{"id":"https://openalex.org/W2104344909","doi":null,"title":"Bacterial cheating drives the population dynamics of cooperative antibiotic resistance plasmids","display_name":"Bacterial cheating drives the population dynamics of cooperative antibiotic resistance plasmids","publication_year":2013,"publication_date":"2013-08-01","ids":{"openalex":"https://openalex.org/W2104344909","mag":"2104344909"},"language":"en","primary_location":{"id":"pmh:oai:dspace.mit.edu:1721.1/98066","doi":null,"is_oa":true,"landing_page_url":"https://orcid.org/0000-0002-4083-7433","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature","raw_type":"Article"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://orcid.org/0000-0002-4083-7433","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040822006","display_name":"Hui Xiao Chao","orcid":"https://orcid.org/0000-0001-7821-6571","observed_orcids":["https://orcid.org/0000-0001-7821-6571"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chao, Hui Xiao","raw_affiliation_strings":["#N#Department of Physics, Massachusetts Institute of Technology, Cambridge MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#Department of Physics, Massachusetts Institute of Technology, Cambridge MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007915598","display_name":"Tatiana Artemova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Artemova, Tatiana","raw_affiliation_strings":["#N#Department of Physics, Massachusetts Institute of Technology, Cambridge MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#Department of Physics, Massachusetts Institute of Technology, Cambridge MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003202779","display_name":"Jeff Gore","orcid":"https://orcid.org/0000-0003-4583-8555","observed_orcids":["https://orcid.org/0000-0003-4583-8555"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gore, Jeff","raw_affiliation_strings":["[Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA, USA]","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050716408","display_name":"Eugene Anatoly Yurtsev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yurtsev, Eugene","raw_affiliation_strings":["#N#Department of Physics, Massachusetts Institute of Technology, Cambridge MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#Department of Physics, Massachusetts Institute of Technology, Cambridge MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085611485","display_name":"Manoshi Sen Datta","orcid":"https://orcid.org/0000-0002-2606-6994","observed_orcids":["https://orcid.org/0000-0002-2606-6994"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Datta, Manoshi Sen","raw_affiliation_strings":["#N#Department of Physics, Massachusetts Institute of Technology, Cambridge MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#Department of Physics, Massachusetts Institute of Technology, Cambridge MA, USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":7.4976,"has_fulltext":false,"cited_by_count":227,"citation_normalized_percentile":{"value":0.97762053,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.4602000117301941,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.4602000117301941,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.295199990272522,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11252","display_name":"Evolutionary Game Theory and Cooperation","score":0.05640000104904175,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimicrobial-resistance-plasmids","display_name":"antibiotic resistance plasmids","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cooperative-behavior","display_name":"cooperative behavior","score":0.5569999814033508},{"id":"https://openalex.org/keywords/beta-lactamase","display_name":"beta-lactamase","score":0.8539999723434448},{"id":"https://openalex.org/keywords/beta-lactam-antibiotics","display_name":"beta-lactam antibiotics","score":0.9490000009536743},{"id":"https://openalex.org/keywords/plasmid-spread","display_name":"plasmid spread","score":0.5820000171661377},{"id":"https://openalex.org/keywords/population-dynamics","display_name":"population dynamics","score":0.6980000138282776},{"id":"https://openalex.org/keywords/beta-lactamase-inhibitors","display_name":"beta-lactamase inhibitors","score":0.8550000190734863},{"id":"https://openalex.org/keywords/antibiotic-resistance-evolution","display_name":"antibiotic resistance evolution","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7929179668426514},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.7879050970077515},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.77613765001297},{"id":"https://openalex.org/C2778024590","wikidata":"https://www.wikidata.org/wiki/Q2357432","display_name":"Cheating","level":2,"score":0.656187891960144},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.6130424737930298},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.6123384237289429},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6015199422836304},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5519202351570129},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2680928707122803},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1538527011871338},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.11696898937225342},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:dspace.mit.edu:1721.1/98066","doi":null,"is_oa":true,"landing_page_url":"https://orcid.org/0000-0002-4083-7433","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:dspace.mit.edu:1721.1/98066","doi":null,"is_oa":true,"landing_page_url":"https://orcid.org/0000-0002-4083-7433","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature","raw_type":"Article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W67630626","https://openalex.org/W1505878777","https://openalex.org/W1782368324","https://openalex.org/W1820140377","https://openalex.org/W1895007034","https://openalex.org/W1931911011","https://openalex.org/W1972445536","https://openalex.org/W1974668020","https://openalex.org/W1976378747","https://openalex.org/W1978857736","https://openalex.org/W1980595924","https://openalex.org/W1986790126","https://openalex.org/W1987634568","https://openalex.org/W1996434827","https://openalex.org/W2001615843","https://openalex.org/W2002226163","https://openalex.org/W2005327412","https://openalex.org/W2011253627","https://openalex.org/W2012977051","https://openalex.org/W2016666153","https://openalex.org/W2028067959","https://openalex.org/W2030397243","https://openalex.org/W2031232438","https://openalex.org/W2041755876","https://openalex.org/W2045825103","https://openalex.org/W2054564097","https://openalex.org/W2059795850","https://openalex.org/W2059905849","https://openalex.org/W2073391367","https://openalex.org/W2079309983","https://openalex.org/W2090651792","https://openalex.org/W2097141283","https://openalex.org/W2102892532","https://openalex.org/W2104484234","https://openalex.org/W2110232499","https://openalex.org/W2112256266","https://openalex.org/W2119736715","https://openalex.org/W2121867408","https://openalex.org/W2122916602","https://openalex.org/W2123105630","https://openalex.org/W2123767698","https://openalex.org/W2126115772","https://openalex.org/W2135018996","https://openalex.org/W2148641266","https://openalex.org/W2159307080","https://openalex.org/W2171609823","https://openalex.org/W4232506861"],"related_works":["https://openalex.org/W7167901152","https://openalex.org/W2676659422","https://openalex.org/W3158514322","https://openalex.org/W7160310389","https://openalex.org/W7169706240","https://openalex.org/W4407402893","https://openalex.org/W2408562881","https://openalex.org/W2025216709","https://openalex.org/W2948027143","https://openalex.org/W2895483982"],"abstract_inverted_index":{"Inactivation":[0],"of":[1,27,43,54,70,74,108,130,142],"\u03b2\u2010lactam":[2],"antibiotics":[3],"by":[4,90],"resistant":[5,28,75],"bacteria":[6,15],"is":[7],"a":[8,37,55,59,102,120],"\u2018cooperative\u2019":[9],"behavior":[10],"that":[11,23,57,68,118],"may":[12],"allow":[13],"sensitive":[14],"to":[16,80,85,127,135],"survive":[17],"antibiotic":[18,45,87,111,143],"treatment.":[19],"However,":[20],"the":[21,25,31,52,63,71,77,86,91,128,133,140],"factors":[22],"determine":[24],"fraction":[26,73,83],"cells":[29],"in":[30,40,110],"bacterial":[32,64],"population":[33,78],"remain":[34],"unclear,":[35],"indicating":[36],"fundamental":[38],"gap":[39],"our":[41],"understanding":[42],"how":[44],"resistance":[46],"evolves.":[47],"Here,":[48],"we":[49],"experimentally":[50],"track":[51],"spread":[53,129],"plasmid":[56],"encodes":[58],"\u03b2\u2010lactamase":[60,123],"enzyme":[61],"through":[62],"population.":[65],"We":[66],"find":[67],"independent":[69],"initial":[72],"cells,":[76],"settles":[79],"an":[81],"equilibrium":[82],"proportional":[84],"concentration":[88],"divided":[89],"cell":[92],"density.":[93],"A":[94],"simple":[95],"model":[96,114],"explains":[97],"this":[98],"behavior,":[99],"successfully":[100,116],"predicting":[101],"data":[103],"collapse":[104],"over":[105],"two":[106],"orders":[107],"magnitude":[109],"concentration.":[112],"This":[113],"also":[115],"predicts":[117],"adding":[119],"commonly":[121],"used":[122],"inhibitor":[124],"will":[125],"lead":[126],"resistance,":[131],"highlighting":[132],"need":[134],"incorporate":[136],"social":[137],"dynamics":[138],"into":[139],"study":[141],"resistance.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":9}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
