{"id":"https://openalex.org/W2103993246","doi":"https://doi.org/10.1097/00000542-200612000-00017","title":"Influence of Mannitol and Furosemide, Alone and in Combination, on Brain Water Content after Fluid Percussion Injury","display_name":"Influence of Mannitol and Furosemide, Alone and in Combination, on Brain Water Content after Fluid Percussion Injury","publication_year":2006,"publication_date":"2006-11-18","ids":{"openalex":"https://openalex.org/W2103993246","doi":"https://doi.org/10.1097/00000542-200612000-00017","mag":"2103993246","pmid":"https://pubmed.ncbi.nlm.nih.gov/17122580"},"language":"en","primary_location":{"id":"doi:10.1097/00000542-200612000-00017","doi":"https://doi.org/10.1097/00000542-200612000-00017","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000542-200612000-00017","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020070598","display_name":"Michael M. Todd","orcid":"https://orcid.org/0000-0003-1531-5825","observed_orcids":["https://orcid.org/0000-0003-1531-5825"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael\u00a0M. Todd","raw_affiliation_strings":["Professor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006522457","display_name":"Johann Cutkomp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johann Cutkomp","raw_affiliation_strings":["Research Assistant III"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Assistant III","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110277056","display_name":"Johnny E. Brian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johnny\u00a0E. Brian","raw_affiliation_strings":["Associate Professor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2296,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.64541045,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"105","issue":"6","first_page":"1176","last_page":"1181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mannitol","display_name":"mannitol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/furosemide","display_name":"furosemide","score":1.0},{"id":"https://openalex.org/keywords/brain-water-content","display_name":"brain water content","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.8069999814033508},{"id":"https://openalex.org/keywords/fluid-percussion-injury","display_name":"fluid percussion injury","score":0.9649999737739563},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.8769999742507935},{"id":"https://openalex.org/keywords/plasma-osmolality","display_name":"plasma osmolality","score":0.878000020980835},{"id":"https://openalex.org/keywords/intracranial-pressure","display_name":"intracranial pressure","score":0.9210000038146973},{"id":"https://openalex.org/keywords/osmotic-diuretics","display_name":"osmotic diuretics","score":0.8059999942779541},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2777955127","wikidata":"https://www.wikidata.org/wiki/Q388801","display_name":"Furosemide","level":2,"score":0.9479675889015198},{"id":"https://openalex.org/C2778445172","wikidata":"https://www.wikidata.org/wiki/Q407646","display_name":"Mannitol","level":2,"score":0.9121029376983643},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6265078783035278},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.49197861552238464},{"id":"https://openalex.org/C14705128","wikidata":"https://www.wikidata.org/wiki/Q643555","display_name":"Osmole","level":2,"score":0.47242438793182373},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30461978912353516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2463482916355133},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11409473419189453}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001784","descriptor_name":"Blood Gas Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001784","descriptor_name":"Blood Gas Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001784","descriptor_name":"Blood Gas Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001834","descriptor_name":"Body Water","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001834","descriptor_name":"Body Water","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001834","descriptor_name":"Body Water","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004232","descriptor_name":"Diuretics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004232","descriptor_name":"Diuretics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004232","descriptor_name":"Diuretics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005665","descriptor_name":"Furosemide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005665","descriptor_name":"Furosemide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005665","descriptor_name":"Furosemide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008353","descriptor_name":"Mannitol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008353","descriptor_name":"Mannitol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008353","descriptor_name":"Mannitol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000542-200612000-00017","doi":"https://doi.org/10.1097/00000542-200612000-00017","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000542-200612000-00017","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:17122580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17122580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7200000286102295,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1963558614","https://openalex.org/W1972377977","https://openalex.org/W1976369938","https://openalex.org/W1978711320","https://openalex.org/W1983700796","https://openalex.org/W1991564967","https://openalex.org/W2010601983","https://openalex.org/W2010959301","https://openalex.org/W2021702457","https://openalex.org/W2024735581","https://openalex.org/W2035794401","https://openalex.org/W2041121895","https://openalex.org/W2048281702","https://openalex.org/W2051600991","https://openalex.org/W2064598460","https://openalex.org/W2082262065","https://openalex.org/W2091012631","https://openalex.org/W2094895928","https://openalex.org/W2106857790","https://openalex.org/W2114015880","https://openalex.org/W2124755030","https://openalex.org/W2147783395","https://openalex.org/W2155741230","https://openalex.org/W2163221092","https://openalex.org/W2408261199","https://openalex.org/W2913976147"],"related_works":["https://openalex.org/W1972377977","https://openalex.org/W2320985738","https://openalex.org/W2014301133","https://openalex.org/W1976369938","https://openalex.org/W1997431921","https://openalex.org/W1987564432","https://openalex.org/W2334041505","https://openalex.org/W1040252799","https://openalex.org/W45288573","https://openalex.org/W2048281702"],"abstract_inverted_index":{"BACKGROUND:":[0],"Furosemide":[1],"and":[2,29,32,56,101,134,150,197,255,262],"mannitol":[3,77,85,133,153,234,248],"are":[4],"used":[5],"to":[6,47,113,138,189,211],"reduce":[7],"intracranial":[8],"pressure,":[9],"but":[10],"the":[11,25,130,166,173,202,260,266],"impact":[12,142],"of":[13,17,27,74,132,162,259,271],"furosemide":[14,28,135,238,272],"on":[15,35,221],"edema":[16],"injured":[18,261],"brain":[19,36],"is":[20],"unclear.":[21],"The":[22,159],"authors":[23,267],"examined":[24],"effects":[26,131],"mannitol,":[30,146],"alone":[31,276],"in":[33,39,165,172,201,228,278],"combination,":[34],"water":[37,103,160,199,224,227,257],"content":[38,104,161,200,258],"brain-injured":[40],"rats.":[41],"METHODS:":[42],"Anesthetized":[43],"rats":[44],"were":[45,111,136],"subjected":[46,112],"a":[48,72],"2.2-atm":[49],"left":[50,203],"hemispheric":[51,102],"fluid":[52],"percussion":[53],"injury.":[54],"Two":[55],"three-quarters":[57],"hours":[58],"later,":[59],"animals":[60,110,229],"received":[61],"0.5,":[62],"1,":[63],"4,":[64],"or":[65,82,120,223,277],"8":[66,69,83,87,144,147,151,155,181,216,232,236,246],"g/kg":[67,76,84,145,152,233,247],"mannitol;":[68],"mg/kg":[70,80,88,148,156,237],"furosemide;":[71,81],"combination":[73,279],"4":[75,79,188],"plus":[78,86,154,235],"furosemide.":[89,157],"One":[90],"hour":[91],"later":[92],"(4":[93],"h":[94],"after":[95],"injury),":[96],"plasma":[97,253],"osmolality":[98,184,222,254],"was":[99,105,169],"measured,":[100],"determined":[106],"by":[107],"drying.":[108],"Other":[109],"injury":[114,124],"without":[115],"drug":[116],"treatment":[117],"(impact":[118,209],"only)":[119,210],"did":[121,239],"not":[122,240],"undergo":[123],"(control).":[125],"Pairwise":[126],"group":[127,168,175],"comparisons":[128],"regarding":[129],"restricted":[137],"only":[139],"four":[140],"groups:":[141],"only,":[143],"furosemide,":[149],"RESULTS:":[158],"both":[163],"hemispheres":[164],"impact-only":[167],"greater":[170,177],"than":[171,178],"control":[174],"(left":[176],"right).":[179],"Mannitol,":[180],"g/kg,":[182],"increased":[183,252],"from":[185,205,242],"306":[186],"+/-":[187,191,195,207,213],"351":[190],"6":[192],"mOsm/kg":[193],"(mean":[194],"SD)":[196],"reduced":[198,256],"hemisphere":[204],"80.06":[206],"0.84%":[208],"78.24":[212],"0.73%.":[214],"Furosemide,":[215],"mg/kg,":[217],"had":[218],"no":[219,269],"effect":[220,270],"content.":[225],"Brain":[226],"treated":[230],"with":[231,245,280],"differ":[241],"that":[243],"seen":[244],"alone.":[249],"CONCLUSIONS:":[250],"Mannitol":[251],"contralateral":[263],"hemispheres,":[264],"whereas":[265],"observed":[268],"when":[273],"given":[274],"either":[275],"mannitol.":[281]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}