{"id":"https://openalex.org/W2104349299","doi":"https://doi.org/10.1016/j.bbrc.2006.11.014","title":"Site-directed mutagenesis of conserved aromatic residues in rat squalene epoxidase","display_name":"Site-directed mutagenesis of conserved aromatic residues in rat squalene epoxidase","publication_year":2006,"publication_date":"2006-11-14","ids":{"openalex":"https://openalex.org/W2104349299","doi":"https://doi.org/10.1016/j.bbrc.2006.11.014","mag":"2104349299","pmid":"https://pubmed.ncbi.nlm.nih.gov/17112472"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2006.11.014","doi":"https://doi.org/10.1016/j.bbrc.2006.11.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2006.11.014","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045857743","display_name":"Ikuro Abe","orcid":"https://orcid.org/0000-0002-3640-888X","observed_orcids":["https://orcid.org/0000-0002-3640-888X"]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]},{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ikuro Abe","raw_affiliation_strings":["School of Pharmaceutical Sciences, The 21st Century COE Program, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. abei@ys7.u-shizuoka-ken.ac.jp","PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan","School of Pharmaceutical Sciences, The 21st Century COE Program, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, The 21st Century COE Program, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. abei@ys7.u-shizuoka-ken.ac.jp","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]},{"raw_affiliation_string":"PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, The 21st Century COE Program, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042923923","display_name":"Tsuyoshi Abe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]},{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Abe","raw_affiliation_strings":["School of Pharmaceutical Sciences, The 21st Century COE Program, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, The 21st Century COE Program, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Weiwei Lou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]},{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Weiwei Lou","raw_affiliation_strings":["School of Pharmaceutical Sciences, The 21st Century COE Program, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, The 21st Century COE Program, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040394541","display_name":"Takayoshi Masuoka","orcid":"https://orcid.org/0000-0002-1689-8762","observed_orcids":["https://orcid.org/0000-0002-1689-8762"]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]},{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayoshi Masuoka","raw_affiliation_strings":["School of Pharmaceutical Sciences, The 21st Century COE Program, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, The 21st Century COE Program, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057987343","display_name":"Hiroshi Noguchi","orcid":"https://orcid.org/0000-0003-1735-7586","observed_orcids":["https://orcid.org/0000-0003-1735-7586"]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]},{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Noguchi","raw_affiliation_strings":["School of Pharmaceutical Sciences, The 21st Century COE Program, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, The 21st Century COE Program, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045857743"],"corresponding_institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954","https://openalex.org/I4210086780"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":0.5447,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.53940774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"352","issue":"1","first_page":"259","last_page":"263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.489300012588501,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.489300012588501,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.38429999351501465,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.08789999783039093,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/squalene-epoxidase","display_name":"squalene epoxidase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aromatic-residues","display_name":"aromatic residues","score":0.8389999866485596},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/alanine-substitution-mutants","display_name":"alanine mutants","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/2-3-oxidosqualene","display_name":"2,3-oxidosqualene","score":0.8679999709129333},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.949999988079071},{"id":"https://openalex.org/keywords/product-specificity","display_name":"product specificity","score":0.6830000281333923},{"id":"https://openalex.org/keywords/enzyme-mechanism","display_name":"enzyme mechanism","score":0.7409999966621399},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.6759999990463257},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.5}],"concepts":[{"id":"https://openalex.org/C2780227090","wikidata":"https://www.wikidata.org/wiki/Q2636892","display_name":"Alanine scanning","level":5,"score":0.7317800521850586},{"id":"https://openalex.org/C85411794","wikidata":"https://www.wikidata.org/wiki/Q414248","display_name":"Squalene monooxygenase","level":4,"score":0.7293452620506287},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7056206464767456},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.6920325756072998},{"id":"https://openalex.org/C103408237","wikidata":"https://www.wikidata.org/wiki/Q2642668","display_name":"Site-directed mutagenesis","level":4,"score":0.6450528502464294},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5941421985626221},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5878520607948303},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5506894588470459},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5505868196487427},{"id":"https://openalex.org/C2776703722","wikidata":"https://www.wikidata.org/wiki/Q407560","display_name":"Squalene","level":2,"score":0.5372428894042969},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.5231372714042664},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.49173644185066223},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.4659579396247864},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3874881863594055},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26316037774086},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.22954970598220825},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.062002480030059814},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050603","descriptor_name":"Squalene Monooxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050603","descriptor_name":"Squalene Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050603","descriptor_name":"Squalene Monooxygenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2006.11.014","doi":"https://doi.org/10.1016/j.bbrc.2006.11.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2006.11.014","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:17112472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17112472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310050","display_name":"University of Utah","ror":"https://ror.org/03r0ha626"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320323514","display_name":"Daiichi Sankyo Foundation of Life Science","ror":"https://ror.org/05j492n53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W288019165","https://openalex.org/W1500619872","https://openalex.org/W1972207209","https://openalex.org/W2014141105","https://openalex.org/W2022873969","https://openalex.org/W2026081876","https://openalex.org/W2038955973","https://openalex.org/W2051270929","https://openalex.org/W2053842717","https://openalex.org/W2060884524","https://openalex.org/W2082781136","https://openalex.org/W2092465087","https://openalex.org/W2117051152","https://openalex.org/W2135007868","https://openalex.org/W2189533594","https://openalex.org/W2261217864","https://openalex.org/W2949185352"],"related_works":["https://openalex.org/W2047148416","https://openalex.org/W2014141105","https://openalex.org/W2105549932","https://openalex.org/W2149684335","https://openalex.org/W1540532192","https://openalex.org/W4251965487","https://openalex.org/W2131043281","https://openalex.org/W2910712540","https://openalex.org/W2119263799","https://openalex.org/W2038955973"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
