{"id":"https://openalex.org/W2104079982","doi":"https://doi.org/10.3892/mco.2013.186","title":"Serological and histological indices of hepatocellular carcinoma and tumor volume doubling time","display_name":"Serological and histological indices of hepatocellular carcinoma and tumor volume doubling time","publication_year":2013,"publication_date":"2013-09-17","ids":{"openalex":"https://openalex.org/W2104079982","doi":"https://doi.org/10.3892/mco.2013.186","mag":"2104079982","pmid":"https://pubmed.ncbi.nlm.nih.gov/24649280","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3916198"},"language":"en","primary_location":{"id":"doi:10.3892/mco.2013.186","doi":"https://doi.org/10.3892/mco.2013.186","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mco.2013.186","pdf_url":"http://www.spandidos-publications.com/mco/1/6/977/download","source":{"id":"https://openalex.org/S2754683124","display_name":"Molecular and Clinical Oncology","issn_l":"2049-9450","issn":["2049-9450","2049-9469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/mco/1/6/977/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042353561","display_name":"Naoki Shingaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NAOKI SHINGAKI","raw_affiliation_strings":["Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029428902","display_name":"Hideyuki Tamai","orcid":"https://orcid.org/0000-0003-4511-4573","observed_orcids":["https://orcid.org/0000-0003-4511-4573"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIDEYUKI TAMAI","raw_affiliation_strings":["Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":null,"display_name":"YOSHIYUKI MORI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YOSHIYUKI MORI","raw_affiliation_strings":["Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014162129","display_name":"Kosaku Moribata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KOSAKU MORIBATA","raw_affiliation_strings":["Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108351160","display_name":"Shotaro Enomoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHOTARO ENOMOTO","raw_affiliation_strings":["Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018666278","display_name":"Hisanobu Deguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HISANOBU DEGUCHI","raw_affiliation_strings":["Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100624469","display_name":"Kazuki Ueda","orcid":"https://orcid.org/0000-0001-7139-4404","observed_orcids":["https://orcid.org/0000-0001-7139-4404"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KAZUKI UEDA","raw_affiliation_strings":["Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058849757","display_name":"Izumi Inoue","orcid":"https://orcid.org/0000-0002-8121-0127","observed_orcids":["https://orcid.org/0000-0002-8121-0127"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"IZUMI INOUE","raw_affiliation_strings":["Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085543480","display_name":"Takao Maekita","orcid":"https://orcid.org/0000-0002-4160-7613","observed_orcids":["https://orcid.org/0000-0002-4160-7613"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TAKAO MAEKITA","raw_affiliation_strings":["Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016567710","display_name":"Mikitaka Iguchi","orcid":"https://orcid.org/0000-0003-2579-2262","observed_orcids":["https://orcid.org/0000-0003-2579-2262"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MIKITAKA IGUCHI","raw_affiliation_strings":["Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102019311","display_name":"Jun Kato","orcid":"https://orcid.org/0000-0002-1869-2135","observed_orcids":["https://orcid.org/0000-0002-1869-2135"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"JUN KATO","raw_affiliation_strings":["Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105238401","display_name":"Masao Ichinose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MASAO ICHINOSE","raw_affiliation_strings":["Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-0012, Japan","institution_ids":["https://openalex.org/I190805021"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I190805021"],"apc_list":null,"apc_paid":null,"fwci":0.5544,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.70453095,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":97},"biblio":{"volume":"1","issue":"6","first_page":"977","last_page":"981"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-volume-doubling-time","display_name":"tumor volume doubling time","score":0.9980000257492065},{"id":"https://openalex.org/keywords/afp-l3","display_name":"AFP-L3","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.6019999980926514},{"id":"https://openalex.org/keywords/edmondson-grade","display_name":"Edmondson grade","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tumor-growth-rate","display_name":"tumor growth rate","score":0.7559999823570251},{"id":"https://openalex.org/keywords/malignant-potential","display_name":"malignant potential","score":0.6320000290870667},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/serological-markers","display_name":"serological markers","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8260562419891357},{"id":"https://openalex.org/C48900799","wikidata":"https://www.wikidata.org/wiki/Q1424376","display_name":"Doubling time","level":3,"score":0.6045017242431641},{"id":"https://openalex.org/C2779314089","wikidata":"https://www.wikidata.org/wiki/Q18026830","display_name":"HCCS","level":3,"score":0.5951058864593506},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5191123485565186},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5137695074081421},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5062590837478638},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.49451085925102234},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.43212682008743286},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4308616518974304},{"id":"https://openalex.org/C2780624289","wikidata":"https://www.wikidata.org/wiki/Q306076","display_name":"Alpha-fetoprotein","level":3,"score":0.42383503913879395},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4011078476905823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2853517234325409},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.22113662958145142},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1683349311351776},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3892/mco.2013.186","doi":"https://doi.org/10.3892/mco.2013.186","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mco.2013.186","pdf_url":"http://www.spandidos-publications.com/mco/1/6/977/download","source":{"id":"https://openalex.org/S2754683124","display_name":"Molecular and Clinical Oncology","issn_l":"2049-9450","issn":["2049-9450","2049-9469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Clinical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2937861","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3916198","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3916198","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3916198","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Clin Oncol","raw_type":"Text"},{"id":"pmid:24649280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24649280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and clinical oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/mco.2013.186","doi":"https://doi.org/10.3892/mco.2013.186","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mco.2013.186","pdf_url":"http://www.spandidos-publications.com/mco/1/6/977/download","source":{"id":"https://openalex.org/S2754683124","display_name":"Molecular and Clinical Oncology","issn_l":"2049-9450","issn":["2049-9450","2049-9469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104079982.pdf","grobid_xml":"https://content.openalex.org/works/W2104079982.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W115922021","https://openalex.org/W193043509","https://openalex.org/W1944710770","https://openalex.org/W1963747703","https://openalex.org/W1964829819","https://openalex.org/W1967917844","https://openalex.org/W1972016167","https://openalex.org/W1977043647","https://openalex.org/W1999772124","https://openalex.org/W2003567333","https://openalex.org/W2016044522","https://openalex.org/W2032660643","https://openalex.org/W2055702442","https://openalex.org/W2058719417","https://openalex.org/W2077572075","https://openalex.org/W2092013776","https://openalex.org/W2094174828","https://openalex.org/W2154355149","https://openalex.org/W2414349022","https://openalex.org/W2414987515","https://openalex.org/W2417434449","https://openalex.org/W2429744838","https://openalex.org/W6716115270"],"related_works":["https://openalex.org/W2417434449","https://openalex.org/W3025561831","https://openalex.org/W4412488130","https://openalex.org/W2747469842","https://openalex.org/W2322933182","https://openalex.org/W2890547741","https://openalex.org/W2077572075","https://openalex.org/W2124818962","https://openalex.org/W2360245188","https://openalex.org/W3090907370"],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"(HCC)":[2],"frequently":[3],"develops":[4],"in":[5,78,107,158,180,206],"cirrhotic":[6],"liver":[7],"and":[8,29,52,57,104,119,137,164,170,182,187,193,209,214,234,250,270],"is":[9,30],"one":[10],"of":[11,33,38,55,69,85,116,126,199,253],"the":[12,24,34,47,50,67,70,105,113,133,142,207,224],"most":[13],"common":[14],"malignancies":[15],"worldwide.":[16],"The":[17,41,88,151,175,201],"tumor":[18,26,71],"volume":[19],"doubling":[20,91],"time":[21,92],"(TVDT)":[22],"reflects":[23],"natural":[25],"growth":[27],"rate":[28],"an":[31],"indicator":[32],"biological":[35],"malignant":[36,273],"potential":[37],"a":[39,219,240,265,271],"tumor.":[40],"present":[42],"study":[43],"aimed":[44],"to":[45,112,263],"elucidate":[46],"association":[48],"between":[49,135,223,232],"serological":[51,248],"histological":[53,83,114,197,251],"indices":[54,249],"HCC":[56,86,117,166,184,254,268],"TVDT.":[58],"TVDT":[59,79,138,147,157,192,235],"was":[60,102,139,167,185,212,230,243],"analyzed":[61,140],"for":[62,94,121,141,145],"53":[63],"HCCs":[64,96],"by":[65],"measuring":[66],"enlargement":[68],"diameter":[72],"on":[73],"dynamic":[74],"computed":[75],"tomography.":[76],"Differences":[77],"were":[80,109,261],"compared":[81,110],"among":[82,246],"grades":[84,252],"differentiation.":[87,255],"\u03b1\u2011fetoprotein":[89,127],"(AFP)":[90],"(T2AFP)":[93],"44":[95,131],"with":[97,196,218],"AFP":[98],"levels":[99],">200":[100],"ng/ml":[101],"calculated":[103],"differences":[106],"T2AFP":[108,136,179,194,205,233,258],"according":[111],"grade":[115,160],"differentiation":[118],"positivity":[120],"Lens":[122],"culinaris":[123],"agglutinin\u2011reactive":[124],"fraction":[125],"(AFP\u2011L3).":[128],"Among":[129],"these":[130],"HCCs,":[132],"correlation":[134,229,242],"27":[143],"tumors":[144],"which":[146],"could":[148],"be":[149],"calculated.":[150],"mean":[152,176,202],"\u00b1":[153,177,203],"standard":[154],"deviation":[155],"(SD)":[156],"Edmondson":[159],"1":[161],"(Ed1),":[162],"Ed2":[163,181],"Ed3":[165,183],"138.3\u00b1110.3,":[168],"94.9\u00b191.5":[169],"32.2\u00b120.8":[171],"days,":[172,189,216],"respectively":[173,190],"(P<0.05).":[174],"SD":[178,204],"121.0\u00b1167.5":[186],"37.3\u00b124.6":[188],"(P<0.01).":[191,226],"decreased":[195],"dedifferentiation":[198],"HCC.":[200],"AFP\u2011L3\u2011positive":[208],"\u2011negative":[210],"groups":[211,225],"63.2\u00b1101.2":[213],"191.9\u00b1209.9":[215],"respectively,":[217],"statistically":[220],"significant":[221,228,241],"difference":[222],"A":[227,256],"observed":[231,245],"(correlation":[236],"coefficient,":[237],"0.70;":[238],"P<0.01).":[239],"also":[244],"TVDT,":[247],"short":[257],"and/or":[259],"AFP\u2011L3\u2011positivity":[260],"shown":[262],"reflect":[264],"poorly":[266],"differentiated":[267],"histopathology":[269],"higher":[272],"potential.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}