{"id":"https://openalex.org/W2104385249","doi":"https://doi.org/10.1099/mic.0.070409-0","title":"A secreted Plasmodium falciparum kinase reveals a signature motif for classification of tyrosine kinase-like kinases","display_name":"A secreted Plasmodium falciparum kinase reveals a signature motif for classification of tyrosine kinase-like kinases","publication_year":2013,"publication_date":"2013-09-18","ids":{"openalex":"https://openalex.org/W2104385249","doi":"https://doi.org/10.1099/mic.0.070409-0","mag":"2104385249","pmid":"https://pubmed.ncbi.nlm.nih.gov/24045796"},"language":"en","primary_location":{"id":"doi:10.1099/mic.0.070409-0","doi":"https://doi.org/10.1099/mic.0.070409-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/mic.0.070409-0","pdf_url":null,"source":{"id":"https://openalex.org/S196799759","display_name":"Microbiology","issn_l":"1350-0872","issn":["1350-0872","1465-2080"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019859396","display_name":"Abdirahman I. Abdi","orcid":"https://orcid.org/0000-0001-7989-2125","observed_orcids":["https://orcid.org/0000-0001-7989-2125"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2841861","display_name":"Kenya Medical Research Institute","ror":"https://ror.org/04r1cxt79","country_code":"KE","type":"facility","lineage":["https://openalex.org/I2841861"]},{"id":"https://openalex.org/I4210094430","display_name":"Wellcome Centre for Molecular Parasitology","ror":"https://ror.org/00m7w8s72","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210094430","https://openalex.org/I7882870","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I4405267625","display_name":"KEMRI-Wellcome Trust Research Programme","ror":"https://ror.org/03my81p15","country_code":"KE","type":"facility","lineage":["https://openalex.org/I2841861","https://openalex.org/I40120149","https://openalex.org/I4405267625","https://openalex.org/I87048295"]}],"countries":["FR","GB","KE"],"is_corresponding":false,"raw_author_name":"Abdirahman I. Abdi","raw_affiliation_strings":["INSERM U609, Wellcome Trust Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, Scotland, UK","KEMRI-Wellcome Trust Research Programme, PO Box 230-80108, Kilifi, Kenya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U609, Wellcome Trust Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, Scotland, UK","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210094430"]},{"raw_affiliation_string":"KEMRI-Wellcome Trust Research Programme, PO Box 230-80108, Kilifi, Kenya","institution_ids":["https://openalex.org/I2841861","https://openalex.org/I4405267625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057721040","display_name":"Teresa Gil Carvalho","orcid":"https://orcid.org/0000-0002-4947-371X","observed_orcids":["https://orcid.org/0000-0002-4947-371X"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Teresa G. Carvalho","raw_affiliation_strings":["Department of Microbiology, Monash University, Wellington Road, Clayton, VIC 3800, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Monash University, Wellington Road, Clayton, VIC 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020710336","display_name":"Jonathan Wilkes","orcid":"https://orcid.org/0000-0002-0920-6967","observed_orcids":["https://orcid.org/0000-0002-0920-6967"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210094430","display_name":"Wellcome Centre for Molecular Parasitology","ror":"https://ror.org/00m7w8s72","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210094430","https://openalex.org/I7882870","https://openalex.org/I87048295"]}],"countries":["FR","GB"],"is_corresponding":false,"raw_author_name":"Jonathan M. Wilkes","raw_affiliation_strings":["INSERM U609, Wellcome Trust Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U609, Wellcome Trust Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, Scotland, UK","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210094430"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047644295","display_name":"Christian Doerig","orcid":"https://orcid.org/0000-0002-3188-094X","observed_orcids":["https://orcid.org/0000-0002-3188-094X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210094430","display_name":"Wellcome Centre for Molecular Parasitology","ror":"https://ror.org/00m7w8s72","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210094430","https://openalex.org/I7882870","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU","FR","GB"],"is_corresponding":false,"raw_author_name":"Christian Doerig","raw_affiliation_strings":["Department of Microbiology, Monash University, Wellington Road, Clayton, VIC 3800, Australia","INSERM U609, Wellcome Trust Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Monash University, Wellington Road, Clayton, VIC 3800, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"INSERM U609, Wellcome Trust Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, Scotland, UK","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210094430"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2589,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.91544154,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"159","issue":"Pt_12","first_page":"2533","last_page":"2547"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12178","display_name":"Bird parasitology and diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9990000128746033},{"id":"https://openalex.org/keywords/conserved-motifs","display_name":"conserved motifs","score":0.8629999756813049},{"id":"https://openalex.org/keywords/gametocytes","display_name":"gametocytes","score":0.7110000252723694},{"id":"https://openalex.org/keywords/extracellular-proteome","display_name":"extracellular proteome","score":0.824999988079071},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/host-parasite-interactions","display_name":"host-parasite interactions","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7976222038269043},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6196978688240051},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.6114388704299927},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.536615252494812},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5044845342636108},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4749367833137512},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34671732783317566},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3279484510421753},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2723451554775238},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10843238234519958},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1099/mic.0.070409-0","doi":"https://doi.org/10.1099/mic.0.070409-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/mic.0.070409-0","pdf_url":null,"source":{"id":"https://openalex.org/S196799759","display_name":"Microbiology","issn_l":"1350-0872","issn":["1350-0872","1465-2080"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},{"id":"pmid:24045796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24045796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology (Reading, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306133","display_name":"Burroughs Wellcome Fund","ror":"https://ror.org/01d35cw23"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W121555879","https://openalex.org/W1491616831","https://openalex.org/W1765013689","https://openalex.org/W1930237957","https://openalex.org/W1969627566","https://openalex.org/W1970170374","https://openalex.org/W1973460380","https://openalex.org/W1975706324","https://openalex.org/W1976822936","https://openalex.org/W1989742444","https://openalex.org/W1998855105","https://openalex.org/W2005924825","https://openalex.org/W2011129915","https://openalex.org/W2013205499","https://openalex.org/W2025928231","https://openalex.org/W2029600177","https://openalex.org/W2030618676","https://openalex.org/W2033320490","https://openalex.org/W2039109795","https://openalex.org/W2043633262","https://openalex.org/W2043981380","https://openalex.org/W2047667092","https://openalex.org/W2050455405","https://openalex.org/W2055086185","https://openalex.org/W2060913542","https://openalex.org/W2064649157","https://openalex.org/W2064830352","https://openalex.org/W2065262396","https://openalex.org/W2068307748","https://openalex.org/W2070272438","https://openalex.org/W2070760552","https://openalex.org/W2074004956","https://openalex.org/W2081358587","https://openalex.org/W2081598713","https://openalex.org/W2085017982","https://openalex.org/W2101664493","https://openalex.org/W2106232004","https://openalex.org/W2111666869","https://openalex.org/W2114491401","https://openalex.org/W2114520383","https://openalex.org/W2115585343","https://openalex.org/W2121777449","https://openalex.org/W2125121305","https://openalex.org/W2132376143","https://openalex.org/W2133347001","https://openalex.org/W2133892659","https://openalex.org/W2142867136","https://openalex.org/W2145819332","https://openalex.org/W2151831732","https://openalex.org/W2151993654","https://openalex.org/W2152301430","https://openalex.org/W2160891320","https://openalex.org/W2162700421","https://openalex.org/W2170471837","https://openalex.org/W2188779778","https://openalex.org/W2396929981","https://openalex.org/W4234715488","https://openalex.org/W6712066020"],"related_works":["https://openalex.org/W2005924825","https://openalex.org/W2947779124","https://openalex.org/W7097331827","https://openalex.org/W4393368919","https://openalex.org/W2954944521","https://openalex.org/W2766836198","https://openalex.org/W1490785745","https://openalex.org/W2033931764","https://openalex.org/W2254318272","https://openalex.org/W7100543800"],"abstract_inverted_index":{"Thorough":[0],"bioinformatic":[1],"and":[2,73,97,100,155],"phylogenetic":[3],"analyses":[4],"of":[5,18,54,82,126,130,146,149],"Plasmodium":[6],"falciparum":[7],"tyrosine":[8],"kinase-like":[9],"kinase":[10,27,29,105],"(TKL)":[11],"sequences":[12],"revealed":[13],"a":[14,35,62,123],"clear":[15],"evolutionary":[16],"relationship":[17],"PF3D7_1121300":[19],"(thereafter":[20],"called":[21],"PfTKL2)":[22],"to":[23,42,113,158],"the":[24,67,80,101,114,127,140,144,150,159,176],"IL-1":[25],"receptor-associated":[26],"(IRAK)/receptor-like":[28],"(RLK)/Pelle":[30],"protein":[31,89,110],"family.":[32],"We":[33],"identified":[34],"novel":[36],"conserved":[37],"motif":[38],"that":[39,64,135,164],"is":[40,90,111,137],"unique":[41],"this":[43],"family,":[44],"as":[45,47],"well":[46],"an":[48,169],"insertion":[49],"whose":[50],"length":[51],"allows":[52],"distribution":[53],"its":[55,156],"members":[56,148],"into":[57,139],"two":[58],"distinct":[59],"subfamilies,":[60],"in":[61,84,93,98,107,118,153,175],"way":[63],"matches":[65],"exactly":[66],"dichotomy":[68],"between":[69],"'Tube/Tube-like":[70],"kinases'":[71,75],"(TTLKs)":[72],"'Pelle-like":[74],"(PLKs)":[76],"distinguished":[77],"previously":[78],"on":[79],"basis":[81],"features":[83],"accessory":[85],"domains.":[86],"The":[87,109],"PfTKL2":[88,136,165],"expressed":[91],"ubiquitously":[92],"asexual":[94],"blood":[95],"stages":[96],"gametocytes,":[99],"recombinant":[102],"enzyme":[103],"displays":[104],"activity":[106],"vitro.":[108],"exported":[112],"host":[115],"erythrocyte;":[116],"furthermore,":[117],"accordance":[119],"with":[120],"data":[121],"from":[122],"previous":[124],"study":[125],"extracellular":[128,160],"proteome":[129],"Plasmodium-infected":[131],"erythrocytes,":[132],"we":[133,162],"show":[134],"secreted":[138],"culture":[141],"medium.":[142],"Considering":[143],"functions":[145,166],"other":[147],"RLK/Pelle":[151],"family":[152],"immunity,":[154],"secretion":[157],"medium,":[161],"speculate":[163],"may":[167],"include":[168],"immunomodulatory":[170],"role":[171],"promoting":[172],"parasite":[173],"survival":[174],"human":[177],"host.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}