence,":[29],"proportion":[31],"patients":[33],"who":[34],"experience":[35],"status":[36,216],"epilepticus":[37],"while":[38],"receiving":[39],"theophylline":[40,108],"will":[41],"require":[42],"endotracheal":[43,160],"intubation.":[44,161],"The":[45,120],"optimal":[46],"first-line":[47],"therapy":[48,165],"for":[49,129,166],"TAS":[50,62,96,123,141,167],"has":[51],"not":[52,207],"yet":[53],"been":[54],"fully":[55],"investigated.":[56],"We":[57],"compared":[58,143],"54":[59,81],"cases":[60,65,82,148,156],"779":[64],"non-TAS,":[67,130],"that":[68],"had":[69],"presented":[70],"at":[71],"single":[73],"institution":[74],"between":[75],"1991":[76],"2002.":[78],"Among":[79],"the":[80,91,112,118,164,176,197],"TAS,":[84,196],"36":[85],"experienced":[86],"generalized":[87],"tonic-clonic":[88],"seizures,":[89],"remainder":[92],"experiencing":[93],"partial":[94],"seizures.":[95],"occurred":[97],"mainly":[98],"in":[99,115,139,192],"children":[100],"under":[101],"3":[102],"years":[103],"age,":[105],"serum":[107],"levels":[109],"were":[110,168],"within":[111],"therapeutic":[113],"range":[114],"78%":[116],"cases.":[119],"duration":[121],"tended":[124],"longer":[127],"than":[128],"diazepam":[135,188,205],"was":[136],"less":[137],"effective":[138],"controlling":[140],"(45%),":[142],"non-TAS":[145],"(68%).":[146],"Many":[147],"required":[149,159],"repeated":[150],"injections":[151],"diazepam,":[153],"15":[155],"(27%)":[157],"eventually":[158],"Reports":[162],"concerning":[163],"also":[169],"reviewed.":[170],"Theophylline":[171],"is":[172,202,206],"known":[173],"antagonize":[175],"effects":[177],"benzodiazepines,":[179],"this":[181],"may":[182],"explain":[183],"why":[184],"drugs":[185],"relatively":[190],"ineffective":[191],"treating":[193],"TAS.":[194],"In":[195],"prompt":[198],"use":[199],"barbiturates":[201],"recommended":[203],"when":[204],"effective,":[208],"avoid":[210],"potential":[211],"brain":[212],"injury":[213],"secondary":[214],"epilepticus.":[217]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}