{"id":"https://openalex.org/W2104200716","doi":null,"title":"Enhanced induction of anti-tumor CTLs in vitro by a lentivirus-transduced dendritic cell vaccine expressing secondary lymphoid tissue chemokine and mucin 1.","display_name":"Enhanced induction of anti-tumor CTLs in vitro by a lentivirus-transduced dendritic cell vaccine expressing secondary lymphoid tissue chemokine and mucin 1.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2104200716","mag":"2104200716","pmid":"https://pubmed.ncbi.nlm.nih.gov/22393946"},"language":"en","primary_location":{"id":"pmid:22393946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22393946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100630409","display_name":"Bin Wang","orcid":"https://orcid.org/0000-0002-3689-6932","observed_orcids":["https://orcid.org/0000-0002-3689-6932"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Wang","raw_affiliation_strings":["Department of General Surgery, First Affiliated Hospital, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, First Affiliated Hospital, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028285576","display_name":"Yi Zhu","orcid":"https://orcid.org/0000-0002-2222-0106","observed_orcids":["https://orcid.org/0000-0002-2222-0106"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100369399","display_name":"Jingjing Zhang","orcid":"https://orcid.org/0000-0002-7953-1159","observed_orcids":["https://orcid.org/0000-0002-7953-1159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing-jing Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100370673","display_name":"Zheng Chen","orcid":"https://orcid.org/0000-0002-6582-847X","observed_orcids":["https://orcid.org/0000-0002-6582-847X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zheng Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079697460","display_name":"Wenbiao Liang","orcid":"https://orcid.org/0000-0002-9549-5696","observed_orcids":["https://orcid.org/0000-0002-9549-5696"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-biao Liang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068744621","display_name":"Zekuan Xu","orcid":"https://orcid.org/0000-0001-5179-4128","observed_orcids":["https://orcid.org/0000-0001-5179-4128"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ze-kuan Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1418,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.5425041,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"12","issue":"11","first_page":"2811","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cell-vaccine","display_name":"dendritic cell vaccine","score":0.968999981880188},{"id":"https://openalex.org/keywords/lentiviral-transduction","display_name":"lentiviral transduction","score":0.828000009059906},{"id":"https://openalex.org/keywords/muc1","display_name":"MUC1","score":0.7889999747276306},{"id":"https://openalex.org/keywords/ccl21","display_name":"CCL21","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7919999957084656},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.5849999785423279},{"id":"https://openalex.org/keywords/hla-a2-restriction","display_name":"HLA-A2 restriction","score":0.777999997138977},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.598572313785553},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5301395654678345},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.5040234923362732},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.4387105107307434},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4150298833847046},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3943519592285156},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3940194547176361},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.305728554725647},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1752571165561676},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.16633352637290955},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007959","descriptor_name":"Lymphocyte Culture Test, Mixed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018396","descriptor_name":"Mucin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018396","descriptor_name":"Mucin-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018396","descriptor_name":"Mucin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054421","descriptor_name":"Chemokine CCL21","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054421","descriptor_name":"Chemokine CCL21","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D054421","descriptor_name":"Chemokine CCL21","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22393946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22393946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"},{"id":"mag:2104200716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22393946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.800000011920929,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W7188976","https://openalex.org/W28705092","https://openalex.org/W1551626732","https://openalex.org/W1570126059","https://openalex.org/W1769686661","https://openalex.org/W1915721030","https://openalex.org/W1972637236","https://openalex.org/W1982680133","https://openalex.org/W1984183779","https://openalex.org/W1985188479","https://openalex.org/W2010457947","https://openalex.org/W2016844928","https://openalex.org/W2028852768","https://openalex.org/W2037456835","https://openalex.org/W2039090039","https://openalex.org/W2043052307","https://openalex.org/W2048842060","https://openalex.org/W2049560410","https://openalex.org/W2058315838","https://openalex.org/W2060223822","https://openalex.org/W2061291194","https://openalex.org/W2086477728","https://openalex.org/W2086704878","https://openalex.org/W2098315731","https://openalex.org/W2106189045","https://openalex.org/W2108724455","https://openalex.org/W2111220263","https://openalex.org/W2132226366","https://openalex.org/W2132932170","https://openalex.org/W2142281564","https://openalex.org/W2146674901","https://openalex.org/W2154853638","https://openalex.org/W2159614234","https://openalex.org/W2163368383","https://openalex.org/W2170240282","https://openalex.org/W2255505775","https://openalex.org/W2261691410","https://openalex.org/W2329263004","https://openalex.org/W2409560773"],"related_works":["https://openalex.org/W3029184941","https://openalex.org/W3029820412","https://openalex.org/W2050653614","https://openalex.org/W2117552523","https://openalex.org/W1552063778","https://openalex.org/W2166026289","https://openalex.org/W2366730009","https://openalex.org/W2322509339","https://openalex.org/W1594905838","https://openalex.org/W2060569872"],"abstract_inverted_index":{"AIMS:":[0],"Dendritic":[1],"cell":[2,184],"(DC)-based":[3],"cancer":[4,55,183,244],"immunotherapy":[5],"requires":[6],"an":[7,14,216],"immunogenic":[8],"tumor":[9,124,213],"associated":[10],"antigen":[11],"(TAA)":[12],"and":[13,42,79,85,91,97,133,144,154,177,218,223],"effective":[15,209],"strategy":[16,241],"for":[17],"its":[18],"presentation":[19],"to":[20,53],"lymphocytes.":[21],"Here,":[22],"we":[23],"explored":[24],"whether":[25],"transduction":[26,156,230],"of":[27,36,76,99,107,141,231],"DCs":[28,66,100,112,149,175,203,232],"with":[29,69,115,151,161,195,205,233],"lentiviruses":[30,71],"(LVs)":[31],"expressing":[32],"a":[33,116,239],"fusion":[34],"protein":[35,86],"secondary":[37],"lymphoid":[38],"tissue":[39],"chemokine":[40],"(SLC)":[41],"mucin":[43],"1":[44],"(MUC1)":[45],"could":[46,207],"stimulate":[47],"antigen-specific":[48,217],"cytotoxic":[49],"T":[50,108],"cells":[51,56,125,214],"(CTLs)":[52],"human":[54],"in":[57,148,215,221,242],"vitro.":[58],"MATERIALS":[59],"AND":[60],"METHODS:":[61],"HLA-A2+":[62],"peripheral":[63],"blood":[64],"monocyte-derived":[65],"were":[67,87,101,126,158],"transduced":[68,150,204],"recombinant":[70,152],"LV":[72,173,199,234],"at":[73],"different":[74],"multiplicities":[75],"infection":[77],"(MOI),":[78],"MUC1,":[80,142],"SLC":[81,143,224],"or":[82],"SLC-MUC1":[83,145,200],"mRNA":[84],"detected":[88],"by":[89,103,111,128,172,198],"RT-PCR":[90],"Western":[92],"blotting,":[93],"respectively.":[94],"Transduction":[95,160],"efficiencies":[96,157],"phenotypes":[98],"evaluated":[102],"flow":[104],"cytometry.":[105],"Induction":[106],"lymphocyte":[109],"proliferation":[110],"was":[113,146,193],"examined":[114],"Cell":[117],"Count":[118],"Kit-8":[119],"(CCK-8).":[120],"CTL":[121,170,196],"activities":[122],"against":[123,191,212],"analyzed":[127],"lactate":[129],"dehydrogenase":[130],"(LDH)":[131],"cytotoxicity":[132],"enzyme-linked":[134],"immunospot":[135],"(ELISPOT)":[136],"assays.":[137],"RESULTS:":[138],"Stable":[139],"expression":[140],"obtained":[147],"LVs,":[153],"the":[155,167,180],"dose-dependent.":[159],"LVs":[162],"did":[163],"not":[164],"appreciably":[165],"change":[166],"DC":[168],"phenotype.":[169],"induced":[171],"MUC1":[174,206,236],"potently":[176],"specifically":[178],"lysed":[179],"HLA-A2+,":[181],"MUC1+colon":[182],"line":[185],"HCT-116.":[186],"Moreover,":[187],"this":[188],"cytolytic":[189,210],"activity":[190,211],"HCT-116":[192],"enhanced":[194],"stimulated":[197],"DCs.":[201],"CONCLUSIONS:":[202],"induce":[208],"HLA-restricted":[219],"fashion":[220],"vitro,":[222],"promoted":[225],"MUC1-specific":[226],"anti-tumor":[227],"activity.":[228],"The":[229],"SLC-":[235],"may":[237],"be":[238],"promising":[240],"DC-based":[243],"immunotherapy.":[245]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
