{"id":"https://openalex.org/W2104582299","doi":"https://doi.org/10.1084/jem.184.1.141","title":"Mechanisms of transactivation by nuclear factor of activated T cells-1.","display_name":"Mechanisms of transactivation by nuclear factor of activated T cells-1.","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W2104582299","doi":"https://doi.org/10.1084/jem.184.1.141","mag":"2104582299","pmid":"https://pubmed.ncbi.nlm.nih.gov/8691127","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2192690"},"language":"en","primary_location":{"id":"doi:10.1084/jem.184.1.141","doi":"https://doi.org/10.1084/jem.184.1.141","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.184.1.141","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2192690","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011786330","display_name":"Chi Luo","orcid":"https://orcid.org/0000-0001-7669-9506","observed_orcids":["https://orcid.org/0000-0001-7669-9506"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Luo","raw_affiliation_strings":["Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037450235","display_name":"Emmanuel Burgeon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Burgeon","raw_affiliation_strings":["Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080472610","display_name":"Anjana Rao","orcid":"https://orcid.org/0000-0002-1870-1775","observed_orcids":["https://orcid.org/0000-0002-1870-1775"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Rao","raw_affiliation_strings":["Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210117453"],"apc_list":null,"apc_paid":null,"fwci":2.9544,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.9239824,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"184","issue":"1","first_page":"141","last_page":"147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nfat1","display_name":"NFAT1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/nfat","display_name":"NFAT","score":0.8610000014305115},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/transactivation-domain","display_name":"transactivation domain","score":0.8420000076293945},{"id":"https://openalex.org/keywords/dna-binding-domain","display_name":"DNA-binding domain","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cytokine-transcription","display_name":"cytokine gene transcription","score":0.9120000004768372},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.8629999756813049},{"id":"https://openalex.org/keywords/transcription-factor-regulation","display_name":"transcription factor regulation","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.9746387600898743},{"id":"https://openalex.org/C189938988","wikidata":"https://www.wikidata.org/wiki/Q24744925","display_name":"NFAT","level":4,"score":0.9627149105072021},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7911535501480103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6768954992294312},{"id":"https://openalex.org/C49805395","wikidata":"https://www.wikidata.org/wiki/Q910966","display_name":"Nuclear localization sequence","level":3,"score":0.558506190776825},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5206586718559265},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49672967195510864},{"id":"https://openalex.org/C33987129","wikidata":"https://www.wikidata.org/wiki/Q13479514","display_name":"DNA-binding domain","level":4,"score":0.45588621497154236},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4476630687713623},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.4246188998222351},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42070814967155457},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050778","descriptor_name":"NFATC Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1084/jem.184.1.141","doi":"https://doi.org/10.1084/jem.184.1.141","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.184.1.141","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2192690","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2192690","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:8691127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8691127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.284.1954","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.284.1954","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/dd/08/J_Exp_Med_1996_Jul_1_184(1)_141-147.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2192690","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2192690","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1876573012","display_name":null,"funder_award_id":"GM-46227","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2684792491","display_name":"SIGNAL TRANSDUCTION AND GENE INDUCTION IN T LYMPHOCYTES","funder_award_id":"R01GM046227","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4021075622","display_name":null,"funder_award_id":"CA-42471","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4413056288","display_name":"Immune Tolerance and Autoimmunity","funder_award_id":"P01AI035297","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1503524848","https://openalex.org/W1517335434","https://openalex.org/W1525008978","https://openalex.org/W1539959872","https://openalex.org/W1586722842","https://openalex.org/W1601157315","https://openalex.org/W1618754640","https://openalex.org/W1772298148","https://openalex.org/W1777502920","https://openalex.org/W1827812119","https://openalex.org/W1876509169","https://openalex.org/W1918266073","https://openalex.org/W1950580345","https://openalex.org/W1973912514","https://openalex.org/W1982756681","https://openalex.org/W1987784311","https://openalex.org/W1994915896","https://openalex.org/W1997806072","https://openalex.org/W2000536954","https://openalex.org/W2002485919","https://openalex.org/W2011738951","https://openalex.org/W2012597218","https://openalex.org/W2026181894","https://openalex.org/W2029954359","https://openalex.org/W2039766781","https://openalex.org/W2047198875","https://openalex.org/W2049462460","https://openalex.org/W2051237803","https://openalex.org/W2059195281","https://openalex.org/W2059556539","https://openalex.org/W2061029168","https://openalex.org/W2068716929","https://openalex.org/W2082961684","https://openalex.org/W2083692829","https://openalex.org/W2092306121","https://openalex.org/W2112278496","https://openalex.org/W2126891333","https://openalex.org/W2131656392","https://openalex.org/W2137407985","https://openalex.org/W2167361504"],"related_works":["https://openalex.org/W7100043575","https://openalex.org/W2140707292","https://openalex.org/W2089500589","https://openalex.org/W2517268828","https://openalex.org/W2061029168","https://openalex.org/W1654064109","https://openalex.org/W1494629114","https://openalex.org/W7095980566","https://openalex.org/W2165948633","https://openalex.org/W2162950294"],"abstract_inverted_index":{"Nuclear":[0],"factor":[1],"of":[2,19,34,62,75,78,83,126],"activated":[3],"T":[4],"cells-family":[5],"proteins":[6],"(NFAT1/NFATp,":[7],"NFATc,":[8],"NFAT3,":[9],"and":[10,22,53,119],"NFAT4/NFATx/NFATc3)":[11],"play":[12],"a":[13,54],"key":[14],"role":[15],"in":[16,48,72,103,123],"the":[17,26,32,49,60,73,79,84,104,110,124],"transcription":[18,65,128],"cytokine":[20],"genes":[21,24],"other":[23,50,76],"during":[25],"immune":[27],"response.":[28],"We":[29],"have":[30],"defined":[31],"mechanisms":[33],"transactivation":[35,41,86,116],"by":[36,90],"NFAT1.":[37],"NFAT1":[38],"possesses":[39],"two":[40],"domains":[42],"whose":[43],"sequences":[44],"are":[45],"not":[46],"conserved":[47,55,98],"NFAT-family":[51,132],"proteins,":[52],"DNA-binding":[56],"domain":[57,87],"that":[58,95],"mediates":[59],"recruitment":[61],"cooperating":[63],"nuclear":[64],"factors":[66],"even":[67],"when":[68],"it":[69],"is":[70,88,117],"expressed":[71],"absence":[74],"regions":[77],"protein.":[80],"The":[81],"activity":[82],"NH2-terminal":[85],"modulated":[89],"an":[91],"adjacent":[92],"regulatory":[93],"region":[94],"contains":[96],"several":[97],"sequence":[99],"motifs":[100],"represented":[101],"only":[102],"NFAT":[105],"family.":[106],"Our":[107],"results":[108],"emphasize":[109],"multiple":[111],"levels":[112],"at":[113],"which":[114],"NFAT-dependent":[115],"regulated,":[118],"predict":[120],"significant":[121],"differences":[122],"architecture":[125],"cooperative":[127],"complexes":[129],"containing":[130],"different":[131],"proteins.":[133]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
