{"id":"https://openalex.org/W2104064820","doi":"https://doi.org/10.1158/1541-7786.mcr-10-0233","title":"Chk1-Dependent Constitutive Phosphorylation of BLM Helicase at Serine 646 Decreases after DNA Damage","display_name":"Chk1-Dependent Constitutive Phosphorylation of BLM Helicase at Serine 646 Decreases after DNA Damage","publication_year":2010,"publication_date":"2010-08-18","ids":{"openalex":"https://openalex.org/W2104064820","doi":"https://doi.org/10.1158/1541-7786.mcr-10-0233","mag":"2104064820","pmid":"https://pubmed.ncbi.nlm.nih.gov/20719863","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2941563"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.mcr-10-0233","doi":"https://doi.org/10.1158/1541-7786.mcr-10-0233","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-10-0233","pdf_url":"https://aacrjournals.org/mcr/article-pdf/8/9/1234/3146802/1234.pdf","source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/mcr/article-pdf/8/9/1234/3146802/1234.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064652073","display_name":"Sarabpreet Kaur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sarabpreet Kaur","raw_affiliation_strings":["Authors' Affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032826567","display_name":"Priyanka Modi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Priyanka Modi","raw_affiliation_strings":["Authors' Affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101996258","display_name":"Vivek Kumar Srivastava","orcid":"https://orcid.org/0000-0003-0503-1108","observed_orcids":["https://orcid.org/0000-0003-0503-1108"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vivek Srivastava","raw_affiliation_strings":["Authors' Affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057235883","display_name":"Richa Mudgal","orcid":"https://orcid.org/0000-0003-4480-3174","observed_orcids":["https://orcid.org/0000-0003-4480-3174"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Richa Mudgal","raw_affiliation_strings":["Authors' Affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054562322","display_name":"Shweta Tikoo","orcid":"https://orcid.org/0000-0001-5850-8075","observed_orcids":["https://orcid.org/0000-0001-5850-8075"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shweta Tikoo","raw_affiliation_strings":["Authors' Affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102985020","display_name":"Prateek Arora","orcid":"https://orcid.org/0000-0002-8305-3057","observed_orcids":["https://orcid.org/0000-0002-8305-3057"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prateek Arora","raw_affiliation_strings":["Authors' Affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066836332","display_name":"Debasisa Mohanty","orcid":"https://orcid.org/0000-0002-3374-0588","observed_orcids":["https://orcid.org/0000-0002-3374-0588"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Debasisa Mohanty","raw_affiliation_strings":["Authors' Affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007304513","display_name":"Sagar Sengupta","orcid":"https://orcid.org/0000-0002-6365-1770","observed_orcids":["https://orcid.org/0000-0002-6365-1770"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sagar Sengupta","raw_affiliation_strings":["Authors' Affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007304513"],"corresponding_institution_ids":["https://openalex.org/I4210156726"],"apc_list":null,"apc_paid":null,"fwci":0.6069,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.64058081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"9","first_page":"1234","last_page":"1247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blm-helicase","display_name":"BLM helicase","score":1.0},{"id":"https://openalex.org/keywords/chk1-phosphorylation","display_name":"Chk1 phosphorylation","score":0.847000002861023},{"id":"https://openalex.org/keywords/chk2","display_name":"Chk2","score":0.8019999861717224},{"id":"https://openalex.org/keywords/bloom-syndrome","display_name":"Bloom syndrome","score":0.8690000176429749},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9120000004768372},{"id":"https://openalex.org/keywords/nucleolin","display_name":"nucleolin","score":0.8330000042915344},{"id":"https://openalex.org/keywords/pml-nuclear-bodies","display_name":"PML nuclear bodies","score":0.9269999861717224},{"id":"https://openalex.org/keywords/nucleolus","display_name":"nucleolus","score":0.8349999785423279},{"id":"https://openalex.org/keywords/nbs1","display_name":"NBS1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/subnuclear-localization","display_name":"subnuclear localization","score":0.7929999828338623},{"id":"https://openalex.org/keywords/phosphopeptide-mapping","display_name":"phosphopeptide mapping","score":0.5360000133514404},{"id":"https://openalex.org/keywords/phospho-specific-antibodies","display_name":"phospho-specific antibodies","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7747937440872192},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7339473366737366},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.577948808670044},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.5743933916091919},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5645709037780762},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.540181577205658},{"id":"https://openalex.org/C2776525860","wikidata":"https://www.wikidata.org/wiki/Q18029887","display_name":"Nucleolin","level":4,"score":0.5179623365402222},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43757331371307373},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.43749889731407166},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4293721318244934},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.42165929079055786},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3292822241783142},{"id":"https://openalex.org/C183873130","wikidata":"https://www.wikidata.org/wiki/Q30869","display_name":"Nucleolus","level":3,"score":0.17579370737075806},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.09434142708778381},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09387770295143127},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.07771635055541992}],"mesh":[{"descriptor_ui":"D000071877","descriptor_name":"Checkpoint Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001816","descriptor_name":"Bloom Syndrome","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001816","descriptor_name":"Bloom Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010768","descriptor_name":"Phosphoserine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010769","descriptor_name":"Phosphothreonine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053484","descriptor_name":"RecQ Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053484","descriptor_name":"RecQ Helicases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064447","descriptor_name":"Checkpoint Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1158/1541-7786.mcr-10-0233","doi":"https://doi.org/10.1158/1541-7786.mcr-10-0233","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-10-0233","pdf_url":"https://aacrjournals.org/mcr/article-pdf/8/9/1234/3146802/1234.pdf","source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},{"id":"pmid:20719863","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20719863","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer research : MCR","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2170613","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2941563","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2941563","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2941563","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Cancer Res","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.901.2802","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.901.2802","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mcr.aacrjournals.org/content/early/2010/08/10/1541-7786.MCR-10-0233.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.907.26","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.907.26","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mcr.aacrjournals.org/content/8/9/1234.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.mcr-10-0233","doi":"https://doi.org/10.1158/1541-7786.mcr-10-0233","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-10-0233","pdf_url":"https://aacrjournals.org/mcr/article-pdf/8/9/1234/3146802/1234.pdf","source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8733893596","display_name":"Determination of regulatory mechanisms for BLM helicase","funder_award_id":"R01TW007302","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320320290","display_name":"University of Oxford","ror":"https://ror.org/052gg0110"},{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"},{"id":"https://openalex.org/F4320327259","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104064820.pdf","grobid_xml":"https://content.openalex.org/works/W2104064820.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1528493806","https://openalex.org/W1570204439","https://openalex.org/W1963563101","https://openalex.org/W1964143371","https://openalex.org/W1964622938","https://openalex.org/W1967630574","https://openalex.org/W1968676497","https://openalex.org/W1970898019","https://openalex.org/W1992564866","https://openalex.org/W2011096170","https://openalex.org/W2015403140","https://openalex.org/W2017168705","https://openalex.org/W2019396216","https://openalex.org/W2022972203","https://openalex.org/W2029304297","https://openalex.org/W2030639168","https://openalex.org/W2033016953","https://openalex.org/W2035692319","https://openalex.org/W2045305010","https://openalex.org/W2045892846","https://openalex.org/W2050860701","https://openalex.org/W2059971436","https://openalex.org/W2082559623","https://openalex.org/W2085037886","https://openalex.org/W2095362443","https://openalex.org/W2096053293","https://openalex.org/W2103533613","https://openalex.org/W2109610280","https://openalex.org/W2117613018","https://openalex.org/W2123476709","https://openalex.org/W2124204427","https://openalex.org/W2132610154","https://openalex.org/W2132717858","https://openalex.org/W2134129243","https://openalex.org/W2135381292","https://openalex.org/W2137852592","https://openalex.org/W2141934899","https://openalex.org/W2142676108","https://openalex.org/W2150694543","https://openalex.org/W2166288313","https://openalex.org/W2169364535","https://openalex.org/W2326160172","https://openalex.org/W2916483810"],"related_works":["https://openalex.org/W7100551629","https://openalex.org/W7099763752","https://openalex.org/W7042674011","https://openalex.org/W2141934899","https://openalex.org/W2127033334","https://openalex.org/W1547049148","https://openalex.org/W1977126501","https://openalex.org/W2095362443","https://openalex.org/W2610391874","https://openalex.org/W7095297932"],"abstract_inverted_index":{"BLM":[0,17,59,87,102,124,142,151,161,198,220],"helicase,":[1],"the":[2,44,55,62,72,119,138,154,164,172,181,216],"protein":[3],"mutated":[4],"in":[5,10,68,96,105,137,153,221],"Bloom":[6],"syndrome,":[7],"is":[8,18],"involved":[9],"signal":[11],"transduction":[12],"cascades":[13],"after":[14,27,130],"DNA":[15,133,167,224],"damage.":[16,134,225],"phosphorylated":[19,43],"on":[20,88,101,123,197],"multiple":[21],"residues":[22],"by":[23,98,107],"different":[24],"kinases":[25],"either":[26],"stress":[28],"induction":[29],"or":[30],"during":[31],"mitosis.":[32],"Here,":[33],"we":[34,80],"have":[35],"provided":[36],"evidence":[37],"that":[38,82,118,180,194],"both":[39],"Chk1":[40,73,83],"and":[41,75,104,127,145,148,156,169,185,209],"Chk2":[42],"NH(2)-terminal":[45,64],"660":[46],"amino":[47],"acids":[48],"of":[49,58,109,141,166,219],"BLM.":[50],"An":[51],"internal":[52],"region":[53],"within":[54],"DExH":[56],"motif":[57],"negatively":[60],"regulated":[61],"Chk1/Chk2-dependent":[63],"phosphorylation":[65,120,196],"event.":[66],"Using":[67],"silico":[69],"analysis":[70,100,178],"involving":[71],"structure":[74],"its":[76],"known":[77],"substrate":[78],"specificity,":[79],"predicted":[81],"should":[84],"preferentially":[85],"phosphorylate":[86],"serine":[89],"646":[90],"(Ser(646)).":[91],"The":[92],"prediction":[93],"was":[94,125],"validated":[95],"vitro":[97],"phosphopeptide":[99],"mutants":[103],"vivo":[106],"usage":[108],"a":[110,203,213],"newly":[111],"generated":[112],"phosphospecific":[113],"polyclonal":[114],"antibody.":[115],"We":[116],"showed":[117],"at":[121,199],"Ser(646)":[122,189,200],"constitutive":[126],"decreased":[128,150],"rapidly":[129],"exposure":[131],"to":[132,163,183,223],"This":[135],"resulted":[136],"diminished":[139],"interaction":[140],"with":[143,171],"nucleolin":[144,184],"PML":[146,157,186],"isoforms,":[147],"consequently":[149],"accumulation":[152],"nucleolus":[155],"nuclear":[158],"bodies.":[159],"Instead,":[160],"relocalized":[162],"sites":[165],"damage":[168,173],"bound":[170],"sensor":[174],"protein,":[175],"Nbs1.":[176],"Mutant":[177],"confirmed":[179],"binding":[182],"isoforms":[187],"required":[188],"phosphorylation.":[190],"These":[191],"results":[192],"indicated":[193],"Chk1-mediated":[195],"might":[201],"be":[202],"determinant":[204],"for":[205,215],"regulating":[206],"subnuclear":[207],"localization":[208],"could":[210],"act":[211],"as":[212],"marker":[214],"activation":[217],"status":[218],"response":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}