{"id":"https://openalex.org/W2104082467","doi":"https://doi.org/10.1111/j.1467-7652.2010.00552.x","title":"Production of biologically active recombinant human factor H in Physcomitrella","display_name":"Production of biologically active recombinant human factor H in Physcomitrella","publication_year":2010,"publication_date":"2010-08-17","ids":{"openalex":"https://openalex.org/W2104082467","doi":"https://doi.org/10.1111/j.1467-7652.2010.00552.x","mag":"2104082467","pmid":"https://pubmed.ncbi.nlm.nih.gov/20723134"},"language":"en","primary_location":{"id":"doi:10.1111/j.1467-7652.2010.00552.x","doi":"https://doi.org/10.1111/j.1467-7652.2010.00552.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1467-7652.2010.00552.x","pdf_url":null,"source":{"id":"https://openalex.org/S36510773","display_name":"Plant Biotechnology Journal","issn_l":"1467-7644","issn":["1467-7644","1467-7652"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Biotechnology Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062069457","display_name":"Annette B\u00fcttner\u2010Mainik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Annette B\u00fcttner\u2010Mainik","raw_affiliation_strings":["Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048247629","display_name":"Juliana Parsons","orcid":"https://orcid.org/0000-0001-6261-2342","observed_orcids":["https://orcid.org/0000-0001-6261-2342"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Juliana Parsons","raw_affiliation_strings":["Centre for Biological Signalling Studies (BIOSS), Freiburg, Germany","Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Biological Signalling Studies (BIOSS), Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055006997","display_name":"H. Kim Jerome","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hanna J\u00e9r\u00f4me","raw_affiliation_strings":["Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056954068","display_name":"Andrea Hartmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andrea Hartmann","raw_affiliation_strings":["Department Infection Biology, Leibniz Institute for Natural Product Research and Infectionbiology \u2013 Hans Knoell Institute, Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Infection Biology, Leibniz Institute for Natural Product Research and Infectionbiology \u2013 Hans Knoell Institute, Jena, Germany","institution_ids":["https://openalex.org/I4210162077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111163706","display_name":"Stephanie Lamer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephanie Lamer","raw_affiliation_strings":["Core Facility Proteomics, Centre for Systems Biology (ZBSA), Freiburg, Germany","Feiburg Initiative for Systems Biology (FRISYS), Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Facility Proteomics, Centre for Systems Biology (ZBSA), Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Feiburg Initiative for Systems Biology (FRISYS), Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088000243","display_name":"Andreas Schaaf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Schaaf","raw_affiliation_strings":["Current address: greenovation Biotech, 79111 Freiburg, Germany","Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: greenovation Biotech, 79111 Freiburg, Germany","institution_ids":[]},{"raw_affiliation_string":"Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050331440","display_name":"Andreas Schl\u00f6sser","orcid":"https://orcid.org/0000-0003-0612-9932","observed_orcids":["https://orcid.org/0000-0003-0612-9932"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Schlosser","raw_affiliation_strings":["Core Facility Proteomics, Centre for Systems Biology (ZBSA), Freiburg, Germany","Feiburg Initiative for Systems Biology (FRISYS), Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Facility Proteomics, Centre for Systems Biology (ZBSA), Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Feiburg Initiative for Systems Biology (FRISYS), Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067381987","display_name":"Peter F. Zipfel","orcid":"https://orcid.org/0000-0002-6149-2411","observed_orcids":["https://orcid.org/0000-0002-6149-2411"]},"institutions":[{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter F. Zipfel","raw_affiliation_strings":["Department Infection Biology, Leibniz Institute for Natural Product Research and Infectionbiology \u2013 Hans Knoell Institute, Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Infection Biology, Leibniz Institute for Natural Product Research and Infectionbiology \u2013 Hans Knoell Institute, Jena, Germany","institution_ids":["https://openalex.org/I4210162077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002023600","display_name":"Ralf Reski A","orcid":"https://orcid.org/0000-0002-5496-6711","observed_orcids":["https://orcid.org/0000-0002-5496-6711"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Reski","raw_affiliation_strings":["Centre for Biological Signalling Studies (BIOSS), Freiburg, Germany","Feiburg Initiative for Systems Biology (FRISYS), Freiburg, Germany","Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Biological Signalling Studies (BIOSS), Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Feiburg Initiative for Systems Biology (FRISYS), Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086885538","display_name":"Eva L. Decker","orcid":"https://orcid.org/0000-0002-9151-1361","observed_orcids":["https://orcid.org/0000-0002-9151-1361"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Eva L. Decker","raw_affiliation_strings":["Centre for Biological Signalling Studies (BIOSS), Freiburg, Germany","Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Biological Signalling Studies (BIOSS), Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086885538"],"corresponding_institution_ids":["https://openalex.org/I161046081"],"apc_list":{"value":4320,"currency":"USD","value_usd":4320},"apc_paid":null,"fwci":5.943,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.97252531,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":"3","first_page":"373","last_page":"383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.8700000047683716},{"id":"https://openalex.org/keywords/physcomitrella-patens","display_name":"Physcomitrella patens","score":0.9710000157356262},{"id":"https://openalex.org/keywords/complement-regulatory-proteins","display_name":"complement regulatory proteins","score":0.6439999938011169},{"id":"https://openalex.org/keywords/glycoproteins","display_name":"glycoproteins","score":0.47999998927116394},{"id":"https://openalex.org/keywords/atypical-hemolytic-uremic-syndrome","display_name":"atypical hemolytic uremic syndrome","score":0.8360000252723694},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/photobioreactors","display_name":"photobioreactors","score":0.718999981880188},{"id":"https://openalex.org/keywords/peptide-mapping","display_name":"peptide mapping","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2777907127","wikidata":"https://www.wikidata.org/wiki/Q1645541","display_name":"Physcomitrella patens","level":4,"score":0.9076525568962097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7912701368331909},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.7307858467102051},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.4979238510131836},{"id":"https://openalex.org/C10858879","wikidata":"https://www.wikidata.org/wiki/Q899790","display_name":"Signal peptide","level":4,"score":0.4593612849712372},{"id":"https://openalex.org/C145741570","wikidata":"https://www.wikidata.org/wiki/Q7251534","display_name":"Proteogenomics","level":5,"score":0.419096440076828},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4125717580318451},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33292287588119507},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3293432891368866},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32390767335891724},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2260393500328064},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13475748896598816},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.0813121497631073},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017242","descriptor_name":"Complement Factor H","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017242","descriptor_name":"Complement Factor H","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017242","descriptor_name":"Complement Factor H","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017242","descriptor_name":"Complement Factor H","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017242","descriptor_name":"Complement Factor H","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017242","descriptor_name":"Complement Factor H","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019068","descriptor_name":"Bryopsida","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019068","descriptor_name":"Bryopsida","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019068","descriptor_name":"Bryopsida","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019068","descriptor_name":"Bryopsida","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019068","descriptor_name":"Bryopsida","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019068","descriptor_name":"Bryopsida","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1467-7652.2010.00552.x","doi":"https://doi.org/10.1111/j.1467-7652.2010.00552.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1467-7652.2010.00552.x","pdf_url":null,"source":{"id":"https://openalex.org/S36510773","display_name":"Plant Biotechnology Journal","issn_l":"1467-7644","issn":["1467-7644","1467-7652"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Biotechnology Journal","raw_type":"journal-article"},{"id":"pmid:20723134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20723134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant biotechnology journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6800000071525574,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1503240365","https://openalex.org/W1522781629","https://openalex.org/W1554414803","https://openalex.org/W1561451130","https://openalex.org/W1569686393","https://openalex.org/W1578005096","https://openalex.org/W1585321302","https://openalex.org/W1604448504","https://openalex.org/W1964952835","https://openalex.org/W1965972308","https://openalex.org/W1975235665","https://openalex.org/W1975363458","https://openalex.org/W1984441574","https://openalex.org/W1992499023","https://openalex.org/W1997746165","https://openalex.org/W2000540313","https://openalex.org/W2002265100","https://openalex.org/W2002964718","https://openalex.org/W2011323677","https://openalex.org/W2023583264","https://openalex.org/W2027105364","https://openalex.org/W2034147039","https://openalex.org/W2038755858","https://openalex.org/W2047841570","https://openalex.org/W2053194563","https://openalex.org/W2059331079","https://openalex.org/W2059417186","https://openalex.org/W2060037459","https://openalex.org/W2065035248","https://openalex.org/W2068933681","https://openalex.org/W2072417552","https://openalex.org/W2076659021","https://openalex.org/W2078154253","https://openalex.org/W2079679728","https://openalex.org/W2084613632","https://openalex.org/W2084952938","https://openalex.org/W2087400516","https://openalex.org/W2088140700","https://openalex.org/W2088539994","https://openalex.org/W2099354995","https://openalex.org/W2100837269","https://openalex.org/W2103769076","https://openalex.org/W2106812885","https://openalex.org/W2109199201","https://openalex.org/W2127695738","https://openalex.org/W2129781700","https://openalex.org/W2132177439","https://openalex.org/W2133825731","https://openalex.org/W2135689611","https://openalex.org/W2142297287","https://openalex.org/W2145540059","https://openalex.org/W2146755737","https://openalex.org/W2148740955","https://openalex.org/W2153488363","https://openalex.org/W2165276694","https://openalex.org/W2165860335","https://openalex.org/W2167456385","https://openalex.org/W2171513790","https://openalex.org/W2527050689","https://openalex.org/W4244331995","https://openalex.org/W4252944381","https://openalex.org/W4296322132"],"related_works":["https://openalex.org/W2347565453","https://openalex.org/W2968156700","https://openalex.org/W2094251427","https://openalex.org/W2389875307","https://openalex.org/W2810650335","https://openalex.org/W2948159970","https://openalex.org/W4251271885","https://openalex.org/W2129836847","https://openalex.org/W2036754077","https://openalex.org/W2015382202"],"abstract_inverted_index":{"The":[0,137],"human":[1,23,123,187],"complement":[2,231],"regulatory":[3,232],"serum":[4],"protein":[5,97,106,194],"factor":[6],"H":[7],"(FH)":[8],"is":[9,51,83,107],"a":[10,52,134,200],"promising":[11,87],"future":[12],"biopharmaceutical.":[13],"Defects":[14],"in":[15,31,133,169],"the":[16,32,61,90,111,116,121,127,143,146,173,186,192,196,207,213,228],"gene":[17],"encoding":[18],"FH":[19,59,78,124,188,236],"are":[20],"associated":[21],"with":[22,65],"diseases":[24],"like":[25],"severe":[26],"kidney":[27],"and":[28,86,126,190,210],"retinal":[29],"disorders":[30],"form":[33],"of":[34,63,70,74,92,101,120,130,148,206,212],"atypical":[35],"haemolytic":[36],"uremic":[37],"syndrome":[38],"(aHUS),":[39],"membranoproliferative":[40],"glomerulonephritis":[41],"II":[42],"(MPGN":[43],"II)":[44],"or":[45,67,76],"age-related":[46],"macular":[47],"degeneration":[48],"(AMD).":[49],"There":[50],"current":[53],"need":[54,174],"to":[55,80,195,235],"apply":[56],"intact":[57],"full-length":[58,122],"for":[60,89,145,175],"therapy":[62],"patients":[64,82],"congenital":[66],"acquired":[68],"defects":[69],"this":[71,131,152],"protein.":[72],"Application":[73],"purified":[75,98,237],"recombinant":[77,105,193],"(rFH)":[79],"these":[81,93],"an":[84,158],"important":[85],"approach":[88],"treatment":[91],"diseases.":[94],"However,":[95],"neither":[96],"from":[99,238],"plasma":[100],"healthy":[102],"individuals":[103],"nor":[104],"currently":[108],"available":[109],"on":[110],"market.":[112],"Here,":[113],"we":[114,225],"report":[115],"first":[117],"stable":[118],"expression":[119],"cDNA":[125,189],"subsequent":[128],"production":[129,147],"glycoprotein":[132],"plant":[135],"system.":[136],"moss":[138,180],"Physcomitrella":[139],"patens":[140],"perfectly":[141],"suits":[142],"requirements":[144],"complex":[149],"biopharmaceuticals":[150],"as":[151],"eukaryotic":[153],"system":[154],"not":[155],"only":[156],"offers":[157],"outstanding":[159],"genetical":[160],"accessibility,":[161],"but":[162],"moreover,":[163],"proteins":[164],"can":[165],"be":[166],"produced":[167],"safely":[168],"scalable":[170],"photobioreactors":[171],"without":[172],"animal-derived":[176],"medium":[177],"compounds.":[178],"Transgenic":[179],"lines":[181],"were":[182,216],"created,":[183],"which":[184],"express":[185],"target":[191],"culture":[197],"supernatant":[198],"via":[199,218],"moss-derived":[201],"secretion":[202],"signal.":[203],"Correct":[204],"processing":[205],"signal":[208],"peptide":[209,219],"integrity":[211],"moss-produced":[214],"rFH":[215,229],"verified":[217],"mapping":[220],"by":[221],"mass":[222],"spectrometry.":[223],"Ultimately,":[224],"show":[226],"that":[227],"displays":[230],"activity":[233],"comparable":[234],"plasma.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
