{"id":"https://openalex.org/W2104090417","doi":null,"title":"Identification of mutagenic metabolites formed by C-hydroxylation and nitroreduction of 5-nitroacenaphthene in rat liver.","display_name":"Identification of mutagenic metabolites formed by C-hydroxylation and nitroreduction of 5-nitroacenaphthene in rat liver.","publication_year":1982,"publication_date":"1982-04-01","ids":{"openalex":"https://openalex.org/W2104090417","mag":"2104090417","pmid":"https://pubmed.ncbi.nlm.nih.gov/7060001"},"language":"en","primary_location":{"id":"pmid:7060001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7060001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080527856","display_name":"Karam El\u2010Bayoumy","orcid":"https://orcid.org/0000-0002-4198-0696","observed_orcids":["https://orcid.org/0000-0002-4198-0696"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K EL-Bayoumy","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033402104","display_name":"Stephen S. Hecht","orcid":"https://orcid.org/0000-0001-7228-1356","observed_orcids":["https://orcid.org/0000-0001-7228-1356"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S S Hecht","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":null,"apc_paid":null,"fwci":2.499,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.89504243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"42","issue":"4","first_page":"1243","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.11620000004768372,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutagenic-metabolites","display_name":"mutagenic metabolites","score":0.8759999871253967},{"id":"https://openalex.org/keywords/nitro-group-reduction","display_name":"nitro group reduction","score":0.996999979019165},{"id":"https://openalex.org/keywords/liver-microsomal-metabolism","display_name":"liver microsomal metabolism","score":0.6240000128746033},{"id":"https://openalex.org/keywords/salmonella-typhimurium-ta98","display_name":"Salmonella typhimurium TA98","score":0.8690000176429749},{"id":"https://openalex.org/keywords/polycyclic-aromatic-nitro-compounds","display_name":"polycyclic aromatic nitro compounds","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.7704737186431885},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7702134251594543},{"id":"https://openalex.org/C2776639595","wikidata":"https://www.wikidata.org/wiki/Q221696","display_name":"Mutagen","level":3,"score":0.7623437643051147},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.7363145351409912},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.6407355070114136},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6207163333892822},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5068619847297668},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.49993324279785156},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.33507245779037476},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25706416368484497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18540921807289124},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0915338397026062},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073","descriptor_name":"Acenaphthenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006900","descriptor_name":"Hydroxylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7060001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7060001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2104090417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7060001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W571579047","https://openalex.org/W1482213000","https://openalex.org/W1968079518","https://openalex.org/W1982861869","https://openalex.org/W1989410778","https://openalex.org/W1994262605","https://openalex.org/W1996197564","https://openalex.org/W1998250879","https://openalex.org/W1999870189","https://openalex.org/W2065342803","https://openalex.org/W2336107198","https://openalex.org/W2625488208"],"related_works":["https://openalex.org/W2416416873","https://openalex.org/W2091740586","https://openalex.org/W2088098360","https://openalex.org/W1988790147","https://openalex.org/W1994571068","https://openalex.org/W1658067342","https://openalex.org/W2005222826","https://openalex.org/W2004793476","https://openalex.org/W1991416716","https://openalex.org/W2098248348"],"abstract_inverted_index":{"The":[0,22,94],"metabolism":[1],"of":[2,17,50,97,106,129,134,141,148],"the":[3,9,15,74,98,102,121,127,137,145],"mutagen":[4],"and":[5,28,36,41,43,47,52,56,79,81,115,139,143],"carcinogen,":[6],"5-nitroacenaphthene,":[7],"by":[8],"9000":[10,109,122],"x":[11,110,123],"g":[12,111,124],"supernatant":[13,125],"from":[14,126],"livers":[16,128],"Aroclor-pretreated":[18,130],"rats":[19,131],"was":[20,58],"studied.":[21],"major":[23,75],"primary":[24],"metabolites":[25,31,76,84,99],"were":[26,32,63,77,85,113],"1-hydroxy-5-nitroacenaphthene":[27,114],"2-hydroxy-5-nitroacenaphthene.":[29],"These":[30,117],"oxidized":[33],"to":[34,39,45,54],"1-oxo-5-nitroacenaphthene":[35],"2-oxo-5-nitroacenaphthene,":[37],"hydroxylated":[38],"cis-1,2-dihydroxy-5-nitroacenaphthene":[40],"trans-1,2-dihydroxy-5-nitroacenaphthene,":[42],"reduced":[44,146],"1-hydroxy-5-aminoacenaphthene":[46],"2-hydroxy-5-aminoacenaphthene.":[48],"Reduction":[49],"1-":[51],"2-oxo-5-nitroacenaphthene":[53,155],"1-oxo-":[55,153],"2-oxo-5-aminoacenaphthene":[57],"also":[59],"observed.":[60],"When":[61],"incubations":[62],"carried":[64],"out":[65],"in":[66,72,101],"a":[67],"N2-enriched":[68],"atmosphere":[69],"(10%":[70],"O2":[71],"N2),":[73],"1-hydroxy-":[78,149],"2-hydroxy-5-nitroacenaphthene":[80],"2-oxo-5-aminoacenaphthene.":[82],"Selected":[83],"tested":[86],"for":[87],"mutagenicity":[88],"toward":[89],"Salmonella":[90],"typhimurium":[91],"TA":[92],"98.":[93],"most":[95],"mutagenic":[96],"tested,":[100],"presence":[103],"or":[104,150,152,154],"absence":[105],"rat":[107],"liver":[108],"supernatant,":[112],"1-oxo-5-nitroacenaphthene.":[116],"results":[118],"indicate":[119],"that":[120,144],"is":[132],"capable":[133],"catalyzing":[135],"both":[136],"oxidation":[138],"reduction":[140],"5-nitroacenaphthene":[142],"derivatives":[147],"2-hydroxy-":[151],"are":[156],"proximate":[157],"mutagens.":[158]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}