{"id":"https://openalex.org/W2104589754","doi":"https://doi.org/10.1128/iai.73.1.413-421.2005","title":"Pasteurella multocidaToxin Activates Human Monocyte-Derived and Murine Bone Marrow-Derived Dendritic Cells In Vitro but Suppresses Antibody Production In Vivo","display_name":"Pasteurella multocidaToxin Activates Human Monocyte-Derived and Murine Bone Marrow-Derived Dendritic Cells In Vitro but Suppresses Antibody Production In Vivo","publication_year":2004,"publication_date":"2004-12-23","ids":{"openalex":"https://openalex.org/W2104589754","doi":"https://doi.org/10.1128/iai.73.1.413-421.2005","mag":"2104589754","pmid":"https://pubmed.ncbi.nlm.nih.gov/15618179","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/538973"},"language":"en","primary_location":{"id":"doi:10.1128/iai.73.1.413-421.2005","doi":"https://doi.org/10.1128/iai.73.1.413-421.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.73.1.413-421.2005","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/538973","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074212929","display_name":"Kenneth Bagley","orcid":"https://orcid.org/0000-0002-3967-8279","observed_orcids":["https://orcid.org/0000-0002-3967-8279"]},"institutions":[{"id":"https://openalex.org/I4405261596","display_name":"University of Maryland Biotechnology Institute","ror":"https://ror.org/05j636y43","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405261322","https://openalex.org/I4405261596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth C. Bagley","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology","Division of Vaccine Research, Institute of Human Virology, University of Maryland Biotechnology Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"Division of Vaccine Research, Institute of Human Virology, University of Maryland Biotechnology Institute","institution_ids":["https://openalex.org/I4405261596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058504949","display_name":"Sayed F. Abdelwahab","orcid":"https://orcid.org/0000-0002-9636-7485","observed_orcids":["https://orcid.org/0000-0002-9636-7485"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4405261596","display_name":"University of Maryland Biotechnology Institute","ror":"https://ror.org/05j636y43","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405261322","https://openalex.org/I4405261596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sayed F. Abdelwahab","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Maryland School of Medicine, University of Maryland Baltimore, Baltimore, Maryland","Division of Vaccine Research, Institute of Human Virology, University of Maryland Biotechnology Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Maryland School of Medicine, University of Maryland Baltimore, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Division of Vaccine Research, Institute of Human Virology, University of Maryland Biotechnology Institute","institution_ids":["https://openalex.org/I4405261596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011611520","display_name":"Robert G. Tuskan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405261596","display_name":"University of Maryland Biotechnology Institute","ror":"https://ror.org/05j636y43","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405261322","https://openalex.org/I4405261596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert G. Tuskan","raw_affiliation_strings":["Division of Vaccine Research, Institute of Human Virology, University of Maryland Biotechnology Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vaccine Research, Institute of Human Virology, University of Maryland Biotechnology Institute","institution_ids":["https://openalex.org/I4405261596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040770925","display_name":"George K. Lewis","orcid":"https://orcid.org/0000-0003-4815-2604","observed_orcids":["https://orcid.org/0000-0003-4815-2604"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4405261596","display_name":"University of Maryland Biotechnology Institute","ror":"https://ror.org/05j636y43","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405261322","https://openalex.org/I4405261596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George K. Lewis","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Maryland School of Medicine, University of Maryland Baltimore, Baltimore, Maryland","Division of Vaccine Research, Institute of Human Virology, University of Maryland Biotechnology Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Maryland School of Medicine, University of Maryland Baltimore, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Division of Vaccine Research, Institute of Human Virology, University of Maryland Biotechnology Institute","institution_ids":["https://openalex.org/I4405261596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040770925"],"corresponding_institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4405261596"],"apc_list":null,"apc_paid":null,"fwci":0.9609,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.74540737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"73","issue":"1","first_page":"413","last_page":"421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pasteurella-multocida-toxin","display_name":"Pasteurella multocida toxin","score":0.996999979019165},{"id":"https://openalex.org/keywords/dendritic-cell-activation","display_name":"dendritic cell activation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/monocyte-derived-dendritic-cells","display_name":"monocyte-derived dendritic cells","score":0.9319999814033508},{"id":"https://openalex.org/keywords/bone-marrow-derived-dendritic-cells","display_name":"bone marrow-derived dendritic cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/phospholipase-c-beta","display_name":"phospholipase C beta","score":0.9409999847412109},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.9240000247955322},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cholera-toxin","display_name":"cholera toxin","score":0.7200000286102295},{"id":"https://openalex.org/keywords/mucosal-adjuvant","display_name":"mucosal adjuvant","score":0.8769999742507935},{"id":"https://openalex.org/keywords/alloreactive-t-cells","display_name":"alloreactive T cells","score":0.7820000052452087},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9810000061988831}],"concepts":[{"id":"https://openalex.org/C2777006276","wikidata":"https://www.wikidata.org/wiki/Q83586","display_name":"Cholera toxin","level":2,"score":0.732295572757721},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.72428959608078},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5877166390419006},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5665244460105896},{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.5145013332366943},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.474959135055542},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4475390613079071},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4253224730491638},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4056418538093567},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3126031756401062},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3124050498008728},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.18414700031280518},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0736335813999176},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019284","descriptor_name":"Thapsigargin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/iai.73.1.413-421.2005","doi":"https://doi.org/10.1128/iai.73.1.413-421.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.73.1.413-421.2005","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2001268","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/538973","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:538973","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/538973","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:15618179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15618179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2001268","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/538973","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1333508349","display_name":"INTEGRATED AIDS VACCINE DEVELOPMENT PROGRAM","funder_award_id":"1p01ai043046-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3347139557","display_name":null,"funder_award_id":"AI-38192","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5238303019","display_name":"TARGETED MUCOSAL VACCINES AGAINST HIV 1","funder_award_id":"5r01ai038192-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8420415896","display_name":null,"funder_award_id":"AI 43046","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W282661748","https://openalex.org/W1178845529","https://openalex.org/W1500232132","https://openalex.org/W1516048300","https://openalex.org/W1661544713","https://openalex.org/W1971954477","https://openalex.org/W1977321009","https://openalex.org/W1998296446","https://openalex.org/W2010951807","https://openalex.org/W2022714126","https://openalex.org/W2033500180","https://openalex.org/W2037233457","https://openalex.org/W2038170103","https://openalex.org/W2077546705","https://openalex.org/W2079379520","https://openalex.org/W2092128665","https://openalex.org/W2099378799","https://openalex.org/W2101059261","https://openalex.org/W2101533269","https://openalex.org/W2111010367","https://openalex.org/W2111695773","https://openalex.org/W2124446488","https://openalex.org/W2127254182","https://openalex.org/W2131761283","https://openalex.org/W2143481616","https://openalex.org/W2156359508","https://openalex.org/W2163030089","https://openalex.org/W2166676682","https://openalex.org/W2409909234"],"related_works":["https://openalex.org/W2154469397","https://openalex.org/W2048396934","https://openalex.org/W1581692215","https://openalex.org/W2277814872","https://openalex.org/W1977208499","https://openalex.org/W1581634192","https://openalex.org/W1178845529","https://openalex.org/W4313272545","https://openalex.org/W2164178264","https://openalex.org/W2163109266"],"abstract_inverted_index":{"Pasteurella":[0],"multocida":[1],"toxin":[2,111,139],"(PMT)":[3],"is":[4,25,125],"a":[5,48,62,127],"potent":[6],"mitogen":[7],"for":[8,27,51,148],"fibroblasts":[9],"and":[10,19,46,71,88,115,130],"osteoblastic":[11],"cells.":[12],"PMT":[13,37,56,104,124,149],"activates":[14,57],"phospholipase":[15,69],"C-beta":[16],"through":[17,65],"G(q)alpha,":[18],"the":[20,34,66,95,106,134],"activation":[21,67,77],"of":[22,36,68,74,83,91,97,100,109,137],"this":[23,54],"pathway":[24],"responsible":[26],"its":[28],"mitogenic":[29],"activity.":[30],"Here,":[31],"we":[32,121],"investigated":[33],"effects":[35,108,136,147],"on":[38,112],"human":[39,113],"monocyte-derived":[40],"dendritic":[41,119],"cells":[42,87],"(MDDC)":[43],"in":[44,61,94,140,150,155],"vitro":[45,151],"show":[47],"novel":[49],"activity":[50],"PMT.":[52],"In":[53],"regard,":[55],"MDDC":[58,114],"to":[59,153],"mature":[60],"dose-dependent":[63],"manner":[64],"C":[70],"subsequent":[72],"mobilization":[73],"calcium.":[75],"This":[76],"was":[78],"accompanied":[79],"by":[80],"enhanced":[81],"stimulation":[82],"naive":[84],"alloreactive":[85],"T":[86],"dominant":[89],"inhibition":[90],"interleukin-12":[92],"production":[93],"presence":[96],"saturating":[98],"concentrations":[99],"lipopolysaccharide.":[101],"Surprisingly,":[102],"although":[103],"mimics":[105],"activating":[107],"cholera":[110,138],"mouse":[116],"bone":[117],"marrow-derived":[118],"cells,":[120],"found":[122],"that":[123,131],"not":[126],"mucosal":[128],"adjuvant":[129,135],"it":[132],"suppresses":[133],"mice.":[141],"Together,":[142],"these":[143],"results":[144],"indicate":[145],"discordant":[146],"compared":[152],"those":[154],"vivo.":[156]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}