{"id":"https://openalex.org/W2104096969","doi":null,"title":"Association of factor V gene polymorphisms (Leiden; Cambridge; Hong Kong and HR2 haplotype) with recurrent idiopathic pregnancy loss in Tunisia. A case-control study.","display_name":"Association of factor V gene polymorphisms (Leiden; Cambridge; Hong Kong and HR2 haplotype) with recurrent idiopathic pregnancy loss in Tunisia. A case-control study.","publication_year":2006,"publication_date":"2006-04-01","ids":{"openalex":"https://openalex.org/W2104096969","mag":"2104096969","pmid":"https://pubmed.ncbi.nlm.nih.gov/16601830"},"language":"en","primary_location":{"id":"pmid:16601830","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16601830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and haemostasis","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017076689","display_name":"Walid Zammiti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Walid Zammiti","raw_affiliation_strings":["Research Unit of Haematological and Autoimmune Diseases, Faculty of Pharmacy, Monastir, Center University, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit of Haematological and Autoimmune Diseases, Faculty of Pharmacy, Monastir, Center University, Tunisia","institution_ids":["https://openalex.org/I166928557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042229393","display_name":"Nabil Mtiraoui","orcid":"https://orcid.org/0000-0003-4113-3945","observed_orcids":["https://orcid.org/0000-0003-4113-3945"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nabil Mtiraoui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022113230","display_name":"\u00c9ric Mercier","orcid":"https://orcid.org/0000-0001-7917-1918","observed_orcids":["https://orcid.org/0000-0001-7917-1918"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Mercier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114002225","display_name":"Nesrine Abboud","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nesrine Abboud","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113628694","display_name":"Sarra Saidi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarra Saidi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051791762","display_name":"Touhami Mahjoub","orcid":"https://orcid.org/0000-0002-0205-2731","observed_orcids":["https://orcid.org/0000-0002-0205-2731"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Touhami Mahjoub","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045144382","display_name":"Wassim Youssef Almawi","orcid":"https://orcid.org/0000-0003-1633-9757","observed_orcids":["https://orcid.org/0000-0003-1633-9757"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wassim Y Almawi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5075827833","display_name":"Jean\u2010Christophe Gris","orcid":"https://orcid.org/0000-0002-9899-9910","observed_orcids":["https://orcid.org/0000-0002-9899-9910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Christophe Gris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4321,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.89536927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"95","issue":"4","first_page":"612","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-v-leiden","display_name":"factor V Leiden","score":0.9639999866485596},{"id":"https://openalex.org/keywords/inherited-thrombophilia","display_name":"inherited thrombophilia","score":0.9150000214576721},{"id":"https://openalex.org/keywords/recurrent-pregnancy-loss","display_name":"recurrent pregnancy loss","score":0.9269999861717224},{"id":"https://openalex.org/keywords/idiopathic-recurrent-pregnancy-loss","display_name":"idiopathic recurrent pregnancy loss","score":0.7940000295639038},{"id":"https://openalex.org/keywords/tunisian-women","display_name":"Tunisian women","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.785057783126831},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.7566872835159302},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.7311579585075378},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7029678821563721},{"id":"https://openalex.org/C2777175894","wikidata":"https://www.wikidata.org/wiki/Q185986","display_name":"Factor V Leiden","level":4,"score":0.6744488477706909},{"id":"https://openalex.org/C2780842393","wikidata":"https://www.wikidata.org/wiki/Q1570013","display_name":"Thrombophilia","level":3,"score":0.6276269555091858},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.48689189553260803},{"id":"https://openalex.org/C2776046644","wikidata":"https://www.wikidata.org/wiki/Q422831","display_name":"Factor V","level":3,"score":0.4690822660923004},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.45410406589508057},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4157496690750122},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.4149993360042572},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.40360817313194275},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3644198775291443},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36110246181488037},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.21154960989952087},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.19413641095161438},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1336737871170044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12669748067855835},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08110001683235168}],"mesh":[{"descriptor_ui":"D000026","descriptor_name":"Abortion, Habitual","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005165","descriptor_name":"Factor V","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014416","descriptor_name":"Tunisia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16601830","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16601830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and haemostasis","raw_type":"Journal Article"},{"id":"mag:2104096969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16601830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4323284219","https://openalex.org/W2970372714","https://openalex.org/W2270757840","https://openalex.org/W2039369235","https://openalex.org/W1964615575","https://openalex.org/W4393956124","https://openalex.org/W2084948493","https://openalex.org/W1976273832","https://openalex.org/W4293799827","https://openalex.org/W7203605465"],"abstract_inverted_index":{"Inherited":[0],"thrombophilia":[1],"has":[2],"been":[3],"shown":[4],"to":[5,57,148,167,208],"be":[6],"linked":[7],"with":[8,48,97,190,218,249],"fetal":[9],"loss.":[10],"We":[11],"performed":[12],"a":[13,149,232],"case-control":[14],"study":[15,117],"on":[16],"the":[17,23,75,86,124,127,170,257],"association":[18],"between":[19],"thrombosis-related":[20],"polymorphisms":[21],"in":[22,40,69,74,79,92,134],"factor":[24,128,179,221,234],"V":[25,129,180,222],"(FV)":[26],"gene":[27],"(Leiden,":[28],"Cambridge,":[29],"Hong":[30,107],"Kong;":[31],"HR2":[32,88,186,228],"haplotype)":[33],"and":[34,50,61,78,94,106,114,144,163,177,183,192,201,225],"idiopathic":[35,219],"recurrent":[36],"pregnancy":[37,59,120,154,196,238],"loss":[38,197],"(RPL)":[39],"Tunisian":[41,216],"women.":[42],"A":[43],"total":[44],"of":[45,71,81,85,118,126,142,153,159,173,195,243],"348":[46],"women":[47,53,135,217],"RPL,":[49,220],"203":[51],"control":[52],"were":[54,109,188],"studied,":[55],"corresponding":[56],"1,250":[58],"losses":[60,121,155],"1,200":[62],"successful":[63],"pregnancies.":[64],"FV":[65,87,104,185,227],"Leiden":[66,130,181,223],"was":[67,90,132],"seen":[68],"19.4%":[70],"patients":[72,93,100,113],"(4.3%":[73],"homozygous":[76,99,178,184,226],"state)":[77],"5.5%":[80],"controls.":[82,115],"The":[83,116],"prevalence":[84],"haplotype":[89,229],"similar":[91],"controls,":[95],"but":[96,245],"7":[98,140],"for":[101,235],"1":[102],"control.":[103],"Cambridge":[105],"Kong":[108],"absent":[110],"from":[111,169,256],"both":[112],"all":[119],"evidenced":[122],"that":[123],"frequency":[125],"polymorphism":[131,224],"zero":[133],"who":[136],"had":[137],"mis-carried":[138],"before":[139,240],"weeks":[141,158,161,165,199,206,242],"gestation,":[143,244],"then":[145,210],"sharply":[146],"increased":[147,204],"plateau.":[150],"After":[151],"categorization":[152],"(before":[156],"8":[157,162,200,241],"gestation;":[160],"9;":[164],"10":[166,207],"12;":[168],"13th":[171],"week":[172,213,259],"gestation":[174],"onwards),":[175],"heterozygous":[176],"polymorphisms,":[182],"haplotype,":[187],"associated":[189,248],"significant":[191,250],"independent":[193],"risks":[194],"during":[198,205],"9,":[202],"which":[203,253],"12,":[209],"culminated":[211],"after":[212],"12.":[214],"In":[215],"are":[230,246],"not":[231],"risk":[233],"very":[236],"early":[237],"loss,":[239],"thereafter":[247],"clinical":[251],"risks,":[252],"gradually":[254],"increase":[255],"8th":[258],"onwards.":[260]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}