{"id":"https://openalex.org/W2104701019","doi":"https://doi.org/10.1113/jphysiol.2007.143685","title":"Normal hypertrophy accompanied by phosphoryation and activation of AMP\u2010activated protein kinase \u03b11 following overload in LKB1 knockout mice","display_name":"Normal hypertrophy accompanied by phosphoryation and activation of AMP\u2010activated protein kinase \u03b11 following overload in LKB1 knockout mice","publication_year":2008,"publication_date":"2008-01-18","ids":{"openalex":"https://openalex.org/W2104701019","doi":"https://doi.org/10.1113/jphysiol.2007.143685","mag":"2104701019","pmid":"https://pubmed.ncbi.nlm.nih.gov/18202101","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2327866"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.2007.143685","doi":"https://doi.org/10.1113/jphysiol.2007.143685","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.2007.143685","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2327866","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044194965","display_name":"Sean L. McGee","orcid":"https://orcid.org/0000-0001-6953-106X","observed_orcids":["https://orcid.org/0000-0001-6953-106X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Sean L. McGee","raw_affiliation_strings":["Functional Molecular Biology Lab, Division of Molecular Physiology, University of Dundee, Sir James Black Centre, Dow Street, Dundee DD1 5EH, UK","Division of Molecular Physiology, University of Dundee, Dundee, UK","The Department of Physiology, The University of Melbourne, Parkville, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Molecular Biology Lab, Division of Molecular Physiology, University of Dundee, Sir James Black Centre, Dow Street, Dundee DD1 5EH, UK","institution_ids":["https://openalex.org/I177639307"]},{"raw_affiliation_string":"Division of Molecular Physiology, University of Dundee, Dundee, UK","institution_ids":["https://openalex.org/I177639307"]},{"raw_affiliation_string":"The Department of Physiology, The University of Melbourne, Parkville, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113569904","display_name":"Kirsty J. Mustard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kirsty J. Mustard","raw_affiliation_strings":["Division of Molecular Physiology, University of Dundee, Dundee, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Physiology, University of Dundee, Dundee, UK","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046976143","display_name":"David Grahame Hardie","orcid":"https://orcid.org/0000-0002-8373-7379","observed_orcids":["https://orcid.org/0000-0002-8373-7379"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. Grahame Hardie","raw_affiliation_strings":["Division of Molecular Physiology, University of Dundee, Dundee, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Physiology, University of Dundee, Dundee, UK","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112786164","display_name":"Keith Baar","orcid":"https://orcid.org/0000-0001-9337-6186","observed_orcids":["https://orcid.org/0000-0001-9337-6186"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Keith Baar","raw_affiliation_strings":["Division of Molecular Physiology, University of Dundee, Dundee, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Physiology, University of Dundee, Dundee, UK","institution_ids":["https://openalex.org/I177639307"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":4.48,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.96191789,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"586","issue":"6","first_page":"1731","last_page":"1741"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.8457000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.8457000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.11309999972581863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.022299999371170998,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9430000185966492},{"id":"https://openalex.org/keywords/skeletal-muscle-hypertrophy","display_name":"skeletal muscle hypertrophy","score":0.949999988079071},{"id":"https://openalex.org/keywords/muscle-overload","display_name":"muscle overload","score":0.7919999957084656},{"id":"https://openalex.org/keywords/resistance-training","display_name":"resistance training","score":0.8569999933242798},{"id":"https://openalex.org/keywords/endurance-exercise","display_name":"endurance exercise","score":0.7910000085830688},{"id":"https://openalex.org/keywords/camkkbeta","display_name":"CaMKK\u03b2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tak1","display_name":"TAK1","score":0.859000027179718},{"id":"https://openalex.org/keywords/tsc2-phosphorylation","display_name":"TSC2 phosphorylation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.8450000286102295},{"id":"https://openalex.org/keywords/muscle-growth-regulation","display_name":"muscle growth regulation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/muscle-metabolism","display_name":"muscle metabolism","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.7380113005638123},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.6620129346847534},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5964489579200745},{"id":"https://openalex.org/C2778271984","wikidata":"https://www.wikidata.org/wiki/Q17126794","display_name":"Pressure overload","level":4,"score":0.5758861899375916},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.5633457899093628},{"id":"https://openalex.org/C2776780712","wikidata":"https://www.wikidata.org/wiki/Q295240","display_name":"AMP-activated protein kinase","level":5,"score":0.5458413362503052},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5282006859779358},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49061527848243713},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4156005084514618},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3948992192745209},{"id":"https://openalex.org/C3018791406","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Cardiac hypertrophy","level":3,"score":0.35523977875709534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3506200313568115},{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.2915131747722626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2611446976661682},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05300554633140564}],"mesh":[{"descriptor_ui":"D000091162","descriptor_name":"AMP-Activated Protein Kinase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006984","descriptor_name":"Hypertrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006984","descriptor_name":"Hypertrophy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010807","descriptor_name":"Physical Endurance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018763","descriptor_name":"Muscle Fatigue","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1113/jphysiol.2007.143685","doi":"https://doi.org/10.1113/jphysiol.2007.143685","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.2007.143685","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2327866","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2327866","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:18202101","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18202101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire_cris_publications/631af1f2-9cb0-4ead-8f99-e1b4b1775f48","doi":null,"is_oa":false,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/631af1f2-9cb0-4ead-8f99-e1b4b1775f48","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mcgee, S L, Mustard, K J, Hardie, D G & Baar, K 2008, 'Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha 1 following overload in LKB1 knockout mice', Journal of Physiology, vol. 586, no. 6, pp. 1731-1741. https://doi.org/10.1113/jphysiol.2007.143685","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2327866","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2327866","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2534655653","display_name":"The role of mTOR/PDK1 activated protein kinases in the development of skeletal muscle hypertrophy.","funder_award_id":"077426/Z/05/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2536730077","display_name":"Regulation of AMP-activated protein kinase by upstream effectors.","funder_award_id":"080982","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1586159393","https://openalex.org/W1964321721","https://openalex.org/W1969384498","https://openalex.org/W1978763812","https://openalex.org/W1988848089","https://openalex.org/W1990278643","https://openalex.org/W2000659699","https://openalex.org/W2001618355","https://openalex.org/W2011282245","https://openalex.org/W2017931973","https://openalex.org/W2021012077","https://openalex.org/W2030636484","https://openalex.org/W2042265259","https://openalex.org/W2050689899","https://openalex.org/W2056137479","https://openalex.org/W2064764081","https://openalex.org/W2067979493","https://openalex.org/W2068342714","https://openalex.org/W2071272599","https://openalex.org/W2073361547","https://openalex.org/W2074894911","https://openalex.org/W2077544141","https://openalex.org/W2083849298","https://openalex.org/W2094765463","https://openalex.org/W2095454212","https://openalex.org/W2096372899","https://openalex.org/W2098947405","https://openalex.org/W2114349736","https://openalex.org/W2119711962","https://openalex.org/W2123352794","https://openalex.org/W2125732396","https://openalex.org/W2132520315","https://openalex.org/W2141885300","https://openalex.org/W2141909299","https://openalex.org/W2146027431","https://openalex.org/W2149490207","https://openalex.org/W2159620999","https://openalex.org/W2162807947","https://openalex.org/W2163583831","https://openalex.org/W2166714586","https://openalex.org/W2169373333","https://openalex.org/W2169469988","https://openalex.org/W2176414067","https://openalex.org/W2184995059","https://openalex.org/W2253079146","https://openalex.org/W2339005651","https://openalex.org/W4238567307"],"related_works":["https://openalex.org/W2119711962","https://openalex.org/W1982450147","https://openalex.org/W2058342788","https://openalex.org/W3135521738","https://openalex.org/W2117479369","https://openalex.org/W2323050211","https://openalex.org/W3173433547","https://openalex.org/W2283514250","https://openalex.org/W1975883334","https://openalex.org/W2472877843"],"abstract_inverted_index":{"The":[0,155,234],"activation":[1],"of":[2,10,14,68,107,124,128,157,186,205,217,236,241,273,286,299],"the":[3,11,23,42,52,78,108,111,120,125,135,138,143,175,195,202,224,242,246,270,284,297],"AMP-activated":[4],"protein":[5,160],"kinase":[6,55,161,162],"(AMPK)":[7],"and":[8,82,122,137,168,178,197,256],"inhibition":[9],"mammalian":[12],"target":[13],"rapamycin":[15],"complex":[16],"1":[17,64],"(mTORC1)":[18],"is":[19,31,227,275],"hypothesized":[20],"to":[21,254],"underlie":[22],"fact":[24,109],"that":[25,110,223,269,290],"muscle":[26,45,75,280],"growth":[27,46,76,300],"following":[28,191,281],"resistance":[29],"exercise":[30],"decreased":[32],"by":[33,209,261],"concurrent":[34],"endurance":[35],"exercise.":[36],"To":[37,141],"directly":[38],"test":[39],"this":[40,179,257,291],"hypothesis,":[41],"capacity":[43],"for":[44,56],"was":[47,71,207,250,258],"determined":[48],"in":[49,58,74,117,133,174,193,215,230,252,278,283,296],"mice":[50,84],"lacking":[51],"primary":[53],"upstream":[54,144,150,239],"AMPK":[57,129,206,247,274],"skeletal":[59,118,279],"muscle,":[60,119],"LKB1.":[61,154],"Following":[62],"either":[63],"or":[65,220],"4":[66,95],"weeks":[67],"overload,":[69,210,255],"there":[70,211],"no":[72,213],"difference":[73],"between":[77],"wild":[79],"type":[80],"(wt)":[81],"LKB1(-/-)":[83,139],"(1":[85],"week:":[86,96],"wt,":[87,97],"38.8":[88],"+/-":[89,93,99,103,166,171],"7.75%;":[90],"LKB1(-/-),":[91,101],"27.8":[92],"12.98%;":[94],"75.8":[98],"15.2%;":[100],"85.0":[102],"22.6%).":[104],"In":[105],"spite":[106],"LKB1":[112,198,262],"had":[113],"been":[114],"knocked":[115],"out":[116],"phosphorylation":[121,235],"activity":[123,156],"alpha1":[126,203,225,271],"isoform":[127,204,226,272,292],"were":[130,212],"markedly":[131],"increased":[132,173,183,189,251],"both":[134,158,194],"wt":[136,196],"mice.":[140,199],"identify":[142],"kinase(s)":[145],"responsible,":[146],"we":[147],"studied":[148],"potential":[149],"kinases":[151],"other":[152],"than":[153],"Ca(2+)-calmodulin-dependent":[159],"alpha":[163],"(CaMKKalpha)":[164],"(5.05":[165],"0.86-fold)":[167],"CaMKKbeta":[169],"(10.1":[170],"2.59-fold)":[172],"overloaded":[176],"muscles,":[177],"correlated":[180],"with":[181],"their":[182],"expression.":[184],"Phosphorylation":[185],"TAK-1":[187],"also":[188],"10-fold":[190],"overload":[192,282],"Even":[200],"though":[201],"activated":[208,277],"increases":[214],"expression":[216],"mitochondrial":[218],"proteins":[219],"GLUT4,":[221],"indicating":[222],"not":[228,259,302],"involved":[229],"these":[231,266],"metabolic":[232,287],"adaptations.":[233],"TSC2,":[237],"an":[238],"regulator":[240],"TORC1":[243],"pathway,":[244],"at":[245],"site":[248],"(Ser1345)":[249],"response":[253],"affected":[260],"deficiency.":[263],"Taken":[264],"together,":[265],"data":[267],"suggest":[268],"preferentially":[276],"absence":[285],"adaptations,":[288],"suggesting":[289],"might":[293],"be":[294],"important":[295],"regulation":[298],"but":[301],"metabolism.":[303]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
