{"id":"https://openalex.org/W2104703463","doi":"https://doi.org/10.1016/j.canlet.2003.10.006","title":"Identification of critical residues required for the mutation avoidance function of human MutY (hMYH) and implications in colorectal cancer","display_name":"Identification of critical residues required for the mutation avoidance function of human MutY (hMYH) and implications in colorectal cancer","publication_year":2003,"publication_date":"2003-12-24","ids":{"openalex":"https://openalex.org/W2104703463","doi":"https://doi.org/10.1016/j.canlet.2003.10.006","mag":"2104703463","pmid":"https://pubmed.ncbi.nlm.nih.gov/15036665"},"language":"en","primary_location":{"id":"doi:10.1016/j.canlet.2003.10.006","doi":"https://doi.org/10.1016/j.canlet.2003.10.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.canlet.2003.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047935590","display_name":"Steven H. Wooden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven H. Wooden","raw_affiliation_strings":["Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, TX 77555-1071, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, TX 77555-1071, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057084518","display_name":"Heather Bassett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather M. Bassett","raw_affiliation_strings":["Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, TX 77555-1071, USA","University of Texas Medical Branch at Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, TX 77555-1071, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"University of Texas Medical Branch at Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106512573","display_name":"Thomas G. Wood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas G. Wood","raw_affiliation_strings":["Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, TX 77555-1071, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, TX 77555-1071, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071858904","display_name":"Amanda K. McCullough","orcid":"https://orcid.org/0000-0002-9500-4973","observed_orcids":["https://orcid.org/0000-0002-9500-4973"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amanda K. McCullough","raw_affiliation_strings":["The Department of Molecular and Medical Genetics and the Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, OR 97239, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Molecular and Medical Genetics and the Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, OR 97239, USA","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071858904"],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":{"value":4960,"currency":"USD","value_usd":4960},"apc_paid":null,"fwci":1.1493,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.75616775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"205","issue":"1","first_page":"89","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5102999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5102999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.4880000054836273,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-glycosylase","display_name":"DNA glycosylase","score":0.8240000009536743},{"id":"https://openalex.org/keywords/8-oxoguanine","display_name":"8-oxoguanine","score":0.9200000166893005},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.6100000143051147},{"id":"https://openalex.org/keywords/g-c-to-t-a-transversions","display_name":"G:C to T:A transversions","score":0.7590000033378601},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.7929999828338623},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.824999988079071},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.49900001287460327},{"id":"https://openalex.org/keywords/critical-residues","display_name":"critical residues","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6304889917373657},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6081539392471313},{"id":"https://openalex.org/C192396546","wikidata":"https://www.wikidata.org/wiki/Q413156","display_name":"DNA glycosylase","level":4,"score":0.5779173970222473},{"id":"https://openalex.org/C141496672","wikidata":"https://www.wikidata.org/wiki/Q14883437","display_name":"MUTYH","level":5,"score":0.5548158288002014},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.538422703742981},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5186649560928345},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5148066878318787},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49950480461120605},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.47220665216445923},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.44400107860565186},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.43032947182655334},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.423168420791626},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38352203369140625},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.332755982875824}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020137","descriptor_name":"Base Pair Mismatch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045647","descriptor_name":"DNA Glycosylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.canlet.2003.10.006","doi":"https://doi.org/10.1016/j.canlet.2003.10.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.canlet.2003.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},{"id":"pmid:15036665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15036665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G131960621","display_name":"Cellular Response Mechanisms to Environmental Challenge","funder_award_id":"P30ES006676","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G2790886025","display_name":"POLYMORPHIC VARIANTS IN HUMAN MUTY","funder_award_id":"5r01ag017432-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3119154873","display_name":null,"funder_award_id":"ES-06676","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8480139759","display_name":null,"funder_award_id":"AG17432","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1484882395","https://openalex.org/W1910525718","https://openalex.org/W1967960497","https://openalex.org/W1968372250","https://openalex.org/W1973518426","https://openalex.org/W1975225200","https://openalex.org/W2004771177","https://openalex.org/W2011804819","https://openalex.org/W2023654659","https://openalex.org/W2025381901","https://openalex.org/W2026895762","https://openalex.org/W2039260137","https://openalex.org/W2043692125","https://openalex.org/W2044199817","https://openalex.org/W2045474451","https://openalex.org/W2047861171","https://openalex.org/W2048661131","https://openalex.org/W2050320436","https://openalex.org/W2075677662","https://openalex.org/W2075960489","https://openalex.org/W2081145376","https://openalex.org/W2095301528","https://openalex.org/W2112773853","https://openalex.org/W2116429930","https://openalex.org/W2119562750","https://openalex.org/W2128953017","https://openalex.org/W2129294148","https://openalex.org/W2132281009","https://openalex.org/W2147640408","https://openalex.org/W2153315312","https://openalex.org/W2158742644","https://openalex.org/W2163980003","https://openalex.org/W2167168378","https://openalex.org/W2331675392","https://openalex.org/W2983883266","https://openalex.org/W3024340838"],"related_works":["https://openalex.org/W2022119214","https://openalex.org/W1985035771","https://openalex.org/W2042603507","https://openalex.org/W1985443528","https://openalex.org/W2045429793","https://openalex.org/W2110134933","https://openalex.org/W2000211554","https://openalex.org/W7100901980","https://openalex.org/W2132411923","https://openalex.org/W7134749"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
