{"id":"https://openalex.org/W2104376129","doi":"https://doi.org/10.1126/scitranslmed.3002132","title":"NEW: Network-Enabled Wisdom in Biology, Medicine, and Health Care","display_name":"NEW: Network-Enabled Wisdom in Biology, Medicine, and Health Care","publication_year":2012,"publication_date":"2012-01-04","ids":{"openalex":"https://openalex.org/W2104376129","doi":"https://doi.org/10.1126/scitranslmed.3002132","mag":"2104376129","pmid":"https://pubmed.ncbi.nlm.nih.gov/22218693"},"language":"en","primary_location":{"id":"doi:10.1126/scitranslmed.3002132","doi":"https://doi.org/10.1126/scitranslmed.3002132","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.3002132","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071946434","display_name":"Eric E. Schadt","orcid":"https://orcid.org/0000-0002-7892-8808","observed_orcids":["https://orcid.org/0000-0002-7892-8808"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric E. Schadt","raw_affiliation_strings":["Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067811406","display_name":"Johan Bj\u00f6rkegren","orcid":"https://orcid.org/0000-0003-1945-7425","observed_orcids":["https://orcid.org/0000-0003-1945-7425"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210164082","display_name":"Clinical Gene Networks (Sweden)","ror":"https://ror.org/05tfzsp63","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210164082"]},{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE","SE"],"is_corresponding":true,"raw_author_name":"Johan L. M. Bj\u00f6rkegren","raw_affiliation_strings":["Cardiovascular Genomics, Vascular Biology Division, Department of Medical Biophysics and Biochemistry, Karolinska Institutet, 171 77 Stockholm, Sweden","Clinical Gene Networks AB, Karolinska Science Park, 171 77 Stockholm, Sweden","Department of Pathological Anatomy and Forensic Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Genomics, Vascular Biology Division, Department of Medical Biophysics and Biochemistry, Karolinska Institutet, 171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Clinical Gene Networks AB, Karolinska Science Park, 171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I4210164082"]},{"raw_affiliation_string":"Department of Pathological Anatomy and Forensic Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia","institution_ids":["https://openalex.org/I56085075"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5067811406"],"corresponding_institution_ids":["https://openalex.org/I28166907","https://openalex.org/I4210164082","https://openalex.org/I56085075"],"apc_list":null,"apc_paid":null,"fwci":1.8944,"has_fulltext":false,"cited_by_count":131,"citation_normalized_percentile":{"value":0.88969477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"4","issue":"115","first_page":"115rv1","last_page":"115rv1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-networks","display_name":"molecular networks","score":0.9729999899864197},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.875},{"id":"https://openalex.org/keywords/systems-biology","display_name":"systems biology","score":0.6069999933242798},{"id":"https://openalex.org/keywords/disease-pathology","display_name":"disease pathology","score":0.30799999833106995},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.43799999356269836},{"id":"https://openalex.org/keywords/preventive-care","display_name":"preventive medicine","score":0.7749999761581421},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.8429999947547913},{"id":"https://openalex.org/keywords/knowledge-extraction","display_name":"knowledge extraction","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.5897389650344849},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5791472792625427},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.5179118514060974},{"id":"https://openalex.org/C36415437","wikidata":"https://www.wikidata.org/wiki/Q7663871","display_name":"Systems medicine","level":3,"score":0.5040237307548523},{"id":"https://openalex.org/C162264550","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Translational medicine","level":2,"score":0.4919257164001465},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4812321662902832},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4542856216430664},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.42055544257164},{"id":"https://openalex.org/C2986265897","wikidata":"https://www.wikidata.org/wiki/Q23852","display_name":"Human physiology","level":2,"score":0.4174261689186096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3727143406867981},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3647901713848114},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33233773708343506},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.30971795320510864},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18327948451042175},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.09282875061035156},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017048","descriptor_name":"Health Care Costs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017048","descriptor_name":"Health Care Costs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017048","descriptor_name":"Health Care Costs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/scitranslmed.3002132","doi":"https://doi.org/10.1126/scitranslmed.3002132","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.3002132","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},{"id":"pmid:22218693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22218693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science translational medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1967392853","https://openalex.org/W1969296365","https://openalex.org/W1984783889","https://openalex.org/W2008599922","https://openalex.org/W2018545641","https://openalex.org/W2023116290","https://openalex.org/W2025497985","https://openalex.org/W2028197440","https://openalex.org/W2043842514","https://openalex.org/W2047031939","https://openalex.org/W2053611563","https://openalex.org/W2054146128","https://openalex.org/W2056014573","https://openalex.org/W2059844749","https://openalex.org/W2062018774","https://openalex.org/W2067245109","https://openalex.org/W2080460005","https://openalex.org/W2090808827","https://openalex.org/W2091901410","https://openalex.org/W2101037833","https://openalex.org/W2103237492","https://openalex.org/W2118308505","https://openalex.org/W2118745042","https://openalex.org/W2127298691","https://openalex.org/W2134800079","https://openalex.org/W2140079333","https://openalex.org/W2140247552","https://openalex.org/W2157612734","https://openalex.org/W2158375738","https://openalex.org/W2159088440","https://openalex.org/W2161503382","https://openalex.org/W2162765154","https://openalex.org/W2163480486","https://openalex.org/W2165796078","https://openalex.org/W2165937624","https://openalex.org/W2167638767","https://openalex.org/W2168312688","https://openalex.org/W2168790777","https://openalex.org/W2169035256","https://openalex.org/W2187181884","https://openalex.org/W2409738909"],"related_works":["https://openalex.org/W2977132082","https://openalex.org/W2939387356","https://openalex.org/W4362467570","https://openalex.org/W2323902874","https://openalex.org/W3155062071","https://openalex.org/W2284542811","https://openalex.org/W3197989168","https://openalex.org/W2597666696","https://openalex.org/W7070186552","https://openalex.org/W2440703170"],"abstract_inverted_index":{"Complete":[0],"repertoires":[1],"of":[2,25,31,39,47,66,97],"molecular":[3,90],"activity":[4],"in":[5,56,101],"and":[6,33,49,69,76,103,107],"between":[7],"tissues":[8],"provided":[9],"by":[10],"new":[11,99],"high-dimensional":[12],"\"omics\"":[13],"technologies":[14],"hold":[15],"great":[16],"promise":[17],"for":[18],"characterizing":[19],"human":[20],"physiology":[21],"at":[22,36],"all":[23,58],"levels":[24],"biological":[26],"hierarchies.":[27],"The":[28,53],"combined":[29],"effects":[30],"genetic":[32],"environmental":[34],"perturbations":[35],"any":[37],"level":[38],"these":[40],"hierarchies":[41],"can":[42,81],"lead":[43],"to":[44,94,105],"vicious":[45],"cycles":[46],"pathology":[48],"complex":[50],"systemic":[51],"diseases.":[52],"challenge":[54],"lies":[55],"extracting":[57],"relevant":[59],"information":[60,72],"from":[61],"the":[62,95],"rapidly":[63],"increasing":[64],"volumes":[65],"omics":[67],"data":[68],"translating":[70],"this":[71,98],"first":[73],"into":[74,78],"knowledge":[75],"ultimately":[77],"wisdom":[79],"that":[80],"yield":[82],"clinically":[83],"actionable":[84],"results.":[85],"Here,":[86],"we":[87],"discuss":[88],"how":[89],"networks":[91],"are":[92],"central":[93],"implementation":[96],"biology":[100],"medicine":[102],"translation":[104],"preventive":[106],"personalized":[108],"health":[109],"care.":[110]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":14}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
