{"id":"https://openalex.org/W2104147346","doi":"https://doi.org/10.2337/db12-1067","title":"G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion","display_name":"G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion","publication_year":2012,"publication_date":"2012-12-29","ids":{"openalex":"https://openalex.org/W2104147346","doi":"https://doi.org/10.2337/db12-1067","mag":"2104147346","pmid":"https://pubmed.ncbi.nlm.nih.gov/23274894"},"language":"en","primary_location":{"id":"doi:10.2337/db12-1067","doi":"https://doi.org/10.2337/db12-1067","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db12-1067","pdf_url":"https://diabetes.diabetesjournals.org/content/diabetes/62/5/1547.full.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://diabetes.diabetesjournals.org/content/diabetes/62/5/1547.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031203340","display_name":"Lynley D. Pound","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynley D. Pound","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077843010","display_name":"James K. Oeser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James K. Oeser","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063640852","display_name":"Tracy P. O\u2019Brien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracy P. O\u2019Brien","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101680980","display_name":"Yingda Wang","orcid":"https://orcid.org/0009-0001-5688-6299","observed_orcids":["https://orcid.org/0009-0001-5688-6299"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingda Wang","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065848311","display_name":"Chandler J. Faulman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandler J. Faulman","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025127885","display_name":"Prasanna K. Dadi","orcid":"https://orcid.org/0000-0001-5377-5991","observed_orcids":["https://orcid.org/0000-0001-5377-5991"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prasanna K. Dadi","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028282149","display_name":"David Aaron Jacobson","orcid":"https://orcid.org/0000-0003-1816-5375","observed_orcids":["https://orcid.org/0000-0003-1816-5375"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Jacobson","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110142367","display_name":"John C. Hutton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Hutton","raw_affiliation_strings":["Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado","2Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado","institution_ids":["https://openalex.org/I4210087413"]},{"raw_affiliation_string":"2Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025336530","display_name":"Owen P. McGuinness","orcid":"https://orcid.org/0000-0002-1778-3203","observed_orcids":["https://orcid.org/0000-0002-1778-3203"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Owen P. McGuinness","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090188264","display_name":"Masakazu Shiota","orcid":"https://orcid.org/0009-0005-2801-1881","observed_orcids":["https://orcid.org/0009-0005-2801-1881"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masakazu Shiota","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069819556","display_name":"Richard M. O\u2019Brien","orcid":"https://orcid.org/0000-0003-2153-9761","observed_orcids":["https://orcid.org/0000-0003-2153-9761"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard M. O\u2019Brien","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"1Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069819556"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"],"apc_list":null,"apc_paid":null,"fwci":3.3046,"has_fulltext":true,"cited_by_count":84,"citation_normalized_percentile":{"value":0.9179922,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"62","issue":"5","first_page":"1547","last_page":"1556"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g6pc2","display_name":"G6PC2","score":1.0},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.9779999852180481},{"id":"https://openalex.org/keywords/basal-insulin-secretion","display_name":"basal insulin secretion","score":0.824999988079071},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.7459999918937683},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7400000095367432},{"id":"https://openalex.org/keywords/body-fat","display_name":"fat mass","score":0.5789999961853027},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.8560000061988831},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8360000252723694},{"id":"https://openalex.org/keywords/glycolytic-flux","display_name":"glycolytic flux","score":0.9520000219345093},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8471289873123169},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7960682511329651},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6063434481620789},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5594943165779114},{"id":"https://openalex.org/C2779202576","wikidata":"https://www.wikidata.org/wiki/Q24785320","display_name":"Glucose 6-phosphatase","level":3,"score":0.49580177664756775},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.4691808521747589},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.46401533484458923},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.45575469732284546},{"id":"https://openalex.org/C76923068","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Blood sugar regulation","level":3,"score":0.4555354118347168},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.42327550053596497},{"id":"https://openalex.org/C98335778","wikidata":"https://www.wikidata.org/wiki/Q425185","display_name":"Glucokinase","level":3,"score":0.4190024137496948},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.41579556465148926},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.37892696261405945},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3584236800670624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15836644172668457},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12680962681770325},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005952","descriptor_name":"Glucose-6-Phosphatase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005952","descriptor_name":"Glucose-6-Phosphatase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005952","descriptor_name":"Glucose-6-Phosphatase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005952","descriptor_name":"Glucose-6-Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005952","descriptor_name":"Glucose-6-Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005952","descriptor_name":"Glucose-6-Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020297","descriptor_name":"Mice, Congenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020297","descriptor_name":"Mice, Congenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020297","descriptor_name":"Mice, Congenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050154","descriptor_name":"Adiposity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050154","descriptor_name":"Adiposity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050154","descriptor_name":"Adiposity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2337/db12-1067","doi":"https://doi.org/10.2337/db12-1067","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db12-1067","pdf_url":"https://diabetes.diabetesjournals.org/content/diabetes/62/5/1547.full.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:23274894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23274894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2981393","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3636628","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3636628","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3636628","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.2337/db12-1067","doi":"https://doi.org/10.2337/db12-1067","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db12-1067","pdf_url":"https://diabetes.diabetesjournals.org/content/diabetes/62/5/1547.full.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8700000047683716}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1352409854","display_name":null,"funder_award_id":"DK-043748","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1478761210","display_name":null,"funder_award_id":"T32DK007563","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G188987342","display_name":null,"funder_award_id":"P30 DK 057516","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2019238319","display_name":null,"funder_award_id":"P30-DK020593","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2025111146","display_name":null,"funder_award_id":"5T32 DK07563","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2304076072","display_name":null,"funder_award_id":"P60-DK020593","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G248045910","display_name":null,"funder_award_id":"P30 DK  57516","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G259130634","display_name":null,"funder_award_id":"DK-081666","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G291339886","display_name":null,"funder_award_id":"P60-DK20593","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2940777275","display_name":null,"funder_award_id":"DK59637","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2949149951","display_name":null,"funder_award_id":"R01DK043748","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3647626886","display_name":null,"funder_award_id":"R01-DK092589","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3797262831","display_name":null,"funder_award_id":"R01 DK060667","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3989539122","display_name":null,"funder_award_id":"DK 20593","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4060652897","display_name":null,"funder_award_id":"DK-060667","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4099681973","display_name":"Vanderbilt Mouse Metabolic Phenotyping Center","funder_award_id":"U24DK059637","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G429657696","display_name":null,"funder_award_id":"DK78188","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4489401718","display_name":null,"funder_award_id":"R01-DK-052068","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4935539079","display_name":null,"funder_award_id":"DK-92589","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5298413627","display_name":null,"funder_award_id":"R56 DK043748","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5374377950","display_name":"Cloning of molecular targets of Cell Mediated Autoimmunity in Type 1 Diabetes","funder_award_id":"5r01dk052068-13","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6280760032","display_name":"Regulation of Insulin Secretion by G6PC2","funder_award_id":"5r01dk092589-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G642627359","display_name":"Secretagogue Induced Mechanisms Regulating Islet Electrical Activity","funder_award_id":"K01DK081666","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6639498476","display_name":null,"funder_award_id":"P30 DK","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6849778640","display_name":null,"funder_award_id":"R01 DK078188","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G697064070","display_name":"Cloning of molecular targets of CMI in type 1 diabetes","funder_award_id":"R56DK052068","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G841800580","display_name":"Diabetes Research and Training Center","funder_award_id":"5p60dk020593-31","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8436625813","display_name":"Liver glucose Flux in Obesity and Diabetes","funder_award_id":"R56DK060667","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000002043","display_name":null,"funder_award_id":"DK-59637","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000106052","display_name":null,"funder_award_id":"DK 20593","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000900818","display_name":"Vanderbilt Diabetes Research Center","funder_award_id":"5p30dk020593-48","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332965","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24"},{"id":"https://openalex.org/F4320334588","display_name":"Vanderbilt Diabetes Research and Training Center, Vanderbilt University Medical Center","ror":null},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104147346.pdf","grobid_xml":"https://content.openalex.org/works/W2104147346.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1491165075","https://openalex.org/W1568885376","https://openalex.org/W1964738953","https://openalex.org/W1983753601","https://openalex.org/W1995856733","https://openalex.org/W2031149113","https://openalex.org/W2039242258","https://openalex.org/W2050455735","https://openalex.org/W2058268741","https://openalex.org/W2059576421","https://openalex.org/W2060505010","https://openalex.org/W2078156067","https://openalex.org/W2081890649","https://openalex.org/W2082457838","https://openalex.org/W2085856731","https://openalex.org/W2086894303","https://openalex.org/W2090824142","https://openalex.org/W2091533652","https://openalex.org/W2096880956","https://openalex.org/W2098452298","https://openalex.org/W2106603497","https://openalex.org/W2110931744","https://openalex.org/W2111191860","https://openalex.org/W2119706813","https://openalex.org/W2121344598","https://openalex.org/W2124870236","https://openalex.org/W2125038804","https://openalex.org/W2125853346","https://openalex.org/W2126035721","https://openalex.org/W2128902735","https://openalex.org/W2129428538","https://openalex.org/W2133631818","https://openalex.org/W2136454890","https://openalex.org/W2140154699","https://openalex.org/W2143770547","https://openalex.org/W2160352519","https://openalex.org/W2160427234","https://openalex.org/W2161641259","https://openalex.org/W2171750333","https://openalex.org/W2234545288","https://openalex.org/W2283535574","https://openalex.org/W6677855403","https://openalex.org/W6695553026"],"related_works":["https://openalex.org/W2889695791","https://openalex.org/W2082140668","https://openalex.org/W1973049774","https://openalex.org/W1986132654","https://openalex.org/W2068166803","https://openalex.org/W1974106130","https://openalex.org/W2006513370","https://openalex.org/W1532950599","https://openalex.org/W2054690921","https://openalex.org/W2156187506"],"abstract_inverted_index":{"Elevated":[0],"fasting":[1,135],"blood":[2,144],"glucose":[3,41,86,145],"(FBG)":[4],"is":[5],"associated":[6],"with":[7,29,111,155],"increased":[8],"risk":[9],"for":[10,126],"the":[11,71,123],"development":[12],"of":[13,54,73,187],"type":[14],"2":[15],"diabetes":[16],"and":[17,33,63,85,103],"cardiovascular-associated":[18],"mortality.":[19],"Genome-wide":[20],"association":[21],"studies":[22],"(GWAS)":[23],"have":[24],"linked":[25],"polymorphisms":[26],"in":[27,31,55,59,64,75,93,118,122,137,149,170],"G6PC2":[28,43],"variations":[30],"FBG":[32],"body":[34,89],"fat,":[35],"although":[36],"not":[37],"insulin":[38,83,128,140],"sensitivity":[39,84],"or":[40],"tolerance.":[42],"encodes":[44],"an":[45],"islet-specific,":[46],"endoplasmic":[47],"reticulum-resident":[48],"glucose-6-phosphatase":[49],"catalytic":[50],"subunit.":[51],"A":[52],"combination":[53],"situ":[56],"perfused":[57],"pancreas,":[58],"vitro":[60],"isolated":[61,172],"islet,":[62],"vivo":[65],"analyses":[66],"were":[67,142,147,168],"used":[68],"to":[69],"explore":[70],"function":[72],"G6pc2":[74,77,95,115,150,174,181],"mice.":[76,176],"deletion":[78,116],"had":[79],"little":[80],"effect":[81],"on":[82,99],"tolerance,":[87],"whereas":[88,163],"fat":[90],"was":[91,161],"reduced":[92,148],"female":[94],"knockout":[96],"(KO)":[97],"mice":[98],"both":[100],"a":[101,119,132,183],"chow":[102],"high-fat":[104],"diet,":[105],"observations":[106],"that":[107,180,190],"are":[108],"all":[109],"consistent":[110,154],"human":[112,156],"GWAS":[113,157],"data.":[114,158],"resulted":[117],"leftward":[120],"shift":[121],"dose-response":[124],"curve":[125],"glucose-stimulated":[127],"secretion":[129],"(GSIS).":[130],"As":[131],"consequence,":[133],"under":[134],"conditions":[136],"which":[138],"plasma":[139],"levels":[141,146,167],"identical,":[143],"KO":[151,175],"mice,":[152],"again":[153],"Glucose-6-phosphatase":[159],"activity":[160],"reduced,":[162],"basal":[164,188],"cytoplasmic":[165],"calcium":[166],"elevated":[169],"islets":[171],"from":[173],"These":[177],"data":[178],"suggest":[179],"represents":[182],"novel,":[184],"negative":[185],"regulator":[186],"GSIS":[189],"acts":[191],"by":[192],"hydrolyzing":[193],"glucose-6-phosphate,":[194],"thereby":[195],"reducing":[196],"glycolytic":[197],"flux.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}