{"id":"https://openalex.org/W2104298924","doi":"https://doi.org/10.4049/jimmunol.1000462","title":"Type 1 Diabetes in BioBreeding Rats Is Critically Linked to an Imbalance between Th17 and Regulatory T Cells and an Altered TCR Repertoire","display_name":"Type 1 Diabetes in BioBreeding Rats Is Critically Linked to an Imbalance between Th17 and Regulatory T Cells and an Altered TCR Repertoire","publication_year":2010,"publication_date":"2010-07-19","ids":{"openalex":"https://openalex.org/W2104298924","doi":"https://doi.org/10.4049/jimmunol.1000462","mag":"2104298924","pmid":"https://pubmed.ncbi.nlm.nih.gov/20644174"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.1000462","doi":"https://doi.org/10.4049/jimmunol.1000462","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.1000462","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/185/4/2285/1328062/1000462.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/185/4/2285/1328062/1000462.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072348738","display_name":"Jens van den Brandt","orcid":"https://orcid.org/0000-0003-4386-6472","observed_orcids":["https://orcid.org/0000-0003-4386-6472"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jens van den Brandt","raw_affiliation_strings":["Department of Cellular and Molecular Immunology, University of G\u00f6ttingen Medical School , G\u00f6ttingen","Institute for Virology and Immunobiology, University of W\u00fcrzburg , W\u00fcrzburg","*Department of Cellular and Molecular Immunology, University of G\u00f6ttingen Medical School;","\u2020Institute for Virology and Immunobiology, University of W\u00fcrzburg, W\u00fcrzburg; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Immunology, University of G\u00f6ttingen Medical School , G\u00f6ttingen","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]},{"raw_affiliation_string":"Institute for Virology and Immunobiology, University of W\u00fcrzburg , W\u00fcrzburg","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"*Department of Cellular and Molecular Immunology, University of G\u00f6ttingen Medical School;","institution_ids":["https://openalex.org/I74656192"]},{"raw_affiliation_string":"\u2020Institute for Virology and Immunobiology, University of W\u00fcrzburg, W\u00fcrzburg; and","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057660119","display_name":"Henrike Josephine Fischer","orcid":"https://orcid.org/0000-0002-3022-908X","observed_orcids":["https://orcid.org/0000-0002-3022-908X"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Henrike J Fischer","raw_affiliation_strings":["Department of Cellular and Molecular Immunology, University of G\u00f6ttingen Medical School , G\u00f6ttingen","*Department of Cellular and Molecular Immunology, University of G\u00f6ttingen Medical School;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Immunology, University of G\u00f6ttingen Medical School , G\u00f6ttingen","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]},{"raw_affiliation_string":"*Department of Cellular and Molecular Immunology, University of G\u00f6ttingen Medical School;","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008709590","display_name":"Lutz Walter","orcid":"https://orcid.org/0000-0001-9408-3131","observed_orcids":["https://orcid.org/0000-0001-9408-3131"]},"institutions":[{"id":"https://openalex.org/I2801496451","display_name":"German Primate Center","ror":"https://ror.org/02f99v835","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2801496451","https://openalex.org/I315704651"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lutz Walter","raw_affiliation_strings":["Department of Primate Genetics, German Primate Center G\u00f6ttingen , G\u00f6ttingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Primate Genetics, German Primate Center G\u00f6ttingen , G\u00f6ttingen","institution_ids":["https://openalex.org/I2801496451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111892012","display_name":"Thomas H\u00fcnig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas H\u00fcnig","raw_affiliation_strings":["Institute for Virology and Immunobiology, University of W\u00fcrzburg , W\u00fcrzburg","\u2020Institute for Virology and Immunobiology, University of W\u00fcrzburg, W\u00fcrzburg; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology and Immunobiology, University of W\u00fcrzburg , W\u00fcrzburg","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"\u2020Institute for Virology and Immunobiology, University of W\u00fcrzburg, W\u00fcrzburg; and","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112751089","display_name":"Ingrid Kl\u00f6ting","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ingrid Kl\u00f6ting","raw_affiliation_strings":["Department of Laboratory Animal Science, University of Greifswald , Karlsburg ,","\u00a7Department of Laboratory Animal Science, University of Greifswald, Karlsburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Animal Science, University of Greifswald , Karlsburg ,","institution_ids":["https://openalex.org/I36522303"]},{"raw_affiliation_string":"\u00a7Department of Laboratory Animal Science, University of Greifswald, Karlsburg, Germany","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003072830","display_name":"Holger Michael Reichardt","orcid":"https://orcid.org/0000-0003-4647-057X","observed_orcids":["https://orcid.org/0000-0003-4647-057X"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Holger M Reichardt","raw_affiliation_strings":["Department of Cellular and Molecular Immunology, University of G\u00f6ttingen Medical School , G\u00f6ttingen","Institute for Virology and Immunobiology, University of W\u00fcrzburg , W\u00fcrzburg","*Department of Cellular and Molecular Immunology, University of G\u00f6ttingen Medical School;","\u2020Institute for Virology and Immunobiology, University of W\u00fcrzburg, W\u00fcrzburg; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Immunology, University of G\u00f6ttingen Medical School , G\u00f6ttingen","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]},{"raw_affiliation_string":"Institute for Virology and Immunobiology, University of W\u00fcrzburg , W\u00fcrzburg","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"*Department of Cellular and Molecular Immunology, University of G\u00f6ttingen Medical School;","institution_ids":["https://openalex.org/I74656192"]},{"raw_affiliation_string":"\u2020Institute for Virology and Immunobiology, University of W\u00fcrzburg, W\u00fcrzburg; and","institution_ids":["https://openalex.org/I25974101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5003072830"],"corresponding_institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210116730","https://openalex.org/I74656192"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.0571,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.92555338,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"185","issue":"4","first_page":"2285","last_page":"2294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.7529000043869019,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.7529000043869019,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.24539999663829803,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/biobreeding-rat","display_name":"BioBreeding rat","score":0.8949999809265137},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.8579999804496765},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":1.0},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.8059999942779541},{"id":"https://openalex.org/keywords/gimap5","display_name":"GIMAP5","score":0.6010000109672546},{"id":"https://openalex.org/keywords/adoptive-transfer","display_name":"adoptive transfer","score":0.7950000166893005},{"id":"https://openalex.org/keywords/effector-t-cells","display_name":"effector T cells","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cdr3-spectratyping","display_name":"CDR3 spectratyping","score":0.9490000009536743},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.6111965775489807},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.5975103974342346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5740835070610046},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5500508546829224},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5174697041511536},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5129342079162598},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.492406964302063},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45854687690734863},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4571014642715454},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.4215206503868103},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.41416653990745544},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.300661563873291},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.28008612990379333},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25049108266830444},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.24519973993301392},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21309062838554382}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008231","descriptor_name":"Lymphopenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008231","descriptor_name":"Lymphopenia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008231","descriptor_name":"Lymphopenia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011913","descriptor_name":"Rats, Inbred BB","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053645","descriptor_name":"Interleukin-2 Receptor alpha Subunit","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053645","descriptor_name":"Interleukin-2 Receptor alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055647","descriptor_name":"Rats, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.1000462","doi":"https://doi.org/10.4049/jimmunol.1000462","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.1000462","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/185/4/2285/1328062/1000462.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:20644174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20644174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/19214","doi":null,"is_oa":false,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/19214","pdf_url":null,"source":{"id":"https://openalex.org/S7407055187","display_name":"GRO","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.1000462","doi":"https://doi.org/10.4049/jimmunol.1000462","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.1000462","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/185/4/2285/1328062/1000462.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104298924.pdf","grobid_xml":"https://content.openalex.org/works/W2104298924.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W31616221","https://openalex.org/W339724285","https://openalex.org/W1494751405","https://openalex.org/W1520169735","https://openalex.org/W1531937362","https://openalex.org/W1542483197","https://openalex.org/W1570537969","https://openalex.org/W1578742815","https://openalex.org/W1604144627","https://openalex.org/W1656759985","https://openalex.org/W1664413187","https://openalex.org/W1964787243","https://openalex.org/W1970688528","https://openalex.org/W1976778352","https://openalex.org/W1978057084","https://openalex.org/W1990586585","https://openalex.org/W1992139204","https://openalex.org/W1999839870","https://openalex.org/W2001858202","https://openalex.org/W2004910705","https://openalex.org/W2037174767","https://openalex.org/W2038674673","https://openalex.org/W2042074842","https://openalex.org/W2042738483","https://openalex.org/W2043714066","https://openalex.org/W2050192138","https://openalex.org/W2052306755","https://openalex.org/W2060184734","https://openalex.org/W2060351717","https://openalex.org/W2062004063","https://openalex.org/W2062068902","https://openalex.org/W2064847390","https://openalex.org/W2068582444","https://openalex.org/W2069819213","https://openalex.org/W2071953380","https://openalex.org/W2073727431","https://openalex.org/W2091242433","https://openalex.org/W2091537338","https://openalex.org/W2094745429","https://openalex.org/W2103309717","https://openalex.org/W2104491684","https://openalex.org/W2105239353","https://openalex.org/W2112029076","https://openalex.org/W2117644665","https://openalex.org/W2121824369","https://openalex.org/W2127997822","https://openalex.org/W2129798181","https://openalex.org/W2140394517","https://openalex.org/W2150928170","https://openalex.org/W2151336716","https://openalex.org/W2151394849","https://openalex.org/W2152642587","https://openalex.org/W4313307371","https://openalex.org/W6601334061","https://openalex.org/W7074146965"],"related_works":["https://openalex.org/W3150274558","https://openalex.org/W3147849036","https://openalex.org/W1599321472","https://openalex.org/W7097307454","https://openalex.org/W1656759985","https://openalex.org/W7095566837","https://openalex.org/W2302059093","https://openalex.org/W2013839395","https://openalex.org/W2013457508","https://openalex.org/W2128312073"],"abstract_inverted_index":{"Diabetes-prone":[0],"BioBreeding":[1],"(DP-BB)":[2],"rats":[3,33,174],"spontaneously":[4],"develop":[5],"type":[6],"1":[7],"diabetes":[8],"mellitus":[9],"(T1DM)":[10],"on":[11],"grounds":[12],"of":[13,52,72,81,94,104,111,118,128,136,156,210,224],"their":[14],"MHC":[15],"haplotype":[16],"RT1(u)":[17],"and":[18,43,85,178,185,200],"a":[19,119,152,201,221],"point":[20],"mutation":[21],"in":[22,39,61,106,114,138,171,212],"the":[23,49,67,70,73,91,102,134,166,172,181,192,208,225],"Gimap5":[24],"gene.":[25],"In":[26],"this":[27],"study,":[28],"we":[29,161],"report":[30],"that":[31,90,165,194],"DP-BB":[32,107,139,213],"exhibit":[34],"an":[35,59],"increasingly":[36],"severe":[37],"imbalance,":[38],"particular":[40],"between":[41,183],"Th17":[42,184],"regulatory":[44],"T":[45,63,96,197,203],"(T(reg))":[46],"cells,":[47],"within":[48],"first":[50],"months":[51,177],"age.":[53],"This":[54],"can":[55],"be":[56],"assigned":[57],"to":[58,101,207],"excess":[60],"effector":[62,196],"cells":[64,75,97,113,130,146,169],"because":[65],"neither":[66],"percentage":[68],"nor":[69],"function":[71],"T(reg)":[74,112,129,168,186],"is":[76],"compromised.":[77],"Flow":[78],"cytometric":[79],"analysis":[80],"Vbeta":[82],"segment":[83],"usage":[84],"CDR3":[86],"spectratyping":[87],"further":[88,163],"suggest":[89],"disturbed":[92,202],"repertoire":[93,205],"peripheral":[95],"may":[98,216],"also":[99,217],"contribute":[100,206],"development":[103,135,209],"T1DM":[105,137,211],"rats.":[108],"Importantly,":[109],"expansion":[110],"vivo":[115],"by":[116],"means":[117],"CD28":[120],"superagonistic":[121],"Ab":[122],"as":[123,125],"well":[124],"adoptive":[126],"transfer":[127],"efficiently":[131],"interferes":[132],"with":[133,143],"rats,":[140,160,214],"whereas":[141],"treatment":[142],"conventional":[144],"Th":[145],"does":[147],"not":[148],"afford":[149],"protection.":[150],"Using":[151],"newly":[153],"generated":[154],"strain":[155],"enhanced":[157],"GFP":[158],"transgenic":[159],"could":[162],"demonstrate":[164],"transferred":[167],"persist":[170],"recipient":[173],"for":[175,220],"several":[176],"partially":[179],"correct":[180],"imbalance":[182],"cells.":[187],"Thus,":[188],"our":[189],"data":[190],"support":[191],"hypothesis":[193],"unchecked":[195],"cell":[198,204],"action":[199],"which":[215],"have":[218],"implications":[219],"better":[222],"understanding":[223],"human":[226],"disease.":[227]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
