{"id":"https://openalex.org/W2104601239","doi":"https://doi.org/10.1038/msb.2012.37","title":"Inferring transcriptional and microRNA\u2010mediated regulatory programs in glioblastoma","display_name":"Inferring transcriptional and microRNA\u2010mediated regulatory programs in glioblastoma","publication_year":2012,"publication_date":"2012-08-28","ids":{"openalex":"https://openalex.org/W2104601239","doi":"https://doi.org/10.1038/msb.2012.37","mag":"2104601239","pmid":"https://pubmed.ncbi.nlm.nih.gov/22929615","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3435504"},"language":"en","primary_location":{"id":"doi:10.1038/msb.2012.37","doi":"https://doi.org/10.1038/msb.2012.37","is_oa":true,"landing_page_url":"https://doi.org/10.1038/msb.2012.37","pdf_url":null,"source":{"id":"https://openalex.org/S200893805","display_name":"Molecular Systems Biology","issn_l":"1744-4292","issn":["1744-4292"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Systems Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/msb.2012.37","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079474436","display_name":"Manu N. Setty","orcid":"https://orcid.org/0000-0002-0344-2627","observed_orcids":["https://orcid.org/0000-0002-0344-2627"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manu Setty","raw_affiliation_strings":["Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006880768","display_name":"Karim Y. Helmy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karim Helmy","raw_affiliation_strings":["Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006360401","display_name":"Aly Azeem Khan","orcid":"https://orcid.org/0000-0003-3933-8538","observed_orcids":["https://orcid.org/0000-0003-3933-8538"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aly A Khan","raw_affiliation_strings":["Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051582267","display_name":"Joachim Silber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joachim Silber","raw_affiliation_strings":["Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043100469","display_name":"Aaron J. Arvey","orcid":"https://orcid.org/0000-0002-8789-0290","observed_orcids":["https://orcid.org/0000-0002-8789-0290"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Arvey","raw_affiliation_strings":["Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073407734","display_name":"Frank Neezen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank Neezen","raw_affiliation_strings":["Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062472063","display_name":"Phaedra Agius","orcid":"https://orcid.org/0000-0002-1688-992X","observed_orcids":["https://orcid.org/0000-0002-1688-992X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phaedra Agius","raw_affiliation_strings":["Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024476694","display_name":"Jason T. Huse","orcid":"https://orcid.org/0000-0003-4514-0640","observed_orcids":["https://orcid.org/0000-0003-4514-0640","https://orcid.org/0000-0003-4933-9120"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason T Huse","raw_affiliation_strings":["Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076104674","display_name":"Eric C. Holland","orcid":"https://orcid.org/0000-0002-3792-7120","observed_orcids":["https://orcid.org/0000-0002-3792-7120"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric C Holland","raw_affiliation_strings":["Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085231879","display_name":"Christina S. Leslie","orcid":"https://orcid.org/0000-0002-4571-5910","observed_orcids":["https://orcid.org/0000-0002-4571-5910"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christina S Leslie","raw_affiliation_strings":["Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085231879"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":{"value":7990,"currency":"USD","value_usd":7990},"fwci":4.0207,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.94743455,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"605","last_page":"605"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.05490000173449516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.04470000043511391,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/regulatory-programs","display_name":"regulatory programs","score":0.6679999828338623},{"id":"https://openalex.org/keywords/microrna-signature","display_name":"microRNA signature","score":0.4699999988079071},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.703000009059906},{"id":"https://openalex.org/keywords/proneural-subtype","display_name":"proneural subtype","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mir-124","display_name":"miR-124","score":0.925000011920929},{"id":"https://openalex.org/keywords/mir-132","display_name":"miR-132","score":1.0},{"id":"https://openalex.org/keywords/neurospheres","display_name":"neurospheres","score":0.9049999713897705},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9207440614700317},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.808020293712616},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5558649301528931},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5435601472854614},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5384829044342041},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5335671901702881},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5315719842910767},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4956263303756714},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48318687081336975},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42655766010284424},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.41775739192962646},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3575909733772278},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.15512481331825256}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/msb.2012.37","doi":"https://doi.org/10.1038/msb.2012.37","is_oa":true,"landing_page_url":"https://doi.org/10.1038/msb.2012.37","pdf_url":null,"source":{"id":"https://openalex.org/S200893805","display_name":"Molecular Systems Biology","issn_l":"1744-4292","issn":["1744-4292"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Systems Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2439859","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3435504","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3435504","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3435504","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Syst Biol","raw_type":"Text"},{"id":"pmid:22929615","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22929615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular systems biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.353.7045","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.353.7045","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.nature.com/msb/journal/v8/n1/pdf/msb201237.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:78aa18a9a4874fceac1d6c85c18a2495","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/78aa18a9a4874fceac1d6c85c18a2495","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Systems Biology, Vol 8, Iss 1, Pp 1-16 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/msb.2012.37","doi":"https://doi.org/10.1038/msb.2012.37","is_oa":true,"landing_page_url":"https://doi.org/10.1038/msb.2012.37","pdf_url":null,"source":{"id":"https://openalex.org/S200893805","display_name":"Molecular Systems Biology","issn_l":"1744-4292","issn":["1744-4292"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3478406037","display_name":"MSKCC Center for Translational Cancer Genomic Analysis","funder_award_id":"U24CA143840","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1497745584","https://openalex.org/W1595665778","https://openalex.org/W1963840676","https://openalex.org/W1968667083","https://openalex.org/W1970998345","https://openalex.org/W1971623350","https://openalex.org/W1977690815","https://openalex.org/W1983922487","https://openalex.org/W1985115576","https://openalex.org/W1990353372","https://openalex.org/W1999553354","https://openalex.org/W2003135941","https://openalex.org/W2006888839","https://openalex.org/W2007771322","https://openalex.org/W2019562165","https://openalex.org/W2019768326","https://openalex.org/W2025183726","https://openalex.org/W2030362521","https://openalex.org/W2031968704","https://openalex.org/W2032313226","https://openalex.org/W2038874091","https://openalex.org/W2039141906","https://openalex.org/W2041509376","https://openalex.org/W2047606645","https://openalex.org/W2049927505","https://openalex.org/W2054578424","https://openalex.org/W2055374775","https://openalex.org/W2059073003","https://openalex.org/W2064316340","https://openalex.org/W2091934374","https://openalex.org/W2094036688","https://openalex.org/W2096139934","https://openalex.org/W2101182085","https://openalex.org/W2102395431","https://openalex.org/W2104610341","https://openalex.org/W2105528101","https://openalex.org/W2105717378","https://openalex.org/W2106120562","https://openalex.org/W2108420379","https://openalex.org/W2110265246","https://openalex.org/W2111969156","https://openalex.org/W2112367847","https://openalex.org/W2113942802","https://openalex.org/W2115155255","https://openalex.org/W2116634113","https://openalex.org/W2118902496","https://openalex.org/W2121625674","https://openalex.org/W2121906867","https://openalex.org/W2124985265","https://openalex.org/W2127207254","https://openalex.org/W2127835459","https://openalex.org/W2127981279","https://openalex.org/W2131403504","https://openalex.org/W2134672574","https://openalex.org/W2135046866","https://openalex.org/W2137020659","https://openalex.org/W2138255346","https://openalex.org/W2141452279","https://openalex.org/W2144710927","https://openalex.org/W2155517982","https://openalex.org/W2157952888","https://openalex.org/W2161272397","https://openalex.org/W2161289668","https://openalex.org/W2161409973","https://openalex.org/W2162995709","https://openalex.org/W2171808845","https://openalex.org/W2247766769","https://openalex.org/W2335712744","https://openalex.org/W2610952855","https://openalex.org/W4232123484","https://openalex.org/W4252676770"],"related_works":["https://openalex.org/W7211388243","https://openalex.org/W2155870863","https://openalex.org/W7097864933","https://openalex.org/W7095663254","https://openalex.org/W3089124863","https://openalex.org/W1988774162","https://openalex.org/W2133559904","https://openalex.org/W4213281646","https://openalex.org/W3090759141","https://openalex.org/W4402945240"],"abstract_inverted_index":{"Large-scale":[0],"cancer":[1,137],"genomics":[2],"projects":[3],"are":[4,27],"profiling":[5],"hundreds":[6],"of":[7,76,125,134],"tumors":[8],"at":[9],"multiple":[10],"molecular":[11,41],"layers,":[12],"including":[13,53],"copy":[14],"number,":[15],"mRNA":[16],"and":[17,64,68,109,120],"miRNA":[18],"expression,":[19],"but":[20],"the":[21,132],"mechanistic":[22],"relationships":[23],"between":[24],"these":[25],"layers":[26],"often":[28],"excluded":[29],"from":[30],"computational":[31],"models.":[32],"We":[33,56,79,102],"developed":[34],"a":[35,98,122],"supervised":[36],"learning":[37],"framework":[38],"for":[39,86],"integrating":[40],"profiles":[42,63],"with":[43,92],"regulatory":[44,49],"sequence":[45],"information":[46],"to":[47,60,141,146],"reveal":[48],"programs":[50],"in":[51,93,97,113,118,136],"cancer,":[52],"miRNA-mediated":[54],"regulation.":[55],"applied":[57],"our":[58],"approach":[59],"320":[61],"glioblastoma":[62],"identified":[65],"key":[66],"miRNAs":[67,135],"transcription":[69],"factors":[70],"as":[71],"common":[72],"or":[73,148],"subtype-specific":[74],"drivers":[75],"expression":[77,84,95,128],"changes.":[78,129],"confirmed":[80],"that":[81],"predicted":[82,105],"gene":[83],"signatures":[85],"proneural":[87,106,114],"subtype":[88,147],"regulators":[89],"were":[90],"consistent":[91],"vivo":[94],"changes":[96],"PDGF-driven":[99],"mouse":[100],"model.":[101],"tested":[103],"two":[104],"drivers,":[107],"miR-124":[108],"miR-132,":[110],"both":[111],"underexpressed":[112],"tumors,":[115],"by":[116],"overexpression":[117],"neurospheres":[119],"observed":[121],"partial":[123],"reversal":[124],"corresponding":[126],"tumor":[127],"Computationally":[130],"dissecting":[131],"role":[133],"may":[138],"ultimately":[139],"lead":[140],"small":[142],"RNA":[143],"therapeutics":[144],"tailored":[145],"individual.":[149]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":10}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
