{"id":"https://openalex.org/W2104770779","doi":null,"title":"Chromatin Insulators and CTCF: Architects of Epigenetic States during Development.","display_name":"Chromatin Insulators and CTCF: Architects of Epigenetic States during Development.","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2104770779","mag":"2104770779"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-4241","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4241","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4241","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088024497","display_name":"Rituparna Mukhopadhyay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rituparna Mukhopadhyay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088024497"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.5249000191688538,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.5249000191688538,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.44339999556541443,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromatin-insulators","display_name":"chromatin insulators","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ctcf","display_name":"CTCF","score":0.9940000176429749},{"id":"https://openalex.org/keywords/genomic-imprinting","display_name":"genomic imprinting","score":0.996999979019165},{"id":"https://openalex.org/keywords/imprinting-control-regions","display_name":"imprinting control regions","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cpg-methylation","display_name":"CpG methylation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/h19","display_name":"H19","score":0.9039999842643738},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.996999979019165},{"id":"https://openalex.org/keywords/kcnq1","display_name":"KCNQ1","score":0.9570000171661377},{"id":"https://openalex.org/keywords/p57kip2","display_name":"p57KIP2","score":0.9449999928474426},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.6439999938011169},{"id":"https://openalex.org/keywords/developmental-gene-expression","display_name":"developmental gene expression","score":0.6489999890327454},{"id":"https://openalex.org/keywords/mouse-chromosome-7","display_name":"mouse chromosome 7","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2778760011","wikidata":"https://www.wikidata.org/wiki/Q21163346","display_name":"CTCF","level":5,"score":0.969212532043457},{"id":"https://openalex.org/C201492766","wikidata":"https://www.wikidata.org/wiki/Q84087","display_name":"Genomic imprinting","level":5,"score":0.8725203275680542},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.730083167552948},{"id":"https://openalex.org/C94715292","wikidata":"https://www.wikidata.org/wiki/Q624349","display_name":"Imprinting (psychology)","level":3,"score":0.7173526883125305},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6977424621582031},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6763314604759216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6668174266815186},{"id":"https://openalex.org/C212702","wikidata":"https://www.wikidata.org/wiki/Q178150","display_name":"Insulator (electricity)","level":2,"score":0.5512682199478149},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5226349830627441},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5112044811248779},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.49279239773750305},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48902735114097595},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.483849436044693},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.4628064036369324},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.459547221660614},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23188656568527222},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.2072233259677887},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-4241","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4241","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2104770779","doi":null,"is_oa":false,"landing_page_url":"http://uu.diva-portal.org/smash/get/diva2:164506/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-4241","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4241","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":106,"referenced_works":["https://openalex.org/W41831396","https://openalex.org/W1511815964","https://openalex.org/W1523020113","https://openalex.org/W1531390941","https://openalex.org/W1608490912","https://openalex.org/W1629804770","https://openalex.org/W1643500256","https://openalex.org/W1669374546","https://openalex.org/W1673514954","https://openalex.org/W1963807858","https://openalex.org/W1965812853","https://openalex.org/W1967364632","https://openalex.org/W1967414895","https://openalex.org/W1969714073","https://openalex.org/W1969770714","https://openalex.org/W1971458488","https://openalex.org/W1971723950","https://openalex.org/W1972995961","https://openalex.org/W1973075378","https://openalex.org/W1981639631","https://openalex.org/W1981889222","https://openalex.org/W1986085455","https://openalex.org/W1990861922","https://openalex.org/W1995643652","https://openalex.org/W1997667014","https://openalex.org/W2001316126","https://openalex.org/W2002698073","https://openalex.org/W2004010498","https://openalex.org/W2004088290","https://openalex.org/W2006061308","https://openalex.org/W2007366502","https://openalex.org/W2008734507","https://openalex.org/W2010553820","https://openalex.org/W2012759663","https://openalex.org/W2015228025","https://openalex.org/W2019002796","https://openalex.org/W2020428655","https://openalex.org/W2021080331","https://openalex.org/W2022057137","https://openalex.org/W2026882865","https://openalex.org/W2031087599","https://openalex.org/W2035069455","https://openalex.org/W2035915355","https://openalex.org/W2036636377","https://openalex.org/W2042728321","https://openalex.org/W2043622843","https://openalex.org/W2045667699","https://openalex.org/W2046241907","https://openalex.org/W2046799089","https://openalex.org/W2060446375","https://openalex.org/W2060769308","https://openalex.org/W2061911724","https://openalex.org/W2065577070","https://openalex.org/W2066208998","https://openalex.org/W2069080094","https://openalex.org/W2070310945","https://openalex.org/W2070477402","https://openalex.org/W2073157961","https://openalex.org/W2074351361","https://openalex.org/W2074906225","https://openalex.org/W2075805514","https://openalex.org/W2086081150","https://openalex.org/W2092136133","https://openalex.org/W2092986104","https://openalex.org/W2093032186","https://openalex.org/W2096286842","https://openalex.org/W2098846501","https://openalex.org/W2099189400","https://openalex.org/W2099689315","https://openalex.org/W2101345697","https://openalex.org/W2101633713","https://openalex.org/W2102354182","https://openalex.org/W2105387877","https://openalex.org/W2108602703","https://openalex.org/W2109934662","https://openalex.org/W2116599808","https://openalex.org/W2118008591","https://openalex.org/W2118628540","https://openalex.org/W2118781875","https://openalex.org/W2118962630","https://openalex.org/W2120330695","https://openalex.org/W2122022514","https://openalex.org/W2122029913","https://openalex.org/W2130639565","https://openalex.org/W2132530130","https://openalex.org/W2136932227","https://openalex.org/W2137625310","https://openalex.org/W2141567062","https://openalex.org/W2142184151","https://openalex.org/W2143083347","https://openalex.org/W2155239124","https://openalex.org/W2160003307","https://openalex.org/W2162917230","https://openalex.org/W2163235941","https://openalex.org/W2164704209","https://openalex.org/W2168819459","https://openalex.org/W2169702991","https://openalex.org/W2170079644","https://openalex.org/W2170948558","https://openalex.org/W2171195796","https://openalex.org/W2172174991","https://openalex.org/W2178538878","https://openalex.org/W2182683183","https://openalex.org/W2346861477","https://openalex.org/W4299564444","https://openalex.org/W7096145306"],"related_works":["https://openalex.org/W160720852","https://openalex.org/W613653377","https://openalex.org/W610424953","https://openalex.org/W74518495","https://openalex.org/W1499087863","https://openalex.org/W2161772960","https://openalex.org/W350989695","https://openalex.org/W2116599808","https://openalex.org/W2122112013","https://openalex.org/W592087650"],"abstract_inverted_index":{"A":[0],"controlled":[1,51],"and":[2,47,73,94,122,145,151,165,188,221,260,331,352],"efficient":[3],"coordination":[4],"of":[5,14,21,31,44,56,59,79,120,143,158,171,209,223,228,244,257,268,279,293,303,325,343],"gene":[6,161],"expression":[7],"is":[8,24,50,70,74,152,216],"the":[9,29,32,45,63,77,80,90,107,117,128,137,148,155,159,168,177,180,219,224,229,301,316,323],"key":[10],"for":[11,76,218,346],"normal":[12],"development":[13],"an":[15,97,112,311],"organism.":[16],"In":[17,299],"mammals,":[18],"a":[19,35,53,101,186,206,251,266,286,290,340],"subset":[20],"autosomal":[22],"genes":[23,49],"expressed":[25],"monoallelically":[26],"depending":[27],"on":[28,89,147,154,167],"sex":[30],"transmitting":[33],"parent,":[34],"phenomenon":[36],"known":[37,61],"as":[38,62,96,205],"genomic":[39],"imprinting.":[40],"The":[41,213,242,277,319],"imprinted":[42,160],"state":[43],"H19":[46,60,108,121,164,178,230],"Igf2":[48,83],"by":[52],"short":[54],"stretch":[55],"sequences":[57],"upstream":[58],"imprinting":[64,118,210],"control":[65,211],"region":[66,69],"(ICR).":[67],"This":[68],"differentially":[71,225],"methylated":[72,226],"responsible":[75],"repression":[78,142],"maternally":[81],"inherited":[82],"allele.":[84],"It":[85],"harbors":[86],"hypersensitive":[87],"sites":[88,247,270,295,345],"unmethylated":[91],"maternal":[92],"allele":[93],"functions":[95,351],"insulator":[98,103,129,191,202,258,317,335],"that":[99,237,271,307],"binds":[100],"chromatin":[102,190],"protein":[104,214],"CTCF.":[105],"Hence":[106],"ICR,":[109,179],"which":[110],"plays":[111],"important":[113,312],"role":[114,313,333],"in":[115,136,193,233,274,281,285,314,327,334,349],"maintaining":[116,261,328],"status":[119,227],"Igf2,":[123,166],"was":[124],"shown":[125],"to":[126,176,184],"lose":[127],"property":[130,192],"upon":[131],"CpG":[132],"methylation.":[133],"Another":[134],"ICR":[135,182],"Kcnq1":[138,146,181],"locus":[139],"regulates":[140],"long-range":[141],"p57Kip2":[144],"paternal":[149],"allele,":[150],"located":[153],"neighboring":[156],"subdomain":[157],"cluster":[162],"containing":[163],"distal":[169],"end":[170],"mouse":[172],"chromosome":[173],"7.":[174],"Similarly":[175],"appears":[183],"possess":[185],"unidirectional":[187],"methylation-sensitive":[189],"two":[194],"different":[195],"somatic":[196],"cell":[197],"types.":[198],"Hence,":[199],"methylation":[200],"dependent":[201],"activity":[203],"emerges":[204],"common":[207],"feature":[208,239],"regions.":[212],"CTCF":[215,245,280,326,347],"required":[217],"interpretation":[220],"propagation":[222],"ICR.":[231],"Work":[232],"this":[234,238,304],"thesis":[235,305],"shows":[236,306],"applies":[240],"genomewide.":[241],"mapping":[243],"target":[246,269,294,344],"demonstrated":[248],"not":[249],"only":[250],"strong":[252],"link":[253],"between":[254],"CTCF,":[255],"formation":[256],"complexes":[259],"methylation-free":[262,329],"domains,":[263],"but":[264],"also":[265,321],"network":[267],"are":[272],"involved":[273,348],"pivotal":[275],"functions.":[276],"pattern":[278],"vivo":[282],"occupancy":[283],"varies":[284],"lineage-specific":[287],"manner,":[288],"although":[289],"small":[291],"group":[292],"show":[296],"constitutive":[297],"binding.":[298],"conclusion,":[300],"work":[302],"epigenetic":[308],"marks":[309],"play":[310],"regulating":[315],"property.":[318],"studies":[320],"confirm":[322],"importance":[324],"domains":[330],"its":[332],"function.":[336],"Our":[337],"study":[338],"unravels":[339],"new":[341],"range":[342],"divergent":[350],"their":[353],"developmental":[354],"control.":[355]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}