{"id":"https://openalex.org/W2104603012","doi":"https://doi.org/10.1083/jcb.135.5.1249","title":"A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages.","display_name":"A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages.","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W2104603012","doi":"https://doi.org/10.1083/jcb.135.5.1249","mag":"2104603012","pmid":"https://pubmed.ncbi.nlm.nih.gov/8947549","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2121091"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.135.5.1249","doi":"https://doi.org/10.1083/jcb.135.5.1249","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.135.5.1249","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2121091","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036726875","display_name":"Nobukazu Araki","orcid":"https://orcid.org/0000-0001-6160-210X","observed_orcids":["https://orcid.org/0000-0001-6160-210X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Araki","raw_affiliation_strings":["Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M T Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M T Johnson","raw_affiliation_strings":["Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055543052","display_name":"Joel A. Swanson","orcid":"https://orcid.org/0000-0003-0900-8212","observed_orcids":["https://orcid.org/0000-0003-0900-8212"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Swanson","raw_affiliation_strings":["Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":5.2862,"has_fulltext":false,"cited_by_count":958,"citation_normalized_percentile":{"value":0.96670494,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"135","issue":"5","first_page":"1249","last_page":"1260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":1.0},{"id":"https://openalex.org/keywords/macropinocytosis","display_name":"macropinocytosis","score":0.984000027179718},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":1.0},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9890000224113464},{"id":"https://openalex.org/keywords/wortmannin","display_name":"wortmannin","score":0.9089999794960022},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":1.0},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9010000228881836},{"id":"https://openalex.org/keywords/fc-receptors","display_name":"Fc receptors","score":0.6690000295639038},{"id":"https://openalex.org/keywords/macrophage-colony-stimulating-factor","display_name":"macrophage colony-stimulating factor","score":0.8989999890327454},{"id":"https://openalex.org/keywords/pseudopod-extension","display_name":"pseudopod extension","score":0.8679999709129333},{"id":"https://openalex.org/keywords/micropinocytosis","display_name":"micropinocytosis","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C2778308172","wikidata":"https://www.wikidata.org/wiki/Q423565","display_name":"Wortmannin","level":4,"score":0.9549897909164429},{"id":"https://openalex.org/C40017333","wikidata":"https://www.wikidata.org/wiki/Q321362","display_name":"Pinocytosis","level":4,"score":0.8362765312194824},{"id":"https://openalex.org/C38676607","wikidata":"https://www.wikidata.org/wiki/Q6815140","display_name":"Membrane ruffling","level":4,"score":0.8357377052307129},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7835559844970703},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.7388687133789062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7376635670661926},{"id":"https://openalex.org/C199528912","wikidata":"https://www.wikidata.org/wiki/Q165291","display_name":"Pseudopodia","level":3,"score":0.6084831953048706},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.5714552998542786},{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.5351551175117493},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.4826567769050598},{"id":"https://openalex.org/C161478664","wikidata":"https://www.wikidata.org/wiki/Q901955","display_name":"Phagosome","level":3,"score":0.46780088543891907},{"id":"https://openalex.org/C2780245509","wikidata":"https://www.wikidata.org/wiki/Q5023913","display_name":"Calphostin C","level":4,"score":0.4285426139831543},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.4214332401752472},{"id":"https://openalex.org/C2993775838","wikidata":"https://www.wikidata.org/wiki/Q14943002","display_name":"Video microscopy","level":2,"score":0.4208241105079651},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.38179001212120056},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.3046514391899109},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2969842553138733},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.254127562046051},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.21301725506782532},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.16962766647338867},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16825494170188904}],"mesh":[{"descriptor_ui":"D000077191","descriptor_name":"Wortmannin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000730","descriptor_name":"Androstadienes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010588","descriptor_name":"Phagosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010588","descriptor_name":"Phagosomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010873","descriptor_name":"Pinocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015388","descriptor_name":"Organelles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015388","descriptor_name":"Organelles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016173","descriptor_name":"Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1083/jcb.135.5.1249","doi":"https://doi.org/10.1083/jcb.135.5.1249","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.135.5.1249","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2121091","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2121091","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:8947549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8947549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2121091","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2121091","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W32737249","https://openalex.org/W1529396499","https://openalex.org/W1544175192","https://openalex.org/W1557874430","https://openalex.org/W1589063951","https://openalex.org/W1818313483","https://openalex.org/W1915414973","https://openalex.org/W1940165732","https://openalex.org/W1961999388","https://openalex.org/W1981260497","https://openalex.org/W1982304503","https://openalex.org/W1982437598","https://openalex.org/W1989300983","https://openalex.org/W1995402727","https://openalex.org/W2005529016","https://openalex.org/W2010234097","https://openalex.org/W2013131355","https://openalex.org/W2014772845","https://openalex.org/W2031908200","https://openalex.org/W2035033919","https://openalex.org/W2038484123","https://openalex.org/W2043206871","https://openalex.org/W2046974658","https://openalex.org/W2049401036","https://openalex.org/W2063180744","https://openalex.org/W2078564480","https://openalex.org/W2080037386","https://openalex.org/W2086811440","https://openalex.org/W2103642422","https://openalex.org/W2105006553","https://openalex.org/W2108264768","https://openalex.org/W2112417177","https://openalex.org/W2122364201","https://openalex.org/W2145782063","https://openalex.org/W2161827401","https://openalex.org/W2164098579","https://openalex.org/W2172982769","https://openalex.org/W2361081932","https://openalex.org/W4238726741"],"related_works":["https://openalex.org/W2159584083","https://openalex.org/W7100969226","https://openalex.org/W2069957298","https://openalex.org/W2148066376","https://openalex.org/W2188511885","https://openalex.org/W2002905777","https://openalex.org/W7095311739","https://openalex.org/W2801387666","https://openalex.org/W2145355599","https://openalex.org/W2117835384"],"abstract_inverted_index":{"Phosphoinositide":[0],"3-kinase":[1,43,226],"(PI":[2],"3-kinase)":[3],"has":[4],"been":[5],"implicated":[6],"in":[7,46,154,177,185,239],"growth":[8],"factor":[9,137],"signal":[10],"transduction":[11],"and":[12,70,75,118,157,199,244],"vesicular":[13],"membrane":[14],"traffic.":[15],"It":[16],"is":[17,227],"thought":[18],"to":[19,31,143],"mediate":[20],"the":[21,52,55,67,85,144,181,191,204,240],"earliest":[22],"steps":[23],"leading":[24],"from":[25,131,134,217],"ligation":[26],"of":[27,41,54,88,97,162,170,206,233,242],"cell":[28,33,151],"surface":[29,34,152],"receptors":[30,139,142],"increased":[32,158],"ruffling.":[35],"We":[36],"show":[37],"here":[38],"that":[39,109,125,183,224],"inhibitors":[40,68],"PI":[42,225],"inhibit":[44,203],"endocytosis":[45,87,98],"macrophages,":[47],"not":[48,202,228],"by":[49,59,102,128],"interfering":[50],"with":[51,64],"initiation":[53],"process":[56],"but":[57,79,213,236],"rather":[58,237],"preventing":[60],"its":[61],"completion.":[62],"Consistent":[63],"earlier":[65],"studies,":[66],"wortmannin":[69,103,129,198],"LY294002":[71,200],"inhibited":[72],"fluid-phase":[73],"pinocytosis":[74],"Fc":[76,141],"receptor-mediated":[77,86,231],"phagocytosis,":[78],"they":[80],"had":[81],"little":[82],"effect":[83],"on":[84],"diI-labeled,":[89],"acetylated,":[90],"low":[91],"density":[92],"lipoprotein.":[93],"Large":[94],"solute":[95],"probes":[96,106],"reported":[99,173],"greater":[100],"inhibition":[101,127],"than":[104,114],"smaller":[105],"did,":[107],"indicating":[108],"macropinocytosis":[110,117],"was":[111],"affected":[112],"more":[113],"micropinocytosis.":[115],"Since":[116],"phagocytosis":[119],"are":[120],"actin-mediated":[121],"processes,":[122],"we":[123],"expected":[124],"their":[126],"resulted":[130],"deficient":[132],"signaling":[133],"macrophage":[135],"colony-stimulating":[136],"(M-CSF)":[138],"or":[140,164],"actin":[145],"cytoskeleton.":[146],"However,":[147],"video":[148,171],"microscopy":[149],"showed":[150],"ruffling":[153,159,176],"wortmannin-treated":[155,178,186],"cells,":[156],"after":[160],"addition":[161],"M-CSF":[163],"phorbol":[165],"myristate":[166],"acetate.":[167],"Quantitative":[168],"measurements":[169],"data":[172],"slightly":[174],"diminished":[175],"cells.":[179],"Remarkably,":[180],"ruffles":[182],"formed":[184],"macrophages":[187],"all":[188],"receded":[189],"into":[190,195,219,246],"cytoplasm":[192],"without":[193],"closing":[194,218],"macropinosomes.":[196],"Similarly,":[197],"did":[201],"extension":[205],"actin-rich":[207],"pseudopodia":[208],"along":[209],"IgG-opsonized":[210],"sheep":[211],"erythrocytes,":[212],"instead":[214],"prevented":[215],"them":[216],"phagosomes.":[220],"These":[221],"findings":[222],"indicate":[223],"necessary":[229],"for":[230],"stimulation":[232],"pseudopod":[234],"extension,":[235],"functions":[238],"closure":[241],"macropinosomes":[243],"phagosomes":[245],"intracellular":[247],"organelles.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":30},{"year":2021,"cited_by_count":32},{"year":2020,"cited_by_count":39},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":41},{"year":2017,"cited_by_count":35},{"year":2016,"cited_by_count":51},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":50},{"year":2013,"cited_by_count":47},{"year":2012,"cited_by_count":48}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}