{"id":"https://openalex.org/W2104099050","doi":"https://doi.org/10.1186/2110-5820-3-23","title":"Beyond intracranial pressure: optimization of cerebral blood flow, oxygen, and substrate delivery after traumatic brain injury","display_name":"Beyond intracranial pressure: optimization of cerebral blood flow, oxygen, and substrate delivery after traumatic brain injury","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2104099050","doi":"https://doi.org/10.1186/2110-5820-3-23","mag":"2104099050","pmid":"https://pubmed.ncbi.nlm.nih.gov/23837598","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3716965"},"language":"en","primary_location":{"id":"doi:10.1186/2110-5820-3-23","doi":"https://doi.org/10.1186/2110-5820-3-23","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2110-5820-3-23","pdf_url":"https://annalsofintensivecare.springeropen.com/counter/pdf/10.1186/2110-5820-3-23","source":{"id":"https://openalex.org/S113872774","display_name":"Annals of Intensive Care","issn_l":"2110-5820","issn":["2110-5820"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Intensive Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://annalsofintensivecare.springeropen.com/counter/pdf/10.1186/2110-5820-3-23","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000775806","display_name":"Pierre Bouzat","orcid":"https://orcid.org/0000-0003-4667-6738","observed_orcids":["https://orcid.org/0000-0003-4667-6738"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Pierre Bouzat","raw_affiliation_strings":["Department of Intensive Care Medicine, CHUV-University Hospital, Rue du Bugnon 46, BH 08,623, CH-1011 Lausanne, Switzerland. mauro.oddo@chuv.ch","Department of Intensive Care Medicine, CHUV-University Hospital, Rue du Bugnon 46, BH 08.623, CH-1011, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care Medicine, CHUV-University Hospital, Rue du Bugnon 46, BH 08,623, CH-1011 Lausanne, Switzerland. mauro.oddo@chuv.ch","institution_ids":["https://openalex.org/I2802229882"]},{"raw_affiliation_string":"Department of Intensive Care Medicine, CHUV-University Hospital, Rue du Bugnon 46, BH 08.623, CH-1011, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084511286","display_name":"Nathalie Sala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nathalie Sala","raw_affiliation_strings":["Department of Intensive Care Medicine, CHUV-University Hospital, Rue du Bugnon 46, BH 08.623, CH-1011, Lausanne, Switzerland","Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care Medicine, CHUV-University Hospital, Rue du Bugnon 46, BH 08.623, CH-1011, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]},{"raw_affiliation_string":"Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070952722","display_name":"Jean\u2010Fran\u00e7ois Payen","orcid":"https://orcid.org/0000-0001-8400-3839","observed_orcids":["https://orcid.org/0000-0001-8400-3839"]},"institutions":[{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I2800555055","display_name":"Centre Hospitalier Universitaire de Grenoble","ror":"https://ror.org/041rhpw39","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Fran\u00e7ois Payen","raw_affiliation_strings":["Department of Anesthesiology and Intensive Care Medicine, University Hospital, Grenoble, France","Joseph Fourier University, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care Medicine, University Hospital, Grenoble, France","institution_ids":["https://openalex.org/I2800555055"]},{"raw_affiliation_string":"Joseph Fourier University, Grenoble, France","institution_ids":["https://openalex.org/I177483745"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089424249","display_name":"Mauro Oddo","orcid":"https://orcid.org/0000-0002-6155-2525","observed_orcids":["https://orcid.org/0000-0002-6155-2525"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Mauro Oddo","raw_affiliation_strings":["Department of Intensive Care Medicine, CHUV-University Hospital, Rue du Bugnon 46, BH 08.623, CH-1011, Lausanne, Switzerland","Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care Medicine, CHUV-University Hospital, Rue du Bugnon 46, BH 08.623, CH-1011, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]},{"raw_affiliation_string":"Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5089424249"],"corresponding_institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":7.3177,"has_fulltext":true,"cited_by_count":131,"citation_normalized_percentile":{"value":0.97951579,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"23","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/secondary-brain-injury","display_name":"secondary brain injury","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cerebral-oxygen-delivery","display_name":"cerebral oxygen delivery","score":0.8550000190734863},{"id":"https://openalex.org/keywords/intracranial-pressure","display_name":"intracranial pressure","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cerebral-perfusion-pressure","display_name":"cerebral perfusion pressure","score":0.996999979019165},{"id":"https://openalex.org/keywords/multimodal-brain-monitoring","display_name":"multimodal brain monitoring","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cerebral-oxygenation","display_name":"cerebral oxygenation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cerebral-microdialysis","display_name":"cerebral microdialysis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/transcranial-doppler","display_name":"transcranial Doppler","score":0.949999988079071},{"id":"https://openalex.org/keywords/cerebral-hypoxia","display_name":"cerebral hypoxia","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.7946771383285522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7945221662521362},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.7538690567016602},{"id":"https://openalex.org/C154281038","wikidata":"https://www.wikidata.org/wiki/Q629232","display_name":"Cerebral perfusion pressure","level":3,"score":0.7307261824607849},{"id":"https://openalex.org/C2780954326","wikidata":"https://www.wikidata.org/wiki/Q1416096","display_name":"Intracranial pressure","level":2,"score":0.6605828404426575},{"id":"https://openalex.org/C84359808","wikidata":"https://www.wikidata.org/wiki/Q13365173","display_name":"Cerebral autoregulation","level":4,"score":0.5078004002571106},{"id":"https://openalex.org/C2777975874","wikidata":"https://www.wikidata.org/wiki/Q2920572","display_name":"Head injury","level":2,"score":0.47900837659835815},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.40268248319625854},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3790566921234131},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.26365864276885986},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17680951952934265},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.14333024621009827},{"id":"https://openalex.org/C111774379","wikidata":"https://www.wikidata.org/wiki/Q1364253","display_name":"Autoregulation","level":3,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1186/2110-5820-3-23","doi":"https://doi.org/10.1186/2110-5820-3-23","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2110-5820-3-23","pdf_url":"https://annalsofintensivecare.springeropen.com/counter/pdf/10.1186/2110-5820-3-23","source":{"id":"https://openalex.org/S113872774","display_name":"Annals of Intensive Care","issn_l":"2110-5820","issn":["2110-5820"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Intensive Care","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2712270","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3716965","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3716965","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3716965","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Intensive Care","raw_type":"Text"},{"id":"pmid:23837598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23837598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of intensive care","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unil.ch:iris/150979","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/150979","pdf_url":"https://iris.unil.ch/bitstreams/7de376ab-0b8a-470c-b66a-42a841ae48cf/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"review article"},{"id":"pmh:oai:serval.unil.ch:BIB_775E80005E61","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_775E80005E61","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annals of Intensive Care, vol. 3, no. 1, pp. 23","raw_type":"info:eu-repo/semantics/review"}],"best_oa_location":{"id":"doi:10.1186/2110-5820-3-23","doi":"https://doi.org/10.1186/2110-5820-3-23","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2110-5820-3-23","pdf_url":"https://annalsofintensivecare.springeropen.com/counter/pdf/10.1186/2110-5820-3-23","source":{"id":"https://openalex.org/S113872774","display_name":"Annals of Intensive Care","issn_l":"2110-5820","issn":["2110-5820"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Intensive Care","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104099050.pdf","grobid_xml":"https://content.openalex.org/works/W2104099050.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1725828360","https://openalex.org/W1965821059","https://openalex.org/W1965927651","https://openalex.org/W1977330056","https://openalex.org/W1979822267","https://openalex.org/W1981457277","https://openalex.org/W1983678801","https://openalex.org/W1987537450","https://openalex.org/W1987580762","https://openalex.org/W1989684538","https://openalex.org/W1990226314","https://openalex.org/W1995096028","https://openalex.org/W1996865048","https://openalex.org/W1998399203","https://openalex.org/W2000167387","https://openalex.org/W2005333810","https://openalex.org/W2012353054","https://openalex.org/W2013171562","https://openalex.org/W2023341621","https://openalex.org/W2024283264","https://openalex.org/W2024601722","https://openalex.org/W2025332003","https://openalex.org/W2026737478","https://openalex.org/W2026779231","https://openalex.org/W2028546276","https://openalex.org/W2030406076","https://openalex.org/W2031375851","https://openalex.org/W2035331998","https://openalex.org/W2039361265","https://openalex.org/W2040664092","https://openalex.org/W2040691484","https://openalex.org/W2044777557","https://openalex.org/W2046836745","https://openalex.org/W2047296068","https://openalex.org/W2050773908","https://openalex.org/W2053550239","https://openalex.org/W2053620856","https://openalex.org/W2053833290","https://openalex.org/W2056934253","https://openalex.org/W2060646342","https://openalex.org/W2060797100","https://openalex.org/W2064877107","https://openalex.org/W2066748433","https://openalex.org/W2067448822","https://openalex.org/W2069758762","https://openalex.org/W2072019643","https://openalex.org/W2075126103","https://openalex.org/W2075596177","https://openalex.org/W2077225709","https://openalex.org/W2077472616","https://openalex.org/W2082498537","https://openalex.org/W2084904591","https://openalex.org/W2085509818","https://openalex.org/W2087394638","https://openalex.org/W2088344008","https://openalex.org/W2093569692","https://openalex.org/W2099030487","https://openalex.org/W2101577668","https://openalex.org/W2102297199","https://openalex.org/W2105220251","https://openalex.org/W2107450931","https://openalex.org/W2111466276","https://openalex.org/W2111786117","https://openalex.org/W2114864200","https://openalex.org/W2116910933","https://openalex.org/W2117825985","https://openalex.org/W2119224033","https://openalex.org/W2124888829","https://openalex.org/W2128712943","https://openalex.org/W2131465096","https://openalex.org/W2154073619","https://openalex.org/W2157625978","https://openalex.org/W2169100471","https://openalex.org/W2314905115","https://openalex.org/W2316395717","https://openalex.org/W2396068658"],"related_works":["https://openalex.org/W4308998127","https://openalex.org/W4385251423","https://openalex.org/W2913750002","https://openalex.org/W2236868822","https://openalex.org/W2984112102","https://openalex.org/W2942617215","https://openalex.org/W2980890833","https://openalex.org/W4220884864","https://openalex.org/W2097581252","https://openalex.org/W2095912926"],"abstract_inverted_index":{"Monitoring":[0],"and":[1,7,61,63,85,89,130,140,160,162,175,204,211,215],"management":[2,96,152],"of":[3,15,25,33,65,76,83,143,153,171,184,193,198],"intracranial":[4],"pressure":[5,10],"(ICP)":[6],"cerebral":[8,45,55,67,128,200],"perfusion":[9],"(CPP)":[11],"is":[12,48],"a":[13,51,99,164],"standard":[14,103],"care":[16,183],"after":[17,202],"traumatic":[18],"brain":[19,28,112,121,124,155,176,221,224],"injury":[20,84],"(TBI).":[21],"However,":[22],"the":[23,31,40,72,81,141,147,151,169,194,219],"pathophysiology":[24],"so-called":[26,119],"secondary":[27,111,154,199],"injury,":[29],"i.e.,":[30],"cascade":[32],"potentially":[34],"deleterious":[35],"events":[36],"that":[37,118],"occur":[38],"in":[39],"early":[41],"phase":[42],"following":[43],"initial":[44],"insult-after":[46],"TBI,":[47],"complex,":[49],"involving":[50],"subtle":[52],"interplay":[53,78],"between":[54],"blood":[56],"flow":[57],"(CBF),":[58],"oxygen":[59,126,173,214],"delivery":[60,142],"utilization,":[62],"supply":[64,178,217],"main":[66],"energy":[68,177,216],"substrates":[69],"(glucose)":[70],"to":[71,109,137,208,218],"injured":[73,220],"brain.":[74],"Regulation":[75],"this":[77,93],"depends":[79],"on":[80],"type":[82],"may":[86,106,179],"vary":[87],"individually":[88],"over":[90],"time.":[91],"In":[92],"setting,":[94],"patient":[95],"can":[97],"be":[98],"challenging":[100],"task,":[101],"where":[102],"ICP/CPP":[104],"monitoring":[105],"become":[107],"insufficient":[108],"prevent":[110],"injury.":[113,156,188],"Growing":[114],"clinical":[115],"evidence":[116],"demonstrates":[117],"multimodal":[120,165,223],"monitoring,":[122],"including":[123],"tissue":[125],"(PbtO2),":[127],"microdialysis":[129],"transcranial":[131],"Doppler":[132],"among":[133],"others,":[134],"might":[135],"help":[136],"optimize":[138,209],"CBF":[139,210],"oxygen/energy":[144],"substrate":[145],"at":[146],"bedside,":[148],"thereby":[149],"improving":[150],"Looking":[157],"beyond":[158],"ICP":[159],"CPP,":[161],"applying":[163],"therapeutic":[166],"approach":[167],"for":[168],"optimization":[170],"CBF,":[172],"delivery,":[174],"eventually":[180],"improve":[181],"overall":[182],"patients":[185],"with":[186],"head":[187],"This":[189],"review":[190],"summarizes":[191],"some":[192],"important":[195],"pathophysiological":[196],"determinants":[197],"damage":[201],"TBI":[203],"discusses":[205],"novel":[206],"approaches":[207],"provide":[212],"adequate":[213],"using":[222],"monitoring.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
