{"id":"https://openalex.org/W2103974910","doi":"https://doi.org/10.1016/j.juro.2013.02.2966","title":"1487 PERSISTENT PROSTATE CANCER IN PATIENTS TREATED WITH PROSTATE RADIOTHERAPY WHO SUBSEQUENTLY UNDERGO RADICAL CYSTOPROSTATECTOMY FOR BLADDER CANCER","display_name":"1487 PERSISTENT PROSTATE CANCER IN PATIENTS TREATED WITH PROSTATE RADIOTHERAPY WHO SUBSEQUENTLY UNDERGO RADICAL CYSTOPROSTATECTOMY FOR BLADDER CANCER","publication_year":2013,"publication_date":"2013-03-27","ids":{"openalex":"https://openalex.org/W2103974910","doi":"https://doi.org/10.1016/j.juro.2013.02.2966","mag":"2103974910"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2013.02.2966","doi":"https://doi.org/10.1016/j.juro.2013.02.2966","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2013.02.2966","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010551367","display_name":"Joshua J. Meeks","orcid":"https://orcid.org/0000-0002-5444-5510","observed_orcids":["https://orcid.org/0000-0002-5444-5510","https://orcid.org/0000-0001-8535-5545"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joshua Meeks","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034241474","display_name":"Sean Q. Kern","orcid":"https://orcid.org/0000-0001-8753-5726","observed_orcids":["https://orcid.org/0000-0001-8753-5726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sean Kern","raw_affiliation_strings":["Honolulu, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Honolulu, HI","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081611907","display_name":"Michael J. Zel\u00e9fsky","orcid":"https://orcid.org/0000-0002-6090-6424","observed_orcids":["https://orcid.org/0000-0002-6090-6424"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Zelefsky","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015695327","display_name":"Guido M. Dalbagni","orcid":"https://orcid.org/0009-0002-2973-8159","observed_orcids":["https://orcid.org/0009-0002-2973-8159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guido Dalbagni","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112262632","display_name":"James Andrew Eastham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Eastham","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011338373","display_name":"Jaspreet S. Sandhu","orcid":"https://orcid.org/0000-0001-6590-4041","observed_orcids":["https://orcid.org/0000-0001-6590-4041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaspreet Sandhu","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18634534,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"189","issue":"4S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7699999809265137},{"id":"https://openalex.org/keywords/prostate-cancer-radiotherapy","display_name":"prostate cancer radiotherapy","score":0.6790000200271606},{"id":"https://openalex.org/keywords/radical-cystectomy","display_name":"radical cystectomy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9710000157356262},{"id":"https://openalex.org/keywords/biochemical-recurrence","display_name":"biochemical recurrence","score":0.8349999785423279},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.5600000023841858},{"id":"https://openalex.org/keywords/external-beam-radiotherapy","display_name":"external beam radiotherapy","score":0.722000002861023},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9129018783569336},{"id":"https://openalex.org/C2779693010","wikidata":"https://www.wikidata.org/wiki/Q5201279","display_name":"Cystoprostatectomy","level":5,"score":0.7850773334503174},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7517702579498291},{"id":"https://openalex.org/C2775910329","wikidata":"https://www.wikidata.org/wiki/Q245995","display_name":"Cystectomy","level":4,"score":0.6676846742630005},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6388324499130249},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.6010603904724121},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.548225462436676},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5152314305305481},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5041316747665405},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.48739057779312134},{"id":"https://openalex.org/C133507102","wikidata":"https://www.wikidata.org/wiki/Q4712977","display_name":"Genitourinary system","level":2,"score":0.439448744058609},{"id":"https://openalex.org/C2781217009","wikidata":"https://www.wikidata.org/wiki/Q4086927","display_name":"Prostate biopsy","level":4,"score":0.419522762298584},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3932362198829651},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2513718008995056},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23503705859184265}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.juro.2013.02.2966","doi":"https://doi.org/10.1016/j.juro.2013.02.2966","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2013.02.2966","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2136547352","https://openalex.org/W2312512017","https://openalex.org/W1598047779","https://openalex.org/W4392229921","https://openalex.org/W2560677833","https://openalex.org/W2591113431","https://openalex.org/W1968939952","https://openalex.org/W4383879123","https://openalex.org/W2894713544","https://openalex.org/W2098647005"],"abstract_inverted_index":{"You":[0],"have":[1],"accessJournal":[2],"of":[3,126,161,204,233,319,331,353,367,372,379,446,450,493,500,516,538],"UrologyProstate":[4],"Cancer:":[5],"Localized":[6],"(VII)1":[7],"Apr":[8],"20131487":[9],"PERSISTENT":[10],"PROSTATE":[11,17],"CANCER":[12,26],"IN":[13],"PATIENTS":[14],"TREATED":[15],"WITH":[16],"RADIOTHERAPY":[18],"WHO":[19],"SUBSEQUENTLY":[20],"UNDERGO":[21],"RADICAL":[22],"CYSTOPROSTATECTOMY":[23],"FOR":[24],"BLADDER":[25],"Joshua":[27,40,587],"Meeks,":[28],"Sean":[29,52,597],"Kern,":[30],"Michael":[31,63,606],"Zelefsky,":[32],"Guido":[33,75,616],"Dalbagni,":[34],"James":[35,87,626],"Eastham,":[36],"and":[37,99,172,194,294,300,302,333,401,423,460,463,481,486,518,565,583],"Jaspreet":[38,100,636],"Sandhu":[39,102,637],"MeeksJoshua":[41],"Meeks":[42,588],"New":[43,66,78,90,103,589,608,618,628,638],"York,":[44,67,79,91,104,590,609,619,629,639],"NY":[45,68,80,92,105,591,610,620,630,640],"More":[46,57,69,81,93,106,592,601,611,621,631,641],"articles":[47,58,70,82,94,107,593,602,612,622,632,642],"by":[48,59,71,83,95,108,152,221,243,444,560,578,594,603,613,623,633,643],"this":[49,60,72,84,96,109,595,604,614,624,634,644],"author":[50,61,73,85,97,110,596,605,615,625,635,645],",":[51,62,74,86,98],"KernSean":[53],"Kern":[54,598],"Honolulu,":[55,599],"HI":[56,600],"ZelefskyMichael":[64],"Zelefsky":[65,607],"DalbagniGuido":[76],"Dalbagni":[77,617],"EasthamJames":[88],"Eastham":[89,627],"SandhuJaspreet":[101],"View":[111],"All":[112,238,647],"Author":[113],"Informationhttps://doi.org/10.1016/j.juro.2013.02.2966AboutPDF":[114],"ToolsAdd":[115],"to":[116,157,211,340,350,359],"favoritesDownload":[117],"CitationsTrack":[118],"CitationsPermissionsReprints":[119],"ShareFacebookTwitterLinked":[120],"InEmail":[121],"INTRODUCTION":[122],"AND":[123],"OBJECTIVES":[124],"Half":[125],"men":[127,185,251,286,290,313,327,348,415,494,501,553],"with":[128,207,265,365,388,418,437,472,506,513,527,545,554],"prostate":[129,139,382,429,541],"cancer":[130,176,191,383],"(PCa)":[131],"will":[132],"choose":[133],"radiotherapy":[134,259,280],"(RT)":[135],"for":[136,170,189,346],"treatment.":[137,277,539,557],"A":[138,213],"biopsy":[140],"is":[141,150],"not":[142],"routinely":[143],"performed":[144,283],"after":[145,497],"RT":[146,169,208],"as":[147],"a":[148,201,244,329,336,370,507],"recurrence":[149,215],"determined":[151],"elevated":[153],"PSA.":[154],"We":[155,182],"sought":[156],"determine":[158],"the":[159,222,231,249,255,316,448,519,534,550],"incidence":[160],"persistent":[162,473,503],"PCa":[163,171,205,451,505,510],"in":[164,284,325,413,434,509,533,552],"patients":[165,268,368,471],"who":[166,186,199,252],"received":[167,291,305,476,479,483],"definitive":[168],"subsequently":[173],"developed":[174],"bladder":[175,190],"necessitating":[177],"radical":[178],"cystectomy":[179],"(RC).":[180],"METHODS":[181],"identified":[183,220],"78":[184,250],"underwent":[187,253],"RC":[188,254,270,351,360,387,496,551],"between":[192,209,458],"1993":[193],"2012":[195],"at":[196,386],"our":[197,491],"center":[198],"had":[200,328,335,502],"previous":[202],"history":[203,330],"treated":[206,544],"1986":[210],"2010.":[212],"biochemical":[214],"(BCR)":[216],"before":[217,454],"surgery":[218],"was":[219,260,282,321,361,384,452],"treating":[223],"physician,":[224],"PSA":[225,342,357,371],"greater":[226],"than":[227,272],"2":[228,373],"ng/ml":[229,374],"or":[230,309,375,396,405,440],"administration":[232],"androgen":[234],"deprivation":[235],"therapy":[236],"(ADT).":[237],"pathologic":[239],"specimens":[240],"were":[241,344,411,432],"evaluated":[242],"genitourinary":[245],"pathologist.":[246],"RESULTS":[247],"Of":[248,469],"median":[256,317,356],"time":[257,445],"from":[258,275],"77":[261],"months":[262,274],"(IQR":[263,363],"38-118)":[264],"only":[266],"12":[267,289],"undergoing":[269,314,495],"less":[271],"30":[273],"radiation":[276,307,320,529,556],"External":[278],"beam":[279],"(EBRT)":[281],"35":[285],"(45%),":[287],"while":[288],"brachytherapy":[292,301,487],"(15%)":[293],"24":[295],"(31%)":[296],"receiving":[297],"both":[298,484],"EBRT":[299,480,485],"6":[303,395],"(14%)":[304],"unknown":[306],"dose":[308,318,530],"type.":[310],"For":[311],"those":[312,470],"EBRT,":[315],"7020":[322],"cGY.":[323],"One":[324],"three":[326],"ADT":[332],"21%":[334],"known":[337],"BCR":[338],"prior":[339,349,358,555],"RC.":[341],"values":[343],"available":[345],"62":[347],"(80%":[352],"patients).":[354],"The":[355,377,428,540],"0.95":[362],"0.06-2.11)":[364],"24%":[366,464],"having":[369,390],"greater.":[376,441],"rate":[378],"histologic":[380],"gradable":[381,504],"45%":[385,499],"10%":[389],"ungraded":[391],"PCa,":[392,474],"14.1%":[393],"Gleason":[394,399,403,419],"less,":[397],"18%":[398],"7":[400],"13%":[402],"8":[404,420,435],"higher.":[406],"Prostate":[407],"lymph":[408],"node":[409],"metastasis":[410],"found":[412],"four":[414],"(5%)":[416],"associated":[417,512],"(2":[421,425],"men)":[422,426],"9":[424],"tumors.":[427],"surgical":[430],"margins":[431],"positive":[433],"(10%)":[436],"11.5%":[438],"pT3b":[439],"When":[442],"grouped":[443],"radiotherapy,":[447],"prevalence":[449],"100%":[453],"1980":[455,459],"(4/4),":[456],"67%":[457],"2000":[461,466],"(33/49),":[462],"since":[465],"(6/25)":[467],"(p<0.0001).":[468],"11%":[475],"brachytherapy,":[477],"70%":[478],"19%":[482],"(p=0.001).":[488],"CONCLUSIONS":[489],"In":[490],"series":[492],"RT,":[498],"decrease":[508],"rates":[511],"later":[514],"years":[515],"treatment":[517],"combined":[520],"brachytherapy/EBRT":[521],"modality.":[522],"These":[523],"findings":[524],"are":[525],"consistent":[526],"higher":[528],"levels":[531],"administered":[532],"more":[535],"recent":[536],"era":[537],"should":[542],"be":[543],"similar":[546],"oncologic":[547],"attention":[548],"during":[549],"\u00a9":[558],"2013":[559,577],"American":[561,579],"Urological":[562,580],"Association":[563,581],"Education":[564,582],"Research,":[566,584],"Inc.FiguresReferencesRelatedDetails":[567],"Volume":[568],"189Issue":[569],"4SApril":[570],"2013Page:":[571],"e610":[572],"Advertisement":[573,648,649],"Copyright":[574],"&":[575],"Permissions\u00a9":[576],"Inc.MetricsAuthor":[585],"Information":[586],"Expand":[646],"PDF":[650],"downloadLoading":[651],"...":[652]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2016-06-24T00:00:00"}