{"id":"https://openalex.org/W2104373322","doi":"https://doi.org/10.1074/jbc.m002466200","title":"Indirubins Inhibit Glycogen Synthase Kinase-3\u03b2 and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease","display_name":"Indirubins Inhibit Glycogen Synthase Kinase-3\u03b2 and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2104373322","doi":"https://doi.org/10.1074/jbc.m002466200","mag":"2104373322","pmid":"https://pubmed.ncbi.nlm.nih.gov/11013232"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m002466200","doi":"https://doi.org/10.1074/jbc.m002466200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m002466200","pdf_url":"http://www.jbc.org/article/S0021925818442329/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925818442329/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064088755","display_name":"Sophie Leclerc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2802436875","display_name":"Station Biologique de Roscoff","ror":"https://ror.org/03s0pzj56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2802436875","https://openalex.org/I39804081","https://openalex.org/I4210107625"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie Leclerc","raw_affiliation_strings":["CNRS, Cell Cycle Group, Station Biologique, BP 74, Roscoff 29682 Cedex, Bretagne, France","\u2021CNRS, Cell Cycle Group, Station Biologique, BP 74, Roscoff 29682 Cedex, Bretagne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, Cell Cycle Group, Station Biologique, BP 74, Roscoff 29682 Cedex, Bretagne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2802436875"]},{"raw_affiliation_string":"\u2021CNRS, Cell Cycle Group, Station Biologique, BP 74, Roscoff 29682 Cedex, Bretagne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2802436875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000794199","display_name":"Matthieu Garnier","orcid":"https://orcid.org/0000-0001-7391-547X","observed_orcids":["https://orcid.org/0000-0001-7391-547X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2802436875","display_name":"Station Biologique de Roscoff","ror":"https://ror.org/03s0pzj56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2802436875","https://openalex.org/I39804081","https://openalex.org/I4210107625"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Matthieu Garnier","raw_affiliation_strings":["\u2021CNRS, Cell Cycle Group, Station Biologique, BP 74, Roscoff 29682 Cedex, Bretagne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021CNRS, Cell Cycle Group, Station Biologique, BP 74, Roscoff 29682 Cedex, Bretagne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2802436875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048921841","display_name":"Ralph Hoessel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153267046","display_name":"University of Kaiserslautern","ror":"https://ror.org/04zrf7b53","country_code":"DE","type":"education","lineage":["https://openalex.org/I153267046","https://openalex.org/I4387152675"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralph Hoessel","raw_affiliation_strings":["\u00a7Department of Chemistry, Division of Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Erwin-Schro\u0308dinger-Strasse 52, Kaiserslautern 67663, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Department of Chemistry, Division of Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Erwin-Schro\u0308dinger-Strasse 52, Kaiserslautern 67663, Germany","institution_ids":["https://openalex.org/I153267046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039475936","display_name":"Doris Marko","orcid":"https://orcid.org/0000-0001-6568-2944","observed_orcids":["https://orcid.org/0000-0001-6568-2944"]},"institutions":[{"id":"https://openalex.org/I153267046","display_name":"University of Kaiserslautern","ror":"https://ror.org/04zrf7b53","country_code":"DE","type":"education","lineage":["https://openalex.org/I153267046","https://openalex.org/I4387152675"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Doris Marko","raw_affiliation_strings":["\u00a7Department of Chemistry, Division of Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Erwin-Schro\u0308dinger-Strasse 52, Kaiserslautern 67663, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Department of Chemistry, Division of Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Erwin-Schro\u0308dinger-Strasse 52, Kaiserslautern 67663, Germany","institution_ids":["https://openalex.org/I153267046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012045039","display_name":"James A. Bibb","orcid":"https://orcid.org/0000-0002-4148-7770","observed_orcids":["https://orcid.org/0000-0002-4148-7770"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Bibb","raw_affiliation_strings":["\u00b6Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021","\u00b6 Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00b6Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"\u00b6 Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061501049","display_name":"Gretchen L. Snyder","orcid":"https://orcid.org/0000-0003-4749-686X","observed_orcids":["https://orcid.org/0000-0003-4749-686X"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gretchen L. Snyder","raw_affiliation_strings":["\u00b6Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021","\u00b6 Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00b6Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"\u00b6 Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052825834","display_name":"Paul Greengard","orcid":"https://orcid.org/0000-0002-4437-0893","observed_orcids":["https://orcid.org/0000-0002-4437-0893"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Greengard","raw_affiliation_strings":["\u00b6Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021","\u00b6 Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00b6Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"\u00b6 Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051485155","display_name":"Jacek Biernat","orcid":"https://orcid.org/0000-0003-4237-3975","observed_orcids":["https://orcid.org/0000-0003-4237-3975"]},"institutions":[{"id":"https://openalex.org/I4210163743","display_name":"Max Planck Unit for Structural Molecular Biology","ror":"https://ror.org/01qecd649","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210163743"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jacek Biernat","raw_affiliation_strings":["\u2016Max-Planck Unit for Structural Molecular Biology, Notkestrasse 85, Hamburg D-22603, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2016Max-Planck Unit for Structural Molecular Biology, Notkestrasse 85, Hamburg D-22603, Germany","institution_ids":["https://openalex.org/I4210163743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110198276","display_name":"Yong\u2010Zhong Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163743","display_name":"Max Planck Unit for Structural Molecular Biology","ror":"https://ror.org/01qecd649","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210163743"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yong-Zhong Wu","raw_affiliation_strings":["\u2016Max-Planck Unit for Structural Molecular Biology, Notkestrasse 85, Hamburg D-22603, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2016Max-Planck Unit for Structural Molecular Biology, Notkestrasse 85, Hamburg D-22603, Germany","institution_ids":["https://openalex.org/I4210163743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003261774","display_name":"Eva\u2010Maria Mandelkow","orcid":"https://orcid.org/0000-0002-7715-4038","observed_orcids":["https://orcid.org/0000-0002-7715-4038"]},"institutions":[{"id":"https://openalex.org/I4210163743","display_name":"Max Planck Unit for Structural Molecular Biology","ror":"https://ror.org/01qecd649","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210163743"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eva-Maria Mandelkow","raw_affiliation_strings":["\u2016Max-Planck Unit for Structural Molecular Biology, Notkestrasse 85, Hamburg D-22603, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2016Max-Planck Unit for Structural Molecular Biology, Notkestrasse 85, Hamburg D-22603, Germany","institution_ids":["https://openalex.org/I4210163743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019657169","display_name":"Gerhard Eisenbrand","orcid":"https://orcid.org/0000-0003-4079-2463","observed_orcids":["https://orcid.org/0000-0003-4079-2463"]},"institutions":[{"id":"https://openalex.org/I153267046","display_name":"University of Kaiserslautern","ror":"https://ror.org/04zrf7b53","country_code":"DE","type":"education","lineage":["https://openalex.org/I153267046","https://openalex.org/I4387152675"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerhard Eisenbrand","raw_affiliation_strings":["\u00a7Department of Chemistry, Division of Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Erwin-Schro\u0308dinger-Strasse 52, Kaiserslautern 67663, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Department of Chemistry, Division of Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Erwin-Schro\u0308dinger-Strasse 52, Kaiserslautern 67663, Germany","institution_ids":["https://openalex.org/I153267046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012532551","display_name":"Laurent Meijer","orcid":"https://orcid.org/0000-0003-3511-4916","observed_orcids":["https://orcid.org/0000-0003-3511-4916"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2802436875","display_name":"Station Biologique de Roscoff","ror":"https://ror.org/03s0pzj56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2802436875","https://openalex.org/I39804081","https://openalex.org/I4210107625"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Laurent Meijer","raw_affiliation_strings":["\u2021CNRS, Cell Cycle Group, Station Biologique, BP 74, Roscoff 29682 Cedex, Bretagne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021CNRS, Cell Cycle Group, Station Biologique, BP 74, Roscoff 29682 Cedex, Bretagne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2802436875"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5012532551"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2802436875"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":20.8174,"has_fulltext":true,"cited_by_count":723,"citation_normalized_percentile":{"value":0.99753228,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"276","issue":"1","first_page":"251","last_page":"260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/indirubin","display_name":"indirubin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3beta","display_name":"glycogen synthase kinase-3\u03b2","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cdk5-p25","display_name":"CDK5/p25","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/indirubin-3-monoxime","display_name":"indirubin-3'-monoxime","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.6869999766349792},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8149999976158142},{"id":"https://openalex.org/keywords/atp-binding-site","display_name":"ATP binding site","score":0.8679999709129333},{"id":"https://openalex.org/keywords/darpp-32-phosphorylation","display_name":"DARPP-32 phosphorylation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.6610000133514404},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7120000123977661},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.8660804033279419},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.7341818809509277},{"id":"https://openalex.org/C121738310","wikidata":"https://www.wikidata.org/wiki/Q18248262","display_name":"Cyclin-dependent kinase 5","level":5,"score":0.734180212020874},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7026587724685669},{"id":"https://openalex.org/C192118531","wikidata":"https://www.wikidata.org/wiki/Q86360001","display_name":"Glycogen synthase","level":3,"score":0.6654496192932129},{"id":"https://openalex.org/C104629339","wikidata":"https://www.wikidata.org/wiki/Q18258585","display_name":"GSK3B","level":4,"score":0.6447209119796753},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40707671642303467},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4062589108943939},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3443443775177002},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.34317296743392944},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3381812870502472},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.2921515703201294}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010769","descriptor_name":"Phosphothreonine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010769","descriptor_name":"Phosphothreonine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010769","descriptor_name":"Phosphothreonine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010769","descriptor_name":"Phosphothreonine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010769","descriptor_name":"Phosphothreonine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010769","descriptor_name":"Phosphothreonine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016203","descriptor_name":"CDC2 Protein Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016203","descriptor_name":"CDC2 Protein Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016203","descriptor_name":"CDC2 Protein Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016203","descriptor_name":"CDC2 Protein Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016203","descriptor_name":"CDC2 Protein Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016203","descriptor_name":"CDC2 Protein Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019926","descriptor_name":"Cyclin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019926","descriptor_name":"Cyclin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019926","descriptor_name":"Cyclin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038341","descriptor_name":"Glycogen Synthase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038341","descriptor_name":"Glycogen Synthase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038341","descriptor_name":"Glycogen Synthase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051360","descriptor_name":"Cyclin-Dependent Kinase 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051360","descriptor_name":"Cyclin-Dependent Kinase 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051360","descriptor_name":"Cyclin-Dependent Kinase 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051937","descriptor_name":"Dopamine and cAMP-Regulated Phosphoprotein 32","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051937","descriptor_name":"Dopamine and cAMP-Regulated Phosphoprotein 32","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051937","descriptor_name":"Dopamine and cAMP-Regulated Phosphoprotein 32","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m002466200","doi":"https://doi.org/10.1074/jbc.m002466200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m002466200","pdf_url":"http://www.jbc.org/article/S0021925818442329/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11013232","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11013232","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m002466200","doi":"https://doi.org/10.1074/jbc.m002466200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m002466200","pdf_url":"http://www.jbc.org/article/S0021925818442329/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6899999976158142,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1114593466","display_name":null,"funder_award_id":"MH40899","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G5013558822","display_name":null,"funder_award_id":"DA10044","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G8761702540","display_name":null,"funder_award_id":"DQ10044","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G8992209014","display_name":null,"funder_award_id":"MH40899","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320309749","display_name":"Association pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104373322.pdf","grobid_xml":"https://content.openalex.org/works/W2104373322.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W66135227","https://openalex.org/W93514313","https://openalex.org/W97735725","https://openalex.org/W160598539","https://openalex.org/W243593085","https://openalex.org/W359648384","https://openalex.org/W1481663693","https://openalex.org/W1519847602","https://openalex.org/W1540390830","https://openalex.org/W1545201063","https://openalex.org/W1557240175","https://openalex.org/W1563116834","https://openalex.org/W1608295855","https://openalex.org/W1681161665","https://openalex.org/W1777669545","https://openalex.org/W1875580551","https://openalex.org/W1897439129","https://openalex.org/W1919908042","https://openalex.org/W1973141139","https://openalex.org/W1975321314","https://openalex.org/W1978046076","https://openalex.org/W1981631621","https://openalex.org/W1987341255","https://openalex.org/W1989208574","https://openalex.org/W1990922641","https://openalex.org/W1995650022","https://openalex.org/W1999319877","https://openalex.org/W1999328200","https://openalex.org/W2006718453","https://openalex.org/W2012039807","https://openalex.org/W2014898742","https://openalex.org/W2016552601","https://openalex.org/W2019267771","https://openalex.org/W2023578861","https://openalex.org/W2037894077","https://openalex.org/W2038073573","https://openalex.org/W2039468514","https://openalex.org/W2039550162","https://openalex.org/W2040736465","https://openalex.org/W2053668615","https://openalex.org/W2053791137","https://openalex.org/W2057160717","https://openalex.org/W2058085247","https://openalex.org/W2073292164","https://openalex.org/W2077270224","https://openalex.org/W2080443370","https://openalex.org/W2082565204","https://openalex.org/W2089528428","https://openalex.org/W2090236009","https://openalex.org/W2095266894","https://openalex.org/W2097981550","https://openalex.org/W2106762061","https://openalex.org/W2107020701","https://openalex.org/W2108958930","https://openalex.org/W2116644216","https://openalex.org/W2131549312","https://openalex.org/W2135129680","https://openalex.org/W2151003489","https://openalex.org/W2154046401","https://openalex.org/W2169927110","https://openalex.org/W2199940260","https://openalex.org/W2255519525","https://openalex.org/W2313307638","https://openalex.org/W2399621249","https://openalex.org/W2418420980","https://openalex.org/W2466382529","https://openalex.org/W2481759650","https://openalex.org/W2582364278","https://openalex.org/W2936630915","https://openalex.org/W4205424709","https://openalex.org/W4295216797"],"related_works":["https://openalex.org/W4248586904","https://openalex.org/W2318883589","https://openalex.org/W2401632846","https://openalex.org/W2019867611","https://openalex.org/W1831189467","https://openalex.org/W2099143291","https://openalex.org/W1601657500","https://openalex.org/W2366072566","https://openalex.org/W2032842127","https://openalex.org/W2135561672"],"abstract_inverted_index":{"The":[0,26,96],"bis-indole":[1],"indirubin":[2,30],"is":[3,135],"an":[4,65],"active":[5],"ingredient":[6],"of":[7,20,29,48,64,75,78,122,139,143,176,186,195,198,217,227,247,251],"Danggui":[8],"Longhui":[9],"Wan,":[10],"a":[11,76,112],"traditional":[12],"Chinese":[13],"medicine":[14],"recipe":[15],"used":[16],"in":[17,111,149,156,159,171,183,200],"the":[18,120,140,144,172,182,196,201,244],"treatment":[19,175],"chronic":[21],"diseases":[22],"such":[23],"as":[24,42],"leukemias.":[25],"antitumoral":[27,236],"properties":[28,237],"appear":[31],"to":[32,105,115,118,232,239,254],"correlate":[33],"with":[34,133],"their":[35,116,233],"antimitotic":[36,234],"effects.":[37],"Indirubins":[38,165,242],"were":[39,124],"recently":[40,125],"described":[41],"potent":[43],"(IC(50):":[44,61],"50-100":[45],"nm)":[46,63],"inhibitors":[47,60,213,216,229,250],"cyclin-dependent":[49],"kinases":[50],"(CDKs).":[51],"We":[52],"report":[53],"here":[54],"that":[55,90,102,206],"indirubins":[56,92,103],"are":[57,214],"also":[58,100,180],"powerful":[59,215],"5-50":[62],"evolutionarily":[66],"related":[67],"kinase,":[68],"glycogen":[69],"synthase":[70],"kinase-3beta":[71],"(GSK-3":[72],"beta).":[73],"Testing":[74],"series":[77],"indoles":[79],"and":[80,87,158,174,235],"bis-indoles":[81],"against":[82],"GSK-3":[83,106,130,218,224,252],"beta,":[84,131],"CDK1/cyclin":[85],"B,":[86],"CDK5/p25":[88],"shows":[89],"only":[91],"inhibit":[93],"these":[94,223],"kinases.":[95],"structure-activity":[97],"relationship":[98],"study":[99,173],"suggests":[101],"bind":[104],"beta's":[107],"ATP":[108],"binding":[109,117],"pocket":[110],"way":[113],"similar":[114],"CDKs,":[119],"details":[121],"which":[123,221],"revealed":[126],"by":[127,188],"crystallographic":[128],"analysis.":[129],"along":[132],"CDK5,":[134],"responsible":[136],"for":[137],"most":[138],"abnormal":[141],"hyperphosphorylation":[142],"microtubule-binding":[145],"protein":[146],"tau":[147,154],"observed":[148],"Alzheimer's":[150,162],"disease.":[151],"Indirubin-3'-monoxime":[152,179],"inhibits":[153,181],"phosphorylation":[155,185],"vitro":[157],"vivo":[160,184],"at":[161],"disease-specific":[163],"sites.":[164],"may":[166],"thus":[167],"have":[168],"important":[169],"implications":[170],"neurodegenerative":[177],"disorders.":[178],"DARPP-32":[187],"CDK5":[189],"on":[190],"Thr-75,":[191],"thereby":[192],"mimicking":[193],"one":[194],"effects":[197,226],"dopamine":[199],"striatum.":[202],"Finally,":[203],"we":[204],"show":[205],"many,":[207],"but":[208],"not":[209],"all,":[210],"reported":[211],"CDK":[212,228],"beta.":[219],"To":[220],"extent":[222],"beta":[225,253],"actually":[230],"contribute":[231],"remains":[238],"be":[240,255],"determined.":[241],"constitute":[243],"first":[245],"family":[246],"low":[248],"nanomolar":[249],"described.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":30},{"year":2014,"cited_by_count":39},{"year":2013,"cited_by_count":28},{"year":2012,"cited_by_count":43}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}