{"id":"https://openalex.org/W2104147191","doi":"https://doi.org/10.1093/chemse/23.6.683","title":"Effects of GABA on Acutely Isolated Neurons from the Gustatory Zone of the Rat Nucleus of the Solitary Tract","display_name":"Effects of GABA on Acutely Isolated Neurons from the Gustatory Zone of the Rat Nucleus of the Solitary Tract","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W2104147191","doi":"https://doi.org/10.1093/chemse/23.6.683","mag":"2104147191","pmid":"https://pubmed.ncbi.nlm.nih.gov/9915114"},"language":"en","primary_location":{"id":"doi:10.1093/chemse/23.6.683","doi":"https://doi.org/10.1093/chemse/23.6.683","is_oa":false,"landing_page_url":"https://doi.org/10.1093/chemse/23.6.683","pdf_url":null,"source":{"id":"https://openalex.org/S8722945","display_name":"Chemical Senses","issn_l":"0379-864X","issn":["0379-864X","1464-3553"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Senses","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111146085","display_name":"J. Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Du","raw_affiliation_strings":["Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor 48109-1078, USA","Department of Biologic and Materials Sciences, School of Dentistry, University of MichiganAnn Arbor, Ml 48109-1078"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor 48109-1078, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Biologic and Materials Sciences, School of Dentistry, University of MichiganAnn Arbor, Ml 48109-1078","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111492048","display_name":"R. M. Bradley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. M. Bradley","raw_affiliation_strings":["Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan Ann Arbor, Ml 48109-1078","Department of Physiology, Medical School, University of Michigan Ann Arbor, Ml 48109-0622, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan Ann Arbor, Ml 48109-1078","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Physiology, Medical School, University of Michigan Ann Arbor, Ml 48109-0622, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111492048"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":4317,"currency":"USD","value_usd":4317},"apc_paid":null,"fwci":0.3954,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.55000356,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"23","issue":"6","first_page":"683","last_page":"688"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.9789999723434448},{"id":"https://openalex.org/keywords/nucleus-tractus-solitarius","display_name":"nucleus tractus solitarius","score":0.8980000019073486},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.699999988079071},{"id":"https://openalex.org/keywords/gabab-receptors","display_name":"GABAB receptors","score":0.9229999780654907},{"id":"https://openalex.org/keywords/muscimol","display_name":"muscimol","score":0.9950000047683716},{"id":"https://openalex.org/keywords/baclofen","display_name":"baclofen","score":0.9679999947547913},{"id":"https://openalex.org/keywords/picrotoxin","display_name":"picrotoxin","score":0.984000027179718},{"id":"https://openalex.org/keywords/bicuculline","display_name":"bicuculline","score":0.9990000128746033},{"id":"https://openalex.org/keywords/membrane-hyperpolarization","display_name":"membrane hyperpolarization","score":0.8289999961853027},{"id":"https://openalex.org/keywords/input-resistance","display_name":"input resistance","score":0.9850000143051147},{"id":"https://openalex.org/keywords/brainstem","display_name":"brainstem","score":0.6069999933242798},{"id":"https://openalex.org/keywords/isolated-neurons","display_name":"isolated neurons","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2779188335","wikidata":"https://www.wikidata.org/wiki/Q412504","display_name":"Muscimol","level":4,"score":0.8691946268081665},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.7800067663192749},{"id":"https://openalex.org/C2780763569","wikidata":"https://www.wikidata.org/wiki/Q3639734","display_name":"Bicuculline","level":4,"score":0.7767703533172607},{"id":"https://openalex.org/C2779324764","wikidata":"https://www.wikidata.org/wiki/Q416602","display_name":"Picrotoxin","level":4,"score":0.7334361672401428},{"id":"https://openalex.org/C101027131","wikidata":"https://www.wikidata.org/wiki/Q305671","display_name":"GABAB receptor","level":4,"score":0.6672567129135132},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5928183197975159},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.5568926334381104},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.539138913154602},{"id":"https://openalex.org/C2780838160","wikidata":"https://www.wikidata.org/wiki/Q2447639","display_name":"Solitary tract","level":3,"score":0.5218309760093689},{"id":"https://openalex.org/C2776674594","wikidata":"https://www.wikidata.org/wiki/Q306252","display_name":"GABA receptor","level":4,"score":0.4804203510284424},{"id":"https://openalex.org/C79636183","wikidata":"https://www.wikidata.org/wiki/Q5512770","display_name":"GABA receptor antagonist","level":5,"score":0.4643927216529846},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46131396293640137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39996248483657837},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3294597864151001},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.31457674503326416},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0970708429813385}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001418","descriptor_name":"Baclofen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001640","descriptor_name":"Bicuculline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009118","descriptor_name":"Muscimol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010852","descriptor_name":"Picrotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017552","descriptor_name":"Solitary Nucleus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018755","descriptor_name":"GABA Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018756","descriptor_name":"GABA Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/chemse/23.6.683","doi":"https://doi.org/10.1093/chemse/23.6.683","is_oa":false,"landing_page_url":"https://doi.org/10.1093/chemse/23.6.683","pdf_url":null,"source":{"id":"https://openalex.org/S8722945","display_name":"Chemical Senses","issn_l":"0379-864X","issn":["0379-864X","1464-3553"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Senses","raw_type":"journal-article"},{"id":"pmid:9915114","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9915114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical senses","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7794140390","display_name":null,"funder_award_id":"DC00288","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W583930477","https://openalex.org/W651763111","https://openalex.org/W1762877386","https://openalex.org/W1861416370","https://openalex.org/W1989396341","https://openalex.org/W2003846272","https://openalex.org/W2020919581","https://openalex.org/W2024328209","https://openalex.org/W2053986734","https://openalex.org/W2058252746","https://openalex.org/W2097431467","https://openalex.org/W2133875571","https://openalex.org/W2345102367","https://openalex.org/W2395924423"],"related_works":["https://openalex.org/W2048829082","https://openalex.org/W2003846272","https://openalex.org/W2097431467","https://openalex.org/W2271434866","https://openalex.org/W2118788761","https://openalex.org/W3199493602","https://openalex.org/W4295786003","https://openalex.org/W2395924423","https://openalex.org/W2012465299","https://openalex.org/W1969379059"],"abstract_inverted_index":{"Responses":[0],"of":[1,9,91,123,150],"acutely":[2],"isolated":[3,30],"neurons":[4,31,48,93,136],"from":[5],"the":[6,10,81,92,109,115,121,138],"rostral":[7],"nucleus":[8],"solitary":[11],"tract":[12],"(rNST)":[13],"to":[14,56,104],"GABA":[15,57,96,110,124,133],"receptor":[16,69,83,117],"agonists":[17],"and":[18,35,42,61,97,114,140,152],"antagonists":[19],"were":[20,101],"investigated":[21],"using":[22],"whole-cell":[23],"recording":[24],"in":[25,64,76,125,137,147],"current":[26],"clamp":[27],"mode.":[28],"The":[29,67,95],"retain":[32],"their":[33],"morphology":[34],"can":[36],"be":[37,105],"divided":[38],"into":[39],"multipolar,":[40],"elongate":[41],"ovoid":[43],"cell":[44,53],"types.":[45],"Most":[46],"rNST":[47,139],"(97%),":[49],"including":[50],"all":[51,135],"three":[52],"types,":[54],"respond":[55],"with":[58],"membrane":[59],"hyperpolarization":[60],"a":[62,77,126],"reduction":[63],"input":[65,74],"resistance.":[66],"GABA(A)":[68,116],"agonist":[70,84],"muscimol":[71,98],"reduces":[72],"neuronal":[73],"resistance":[75],"concentration-dependent":[78,127],"manner,":[79],"whereas":[80],"GABA(B)":[82],"baclofen":[85],"had":[86],"no":[87],"effect":[88,122],"on":[89],"any":[90],"tested.":[94],"reversal":[99],"potentials":[100],"both":[102],"found":[103],"-75":[106],"mV":[107],"Both":[108],"competitive":[111],"antagonist":[112,118],"picrotoxin":[113],"bicuculline":[119],"block":[120],"manner.":[128],"These":[129],"results":[130],"suggest":[131],"that":[132,141],"activates":[134],"inhibitory":[142],"synaptic":[143],"activity":[144],"is":[145],"important":[146],"brainstem":[148],"processing":[149],"gustatory":[151],"somatosensory":[153],"information.":[154]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
