{"id":"https://openalex.org/W2104356293","doi":"https://doi.org/10.1002/eji.1830100203","title":"Evidence of the presence in normal serum of a carrier of the serum thymic factor (FTS)","display_name":"Evidence of the presence in normal serum of a carrier of the serum thymic factor (FTS)","publication_year":1980,"publication_date":"1980-02-01","ids":{"openalex":"https://openalex.org/W2104356293","doi":"https://doi.org/10.1002/eji.1830100203","mag":"2104356293","pmid":"https://pubmed.ncbi.nlm.nih.gov/7189463"},"language":"en","primary_location":{"id":"doi:10.1002/eji.1830100203","doi":"https://doi.org/10.1002/eji.1830100203","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830100203","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049430192","display_name":"Mireille Dardenne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Mireille Dardenne","raw_affiliation_strings":["INSERM U 25, Ho\u030cpital Necker, Paris","INSERM U 25, H\u01d2pital Necker, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U 25, Ho\u030cpital Necker, Paris","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488"]},{"raw_affiliation_string":"INSERM U 25, H\u01d2pital Necker, Paris","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111796374","display_name":"Jean\u2010Marie Pl\u00e9au","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean\u2010Marie Pl\u00e9au","raw_affiliation_strings":["INSERM U 25, Ho\u030cpital Necker, Paris","INSERM U 25, H\u01d2pital Necker, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U 25, Ho\u030cpital Necker, Paris","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488"]},{"raw_affiliation_string":"INSERM U 25, H\u01d2pital Necker, Paris","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042889303","display_name":"Jean\u2010Fran\u00e7ois Bach","orcid":"https://orcid.org/0000-0002-1282-6067","observed_orcids":["https://orcid.org/0000-0002-1282-6067"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean\u2010Fran\u00e7ois Bach","raw_affiliation_strings":["INSERM U 25, Ho\u030cpital Necker, Paris","INSERM U 25, H\u01d2pital Necker, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U 25, Ho\u030cpital Necker, Paris","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488"]},{"raw_affiliation_string":"INSERM U 25, H\u01d2pital Necker, Paris","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049430192"],"corresponding_institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":2.5142,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.89510998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"10","issue":"2","first_page":"83","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-thymic-factor","display_name":"serum thymic factor","score":0.9419999718666077},{"id":"https://openalex.org/keywords/fts","display_name":"FTS","score":0.8399999737739563},{"id":"https://openalex.org/keywords/serum-proteins","display_name":"serum proteins","score":0.515999972820282},{"id":"https://openalex.org/keywords/rosette-assay","display_name":"rosette assay","score":0.8510000109672546},{"id":"https://openalex.org/keywords/molecular-weight","display_name":"molecular weight","score":0.6240000128746033},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.6460000276565552},{"id":"https://openalex.org/keywords/prealbumin","display_name":"prealbumin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/protein-binding","display_name":"protein binding","score":0.5460000038146973},{"id":"https://openalex.org/keywords/biological-half-life","display_name":"biological half-life","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C163994747","wikidata":"https://www.wikidata.org/wiki/Q2916358","display_name":"Sephadex","level":3,"score":0.6630709171295166},{"id":"https://openalex.org/C2781414804","wikidata":"https://www.wikidata.org/wiki/Q7368701","display_name":"Rosette (schizont appearance)","level":2,"score":0.613909900188446},{"id":"https://openalex.org/C124815738","wikidata":"https://www.wikidata.org/wiki/Q41509","display_name":"Mole","level":2,"score":0.4749048948287964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4619287848472595},{"id":"https://openalex.org/C86807702","wikidata":"https://www.wikidata.org/wiki/Q2620381","display_name":"Bovine serum albumin","level":2,"score":0.45722025632858276},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43767470121383667},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4291648864746094},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.42385366559028625},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.4155944883823395},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.399397075176239},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3134007155895233},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21070095896720886},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07511469721794128}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007164","descriptor_name":"Immunosorbents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011228","descriptor_name":"Prealbumin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012397","descriptor_name":"Rosette Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013935","descriptor_name":"Thymic Factor, Circulating","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013951","descriptor_name":"Thymus Hormones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/eji.1830100203","doi":"https://doi.org/10.1002/eji.1830100203","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830100203","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:7189463","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7189463","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1980-3919","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1980/2920","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1980","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1503709544","https://openalex.org/W1535450874","https://openalex.org/W1929432579","https://openalex.org/W1995721079","https://openalex.org/W2043408212","https://openalex.org/W2065400946","https://openalex.org/W2086875701","https://openalex.org/W2095378223","https://openalex.org/W2103640732"],"related_works":["https://openalex.org/W2074972758","https://openalex.org/W283560451","https://openalex.org/W7098235022","https://openalex.org/W2315824816","https://openalex.org/W1929432579","https://openalex.org/W4249505317","https://openalex.org/W2058830606","https://openalex.org/W1938319221","https://openalex.org/W2005895258","https://openalex.org/W1990540517"],"abstract_inverted_index":{"Chromatography":[0],"of":[1,13,16,26,39,51,61,75,79,83,93,119,122,124,150],"normal":[2,151],"human":[3],"or":[4,126],"mouse":[5],"serum":[6,28,60,111],"on":[7,97],"Sephadex":[8],"G-150":[9],"revealed":[10],"the":[11,19,24,27,36,44,80,88,120,140],"presence":[12],"two":[14],"peaks":[15,56,85],"activity":[17,143],"in":[18,59,69,110],"rosette":[20,89],"assay":[21],"used":[22],"for":[23,139],"characterization":[25],"thymic":[29],"factor":[30],"(FTS).":[31],"One":[32],"peak":[33],"corresponded":[34],"to":[35,46,134],"elution":[37],"volume":[38],"FTS":[40,107,132],"(mol.":[41],"wt.":[42,118,148],"867),":[43],"other":[45],"molecules":[47],"with":[48,102,115,145],"mol.":[49,117,147],"wts.":[50],"40":[52],"000-60":[53],"000.":[54],"Both":[55],"were":[57],"absent":[58],"thymectomized":[62],"(Tx)":[63],"mice":[64,72],"but":[65],"could":[66],"be":[67],"induced":[68],"such":[70],"Tx":[71],"by":[73,87,112],"injection":[74],"synthetic":[76],"FTS.":[77],"Study":[78],"biological":[81,141],"half-life":[82],"both":[84],"(assessed":[86],"assay)":[90],"and":[91],"demonstration":[92],"their":[94],"specific":[95],"retention":[96],"anti-FTS":[98],"immunosorbent":[99],"indicate,":[100],"altogether":[101],"direct":[103],"binding":[104],"experiments,":[105],"that":[106,123,131],"is":[108,129,137],"transported":[109],"a":[113,116],"molecule":[114,136],"order":[121],"albumin":[125],"prealbumin.":[127],"It":[128],"apparent":[130],"bound":[133],"this":[135],"responsible":[138],"FTS-like":[142],"associated":[144],"large":[146],"fractions":[149],"serum.":[152]},"counts_by_year":[{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}