{"id":"https://openalex.org/W2104643170","doi":"https://doi.org/10.1074/jbc.m006533200","title":"Presence and Activation of Nuclear Phosphoinositide 3-Kinase C2\u03b2 during Compensatory Liver Growth","display_name":"Presence and Activation of Nuclear Phosphoinositide 3-Kinase C2\u03b2 during Compensatory Liver Growth","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W2104643170","doi":"https://doi.org/10.1074/jbc.m006533200","mag":"2104643170","pmid":"https://pubmed.ncbi.nlm.nih.gov/11278304"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m006533200","doi":"https://doi.org/10.1074/jbc.m006533200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m006533200","pdf_url":"http://www.jbc.org/article/S002192581931703X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192581931703X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077495099","display_name":"Aleksandra Sin\u0111i\u0107","orcid":"https://orcid.org/0000-0002-5852-0709","observed_orcids":["https://orcid.org/0000-0002-5852-0709"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]},{"id":"https://openalex.org/I4405260292","display_name":"Hrvatski institut za istra\u017eivanje mozga","ror":"https://ror.org/03hhshb57","country_code":"HR","type":"facility","lineage":["https://openalex.org/I181343428","https://openalex.org/I4405260292"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Aleksandra Sin\u0111i\u0107","raw_affiliation_strings":["Department of Physiology and Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Salata 3, Zagreb 10,000, Croatia, the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Salata 3, Zagreb 10,000, Croatia, the","institution_ids":["https://openalex.org/I181343428","https://openalex.org/I4405260292"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Aleksandra Aleksandrova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]},{"id":"https://openalex.org/I4405260292","display_name":"Hrvatski institut za istra\u017eivanje mozga","ror":"https://ror.org/03hhshb57","country_code":"HR","type":"facility","lineage":["https://openalex.org/I181343428","https://openalex.org/I4405260292"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Aleksandra Aleksandrova","raw_affiliation_strings":["Department of Physiology and Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Salata 3, Zagreb 10,000, Croatia, the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Salata 3, Zagreb 10,000, Croatia, the","institution_ids":["https://openalex.org/I181343428","https://openalex.org/I4405260292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081306238","display_name":"Alan P. Fields","orcid":"https://orcid.org/0000-0001-9529-0888","observed_orcids":["https://orcid.org/0000-0001-9529-0888"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan P. Fields","raw_affiliation_strings":["Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555-1048, and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555-1048, and the","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036085776","display_name":"Stefano Volinia","orcid":"https://orcid.org/0000-0003-0910-3893","observed_orcids":["https://orcid.org/0000-0003-0910-3893"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Volinia","raw_affiliation_strings":["Dip. di Morfologia ed Embriologia, Universita degli Studi, Via Fossato di Mortara 64/b, Ferrara 44100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dip. di Morfologia ed Embriologia, Universita degli Studi, Via Fossato di Mortara 64/b, Ferrara 44100, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071936088","display_name":"Hrvoje Banf\u00ed\u0188","orcid":"https://orcid.org/0000-0002-6005-8453","observed_orcids":["https://orcid.org/0000-0002-6005-8453"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]},{"id":"https://openalex.org/I4405260292","display_name":"Hrvatski institut za istra\u017eivanje mozga","ror":"https://ror.org/03hhshb57","country_code":"HR","type":"facility","lineage":["https://openalex.org/I181343428","https://openalex.org/I4405260292"]}],"countries":["HR"],"is_corresponding":true,"raw_author_name":"Hrvoje Banfi\u0107","raw_affiliation_strings":["Department of Physiology and Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Salata 3, Zagreb 10,000, Croatia, the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Salata 3, Zagreb 10,000, Croatia, the","institution_ids":["https://openalex.org/I181343428","https://openalex.org/I4405260292"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5071936088"],"corresponding_institution_ids":["https://openalex.org/I181343428","https://openalex.org/I4405260292"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.7141,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.93008542,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"276","issue":"21","first_page":"17754","last_page":"17761"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.19030000269412994,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.040800001472234726,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/partial-hepatectomy","display_name":"partial hepatectomy","score":0.9739999771118164},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-phosphate","display_name":"phosphatidylinositol 3-phosphate","score":0.9449999928474426},{"id":"https://openalex.org/keywords/calpain-mediated-proteolysis","display_name":"calpain-mediated proteolysis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/calpeptin","display_name":"calpeptin","score":0.8050000071525574},{"id":"https://openalex.org/keywords/wortmannin","display_name":"wortmannin","score":0.75},{"id":"https://openalex.org/keywords/phosphatidylinositol-4-phosphate","display_name":"phosphatidylinositol 4-phosphate","score":0.8560000061988831},{"id":"https://openalex.org/keywords/phosphatidylinositol-4-5-bisphosphate","display_name":"phosphatidylinositol 4,5-bisphosphate","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C2781322055","wikidata":"https://www.wikidata.org/wiki/Q423725","display_name":"Phosphoinositide 3-kinase","level":4,"score":0.782766580581665},{"id":"https://openalex.org/C2778308172","wikidata":"https://www.wikidata.org/wiki/Q423565","display_name":"Wortmannin","level":4,"score":0.7746286392211914},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.7682220935821533},{"id":"https://openalex.org/C56928146","wikidata":"https://www.wikidata.org/wiki/Q2934402","display_name":"Calpain","level":3,"score":0.6296589374542236},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5050254464149475},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.47875919938087463},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.4543749988079071},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4422064423561096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4270515739917755},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.41974273324012756},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3889307677745819},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3813340961933136},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37971481680870056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3537176847457886},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33581608533859253},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3211347460746765},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.20431819558143616}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m006533200","doi":"https://doi.org/10.1074/jbc.m006533200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m006533200","pdf_url":"http://www.jbc.org/article/S002192581931703X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11278304","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11278304","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m006533200","doi":"https://doi.org/10.1074/jbc.m006533200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m006533200","pdf_url":"http://www.jbc.org/article/S002192581931703X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104643170.pdf","grobid_xml":"https://content.openalex.org/works/W2104643170.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W8674198","https://openalex.org/W170591362","https://openalex.org/W1496484890","https://openalex.org/W1515371688","https://openalex.org/W1517921781","https://openalex.org/W1525061031","https://openalex.org/W1563546689","https://openalex.org/W1868324460","https://openalex.org/W1885849736","https://openalex.org/W1971547187","https://openalex.org/W1983276056","https://openalex.org/W1984453879","https://openalex.org/W1985684591","https://openalex.org/W1989040424","https://openalex.org/W1997876679","https://openalex.org/W2002127663","https://openalex.org/W2003465766","https://openalex.org/W2008815341","https://openalex.org/W2009976155","https://openalex.org/W2010747804","https://openalex.org/W2019842236","https://openalex.org/W2022832882","https://openalex.org/W2032784006","https://openalex.org/W2034622316","https://openalex.org/W2045618968","https://openalex.org/W2050901966","https://openalex.org/W2051025707","https://openalex.org/W2051337966","https://openalex.org/W2059072734","https://openalex.org/W2066267886","https://openalex.org/W2067000579","https://openalex.org/W2071328955","https://openalex.org/W2072787132","https://openalex.org/W2079873628","https://openalex.org/W2080037386","https://openalex.org/W2084653094","https://openalex.org/W2092502313","https://openalex.org/W2094314261","https://openalex.org/W2100837269","https://openalex.org/W2134242970","https://openalex.org/W2168144016","https://openalex.org/W2182893955","https://openalex.org/W2300221077","https://openalex.org/W2339743264"],"related_works":["https://openalex.org/W1982803897","https://openalex.org/W7042625798","https://openalex.org/W2015996732","https://openalex.org/W2003465766","https://openalex.org/W1976658707","https://openalex.org/W1998708517","https://openalex.org/W2032784006","https://openalex.org/W2048622566","https://openalex.org/W1820235756","https://openalex.org/W2045247714"],"abstract_inverted_index":{"Highly":[0],"purified":[1],"liver":[2,190],"nuclei":[3,15,44,123,150,186],"incorporated":[4],"radiolabeled":[5],"phosphate":[6],"into":[7,55],"phosphatidylinositol":[8],"4-phosphate":[9],"(PtdIns(4)P),":[10],"PtdIns(4,5)P(2),":[11],"and":[12,74,162],"PtdIns(3,4,5)P(3).":[13],"When":[14,120],"were":[16,124],"depleted":[17],"of":[18,23,53,94,105,114,202],"their":[19],"membrane,":[20],"no":[21,36],"radiolabeling":[22],"PtdIns(3,4,5)P(3)":[24],"could":[25,167],"be":[26,168,207],"detected":[27],"showing":[28],"that":[29,111],"within":[30],"the":[31,51,149,158,171,184,188],"intranuclear":[32],"region":[33],"there":[34,192],"are":[35],"class":[37],"I":[38],"phosphoinositide":[39],"3-kinases":[40],"(PI3K)s.":[41],"In":[42],"membrane-depleted":[43,122,185],"harvested":[45,151],"20":[46,98,152],"h":[47,99,153],"after":[48,100,154],"partial":[49,101,155],"hepatectomy,":[50],"incorporation":[52],"radiolabel":[54],"PtdIns(3)P":[56,197],"was":[57,108,144],"observed":[58,112],"together":[59,137],"with":[60,138,148],"an":[61,139,194],"increase":[62,140,163,195],"in":[63,141,164,178,183,196],"immunoprecipitable":[64],"PI3K-C2beta":[65,88,142,165,203],"activity,":[66],"which":[67,205],"is":[68,116,193],"sensitive":[69],"to":[70,126,132],"wortmannin":[71],"(10":[72],"nm)":[73],"shows":[75],"strong":[76],"preference":[77],"for":[78],"PtdIns":[79],"over":[80],"PtdIns(4)P":[81],"as":[82,199],"a":[83,90,200,208],"substrate.":[84],"On":[85],"Western":[86],"blots":[87],"revealed":[89],"single":[91],"immunoreactive":[92],"band":[93],"180":[95],"kDa,":[96],"whereas":[97],"hepatectomy":[102],"gel":[103,135,160],"shift":[104,136,161],"18":[106],"kDa":[107],"noticed,":[109],"suggesting":[110],"activation":[113],"enzyme":[115],"achieved":[117],"by":[118,170],"proteolysis.":[119],"intact":[121],"subjected":[125],"short":[127],"term":[128],"(20":[129],"min)":[130],"exposure":[131],"micro-calpain,":[133],"similar":[134],"activity":[143,166],"observed,":[145],"when":[146],"compared":[147],"hepatectomy.":[156],"Moreover,":[157],"above-mentioned":[159],"prevented":[169],"calpain":[172],"inhibitor":[173],"calpeptin.":[174],"The":[175],"data":[176],"presented":[177],"this":[179],"report":[180],"show":[181],"that,":[182],"during":[187],"compensatory":[189],"growth,":[191],"formation":[198],"result":[201],"activation,":[204],"may":[206],"calpain-mediated":[209],"event.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
